CO5580823A2 - Amidas de acido antranilico y su uso como inhibidores de tirosina-cinasa del receptor de vegf - Google Patents

Amidas de acido antranilico y su uso como inhibidores de tirosina-cinasa del receptor de vegf

Info

Publication number
CO5580823A2
CO5580823A2 CO04043909A CO04043909A CO5580823A2 CO 5580823 A2 CO5580823 A2 CO 5580823A2 CO 04043909 A CO04043909 A CO 04043909A CO 04043909 A CO04043909 A CO 04043909A CO 5580823 A2 CO5580823 A2 CO 5580823A2
Authority
CO
Colombia
Prior art keywords
treatment
amidas
lower alkyl
kinase inhibitors
vegf receptor
Prior art date
Application number
CO04043909A
Other languages
English (en)
Inventor
Guido Bold
Pascal Furet
Paul William Manley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO5580823A2 publication Critical patent/CO5580823A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms

Abstract

1.- Una amida de ácido antranílico de la fórmula I: en donde:R1 representa H o alquilo inferior, R2 representa H o alquilo inferior, R3 representa perfluoroalquilo inferior, y X es O ó S, o un N-óxido o un tautómero de la misma, o una sal de esta amida de ácido antranílico, su N-óxido o su tautómero.2.- Una amida de ácido antranílico de la fórmula I de acuerdo con la reivindicación 1, en donde:R1 representa H o alquilo inferior, R2 representa H o alquilo inferior, R3 representa trifluorometilo, y X es O,o un N-óxido o un tautómero de la misma,o una sal de esta amida de ácido antranílico, su N-óxido o su tautómero.3.- Una amida de ácido antranílico de la fórmula I de acuerdo con la reivindicación 1, en donde:R1 representa H o metilo, R2 representa H o metilo, R3 representa trifluorometilo, y X es O, o un tautómero de la misma, o una sal de esta amida de ácido antranílico o su tautómero.4.- Una amida de ácido antranílico de la fórmula I de acuerdo con la reivindicación 1, seleccionada a partir de:2-[[6-metoxi-3-piridinil]metil]amino-N-[3-(trifluorometil) fenil]benzamida, sal de clorhidrato, 2-[[6-metoxi-3-piridinil]metil]amino-N-[2-metil-1-3-(trifluoro-metil)fenil]benzamida,2-[[(1,6-dihidro-6-oxo-3-piridinil)metil]amino]-N-[3-(trifluorometil)fenil]benzamida, y 2-[[(1,6-dihidro-6-oxo-3-piridinil)metil]amino]-N-[2-metil-3-(trifluorometiI)fenil]-benzamida, o un N-óxido o un tautómero de la misma, o una sal de esta amida de ácido antranílico, su N-óxido o su tautómero.
CO04043909A 2001-11-08 2004-05-12 Amidas de acido antranilico y su uso como inhibidores de tirosina-cinasa del receptor de vegf CO5580823A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0126902.6A GB0126902D0 (en) 2001-11-08 2001-11-08 Organic compounds

Publications (1)

Publication Number Publication Date
CO5580823A2 true CO5580823A2 (es) 2005-11-30

Family

ID=9925448

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04043909A CO5580823A2 (es) 2001-11-08 2004-05-12 Amidas de acido antranilico y su uso como inhibidores de tirosina-cinasa del receptor de vegf

Country Status (28)

Country Link
US (2) US7091224B2 (es)
EP (1) EP1446382B1 (es)
JP (1) JP2005511602A (es)
KR (1) KR100602977B1 (es)
CN (1) CN1300113C (es)
AT (1) ATE496889T1 (es)
AU (1) AU2002351909B2 (es)
BR (1) BR0213970A (es)
CA (1) CA2463968C (es)
CO (1) CO5580823A2 (es)
DE (1) DE60239073D1 (es)
ES (1) ES2360283T3 (es)
GB (1) GB0126902D0 (es)
HR (1) HRP20040411A2 (es)
IL (1) IL161747A0 (es)
MX (1) MXPA04004391A (es)
NO (1) NO327231B1 (es)
NZ (1) NZ532590A (es)
PE (1) PE20030714A1 (es)
PL (1) PL368416A1 (es)
PT (1) PT1446382E (es)
RU (1) RU2318811C2 (es)
SA (1) SA02230412B1 (es)
TW (1) TWI260222B (es)
UA (1) UA77446C2 (es)
WO (1) WO2003040102A1 (es)
YU (1) YU36004A (es)
ZA (1) ZA200402940B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7307088B2 (en) * 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
US7615565B2 (en) 2002-07-31 2009-11-10 Bayer Schering Pharma Aktiengesellschaft VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
GB0229022D0 (en) * 2002-12-12 2003-01-15 Novartis Ag Organic Compounds
DE10327719A1 (de) * 2003-06-13 2005-01-20 Schering Ag VEGFR-2 und VEGFR-3 Inhibitorische Anthranylamidpyridone
US7202260B2 (en) 2003-06-13 2007-04-10 Schering Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones
US7129252B2 (en) * 2003-06-16 2006-10-31 Guoqing P Chen Six membered amino-amide derivatives an angiogenisis inhibitors
UA89035C2 (ru) 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
EP1568368A1 (en) * 2004-02-26 2005-08-31 Schering Aktiengesellschaft Pharmaceutical combination comprising a CDK inhibitor and a VEGF receptor inhibitor
EP1655295A1 (en) 2004-11-03 2006-05-10 Schering Aktiengesellschaft Anthranilamide pyridinureas as VEGF receptor kinase inhibitors
US7906533B2 (en) 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
EP1657241A1 (en) 2004-11-03 2006-05-17 Schering Aktiengesellschaft Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors
AU2005312721B9 (en) 2004-12-07 2012-08-02 Toyama Chemical Co., Ltd. Novel anthranilic acid derivative or salt thereof
US7547782B2 (en) * 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
CN101323629B (zh) * 2007-02-16 2011-08-17 江苏正大天晴药业股份有限公司 4-{6-[5-(2-氯-6-甲基苯胺甲酰基)-噻唑-2-氨基]-2-甲基嘧啶-4}-哌嗪-1-甲基磷酸二乙酯
CN102131782B (zh) 2008-08-27 2014-07-30 利奥制药有限公司 作为vegf-2受体和蛋白酪氨酸激酶抑制剂的吡啶衍生物
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
GB201322538D0 (en) 2013-06-21 2014-02-05 Immusmol Sas Method for detecting small molecules in a sample
CN107954893A (zh) * 2017-11-28 2018-04-24 兰州纬寰生物科技有限公司 邻氨基苯甲酰胺衍生物及制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9824579D0 (en) * 1998-11-10 1999-01-06 Novartis Ag Organic compounds
UA71587C2 (uk) * 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів

Also Published As

Publication number Publication date
CA2463968A1 (en) 2003-05-15
JP2005511602A (ja) 2005-04-28
PE20030714A1 (es) 2003-10-13
US7482369B2 (en) 2009-01-27
TW200300087A (en) 2003-05-16
BR0213970A (pt) 2004-08-31
CN1585750A (zh) 2005-02-23
PT1446382E (pt) 2011-05-03
NZ532590A (en) 2005-12-23
ATE496889T1 (de) 2011-02-15
TWI260222B (en) 2006-08-21
US20050096356A1 (en) 2005-05-05
MXPA04004391A (es) 2005-12-12
RU2318811C2 (ru) 2008-03-10
YU36004A (sh) 2006-08-17
ZA200402940B (en) 2005-02-10
ES2360283T3 (es) 2011-06-02
GB0126902D0 (en) 2002-01-02
HRP20040411A2 (en) 2005-04-30
EP1446382A1 (en) 2004-08-18
SA02230412B1 (ar) 2007-07-31
CA2463968C (en) 2011-02-22
KR100602977B1 (ko) 2006-07-20
NO20042187L (no) 2004-05-26
PL368416A1 (en) 2005-03-21
IL161747A0 (en) 2005-11-20
UA77446C2 (en) 2006-12-15
CN1300113C (zh) 2007-02-14
EP1446382B1 (en) 2011-01-26
WO2003040102A1 (en) 2003-05-15
KR20050044382A (ko) 2005-05-12
AU2002351909B2 (en) 2007-04-26
US7091224B2 (en) 2006-08-15
US20060178409A1 (en) 2006-08-10
RU2004117543A (ru) 2006-01-10
DE60239073D1 (de) 2011-03-10
NO327231B1 (no) 2009-05-18

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