CO6190620A2 - Triazoles biciclicos como moduladores de la proteina cinasa - Google Patents
Triazoles biciclicos como moduladores de la proteina cinasaInfo
- Publication number
- CO6190620A2 CO6190620A2 CO09040677A CO09040677A CO6190620A2 CO 6190620 A2 CO6190620 A2 CO 6190620A2 CO 09040677 A CO09040677 A CO 09040677A CO 09040677 A CO09040677 A CO 09040677A CO 6190620 A2 CO6190620 A2 CO 6190620A2
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- unsubstituted
- independently
- heteroaryl
- heterocycloalkyl
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyano, hydroxyl Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86255206P | 2006-10-23 | 2006-10-23 | |
| US87030906P | 2006-12-15 | 2006-12-15 | |
| US91376607P | 2007-04-24 | 2007-04-24 | |
| US95284007P | 2007-07-30 | 2007-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6190620A2 true CO6190620A2 (es) | 2010-08-19 |
Family
ID=38956385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09040677A CO6190620A2 (es) | 2006-10-23 | 2009-04-22 | Triazoles biciclicos como moduladores de la proteina cinasa |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8507489B2 (https=) |
| EP (1) | EP2084162B1 (https=) |
| JP (1) | JP5378222B2 (https=) |
| KR (1) | KR20090071612A (https=) |
| AR (1) | AR063520A1 (https=) |
| AU (1) | AU2007309149C1 (https=) |
| BR (1) | BRPI0717320A2 (https=) |
| CA (1) | CA2667428A1 (https=) |
| CO (1) | CO6190620A2 (https=) |
| CR (1) | CR10803A (https=) |
| DK (1) | DK2084162T3 (https=) |
| EA (1) | EA200970403A1 (https=) |
| ES (1) | ES2393130T3 (https=) |
| IL (1) | IL197958A0 (https=) |
| MA (1) | MA30871B1 (https=) |
| MX (1) | MX2009004059A (https=) |
| NO (1) | NO20091618L (https=) |
| NZ (1) | NZ575336A (https=) |
| PE (1) | PE20080893A1 (https=) |
| PL (1) | PL2084162T3 (https=) |
| PT (1) | PT2084162E (https=) |
| SV (1) | SV2009003235A (https=) |
| TN (1) | TN2009000142A1 (https=) |
| TW (1) | TW200835492A (https=) |
| WO (1) | WO2008051808A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8792501A1 (es) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| TWI365185B (en) | 2008-07-24 | 2012-06-01 | Lilly Co Eli | Amidophenoxyindazoles useful as inhibitors of c-met |
| UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| EP2165710A1 (en) | 2008-09-19 | 2010-03-24 | Institut Curie | Tyrosine kinase receptor Tyro3 as a therapeutic target in the treatment of a bladder tumor |
| US8592448B2 (en) | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
| FR2941949B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941952B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941951B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941950B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| EA201200260A1 (ru) | 2009-08-12 | 2012-09-28 | Новартис Аг | Гетероциклические гидразоны и их применение для лечения рака и воспаления |
| CA2771432A1 (en) | 2009-08-20 | 2011-02-24 | Novartis Ag | Heterocyclic oxime compounds |
| EA030141B1 (ru) | 2009-12-31 | 2018-06-29 | Хатчисон Медифарма Лимитед | Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения |
| EP2569315A1 (en) | 2010-05-14 | 2013-03-20 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
| UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
| WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
| CN102532141A (zh) | 2010-12-08 | 2012-07-04 | 中国科学院上海药物研究所 | [1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途 |
| US8765760B2 (en) | 2011-01-11 | 2014-07-01 | Sunovion Pharmaceuticals, Inc. | [1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases |
| CN103459396B (zh) * | 2011-02-10 | 2015-08-19 | 诺瓦提斯公司 | 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物 |
| EP2673277A1 (en) | 2011-02-10 | 2013-12-18 | Novartis AG | [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase |
| JP2014513724A (ja) | 2011-05-16 | 2014-06-05 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 融合二環キナーゼ阻害剤 |
| CA2848809A1 (en) | 2011-09-15 | 2013-03-21 | Novartis Ag | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase |
| CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
| AU2013243097A1 (en) | 2012-04-03 | 2014-10-09 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
| JP2015512447A (ja) | 2012-04-03 | 2015-04-27 | ノバルティス アーゲー | チロシンキナーゼ阻害薬の組合せおよびその使用 |
| CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术（太仓）有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
| WO2014089904A1 (en) | 2012-12-10 | 2014-06-19 | Abbvie Inc. | Triazinone compounds |
| US9364405B2 (en) | 2013-03-13 | 2016-06-14 | Avon Products, Inc. | Tyrosinase inhibitors |
| WO2014158943A1 (en) * | 2013-03-13 | 2014-10-02 | Avon Products, Inc | Tyrosinase inhibitors |
| MX2015011438A (es) * | 2013-03-13 | 2016-02-03 | Hoffmann La Roche | Procedimiento para preparar compuestos benzoxazepina. |
| US20150174034A1 (en) | 2013-03-13 | 2015-06-25 | Avon Products, Inc. | Tyrosinase inhibitors |
| WO2014174478A1 (en) | 2013-04-26 | 2014-10-30 | Novartis Ag | Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor |
| WO2014180182A1 (zh) * | 2013-05-10 | 2014-11-13 | 江苏豪森药业股份有限公司 | [1,2,4]三唑并[4,3-a]吡啶类衍生物，其制备方法或其在医药上的应用 |
| WO2017049711A1 (zh) | 2015-09-24 | 2017-03-30 | 上海海聚生物科技有限公司 | 喹啉类衍生物、其药物组合物、制备方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604091A (en) | 1984-03-01 | 1997-02-18 | Microgenics Corporation | Methods for protein binding enzyme complementation |
| JPS60194443A (ja) * | 1984-03-16 | 1985-10-02 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| JPS62228086A (ja) * | 1985-12-23 | 1987-10-06 | Takeda Chem Ind Ltd | セフエム化合物 |
| EP0228061A3 (en) | 1985-12-23 | 1988-12-14 | Takeda Chemical Industries, Ltd. | Cephem compounds |
| GB9918035D0 (en) | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
| WO2002083139A1 (en) * | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
| US6960584B2 (en) * | 2001-04-10 | 2005-11-01 | Merck & Co., Inc. | Inhibitors of Akt activity |
| US20030229453A1 (en) | 2002-04-09 | 2003-12-11 | Antonysamy Stephen Suresh | Crystals and structures of PAK4KD kinase PAK4KD |
| WO2004058769A2 (en) * | 2002-12-18 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Triazolopyridazines as protein kinases inhibitors |
| US7122548B2 (en) * | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| CA2573573A1 (en) * | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| ES2355923T3 (es) | 2004-08-26 | 2011-04-01 | Pfizer, Inc. | Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa. |
| MX2007007797A (es) | 2004-12-27 | 2007-08-23 | Alcon Inc | Analogo de aminopirazina para tratar glaucoma y otras enfermedades mediadas por rho cinasa. |
-
2007
- 2007-10-18 BR BRPI0717320-2A2A patent/BRPI0717320A2/pt not_active IP Right Cessation
- 2007-10-18 EA EA200970403A patent/EA200970403A1/ru unknown
- 2007-10-18 JP JP2009533541A patent/JP5378222B2/ja not_active Expired - Fee Related
- 2007-10-18 WO PCT/US2007/081841 patent/WO2008051808A2/en not_active Ceased
- 2007-10-18 CA CA002667428A patent/CA2667428A1/en not_active Abandoned
- 2007-10-18 PT PT07844414T patent/PT2084162E/pt unknown
- 2007-10-18 AU AU2007309149A patent/AU2007309149C1/en not_active Ceased
- 2007-10-18 NZ NZ575336A patent/NZ575336A/en not_active IP Right Cessation
- 2007-10-18 DK DK07844414.8T patent/DK2084162T3/da active
- 2007-10-18 MX MX2009004059A patent/MX2009004059A/es active IP Right Grant
- 2007-10-18 ES ES07844414T patent/ES2393130T3/es active Active
- 2007-10-18 EP EP07844414A patent/EP2084162B1/en active Active
- 2007-10-18 PL PL07844414T patent/PL2084162T3/pl unknown
- 2007-10-18 KR KR1020097008200A patent/KR20090071612A/ko not_active Abandoned
- 2007-10-18 US US12/442,566 patent/US8507489B2/en not_active Expired - Fee Related
- 2007-10-22 TW TW096139480A patent/TW200835492A/zh unknown
- 2007-10-23 PE PE2007001437A patent/PE20080893A1/es not_active Application Discontinuation
- 2007-10-23 AR ARP070104680A patent/AR063520A1/es not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197958A patent/IL197958A0/en unknown
- 2009-04-15 TN TNP2009000142A patent/TN2009000142A1/fr unknown
- 2009-04-22 CO CO09040677A patent/CO6190620A2/es not_active Application Discontinuation
- 2009-04-23 SV SV2009003235A patent/SV2009003235A/es not_active Application Discontinuation
- 2009-04-23 NO NO20091618A patent/NO20091618L/no not_active Application Discontinuation
- 2009-05-07 MA MA31849A patent/MA30871B1/fr unknown
- 2009-05-19 CR CR10803A patent/CR10803A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK2084162T3 (da) | 2012-10-01 |
| PL2084162T3 (pl) | 2013-01-31 |
| AU2007309149A1 (en) | 2008-05-02 |
| TW200835492A (en) | 2008-09-01 |
| EA200970403A1 (ru) | 2009-10-30 |
| WO2008051808A3 (en) | 2008-07-24 |
| PT2084162E (pt) | 2012-10-09 |
| SV2009003235A (es) | 2009-10-15 |
| PE20080893A1 (es) | 2008-08-26 |
| ES2393130T3 (es) | 2012-12-18 |
| NO20091618L (no) | 2009-05-22 |
| NZ575336A (en) | 2012-04-27 |
| IL197958A0 (en) | 2009-12-24 |
| AU2007309149B2 (en) | 2012-09-06 |
| AR063520A1 (es) | 2009-01-28 |
| WO2008051808A2 (en) | 2008-05-02 |
| MA30871B1 (fr) | 2009-11-02 |
| US8507489B2 (en) | 2013-08-13 |
| MX2009004059A (es) | 2009-04-27 |
| EP2084162B1 (en) | 2012-09-12 |
| CA2667428A1 (en) | 2008-05-02 |
| EP2084162A2 (en) | 2009-08-05 |
| CR10803A (es) | 2009-06-16 |
| JP2010507578A (ja) | 2010-03-11 |
| BRPI0717320A2 (pt) | 2013-10-22 |
| AU2007309149C1 (en) | 2013-04-04 |
| TN2009000142A1 (en) | 2010-10-18 |
| JP5378222B2 (ja) | 2013-12-25 |
| KR20090071612A (ko) | 2009-07-01 |
| US20090258855A1 (en) | 2009-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |