UA114911C2 - Арилетинілові похідні - Google Patents
Арилетинілові похідніInfo
- Publication number
- UA114911C2 UA114911C2 UAA201500231A UAA201500231A UA114911C2 UA 114911 C2 UA114911 C2 UA 114911C2 UA A201500231 A UAA201500231 A UA A201500231A UA A201500231 A UAA201500231 A UA A201500231A UA 114911 C2 UA114911 C2 UA 114911C2
- Authority
- UA
- Ukraine
- Prior art keywords
- formula
- derivatives
- mglur5
- enantiomer
- chlorine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Даний винахід стосується до етинілпохідних формули І EMBED ISISServer , I де R1 позначає феніл, який можливо заміщений 1-2 атомами галогену, вибраними з фтору або хлору; в енантіомерно чистому вигляді або до її фармацевтично прийнятної кислотно-адитивної солі. Було виявлено, що сполуки загальної формули І є алостеричними модуляторами метаботропних глутаматних рецепторів підтипу 5 (mGluR5).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176662 | 2012-07-17 | ||
| PCT/EP2013/064747 WO2014012851A1 (en) | 2012-07-17 | 2013-07-12 | Arylethynyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA114911C2 true UA114911C2 (uk) | 2017-08-28 |
Family
ID=48782352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201500231A UA114911C2 (uk) | 2012-07-17 | 2013-07-12 | Арилетинілові похідні |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US20150133505A1 (uk) |
| EP (1) | EP2875000B1 (uk) |
| JP (1) | JP6089104B2 (uk) |
| KR (1) | KR101631041B1 (uk) |
| CN (1) | CN104364233B (uk) |
| AR (1) | AR091764A1 (uk) |
| AU (1) | AU2013292142B2 (uk) |
| BR (1) | BR112014029015A2 (uk) |
| CA (1) | CA2871389C (uk) |
| CL (1) | CL2014003160A1 (uk) |
| CO (1) | CO7111256A2 (uk) |
| CR (1) | CR20140531A (uk) |
| CY (1) | CY1118205T1 (uk) |
| DK (1) | DK2875000T3 (uk) |
| EA (1) | EA026593B1 (uk) |
| ES (1) | ES2600133T3 (uk) |
| HK (1) | HK1202544A1 (uk) |
| HR (1) | HRP20161691T1 (uk) |
| HU (1) | HUE030177T2 (uk) |
| IL (1) | IL236362A (uk) |
| LT (1) | LT2875000T (uk) |
| MA (1) | MA20150280A2 (uk) |
| MX (1) | MX358998B (uk) |
| MY (1) | MY167810A (uk) |
| NZ (1) | NZ701849A (uk) |
| PE (1) | PE20150184A1 (uk) |
| PH (1) | PH12014502695A1 (uk) |
| PL (1) | PL2875000T3 (uk) |
| PT (1) | PT2875000T (uk) |
| RS (1) | RS55313B1 (uk) |
| SG (1) | SG11201407050UA (uk) |
| SI (1) | SI2875000T1 (uk) |
| TW (1) | TWI473799B (uk) |
| UA (1) | UA114911C2 (uk) |
| WO (1) | WO2014012851A1 (uk) |
| ZA (1) | ZA201408514B (uk) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| CN104603110B (zh) * | 2012-10-18 | 2016-08-31 | 霍夫曼-拉罗奇有限公司 | 作为mGluR5受体活性的调节剂的乙炔基衍生物 |
| AU2016273751B2 (en) | 2015-06-03 | 2020-04-02 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| CN107580598B (zh) | 2015-07-15 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 作为代谢型谷氨酸受体调节剂的乙炔基衍生物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19546462A1 (de) * | 1995-12-13 | 1997-06-19 | Bayer Ag | Diarylacetylenketone |
| ATE283258T1 (de) | 2003-05-19 | 2004-12-15 | Servier Lab | Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| KR20100033981A (ko) | 2007-06-03 | 2010-03-31 | 벤더르빌트 유니버시티 | 벤즈아미드 대사성 글루타민산염 수용체5 양성 알로스테릭 조절자 및 이의 제조 및 사용방법 |
| CN101544892B (zh) * | 2009-05-07 | 2012-10-03 | 石家庄诚志永华显示材料有限公司 | 一种合成二芳基乙炔类单体液晶的方法 |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| CA2829170C (en) * | 2011-04-26 | 2019-02-26 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
-
2013
- 2013-07-12 MY MYPI2014003059A patent/MY167810A/en unknown
- 2013-07-12 RS RS20160979A patent/RS55313B1/sr unknown
- 2013-07-12 LT LTEP13735315.7T patent/LT2875000T/lt unknown
- 2013-07-12 DK DK13735315.7T patent/DK2875000T3/en active
- 2013-07-12 PE PE2014002231A patent/PE20150184A1/es active IP Right Grant
- 2013-07-12 NZ NZ701849A patent/NZ701849A/en not_active IP Right Cessation
- 2013-07-12 UA UAA201500231A patent/UA114911C2/uk unknown
- 2013-07-12 SI SI201330415A patent/SI2875000T1/sl unknown
- 2013-07-12 PL PL13735315T patent/PL2875000T3/pl unknown
- 2013-07-12 BR BR112014029015A patent/BR112014029015A2/pt not_active Application Discontinuation
- 2013-07-12 EP EP13735315.7A patent/EP2875000B1/en active Active
- 2013-07-12 AU AU2013292142A patent/AU2013292142B2/en not_active Ceased
- 2013-07-12 CN CN201380031736.9A patent/CN104364233B/zh active Active
- 2013-07-12 CA CA2871389A patent/CA2871389C/en not_active Expired - Fee Related
- 2013-07-12 JP JP2015521004A patent/JP6089104B2/ja active Active
- 2013-07-12 HU HUE13735315A patent/HUE030177T2/en unknown
- 2013-07-12 ES ES13735315.7T patent/ES2600133T3/es active Active
- 2013-07-12 PT PT137353157T patent/PT2875000T/pt unknown
- 2013-07-12 MA MA37795A patent/MA20150280A2/fr unknown
- 2013-07-12 KR KR1020157001019A patent/KR101631041B1/ko active IP Right Grant
- 2013-07-12 EA EA201492274A patent/EA026593B1/ru not_active IP Right Cessation
- 2013-07-12 SG SG11201407050UA patent/SG11201407050UA/en unknown
- 2013-07-12 MX MX2014014950A patent/MX358998B/es active IP Right Grant
- 2013-07-12 WO PCT/EP2013/064747 patent/WO2014012851A1/en active Application Filing
- 2013-07-15 AR ARP130102507 patent/AR091764A1/es not_active Application Discontinuation
- 2013-07-16 TW TW102125419A patent/TWI473799B/zh not_active IP Right Cessation
-
2014
- 2014-10-23 CO CO14235289A patent/CO7111256A2/es unknown
- 2014-11-19 ZA ZA2014/08514A patent/ZA201408514B/en unknown
- 2014-11-20 CR CR20140531A patent/CR20140531A/es unknown
- 2014-11-21 CL CL2014003160A patent/CL2014003160A1/es unknown
- 2014-12-03 PH PH12014502695A patent/PH12014502695A1/en unknown
- 2014-12-18 IL IL236362A patent/IL236362A/en active IP Right Grant
-
2015
- 2015-01-15 US US14/597,375 patent/US20150133505A1/en not_active Abandoned
- 2015-03-31 HK HK15103216.5A patent/HK1202544A1/zh unknown
- 2015-10-26 US US14/923,308 patent/US9328090B2/en active Active
-
2016
- 2016-11-04 CY CY20161101133T patent/CY1118205T1/el unknown
- 2016-12-12 HR HRP20161691TT patent/HRP20161691T1/hr unknown
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