CO6241161A2 - Complejos de hierro y derivados de carbohidrato solubles en agua su produccion y medicamentos que contienen los mismos - Google Patents
Complejos de hierro y derivados de carbohidrato solubles en agua su produccion y medicamentos que contienen los mismosInfo
- Publication number
- CO6241161A2 CO6241161A2 CO09118656A CO09118656A CO6241161A2 CO 6241161 A2 CO6241161 A2 CO 6241161A2 CO 09118656 A CO09118656 A CO 09118656A CO 09118656 A CO09118656 A CO 09118656A CO 6241161 A2 CO6241161 A2 CO 6241161A2
- Authority
- CO
- Colombia
- Prior art keywords
- oxidation
- esters
- products
- water
- mixture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/18—Oxidised starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/18—Oxidised starch
- C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- Un complejo soluble en agua de hierro y derivado de carbohidrato, obtenible a partir de una solución acuosa de sal de hierro (III) y de una solución acuosa del producto de oxidación y la derivatización subsiguiente de una o varias maltodextrinas, en donde se lleva a cabo la oxidación con una solución acuosa de hipoclorito con un valor de pH en el intervalo alcalino, en donde, con el empleo de una maltodextrina cuyo equivalente de dextrosa se encuentra entre 5 y 20 y con el empleo de una mezcla de varias maltodextrinas, el equivalente de dextrosa de la mezcla se encuentra entre 5 y 20 y el equivalente de dextrosa de las maltodextrina individuales que forman parte de la mezcla se encuentra entre 5 y 40, y se lleva a cabo la derivatización subsiguiente con un reactivo adecuado. 2.- El complejo soluble en agua de hierro y carbohidrato de conformidad con la reivindicación 1, caracterizado además porque los derivados de maltodextrina obtenidos por oxidación y derivatización se seleccionan entre ésteres de ácidos carboxílicos monobásicos y polibásicos, productos de oxidación en C2/C3, productos de carboxialquilación, carbamatos, éteres, amidas, anhídricos y ésteres de ácidos inorgánicos. 3.- El complejo de conformidad con la reivindicación 1 ó 2 caracterizada además porque los derivados de maltodextrina obtenidos por oxidación y derivación se seleccionan entre ésteres de ácidos carboxílicos, ésteres mixtos de ácidos dicarboxílicos, productos de carboxilación, productos de oxidación en C2/C3, fosfatos y sulfatos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109081A EP1997833A1 (de) | 2007-05-29 | 2007-05-29 | Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6241161A2 true CO6241161A2 (es) | 2011-01-20 |
Family
ID=38287550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09118656A CO6241161A2 (es) | 2007-05-29 | 2009-10-22 | Complejos de hierro y derivados de carbohidrato solubles en agua su produccion y medicamentos que contienen los mismos |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8263577B2 (es) |
| EP (2) | EP1997833A1 (es) |
| JP (1) | JP5259700B2 (es) |
| KR (1) | KR101168085B1 (es) |
| CN (1) | CN101679530B (es) |
| AR (1) | AR065997A1 (es) |
| AU (1) | AU2008257683B2 (es) |
| BR (1) | BRPI0811985B8 (es) |
| CA (1) | CA2682587C (es) |
| CL (1) | CL2008001549A1 (es) |
| CO (1) | CO6241161A2 (es) |
| ES (1) | ES2547304T3 (es) |
| GT (1) | GT200900308A (es) |
| HK (1) | HK1140219A1 (es) |
| IL (1) | IL201294A (es) |
| MA (1) | MA31456B1 (es) |
| MX (1) | MX2009012889A (es) |
| MY (1) | MY158004A (es) |
| NZ (1) | NZ581487A (es) |
| PE (1) | PE20090317A1 (es) |
| PL (1) | PL2148890T3 (es) |
| PT (1) | PT2148890E (es) |
| RU (1) | RU2441881C2 (es) |
| TN (1) | TN2009000443A1 (es) |
| TW (1) | TWI372621B (es) |
| WO (1) | WO2008145586A1 (es) |
| ZA (1) | ZA200907672B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10249552A1 (de) * | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| EP2626074A1 (en) | 2006-01-06 | 2013-08-14 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron |
| EP3156075B1 (en) | 2009-03-25 | 2020-10-14 | Pharmacosmos Holding A/S | An oligosaccharide and a process for preparation thereof |
| WO2011055374A2 (en) * | 2009-11-04 | 2011-05-12 | Symed Labs Limited | Process for the preparation of iron (iii) carboxymaltose complex |
| ES2660202T3 (es) | 2010-03-23 | 2018-03-21 | Vifor (International) Ag | Compuestos del complejo Fe (iii) para el tratamiento y la profilaxis de los síntomas de deficiencia de hierro y las anemias ferropénicas |
| CN101891832B (zh) * | 2010-07-22 | 2012-01-04 | 山东农业大学 | 一种无碱均相生产氧化淀粉方法 |
| WO2012104204A1 (en) | 2011-01-31 | 2012-08-09 | Vifor (International) Ag | Iron-carbohydrate complex compounds for the intravenous therapy of malaria |
| WO2013056085A1 (en) * | 2011-10-13 | 2013-04-18 | Vidasym, Inc. | Iron-fiber composition, preparation and uses thereof |
| JP6417339B2 (ja) | 2013-03-08 | 2018-11-07 | ヴィダシム・インコーポレーテッド | 金属イオン−機能性繊維成分錯体組成物、その調製および使用 |
| US9370202B2 (en) * | 2013-03-15 | 2016-06-21 | LG Bionano, LLC | Encapsulated metal ion nanoclusters |
| US20180105609A1 (en) * | 2015-03-23 | 2018-04-19 | Suven Life Sciences Limited | Preparation of water soluble trivalent iron carbohydrate complexes |
| CN105125577B (zh) * | 2015-07-29 | 2018-05-18 | 南京生命能科技开发有限公司 | 一种稳定的糖-铁复合物及其制备方法 |
| CN105520955B (zh) * | 2015-12-21 | 2018-05-11 | 南京生命能科技开发有限公司 | 一种羧基麦芽糖铁药用组合物及其制备方法 |
| WO2019193608A1 (en) * | 2018-04-05 | 2019-10-10 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of iron (iii) carboxymaltose |
| CN115368478B (zh) * | 2021-05-21 | 2023-07-04 | 武汉科福新药有限责任公司 | 一种羧基麦芽糖铁的制备方法 |
| CN115368477B (zh) * | 2021-05-21 | 2023-05-02 | 武汉科福新药有限责任公司 | 高得率、高含铁量的羧基麦芽糖铁的制备方法 |
| CN115322265A (zh) * | 2022-08-29 | 2022-11-11 | 滨州学院 | 一种羧基麦芽糖控制性氧化与纯化工艺 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| DE10249552A1 (de) * | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US7964568B2 (en) * | 2003-05-30 | 2011-06-21 | Chromaceutical Advanced Technologies, Inc. | Synthesis of high molecular weight iron-saccharidic complexes |
| ITMO20050056A1 (it) | 2005-03-15 | 2006-09-16 | Biofer Spa | Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi. |
| EP1757299A1 (de) * | 2005-08-25 | 2007-02-28 | Vifor (International) Ag | Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung |
-
2007
- 2007-05-29 EP EP07109081A patent/EP1997833A1/de not_active Withdrawn
-
2008
- 2008-04-09 AR ARP080101467A patent/AR065997A1/es not_active Application Discontinuation
- 2008-04-30 TW TW097115868A patent/TWI372621B/zh not_active IP Right Cessation
- 2008-05-21 EP EP08759877.7A patent/EP2148890B1/de active Active
- 2008-05-21 RU RU2009149175/05A patent/RU2441881C2/ru active
- 2008-05-21 BR BRPI0811985A patent/BRPI0811985B8/pt not_active IP Right Cessation
- 2008-05-21 NZ NZ581487A patent/NZ581487A/en not_active IP Right Cessation
- 2008-05-21 CA CA2682587A patent/CA2682587C/en not_active Expired - Fee Related
- 2008-05-21 PL PL08759877T patent/PL2148890T3/pl unknown
- 2008-05-21 MX MX2009012889A patent/MX2009012889A/es active IP Right Grant
- 2008-05-21 PT PT87598777T patent/PT2148890E/pt unknown
- 2008-05-21 AU AU2008257683A patent/AU2008257683B2/en not_active Ceased
- 2008-05-21 KR KR1020097023006A patent/KR101168085B1/ko active IP Right Grant
- 2008-05-21 ES ES08759877.7T patent/ES2547304T3/es active Active
- 2008-05-21 CN CN2008800178628A patent/CN101679530B/zh not_active Expired - Fee Related
- 2008-05-21 JP JP2010509794A patent/JP5259700B2/ja not_active Expired - Fee Related
- 2008-05-21 WO PCT/EP2008/056276 patent/WO2008145586A1/de active Application Filing
- 2008-05-21 US US12/599,343 patent/US8263577B2/en active Active
- 2008-05-21 MY MYPI20094711A patent/MY158004A/en unknown
- 2008-05-28 PE PE2008000908A patent/PE20090317A1/es not_active Application Discontinuation
- 2008-05-28 CL CL2008001549A patent/CL2008001549A1/es unknown
-
2009
- 2009-10-01 IL IL201294A patent/IL201294A/en not_active IP Right Cessation
- 2009-10-22 CO CO09118656A patent/CO6241161A2/es active IP Right Grant
- 2009-10-23 TN TNP2009000443A patent/TN2009000443A1/fr unknown
- 2009-11-02 ZA ZA200907672A patent/ZA200907672B/xx unknown
- 2009-11-27 GT GT200900308A patent/GT200900308A/es unknown
- 2009-12-21 MA MA32435A patent/MA31456B1/fr unknown
-
2010
- 2010-06-25 HK HK10106277.9A patent/HK1140219A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused | ||
| FG | Application granted |