CO5320599A1 - Inhibidores no peptidilicos de la union a las celulas depen dientes de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias - Google Patents

Inhibidores no peptidilicos de la union a las celulas depen dientes de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias

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Publication number
CO5320599A1
CO5320599A1 CO99040934A CO99040934A CO5320599A1 CO 5320599 A1 CO5320599 A1 CO 5320599A1 CO 99040934 A CO99040934 A CO 99040934A CO 99040934 A CO99040934 A CO 99040934A CO 5320599 A1 CO5320599 A1 CO 5320599A1
Authority
CO
Colombia
Prior art keywords
heteroaryl
aryl
vla
autoimmune
union
Prior art date
Application number
CO99040934A
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English (en)
Spanish (es)
Inventor
Allen Jacob Duplantier
Anthony John Milici
Louis Stanley Chupak
Original Assignee
Pfizer Prod Inc
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Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5320599A1 publication Critical patent/CO5320599A1/es

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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CO99040934A 1998-06-30 1999-06-30 Inhibidores no peptidilicos de la union a las celulas depen dientes de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias CO5320599A1 (es)

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Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
IL139835A (en) 1998-06-12 2005-11-20 Sod Conseils Rech Applic Imidazolyl derivatives and their use as somatostatin receptor ligands
PL345308A1 (en) * 1998-06-30 2001-12-03 Pfizer Prod Inc Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
US6518292B1 (en) * 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
US6756378B2 (en) * 1999-06-30 2004-06-29 Pharmacopeia Drug Discovery, Inc. VLA-4 inhibitor compounds
CN1391473A (zh) * 1999-06-30 2003-01-15 第一制药株式会社 Vla－4抑制剂化合物
AP2002002565A0 (en) 1999-12-28 2002-06-30 Pfizer Prod Inc Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases.
WO2001056994A1 (en) * 2000-02-04 2001-08-09 Biogen, Inc. Integrin antagonists
AU2001268607A1 (en) 2000-06-21 2002-01-02 Bristol-Myers Squibb Company Piperidine amides as modulators of chemokine receptor activity
AU7909801A (en) * 2000-08-01 2002-02-13 Sod Conseils Rech Applic Imidazolyl derivatives
GB2367816A (en) * 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
EP1346982B1 (en) 2000-12-28 2011-09-14 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
DE10111877A1 (de) * 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CA2446136C (en) 2001-05-03 2011-07-05 Galileo Pharmaceuticals, Inc. Pyruvate derivatives
DK1392306T3 (da) * 2001-06-06 2008-05-19 Aventis Pharma Ltd Substituerede tetrahydroisoquinoliner til anvendelse i behandlingen af inflammatoriske sygdomme
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
WO2003024401A2 (en) * 2001-09-18 2003-03-27 Bristol-Myers Squibb Company Piperizinones as modulators of chemokine receptor activity
WO2003105771A2 (en) 2002-06-17 2003-12-24 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
AU2003259131A1 (en) 2002-07-09 2004-01-23 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
ATE555106T1 (de) 2003-07-24 2012-05-15 Daiichi Sankyo Co Ltd Cyclohexancarbonsäureverbindung
GB0402812D0 (en) * 2004-02-09 2004-03-10 Tanabe Seiyaku Co Novel compounds
US7309709B2 (en) * 2004-04-01 2007-12-18 Pfizer Inc. Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders
TW200610754A (en) * 2004-06-14 2006-04-01 Daiichi Seiyaku Co Vla-4 inhibitor
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
WO2007069635A1 (ja) 2005-12-13 2007-06-21 Daiichi Sankyo Company, Limited Ｖｌａ－４阻害薬
US20120258093A1 (en) 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
WO2019028362A1 (en) 2017-08-04 2019-02-07 Dyax Corp. INHIBITORS OF PLASMATIC KALLIKREIN AND USES THEREOF
US20240301512A1 (en) 2021-01-29 2024-09-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
US5294713A (en) * 1991-08-23 1994-03-15 Takeda Chemical Industries, Ltd. 2-piperazinone compounds and their use
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
PL345308A1 (en) * 1998-06-30 2001-12-03 Pfizer Prod Inc Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases

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PL345308A1 (en) 2001-12-03
EP1091943B1 (en) 2005-11-30
SK20052000A3 (sk) 2002-08-06
CN1308616A (zh) 2001-08-15
BR9911701A (pt) 2001-03-20
CZ20004909A3 (cs) 2002-04-17
JP3676677B2 (ja) 2005-07-27
NO20006600D0 (no) 2000-12-22
IL139584A0 (en) 2002-02-10
WO2000000477A1 (en) 2000-01-06
AP9901561A0 (en) 1999-06-30
AU3841699A (en) 2000-01-17
HRP20000917A2 (en) 2002-02-28
EA200001238A1 (ru) 2001-08-27
EA004792B1 (ru) 2004-08-26
BG105190A (en) 2001-12-29
US6355662B1 (en) 2002-03-12
CA2336625A1 (en) 2000-01-06
AU758939B2 (en) 2003-04-03
MA26640A1 (fr) 2004-12-20
HUP0102477A2 (hu) 2002-05-29
US6306887B1 (en) 2001-10-23
ATE311371T1 (de) 2005-12-15
ID27414A (id) 2001-04-05
OA11577A (en) 2004-07-26
TNSN99110A1 (fr) 2005-11-10
NO20006600L (no) 2001-02-21
KR20010083081A (ko) 2001-08-31
HN1999000099A (es) 1999-11-11
GT199900101A (es) 2000-12-16
AR015312A1 (es) 2001-04-18
HUP0102477A3 (en) 2002-08-28
YU77600A (sh) 2004-03-12
JP2002519344A (ja) 2002-07-02
PE20000762A1 (es) 2000-08-24
ZA993777B (en) 2000-12-04
PA8477001A1 (es) 2000-05-24
EP1091943A1 (en) 2001-04-18
IS5720A (is) 2000-11-21
DE69928667D1 (de) 2006-01-05
AP1236A (en) 2004-01-14
NZ508033A (en) 2002-12-20
TR200003848T2 (tr) 2001-06-21
UA66864C2 (uk) 2004-06-15
DE69928667T2 (de) 2006-08-10

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