HN1999000099A - Inhibidores no peptidilicos de la union a las celulas dependientes de vla- 4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias. - Google Patents

Inhibidores no peptidilicos de la union a las celulas dependientes de vla- 4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias.

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Publication number
HN1999000099A
HN1999000099A HN1999000099A HN1999000099A HN1999000099A HN 1999000099 A HN1999000099 A HN 1999000099A HN 1999000099 A HN1999000099 A HN 1999000099A HN 1999000099 A HN1999000099 A HN 1999000099A HN 1999000099 A HN1999000099 A HN 1999000099A
Authority
HN
Honduras
Prior art keywords
inhibitors
peptidilic
vela
autoimmune
union
Prior art date
Application number
HN1999000099A
Other languages
English (en)
Inventor
Allen Jacob Duplantier
Jhony John Milici
Louis Stanley Chupak
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HN1999000099A publication Critical patent/HN1999000099A/es

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE TIENEN UNA ESTRUCTURA NO PEPTIDILICA Y SON ACTIVOS COMO POTENTES INHIBIDORES DE LA UNION DEL ANTIGENO-4 MUY TARDIO A PROTEINAS COMO LA MOLECULA DE ADHESION CELULAR 1 (VCAM-1), EL DOMINIO HepII/IIICS (regi¢n CS-1) DE FIBRONECTINA Y OSTEOPONTINA.
HN1999000099A 1998-06-30 1999-06-17 Inhibidores no peptidilicos de la union a las celulas dependientes de vla- 4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias. HN1999000099A (es)

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EP1244656A1 (en) 1999-12-28 2002-10-02 Pfizer Products Inc. Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
AU2001234741A1 (en) * 2000-02-04 2001-08-14 Biogen, Inc. Integrin antagonists
JP2004516237A (ja) * 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのピペリジンアミド類
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GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
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IL139584A0 (en) 2002-02-10
PE20000762A1 (es) 2000-08-24
CA2336625A1 (en) 2000-01-06
BR9911701A (pt) 2001-03-20
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AU3841699A (en) 2000-01-17
WO2000000477A1 (en) 2000-01-06
US6306887B1 (en) 2001-10-23
TR200003848T2 (tr) 2001-06-21
AP9901561A0 (en) 1999-06-30
AP1236A (en) 2004-01-14
GT199900101A (es) 2000-12-16
KR20010083081A (ko) 2001-08-31
CZ20004909A3 (cs) 2002-04-17
ZA993777B (en) 2000-12-04
CN1308616A (zh) 2001-08-15
TNSN99110A1 (fr) 2005-11-10
HUP0102477A2 (hu) 2002-05-29
OA11577A (en) 2004-07-26
HUP0102477A3 (en) 2002-08-28
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EA200001238A1 (ru) 2001-08-27
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CO5320599A1 (es) 2003-09-30
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