CO6170355A2 - Inhibidores prolil hidroxilasa y metodos de uso - Google Patents

Inhibidores prolil hidroxilasa y metodos de uso

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Publication number
CO6170355A2
CO6170355A2 CO09006711A CO09006711A CO6170355A2 CO 6170355 A2 CO6170355 A2 CO 6170355A2 CO 09006711 A CO09006711 A CO 09006711A CO 09006711 A CO09006711 A CO 09006711A CO 6170355 A2 CO6170355 A2 CO 6170355A2
Authority
CO
Colombia
Prior art keywords
hydrogen
cyclic
linear
branched
independently
Prior art date
Application number
CO09006711A
Other languages
English (en)
Inventor
Richard Masaru Kawamoto
Artem G Edokimov
Kenneth Donald Greis
Angelique Boyer
Shengde Wu
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38728868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6170355(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO6170355A2 publication Critical patent/CO6170355A2/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • C07D213/65—One oxygen atom attached in position 3 or 5
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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Abstract

1.- Un compuesto que tiene la Fórmula:en donde X es N o CH;R y R1 son cada uno independientemente una unidad seleccionada de:i) hidrógeno;ii) fenilo sustituido o no sustituido; y iii) heteroarilo sustituido o no sustituido; dichas sustituciones seleccionadas de:i) Cicloalquilo cíclico, lineal o ramificado C1-C4;ii) Alcoxi cíclico, lineal o ramificado C1-C4; iii) Haloalquilo cíclico, lineal o ramificado C1-C4;iv) halógeno;v) -CN; vi) -NHC(O)R4 vii) -C(O)NR5aR5b; viii) heteroarilo ; oix) dos sustituciones se pueden tomar juntas para formar un anillo fusionado que tiene de 5 a 7 átomos;R4 es alquilo cíclico, lineal o ramificado C1-C4;R5a y R5b son cada uno independientemente:i) hidrógeno;ii) Cicloalquilo cíclico, lineal o ramificado C1-C4; oiii) R5a y R5b se pueden tomar juntos para formar un anillo que tiene de 3 a 7 átomos; R2 se selecciona de: i) -OR6; oii) -NR7aR7b;R6 es hidrógeno o cicloalquilo cíclico, lineal o ramificado C1-C4;R7a y R7b son cada uno independientemente:i) hidrógeno;ii) Cicloalquilo cíclico, lineal o ramificado C1-C4; oiii) R7a y R7b se pueden tomar juntos para formar un anillo que tiene de 3 a 7 átomos del anillo;Y se selecciona de:i) hidrógeno;ii) -OR3;es hidrógeno, metilo, o etilo;L es una unidad de ligado que tiene la Fórmula: R8a y R8b son cada uno independientemente hidrógeno, metilo, o etilo; el índice n es de 1 a 3; R9 es hidrógeno o metilo.
CO09006711A 2006-06-26 2009-01-26 Inhibidores prolil hidroxilasa y metodos de uso CO6170355A2 (es)

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EP (6) EP3357911B1 (es)
JP (1) JP5113838B2 (es)
KR (1) KR101130592B1 (es)
CN (1) CN101506149B (es)
AT (1) ATE485264T1 (es)
AU (1) AU2007265460B2 (es)
BR (1) BRPI0713350B1 (es)
CA (1) CA2659682C (es)
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NZ (3) NZ601731A (es)
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SI (2) SI2044005T1 (es)
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US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
HUE041300T2 (hu) 2006-06-26 2019-05-28 Akebia Therapeutics Inc Prolilhidroxiláz inhibitorok és alkalmazási eljárások
JP5557832B2 (ja) * 2008-03-18 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 置換４−ヒドロキシピリジン−５−カルボキサミド
CA2722028C (en) * 2008-04-22 2013-09-24 Daiichi Sankyo Company, Limited 5-hydroxypyrimidine-4-carboxamide compound
JP6022769B2 (ja) 2008-04-28 2016-11-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ プロリルヒドロキシラーゼ阻害物質としてのベンゾイミダゾール
WO2009134850A1 (en) * 2008-04-30 2009-11-05 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
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