CO5560586A2 - Acido n-(5-clorosaliciloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides - Google Patents

Acido n-(5-clorosaliciloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides

Info

Publication number
CO5560586A2
CO5560586A2 CO04013136A CO04013136A CO5560586A2 CO 5560586 A2 CO5560586 A2 CO 5560586A2 CO 04013136 A CO04013136 A CO 04013136A CO 04013136 A CO04013136 A CO 04013136A CO 5560586 A2 CO5560586 A2 CO 5560586A2
Authority
CO
Colombia
Prior art keywords
pth
pharmaceutical composition
composition according
acid
chlorosaliciloil
Prior art date
Application number
CO04013136A
Other languages
English (en)
Inventor
Moise Azria
Simon David Bateman
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO5560586A2 publication Critical patent/CO5560586A2/es

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones

Abstract

1.- Una composición farmacéutica para suministro oral, que comprende una cantidad terapéuticamente efectiva de un fragmento de PTH y 5-CNAC, dicho fragmento de PTH seleccionado de PTH (1-28) a PTH (1-41).2.- Una composición farmacéutica de acuerdo con la reivindicación 1, en donde la PTH se selecciona de PTH (1-28), PTH (1-31), PTH (1-34), PTH (1-37), PTH (1-38) Y PTH (1-41).3.- Una composición farmacéutica de acuerdo con la reivindicación 1, en donde PTH es PTH (1-34).4.- Una composición farmacéutica de acuerdo con la reivindicación 1, en donde la PTH es PTH recombinante.5.- Una composición farmacéutica de acuerdo con la reivindicación 3, en donde la PTH es PTH recombinante.6.- Una composición farmacéutica de acuerdo con la reivindicación 1, en donde la PTH es hormona paratiroides humana.7.- Una composición farmacéutica de acuerdo con la reivindicación 6, en donde la hormona paratiroides humana es hPTH (1-34).8.- Una composición farmacéutica de acuerdo con la reivindicación 1, en donde el 5-CNAC se selecciona del ácido libre, la sal disódica de ácido N-(5-clorosaliciloil)-8-aminocaprílico y su monohidrato.
CO04013136A 2001-08-17 2004-02-17 Acido n-(5-clorosaliciloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides CO5560586A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31304801P 2001-08-17 2001-08-17

Publications (1)

Publication Number Publication Date
CO5560586A2 true CO5560586A2 (es) 2005-09-30

Family

ID=23214149

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04013136A CO5560586A2 (es) 2001-08-17 2004-02-17 Acido n-(5-clorosaliciloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides

Country Status (26)

Country Link
US (4) US20040242478A1 (es)
EP (1) EP1420827B8 (es)
JP (2) JP4959917B2 (es)
KR (1) KR20040030120A (es)
CN (1) CN1279981C (es)
AT (1) ATE443527T1 (es)
AU (1) AU2002333443C1 (es)
BR (1) BRPI0211932B1 (es)
CA (1) CA2453646C (es)
CO (1) CO5560586A2 (es)
CY (1) CY1109661T1 (es)
DE (1) DE60233803D1 (es)
DK (1) DK1420827T3 (es)
EC (1) ECSP044961A (es)
ES (1) ES2333587T3 (es)
HU (1) HUP0401441A3 (es)
IL (2) IL159714A0 (es)
MX (1) MXPA04001418A (es)
NO (1) NO328069B1 (es)
NZ (1) NZ531018A (es)
PL (1) PL210258B1 (es)
PT (1) PT1420827E (es)
RU (1) RU2322256C2 (es)
SI (1) SI1420827T1 (es)
WO (1) WO2003015822A1 (es)
ZA (1) ZA200400242B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101837120A (zh) * 2001-06-01 2010-09-22 诺瓦提斯公司 口服施用甲状旁腺激素和降钙素
NZ531018A (en) * 2001-08-17 2006-03-31 Novartis Ag 5-CNAC as oral delivery agent for parathyroid hormone fragments
DE60318192T2 (de) * 2002-04-10 2008-04-30 The University Of Virginia Patent Foundation Verwendung von a2a adenosin rezeptor agonisten und anti-pathogene mittel enthaltenden kombinationen zur behandlung von entzündungskrankheiten
US20050054557A1 (en) * 2002-05-09 2005-03-10 Goldberg Michael M. Compositions for delivering parathyroid hormone and calcitonin
PT2316473E (pt) 2003-07-23 2013-09-20 Novartis Ag Utilização de calcitonina na osteoartrite
GB0427600D0 (en) * 2004-12-16 2005-01-19 Novartis Ag Organic compounds
US8110547B2 (en) * 2005-01-12 2012-02-07 Emisphere Technologies, Inc. Compositions for buccal delivery of parathyroid hormone
EP1896134A2 (en) * 2005-06-13 2008-03-12 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders
EP1937627A4 (en) 2005-09-19 2010-09-01 Emisphere Tech Inc CRYSTALLINE FORMS OF N-(5-CHLOROSALICYLOYL) -8-AMINOCAPRYL ACETATE
GB0522566D0 (en) * 2005-11-04 2005-12-14 Novartis Ag Organic compounds
EP1945245A2 (en) * 2005-11-10 2008-07-23 The Board of Control of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
JP5042312B2 (ja) * 2006-08-31 2012-10-03 ノバルティス アーゲー Hghを含む経口送達用医薬組成物
PL2131810T3 (pl) * 2007-03-02 2011-09-30 Novartis Ag Podawanie doustne kalcytoniny
NZ585080A (en) 2007-11-02 2012-05-25 Emisphere Tech Inc Composition comprising Vitamin B12 and N-[8-(2-hydroxybenzoyl) amino ]caprylic acid and salts thereof for treating Vitamin B12 deficiency
JP2013512688A (ja) 2009-12-07 2013-04-18 ミシガン テクノロジカル ユニバーシティ クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法
WO2012130193A1 (en) 2011-03-31 2012-10-04 Zentiva, K.S. Non-covalent soluble complexes of teriparatide with polysaccharides and a dosage form of teriparatide for oral administration
IL253802B (en) * 2015-02-09 2022-06-01 Entera Bio Ltd A preparation for the treatment of osteoporosis
KR101796604B1 (ko) * 2016-08-30 2017-11-10 목포대학교 산학협력단 위장관 흡수증진제를 함유하는 부갑상선 호르몬의 경구 투여 제형

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US4692433A (en) * 1983-10-12 1987-09-08 The Regents Of The University Of California Method and composition for regulating serum calcium levels of mammals
EP0618805A1 (en) * 1991-12-17 1994-10-12 PROCTER & GAMBLE PHARMACEUTICALS, INC. Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone
JP3717925B2 (ja) * 1992-09-29 2005-11-16 ネクター セラピューティクス 副甲状腺ホルモンの活性フラグメントの肺導入
US5773647A (en) * 1997-02-07 1998-06-30 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DK0993831T3 (da) * 1997-02-07 2008-03-25 Emisphere Tech Inc Forbindelser og præparater til tilförsel af aktive stoffer
JP2003533167A (ja) * 1998-11-25 2003-11-11 ザ ゼネラル ホスピタル コーポレーション アミノ末端改変副甲状腺ホルモン(pth)アナログ
NZ534409A (en) * 1999-04-05 2006-03-31 Emisphere Tech Inc Disodium salts, monohydrates, and ethanol solvates for delivering active agents
ES2386263T3 (es) * 2000-03-21 2012-08-14 Emisphere Technologies, Inc. Método de preparación de salicilamidas alquiladas mediante un producto intermedio de dicarboxilato
CN101837120A (zh) 2001-06-01 2010-09-22 诺瓦提斯公司 口服施用甲状旁腺激素和降钙素
NZ531018A (en) * 2001-08-17 2006-03-31 Novartis Ag 5-CNAC as oral delivery agent for parathyroid hormone fragments
EP1651248B1 (en) * 2003-07-11 2009-09-09 Novartis AG Orally dosed pharmaceutical compositions comprising a delivery agent in micronized form

Also Published As

Publication number Publication date
JP2005501852A (ja) 2005-01-20
SI1420827T1 (sl) 2010-01-29
HUP0401441A2 (hu) 2004-12-28
AU2002333443B2 (en) 2006-06-29
RU2322256C2 (ru) 2008-04-20
US20040242478A1 (en) 2004-12-02
US20060217313A1 (en) 2006-09-28
ZA200400242B (en) 2004-11-18
WO2003015822A1 (en) 2003-02-27
CN1279981C (zh) 2006-10-18
EP1420827B8 (en) 2009-12-23
BR0211932A (pt) 2004-10-26
PL365388A1 (en) 2005-01-10
US20120088725A1 (en) 2012-04-12
DE60233803D1 (de) 2009-11-05
ATE443527T1 (de) 2009-10-15
EP1420827A1 (en) 2004-05-26
CN1543357A (zh) 2004-11-03
JP2009242410A (ja) 2009-10-22
AU2002333443C1 (en) 2009-10-08
ES2333587T3 (es) 2010-02-24
JP4959917B2 (ja) 2012-06-27
HUP0401441A3 (en) 2012-09-28
IL159714A (en) 2010-12-30
EP1420827B1 (en) 2009-09-23
BRPI0211932B1 (pt) 2016-12-06
CY1109661T1 (el) 2014-08-13
MXPA04001418A (es) 2004-05-27
ECSP044961A (es) 2004-03-23
PT1420827E (pt) 2009-12-15
IL159714A0 (en) 2004-06-20
NO20040598L (no) 2004-02-10
DK1420827T3 (da) 2009-12-21
US9272040B2 (en) 2016-03-01
NO328069B1 (no) 2009-11-23
NZ531018A (en) 2006-03-31
PL210258B1 (pl) 2011-12-30
US20090264367A1 (en) 2009-10-22
RU2004107899A (ru) 2005-05-10
CA2453646C (en) 2008-09-30
CA2453646A1 (en) 2003-02-27
KR20040030120A (ko) 2004-04-08

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