AR039554A1 - Compuestos derivados de aminopirimidina y aminopiridina, su empleo, un metodo para su preparacion, composiciones que los comprenden, y compuestos intermediarios - Google Patents
Compuestos derivados de aminopirimidina y aminopiridina, su empleo, un metodo para su preparacion, composiciones que los comprenden, y compuestos intermediariosInfo
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- AR039554A1 AR039554A1 ARP020104262A ARP020104262A AR039554A1 AR 039554 A1 AR039554 A1 AR 039554A1 AR P020104262 A ARP020104262 A AR P020104262A AR P020104262 A ARP020104262 A AR P020104262A AR 039554 A1 AR039554 A1 AR 039554A1
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- alkyl
- cycloalkyl
- hydrogen
- aryl
- independently
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Compuestos derivados de aminopirimidina y aminopiridina que tienen la fórmula (1), en la cual: uno de V ó X es N y el otro es CRa, ó ambos V y X son CRa (donde cada Ra es independientemente hidrógeno, alquilo (C1-6), cicloalquilo (C3-7) ó cicloalquil (C3-7)-alquilo (C1-6); Y es O, S ó NR; donde R es hidrógeno, CN, NO2, (alquilo C1-10), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), alquenilo (C3-10) ó alquinilo (C2-10); Z es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-6)-alquilo (C1-6), alquenilo (C2-6), alquinilo (C2-6) ó N(R2)(R3); R1 es hidrógeno, alquilo (C1-10), alquenilo (C3-10), alquinilo (C2-10), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), heteroalquilo (C1-10), heterociclilo, heterociclil-alquilo (C1-6), arilo, aril-alquilo (C1-4), aril-heteroalquilo (C1-4), heteroaril-alquilo (C1-4), heteroaril-heteroalquilo (C1-4), C(O)R11 ó alquileno (C1-6)-C(O)R11; R11 es hidrógeno, alquilo (C1-6) ó NR12R13 (donde R12 y R13 son independientemente hidrógeno, alquilo (C1-6) ó heteroalquilo (C1-6)); R2 y R3 son independientemente hidrógeno, alquilo (C1-10), alquenilo (C3-10), alquinilo (C2-10), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6) ó heteroalquilo (C1-10), ó R2 y R3 pueden combinarse para formar un anillo heterocíclico de 5-7 miembros; R4 es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), alquenilo (C2-6) ó alquinilo (C2-6); A es hidrógeno, alquilo (C1-10), alquenilo (C3-10), alquinilo (C2-10), haloalquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), heteroalquilo (C1-10), heterociclilo, heterociclil-alquilo (C1-6), cicloalquilo (C3-7) heterosustituido, arilo, aril-alquilo (C1-4), aril-heteroalquilo (C1-4), heteroarilo, heteroaril-alquilo (C1-4), heteroaril-heteroalquilo (C1-4) ó RaRbNC(=X)- donde Ra y Rb son independientemente hidrógeno, alquilo (C1-4) ó arilo y X es O ó S; B es un anillo aromático de cinco o seis miembros sustituido o no sustituido, que contiene al menos un átomo de nitrógeno, y entre 0 y 3 heteroátomos adicionales, donde los sustituyentes del anillo B se seleccionan entre halógeno, CF3, CF3O, alquilo (C1-6), amino, alquilamino (C1-6), di-alquilamino (C1-6), ciano, nitro, sulfonamido, acilo, acilamino y carboxamido; U es -NR5-, -O- ó -S-; y, R5 es hidrógeno ó alquilo (C1-6); y sales farmacéuticamente aceptables de los mismos; donde el término "heteroalquilo" se refiere a un radical alquilo (C1-6) con uno, dos o tres sustituyentes independientemente seleccionados entre ciano, -ORa, -NRbRc, y -S(O)nRd (donde n es un entero que oscila entre 0 y 2); entendiendo que el punto de unión del radical heteroalquilo es a través de un átomo de carbono del radical heteroalquilo, y Ra es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), arilo, aril-alquilo (C1-6), alcoxicarbonilo (C1-6), ariloxicarbonilo, carboxamido, ó mono- o di-alquil (C1-6) carbamoilo, Rb es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), arilo ó aril-alquilo (C1-6), Rc es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), arilo, aril-alquilo (C1-6), alcoxicarbonilo (C1-6), ariloxicarbonilo, carboxamido, mono- o di-alquil (C1-6) carbamoilo, alquilsulfonilo (C1-6), -C(O)R', ó -S(O)nR' (donde n es un entero que oscila entre 0 y 2; donde R' es hidrógeno, alquilo (C1-6) ó arilo), Rd es hidrógeno (siempre y cuando n sea 0), alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), arilo, aril-alquilo (C1-6), amino, monoalquilamino (C1-6), dialquilamino (C1-6), ó hidroxialquilo (C1-6); el término "heteroarilo" se refiere a un radical monocíclico o bicíclico monovalente que tiene entre 5 y 12 átomos en el anillo, que tiene al menos un anillo aromático que contiene uno, dos o tres heteroátomos en el anillo seleccionados entre N, O, ó S, y el resto de los átomos del anillo son C, entendiendo que el punto de unión del radical heteroarilo será en un anillo aromático, y el anillo heteroarilo está opcionalmente sustituido en forma independiente por uno a cuatro sustituyentes seleccionados entre alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), halo, nitro, ciano, hidroxi, alcoxi (C1-6), amino, acilamino, monoalquilamino (C1-6), dialquilamino (C1-6), haloalquilo (C1-6), haloalcoxi (C1-6), heteroalquilo (C1-6), -COR (donde R es hidrógeno, alquilo (C1-6), fenilo ó fenilalquilo (C1-6)), -(CR'R")n-COOR (donde n es un entero que oscila entre 0 y 5, R' y R" son independientemente hidrógeno ó alquilo (C1-6), y R es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), fenilo ó fenilalquilo (C1-6)), ó -(CR'R")n-CONRaRb (donde n es un entero que oscila entre 0 y 5, R' y R" son independientemente hidrógeno ó alquilo (C1-6), y Ra y Rb son, independientemente uno del otro, hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-(alquilo C1-6), fenilo ó fenilalquilo (C1-6)); el término "heterociclilo" se refiere a un radical cíclico no aromático saturado o insaturado que tiene entre 3 y 8 átomos en el anillo, donde uno o dos átomos del anillo son heteroátomos seleccionados entre O, NR (donde R es independientemente hidrógeno, alquilo (C1-6), ó cualquiera de los sustituyentes que se mencionan más adelante), ó S(O)n (donde n es un entero que oscila entre 0 y 2), y el resto de los átomos del anillo son C, donde uno o dos átomos de C pueden ser reemplazados opcionalmente por un grupo carbonilo, y el anillo de heterociclilo puede estar opcionalmente sustituido en forma independiente por uno, dos o tres sustituyentes seleccionados entre alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), aril-alquilo (C1-6), halo, nitro, ciano, cianoalquilo (C1-6), hidroxi, alcoxi (C1-6), amino, monoalquilamino (C1-6), dialquilamino (C1-6), haloalquilo (C1-6), haloalcoxi (C1-6), -(CR'R")n-COR (donde n es un entero que oscila entre 0 y 5, R' y R" son independientemente hidrógeno ó alquilo (C1-6), R es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), fenilo, ó fenilalquilo (C1-6)), -(CR'R")n-COOR (donde n es un entero que oscila entre 0 y 5, R' y R" son independientemente hidrógeno ó alquilo (C1-6), y R es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), fenilo ó fenilalquilo (C1-6)), -(CR'R")n-C(=Q)NRaRb (donde Q es O ó S, n es un entero que oscila entre 0 y 5, R' y R" son independientemente hidrógeno ó alquilo (C1-6), y Ra y Rb son, independientemente uno del otro, hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquilo (C3-7)-alquilo (C1-6), heteroalquilo (C1-6), fenilo ó fenilalquilo (C1-6)), ó -(CR'R")n1-S(O)nRd (donde n1 es un entero que oscila entre 0 y 5, Rd es hidrógeno (siempre y cuando n sea 0), alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), arilo, aril-alquilo (C1-6), amino, monoalquilamino (C1-6), dialquilamino (C1-6), ó hidroxialquilo (C1-6), y n es un entero que oscila entre 0 y 2); el término "arilo" se refiere a un radical de hidrocarburo aromático monocíclico o bicíclico monovalente que tiene entre 6 y 10 átomos en el anillo, que está opcionalmente sustituido independientemente por uno a cuatro sustituyentes seleccionados entre alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), fenilo, halo, nitro, ciano, cianoalquilo (C1-6), hidroxi, alcoxi (C1-6), amino, acilamino, monoalquilamino (C1-6), dialquilamino (C1-6), haloalquilo (C1-6), haloalcoxi (C1-6), heteroalquilo (C1-6), COR (donde R es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), fenilo ó fenilalquilo (C1-6)), -S(O)n-Rd (donde n es un entero que oscila entre 0 y 2, y cuando n es 0, Rd es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), ó cicloalquil (C3-7)-alquilo (C1-6), y cuando n es 1 ó 2, Rd es alquilo (C1-6), cicloalquilo (C3-7), cicloalquilo (C3-7)-alquilo (C1-6), amino, acilamino, monoalquilamino (C1-6), ó dialquilamino (C1-6)), -NS(O)2Rf (donde Rf es alquilo (C1-6) ó arilo), -NHCORe (donde Re es amino, alquilamino (C1-6), dialquilamino (C1-6) ó alcoxi (C1-4)), -(CR'R")n-COOR (donde n es un entero que oscila entre 0 y 5, R' y R" son independientemente hidrógeno ó alquilo (C1-6), y R es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquilo (C3-7)-alquilo (C1-6), fenilo ó fenilalquilo (C1-6)), -(CR'R")nS(O)n-Rd (donde n es un entero que oscila entre 0 y 2, y cuando n es 0, Rd es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), ó cicloalquil (C3-7)-alquilo (C1-6), y cuando n es 1 ó 2, Rd es alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), amino, acilamino, monoalquilamino (C1-6), ó dialquilamino (C1-6)), -(CR'R")n-CONRaRb (donde n es un entero que oscila entre 0 y 5, R' y R" son independientemente hidrógeno ó alquilo (C1-6), y Ra y Rb son, independientemente uno del otro, hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), fenilalcoxi (C1-4) ó fenilalquilo (C1-6)) ó cualesquiera dos átomos de carbono adyacentes están sustituidos por -O(CH2)nO- (donde n es 1 ó 2); el término "acilo" se refiere al grupo -C(O)R', donde R' es hidrógeno, alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), arilo y aril-alquilo (C1-6); el término "cicloalquilo heterosustituido" se refiere a un grupo cicloalquilo (C3-7) en donde uno, dos o tres átomos de hidrógeno se reemplazan por sustituyentes seleccionados independientemente entre el grupo que comprende ciano, cianometilo, hidroxi, hidroximetilo, alcoxi (C1-6), amino, acilamino, monoalquilamino (C1-6), dialquilamino (C1-6), -SOnR (donde n es un entero que oscila entre 0 y 2 y cuando n es 0, R es hidrógeno ó alquilo (C1-6) y cuando n es 1 ó 2, R es alquilo (C1-6), cicloalquilo (C3-7), cicloalquil (C3-7)-alquilo (C1-6), arilo, aril-alquilo (C1-6), heteroarilo, amino, acilamino, monoalquilamino (C1-6), dialquilamino (C1-6), ó hidroxialquilo (C1-6)) ó -NHSO2R d
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US33831201P | 2001-11-07 | 2001-11-07 |
Publications (1)
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AR039554A1 true AR039554A1 (es) | 2005-02-23 |
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Application Number | Title | Priority Date | Filing Date |
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ARP020104262A AR039554A1 (es) | 2001-11-07 | 2002-11-07 | Compuestos derivados de aminopirimidina y aminopiridina, su empleo, un metodo para su preparacion, composiciones que los comprenden, y compuestos intermediarios |
Country Status (12)
Country | Link |
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US (2) | US6846828B2 (es) |
EP (1) | EP1444223A1 (es) |
JP (1) | JP2005511608A (es) |
KR (1) | KR20050042062A (es) |
CN (1) | CN1582284A (es) |
AR (1) | AR039554A1 (es) |
BR (1) | BR0213899A (es) |
CA (1) | CA2465711A1 (es) |
MX (1) | MXPA04004166A (es) |
PL (1) | PL370480A1 (es) |
RU (1) | RU2308455C2 (es) |
WO (1) | WO2003040131A1 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
JP2005524672A (ja) * | 2002-03-09 | 2005-08-18 | アストラゼネカ アクチボラグ | Cdk阻害活性を有するイミダゾリル置換ピリミジン誘導体 |
GB0205690D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205688D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
AU2003270701B2 (en) | 2002-10-31 | 2009-11-12 | Amgen Inc. | Antiinflammation agents |
CN100441569C (zh) * | 2003-02-24 | 2008-12-10 | 横滨橡胶株式会社 | 化合物和使用了该化合物的组合物 |
GB0311274D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
GB0311276D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
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GB2095240A (en) * | 1981-03-05 | 1982-09-29 | Fujisawa Pharmaceutical Co | Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
EP0457717B1 (de) | 1990-05-16 | 1995-10-25 | Sulzer Chemtech AG | Verfahren zur gerichteten fraktionierten Kristallisation |
EP0457727A1 (de) * | 1990-05-17 | 1991-11-21 | Ciba-Geigy Ag | Schädlingsbekämpfungsmittel |
IL106786A (en) * | 1992-09-10 | 1997-02-18 | Basf Ag | Substituted pyridine derivatives and fungicidal compositions containing them |
ES2250363T3 (es) * | 2000-02-02 | 2006-04-16 | Dorian Bevec | Guanilhidrazonas aromaticas farmaceuticamente activas. |
IL155519A0 (en) | 2000-10-26 | 2003-11-23 | Tularik Inc | Antiinflammation agents |
-
2002
- 2002-10-31 CN CNA02822194XA patent/CN1582284A/zh active Pending
- 2002-10-31 WO PCT/EP2002/012164 patent/WO2003040131A1/en active Application Filing
- 2002-10-31 CA CA002465711A patent/CA2465711A1/en not_active Abandoned
- 2002-10-31 JP JP2003542177A patent/JP2005511608A/ja active Pending
- 2002-10-31 KR KR1020047006970A patent/KR20050042062A/ko not_active Application Discontinuation
- 2002-10-31 MX MXPA04004166A patent/MXPA04004166A/es not_active Application Discontinuation
- 2002-10-31 BR BR0213899-9A patent/BR0213899A/pt not_active IP Right Cessation
- 2002-10-31 RU RU2004117545/04A patent/RU2308455C2/ru not_active IP Right Cessation
- 2002-10-31 EP EP02785344A patent/EP1444223A1/en not_active Withdrawn
- 2002-10-31 PL PL02370480A patent/PL370480A1/xx not_active Application Discontinuation
- 2002-11-06 US US10/288,968 patent/US6846828B2/en not_active Expired - Fee Related
- 2002-11-07 AR ARP020104262A patent/AR039554A1/es not_active Application Discontinuation
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US20030144303A1 (en) | 2003-07-31 |
US6846828B2 (en) | 2005-01-25 |
JP2005511608A (ja) | 2005-04-28 |
US7157580B2 (en) | 2007-01-02 |
WO2003040131A1 (en) | 2003-05-15 |
RU2004117545A (ru) | 2005-05-27 |
MXPA04004166A (es) | 2004-07-08 |
US20050107403A1 (en) | 2005-05-19 |
EP1444223A1 (en) | 2004-08-11 |
RU2308455C2 (ru) | 2007-10-20 |
PL370480A1 (en) | 2005-05-30 |
CA2465711A1 (en) | 2003-05-15 |
BR0213899A (pt) | 2004-08-31 |
KR20050042062A (ko) | 2005-05-04 |
CN1582284A (zh) | 2005-02-16 |
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