AR063520A1 - Triazoles biciclicos como moduladores de proteina quinasa - Google Patents
Triazoles biciclicos como moduladores de proteina quinasaInfo
- Publication number
- AR063520A1 AR063520A1 ARP070104680A ARP070104680A AR063520A1 AR 063520 A1 AR063520 A1 AR 063520A1 AR P070104680 A ARP070104680 A AR P070104680A AR P070104680 A ARP070104680 A AR P070104680A AR 063520 A1 AR063520 A1 AR 063520A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- independently
- heteroaryl
- aryl
- Prior art date
Links
- 102000001253 Protein Kinase Human genes 0.000 title abstract 2
- 108060006633 protein kinase Proteins 0.000 title abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 19
- 125000003118 aryl group Chemical group 0.000 abstract 14
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 150000002431 hydrogen Chemical group 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 8
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 7
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 7
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 7
- -1 bicyclic triazoles Chemical class 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical group 0.000 abstract 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 101100173726 Arabidopsis thaliana OR23 gene Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86255206P | 2006-10-23 | 2006-10-23 | |
| US87030906P | 2006-12-15 | 2006-12-15 | |
| US91376607P | 2007-04-24 | 2007-04-24 | |
| US95284007P | 2007-07-30 | 2007-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063520A1 true AR063520A1 (es) | 2009-01-28 |
Family
ID=38956385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104680A AR063520A1 (es) | 2006-10-23 | 2007-10-23 | Triazoles biciclicos como moduladores de proteina quinasa |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8507489B2 (https=) |
| EP (1) | EP2084162B1 (https=) |
| JP (1) | JP5378222B2 (https=) |
| KR (1) | KR20090071612A (https=) |
| AR (1) | AR063520A1 (https=) |
| AU (1) | AU2007309149C1 (https=) |
| BR (1) | BRPI0717320A2 (https=) |
| CA (1) | CA2667428A1 (https=) |
| CO (1) | CO6190620A2 (https=) |
| CR (1) | CR10803A (https=) |
| DK (1) | DK2084162T3 (https=) |
| EA (1) | EA200970403A1 (https=) |
| ES (1) | ES2393130T3 (https=) |
| IL (1) | IL197958A0 (https=) |
| MA (1) | MA30871B1 (https=) |
| MX (1) | MX2009004059A (https=) |
| NO (1) | NO20091618L (https=) |
| NZ (1) | NZ575336A (https=) |
| PE (1) | PE20080893A1 (https=) |
| PL (1) | PL2084162T3 (https=) |
| PT (1) | PT2084162E (https=) |
| SV (1) | SV2009003235A (https=) |
| TN (1) | TN2009000142A1 (https=) |
| TW (1) | TW200835492A (https=) |
| WO (1) | WO2008051808A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8792501A1 (es) | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| TWI365185B (en) | 2008-07-24 | 2012-06-01 | Lilly Co Eli | Amidophenoxyindazoles useful as inhibitors of c-met |
| UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| EP2165710A1 (en) * | 2008-09-19 | 2010-03-24 | Institut Curie | Tyrosine kinase receptor Tyro3 as a therapeutic target in the treatment of a bladder tumor |
| JP2012509342A (ja) | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン |
| FR2941952B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941950B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941951B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| FR2941949B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| JP5781510B2 (ja) | 2009-08-12 | 2015-09-24 | ノバルティス アーゲー | ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用 |
| JP5775871B2 (ja) | 2009-08-20 | 2015-09-09 | ノバルティス アーゲー | ヘテロ環式オキシム化合物 |
| EP3795573B1 (en) | 2009-12-31 | 2022-07-06 | Hutchison Medipharma Limited | Certain triazolopyrazines, compositions thereof and methods of use therefor |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| WO2011143646A1 (en) | 2010-05-14 | 2011-11-17 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
| AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
| UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
| WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
| CN102532141A (zh) | 2010-12-08 | 2012-07-04 | 中国科学院上海药物研究所 | [1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途 |
| CN107141309A (zh) | 2011-01-11 | 2017-09-08 | 桑诺维恩药品公司 | 杂芳基化合物及其使用方法 |
| WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
| CN103459396B (zh) * | 2011-02-10 | 2015-08-19 | 诺瓦提斯公司 | 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物 |
| EP2710003A1 (en) | 2011-05-16 | 2014-03-26 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
| CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
| EA026655B1 (ru) | 2011-09-15 | 2017-05-31 | Новартис Аг | 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ |
| MX2014011987A (es) | 2012-04-03 | 2014-11-10 | Novartis Ag | Combinaciones de inhibidores de cinasa de tirosina y su uso. |
| JP2015512425A (ja) | 2012-04-03 | 2015-04-27 | ノバルティス アーゲー | チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用 |
| CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术（太仓）有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
| WO2014089904A1 (en) | 2012-12-10 | 2014-06-19 | Abbvie Inc. | Triazinone compounds |
| WO2014158943A1 (en) * | 2013-03-13 | 2014-10-02 | Avon Products, Inc | Tyrosinase inhibitors |
| US9364405B2 (en) | 2013-03-13 | 2016-06-14 | Avon Products, Inc. | Tyrosinase inhibitors |
| US20150174034A1 (en) | 2013-03-13 | 2015-06-25 | Avon Products, Inc. | Tyrosinase inhibitors |
| JP6363120B2 (ja) * | 2013-03-13 | 2018-07-25 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾオキサゼピン化合物の作製方法 |
| WO2014174478A1 (en) | 2013-04-26 | 2014-10-30 | Novartis Ag | Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor |
| AU2014262326B2 (en) | 2013-05-10 | 2018-03-22 | Jiangsu Hansoh Pharmaceutical Co., Ltd. | [1,2,4] triazol [4,3-a] pyridine derivate, preparation method therefor or medical application thereof |
| WO2017049711A1 (zh) | 2015-09-24 | 2017-03-30 | 上海海聚生物科技有限公司 | 喹啉类衍生物、其药物组合物、制备方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604091A (en) | 1984-03-01 | 1997-02-18 | Microgenics Corporation | Methods for protein binding enzyme complementation |
| JPS60194443A (ja) * | 1984-03-16 | 1985-10-02 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| EP0228061A3 (en) * | 1985-12-23 | 1988-12-14 | Takeda Chemical Industries, Ltd. | Cephem compounds |
| JPS62228086A (ja) * | 1985-12-23 | 1987-10-06 | Takeda Chem Ind Ltd | セフエム化合物 |
| GB9918035D0 (en) | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
| WO2002083675A2 (en) | 2001-04-10 | 2002-10-24 | Merck Sharp & Dohme Limited | Inhibitors of akt activity |
| WO2002083139A1 (en) * | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
| US20030229453A1 (en) | 2002-04-09 | 2003-12-11 | Antonysamy Stephen Suresh | Crystals and structures of PAK4KD kinase PAK4KD |
| WO2004058769A2 (en) * | 2002-12-18 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Triazolopyridazines as protein kinases inhibitors |
| US7122548B2 (en) * | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| MX2007001126A (es) * | 2004-07-27 | 2007-09-25 | Sgx Pharmaceuticals Inc | Moduladores de heterociclo cinasa de anillo fusionado. |
| ME01309B (me) | 2004-08-26 | 2013-12-20 | Pfizer | Pirazolom supstituirani heteroarilni spojevi kao inhibitori proteinskih kinaza |
| WO2006071548A2 (en) | 2004-12-27 | 2006-07-06 | Alcon, Inc. | Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases |
-
2007
- 2007-10-18 AU AU2007309149A patent/AU2007309149C1/en not_active Ceased
- 2007-10-18 PL PL07844414T patent/PL2084162T3/pl unknown
- 2007-10-18 EA EA200970403A patent/EA200970403A1/ru unknown
- 2007-10-18 WO PCT/US2007/081841 patent/WO2008051808A2/en not_active Ceased
- 2007-10-18 ES ES07844414T patent/ES2393130T3/es active Active
- 2007-10-18 MX MX2009004059A patent/MX2009004059A/es active IP Right Grant
- 2007-10-18 CA CA002667428A patent/CA2667428A1/en not_active Abandoned
- 2007-10-18 BR BRPI0717320-2A2A patent/BRPI0717320A2/pt not_active IP Right Cessation
- 2007-10-18 PT PT07844414T patent/PT2084162E/pt unknown
- 2007-10-18 JP JP2009533541A patent/JP5378222B2/ja not_active Expired - Fee Related
- 2007-10-18 DK DK07844414.8T patent/DK2084162T3/da active
- 2007-10-18 NZ NZ575336A patent/NZ575336A/en not_active IP Right Cessation
- 2007-10-18 US US12/442,566 patent/US8507489B2/en not_active Expired - Fee Related
- 2007-10-18 KR KR1020097008200A patent/KR20090071612A/ko not_active Abandoned
- 2007-10-18 EP EP07844414A patent/EP2084162B1/en active Active
- 2007-10-22 TW TW096139480A patent/TW200835492A/zh unknown
- 2007-10-23 AR ARP070104680A patent/AR063520A1/es not_active Application Discontinuation
- 2007-10-23 PE PE2007001437A patent/PE20080893A1/es not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197958A patent/IL197958A0/en unknown
- 2009-04-15 TN TNP2009000142A patent/TN2009000142A1/fr unknown
- 2009-04-22 CO CO09040677A patent/CO6190620A2/es not_active Application Discontinuation
- 2009-04-23 NO NO20091618A patent/NO20091618L/no not_active Application Discontinuation
- 2009-04-23 SV SV2009003235A patent/SV2009003235A/es not_active Application Discontinuation
- 2009-05-07 MA MA31849A patent/MA30871B1/fr unknown
- 2009-05-19 CR CR10803A patent/CR10803A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US8507489B2 (en) | 2013-08-13 |
| NO20091618L (no) | 2009-05-22 |
| DK2084162T3 (da) | 2012-10-01 |
| BRPI0717320A2 (pt) | 2013-10-22 |
| JP5378222B2 (ja) | 2013-12-25 |
| EP2084162B1 (en) | 2012-09-12 |
| PT2084162E (pt) | 2012-10-09 |
| NZ575336A (en) | 2012-04-27 |
| EA200970403A1 (ru) | 2009-10-30 |
| KR20090071612A (ko) | 2009-07-01 |
| WO2008051808A2 (en) | 2008-05-02 |
| CA2667428A1 (en) | 2008-05-02 |
| PL2084162T3 (pl) | 2013-01-31 |
| WO2008051808A3 (en) | 2008-07-24 |
| JP2010507578A (ja) | 2010-03-11 |
| ES2393130T3 (es) | 2012-12-18 |
| PE20080893A1 (es) | 2008-08-26 |
| MX2009004059A (es) | 2009-04-27 |
| EP2084162A2 (en) | 2009-08-05 |
| CR10803A (es) | 2009-06-16 |
| IL197958A0 (en) | 2009-12-24 |
| TW200835492A (en) | 2008-09-01 |
| US20090258855A1 (en) | 2009-10-15 |
| CO6190620A2 (es) | 2010-08-19 |
| AU2007309149A1 (en) | 2008-05-02 |
| SV2009003235A (es) | 2009-10-15 |
| TN2009000142A1 (en) | 2010-10-18 |
| AU2007309149B2 (en) | 2012-09-06 |
| AU2007309149C1 (en) | 2013-04-04 |
| MA30871B1 (fr) | 2009-11-02 |
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