IS5720A - Latar gegn peptídýli af VLA-4 skilyrtri frumutengingu gagnlegir til meðhöndlunar á bólguvaldandi-, sjálfónæmis, og öndunarsjúkdómum - Google Patents
Latar gegn peptídýli af VLA-4 skilyrtri frumutengingu gagnlegir til meðhöndlunar á bólguvaldandi-, sjálfónæmis, og öndunarsjúkdómumInfo
- Publication number
- IS5720A IS5720A IS5720A IS5720A IS5720A IS 5720 A IS5720 A IS 5720A IS 5720 A IS5720 A IS 5720A IS 5720 A IS5720 A IS 5720A IS 5720 A IS5720 A IS 5720A
- Authority
- IS
- Iceland
- Prior art keywords
- vla
- autoimmune
- latency
- inflammatory
- inhibitors
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 title 1
- 230000001363 autoimmune Effects 0.000 title 1
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 title 1
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9118098P | 1998-06-30 | 1998-06-30 | |
| PCT/IB1999/000973 WO2000000477A1 (en) | 1998-06-30 | 1999-05-31 | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS5720A true IS5720A (is) | 2000-11-21 |
Family
ID=22226483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS5720A IS5720A (is) | 1998-06-30 | 2000-11-21 | Latar gegn peptídýli af VLA-4 skilyrtri frumutengingu gagnlegir til meðhöndlunar á bólguvaldandi-, sjálfónæmis, og öndunarsjúkdómum |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US6355662B1 (is) |
| EP (1) | EP1091943B1 (is) |
| JP (1) | JP3676677B2 (is) |
| KR (1) | KR20010083081A (is) |
| CN (1) | CN1308616A (is) |
| AP (1) | AP1236A (is) |
| AR (1) | AR015312A1 (is) |
| AT (1) | ATE311371T1 (is) |
| AU (1) | AU758939B2 (is) |
| BG (1) | BG105190A (is) |
| BR (1) | BR9911701A (is) |
| CA (1) | CA2336625A1 (is) |
| CO (1) | CO5320599A1 (is) |
| CZ (1) | CZ20004909A3 (is) |
| DE (1) | DE69928667T2 (is) |
| EA (1) | EA004792B1 (is) |
| GT (1) | GT199900101A (is) |
| HN (1) | HN1999000099A (is) |
| HR (1) | HRP20000917A2 (is) |
| HU (1) | HUP0102477A3 (is) |
| ID (1) | ID27414A (is) |
| IL (1) | IL139584A0 (is) |
| IS (1) | IS5720A (is) |
| MA (1) | MA26640A1 (is) |
| NO (1) | NO20006600L (is) |
| NZ (1) | NZ508033A (is) |
| OA (1) | OA11577A (is) |
| PA (1) | PA8477001A1 (is) |
| PE (1) | PE20000762A1 (is) |
| PL (1) | PL345308A1 (is) |
| SK (1) | SK20052000A3 (is) |
| TN (1) | TNSN99110A1 (is) |
| TR (1) | TR200003848T2 (is) |
| UA (1) | UA66864C2 (is) |
| WO (1) | WO2000000477A1 (is) |
| YU (1) | YU77600A (is) |
| ZA (1) | ZA993777B (is) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6992107B1 (en) | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
| WO1999064401A2 (en) | 1998-06-12 | 1999-12-16 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Imidazolyl derivatives and their use as somatostatin receptor ligands |
| OA11577A (en) * | 1998-06-30 | 2004-07-26 | Pfizer Prod Inc | Non-peptidyl inhibitors of VLA-4 dependent cell vinding useful in treating inflammatory, autoimmune,and respiratory diseases. |
| US6518292B1 (en) * | 1999-03-12 | 2003-02-11 | Bristol-Myers Squibb Co. | Heterocyclic aromatic compounds usefuls as growth hormone secretagogues |
| MXPA01013406A (es) * | 1999-06-30 | 2003-09-04 | Daiichi Seiyaku Co | Compuestos inhibidores de vla-4. |
| US6756378B2 (en) * | 1999-06-30 | 2004-06-29 | Pharmacopeia Drug Discovery, Inc. | VLA-4 inhibitor compounds |
| AU2018301A (en) | 1999-12-28 | 2001-07-24 | Pfizer Products Inc. | Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
| WO2001056994A1 (en) * | 2000-02-04 | 2001-08-09 | Biogen, Inc. | Integrin antagonists |
| JP2004516237A (ja) * | 2000-06-21 | 2004-06-03 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | ケモカイン受容体活性調節剤としてのピペリジンアミド類 |
| ES2282275T3 (es) * | 2000-08-01 | 2007-10-16 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivados de imidazolilo. |
| GB2367816A (en) * | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
| AU2002219555B2 (en) | 2000-12-28 | 2006-11-30 | Daiichi Pharmaceutical Co., Ltd. | VLA-4 Inhibitors |
| DE10111877A1 (de) * | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| CA2446136C (en) | 2001-05-03 | 2011-07-05 | Galileo Pharmaceuticals, Inc. | Pyruvate derivatives |
| ATE383858T1 (de) * | 2001-06-06 | 2008-02-15 | Aventis Pharma Ltd | Substituierte tetrhydroisochinolin-derivate zur behandlung von entzündlichen erkrankungen |
| GB2377933A (en) | 2001-07-06 | 2003-01-29 | Bayer Ag | Succinic acid derivatives useful as integrin antagonists |
| DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
| US6974869B2 (en) * | 2001-09-18 | 2005-12-13 | Bristol-Myers Squibb Pharma Company | Piperizinones as modulators of chemokine receptor activity |
| AU2003276043A1 (en) | 2002-06-17 | 2003-12-31 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
| EP1656368A4 (en) * | 2002-07-09 | 2009-08-26 | Bristol Myers Squibb Co | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AGENTS AND ANTIABESITY AND THEIR MANUFACTURING PROCESS |
| KR101051842B1 (ko) | 2003-07-24 | 2011-07-25 | 다이이찌 세이야꾸 가부시기가이샤 | 시클로헥산카르복실산류 |
| GB0402812D0 (en) * | 2004-02-09 | 2004-03-10 | Tanabe Seiyaku Co | Novel compounds |
| US7309709B2 (en) * | 2004-04-01 | 2007-12-18 | Pfizer Inc. | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders |
| TW200610754A (en) * | 2004-06-14 | 2006-04-01 | Daiichi Seiyaku Co | Vla-4 inhibitor |
| US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| EP1961750B1 (en) | 2005-12-13 | 2013-09-18 | Daiichi Sankyo Company, Limited | Vla-4 inhibitory drug |
| US20120258093A1 (en) | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
| CA3070717A1 (en) | 2017-08-04 | 2019-02-07 | Dyax Corp. | Inhibitors of plasma kallikrein and uses thereof |
| WO2022162164A1 (en) | 2021-01-29 | 2022-08-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU646966B2 (en) * | 1991-08-23 | 1994-03-10 | Takeda Chemical Industries Ltd. | 2-piperazinone compounds, their production and use |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| OA11577A (en) * | 1998-06-30 | 2004-07-26 | Pfizer Prod Inc | Non-peptidyl inhibitors of VLA-4 dependent cell vinding useful in treating inflammatory, autoimmune,and respiratory diseases. |
-
1999
- 1999-05-31 OA OA1200000361A patent/OA11577A/en unknown
- 1999-05-31 ID IDW20002723A patent/ID27414A/id unknown
- 1999-05-31 EA EA200001238A patent/EA004792B1/ru not_active IP Right Cessation
- 1999-05-31 CN CN99808134A patent/CN1308616A/zh active Pending
- 1999-05-31 HU HU0102477A patent/HUP0102477A3/hu unknown
- 1999-05-31 CZ CZ20004909A patent/CZ20004909A3/cs unknown
- 1999-05-31 YU YU77600A patent/YU77600A/sh unknown
- 1999-05-31 WO PCT/IB1999/000973 patent/WO2000000477A1/en not_active Application Discontinuation
- 1999-05-31 AT AT99921046T patent/ATE311371T1/de not_active IP Right Cessation
- 1999-05-31 IL IL13958499A patent/IL139584A0/xx unknown
- 1999-05-31 DE DE69928667T patent/DE69928667T2/de not_active Expired - Fee Related
- 1999-05-31 PL PL99345308A patent/PL345308A1/xx not_active Application Discontinuation
- 1999-05-31 CA CA002336625A patent/CA2336625A1/en not_active Abandoned
- 1999-05-31 TR TR2000/03848T patent/TR200003848T2/xx unknown
- 1999-05-31 US US09/403,846 patent/US6355662B1/en not_active Expired - Fee Related
- 1999-05-31 KR KR1020007015120A patent/KR20010083081A/ko not_active Abandoned
- 1999-05-31 JP JP2000557238A patent/JP3676677B2/ja not_active Expired - Fee Related
- 1999-05-31 UA UA2000127651A patent/UA66864C2/uk unknown
- 1999-05-31 AU AU38416/99A patent/AU758939B2/en not_active Ceased
- 1999-05-31 BR BR9911701-0A patent/BR9911701A/pt not_active IP Right Cessation
- 1999-05-31 SK SK2005-2000A patent/SK20052000A3/sk unknown
- 1999-05-31 HR HR20000917A patent/HRP20000917A2/hr not_active Application Discontinuation
- 1999-05-31 NZ NZ508033A patent/NZ508033A/xx unknown
- 1999-05-31 EP EP99921046A patent/EP1091943B1/en not_active Expired - Lifetime
- 1999-06-03 AP APAP/P/1999/001561A patent/AP1236A/en active
- 1999-06-04 ZA ZA9903777A patent/ZA993777B/xx unknown
- 1999-06-07 MA MA25611A patent/MA26640A1/fr unknown
- 1999-06-09 TN TNTNSN99110A patent/TNSN99110A1/fr unknown
- 1999-06-16 AR ARP990102883A patent/AR015312A1/es not_active Application Discontinuation
- 1999-06-17 HN HN1999000099A patent/HN1999000099A/es unknown
- 1999-06-23 US US09/338,832 patent/US6306887B1/en not_active Expired - Fee Related
- 1999-06-25 PE PE1999000583A patent/PE20000762A1/es not_active Application Discontinuation
- 1999-06-25 GT GT199900101A patent/GT199900101A/es unknown
- 1999-06-29 PA PA19998477001A patent/PA8477001A1/es unknown
- 1999-06-30 CO CO99040934A patent/CO5320599A1/es not_active Application Discontinuation
-
2000
- 2000-11-21 IS IS5720A patent/IS5720A/is unknown
- 2000-12-22 NO NO20006600A patent/NO20006600L/no not_active Application Discontinuation
-
2001
- 2001-01-26 BG BG105190A patent/BG105190A/xx unknown
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