BR9911701A - Inibidores não peptidila da ligação à célula dependente de vla-4 úteis no tratamento de doenças inflamatórias, auto-imunes e respiratórias - Google Patents

Inibidores não peptidila da ligação à célula dependente de vla-4 úteis no tratamento de doenças inflamatórias, auto-imunes e respiratórias

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Publication number
BR9911701A
BR9911701A BR9911701-0A BR9911701A BR9911701A BR 9911701 A BR9911701 A BR 9911701A BR 9911701 A BR9911701 A BR 9911701A BR 9911701 A BR9911701 A BR 9911701A
Authority
BR
Brazil
Prior art keywords
vla
inflammatory
autoimmune
cell binding
dependent cell
Prior art date
Application number
BR9911701-0A
Other languages
English (en)
Inventor
Allen Jacob Duplantier
Anthony John Milici
Louis Stanley Chupak
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9911701A publication Critical patent/BR9911701A/pt

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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Abstract

Patente de Invenção: <B>"INIBIDORES NãO PEPTIDILA DA LIGAçãO à CéLULA DEPENDENTE DE VLA-4 úTEIS NO TRATAMENTO DE DOENçAS INFLAMATóRIAS, AUTO-IMUNES E RESPIRATóRIAS"<D>. Compostos de Fórmula (1.0.0): são descritos, em que A é por exemplo arila, heteroarila ou heterociclila, Y é preferivelmente -C(=O)-; B é independentemente selecionado de um grupo de porções, as mais preferidas das quais são as de Fórmulas parciais (1.1.2) e (1.1.6): e E é uma ligação simples, oxigênio, 1,1-ciclopropila, C(CH~ 3~)~ 2~, CF~ 2~, ou uma porção em ponte de Fórmula parcial (1.9.0): onde R¹~ a~ é hidrogênio quando R¹ tem o significado de um substituinte monovalente; e R¹~ a~ é uma ligação simples quando R¹ tem o significado de um substituinte divalente. Tais compostos são úteis em métodos de tratamento ou prevenção de uma doença inflamatória, auto-imune ou respiratória pela inibição da adesão de célula e processos patogênicos conseq³entes ou associados subseq³entemente mediados por VLA-4.
BR9911701-0A 1998-06-30 1999-05-31 Inibidores não peptidila da ligação à célula dependente de vla-4 úteis no tratamento de doenças inflamatórias, auto-imunes e respiratórias BR9911701A (pt)

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US9118098P 1998-06-30 1998-06-30
PCT/IB1999/000973 WO2000000477A1 (en) 1998-06-30 1999-05-31 Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases

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