CO5261552A1 - Procedimiento para la obtencion de 1,2,3,4-tetrahidroquino- linas 4-carboxiamino-2-sustituidas - Google Patents

Procedimiento para la obtencion de 1,2,3,4-tetrahidroquino- linas 4-carboxiamino-2-sustituidas

Info

Publication number
CO5261552A1
CO5261552A1 CO00085289A CO00085289A CO5261552A1 CO 5261552 A1 CO5261552 A1 CO 5261552A1 CO 00085289 A CO00085289 A CO 00085289A CO 00085289 A CO00085289 A CO 00085289A CO 5261552 A1 CO5261552 A1 CO 5261552A1
Authority
CO
Colombia
Prior art keywords
ethyl
salt
quinoline
dihydro
trifluoromethyl
Prior art date
Application number
CO00085289A
Other languages
English (en)
Spanish (es)
Inventor
Damon David Burns
Robert Wayne Dugger
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5261552A1 publication Critical patent/CO5261552A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CO00085289A 1999-11-30 2000-11-09 Procedimiento para la obtencion de 1,2,3,4-tetrahidroquino- linas 4-carboxiamino-2-sustituidas CO5261552A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
CO5261552A1 true CO5261552A1 (es) 2003-03-31

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00085289A CO5261552A1 (es) 1999-11-30 2000-11-09 Procedimiento para la obtencion de 1,2,3,4-tetrahidroquino- linas 4-carboxiamino-2-sustituidas

Country Status (44)

Country Link
US (1) US6313142B1 (OSRAM)
EP (1) EP1125929B1 (OSRAM)
JP (1) JP3579345B2 (OSRAM)
KR (1) KR100408177B1 (OSRAM)
CN (1) CN1173953C (OSRAM)
AP (1) AP2000002011A0 (OSRAM)
AR (1) AR029775A1 (OSRAM)
AT (1) ATE315028T1 (OSRAM)
AU (1) AU784694B2 (OSRAM)
BG (1) BG105009A (OSRAM)
BR (1) BR0005636A (OSRAM)
CA (1) CA2327029C (OSRAM)
CO (1) CO5261552A1 (OSRAM)
CY (1) CY1104989T1 (OSRAM)
CZ (1) CZ20004407A3 (OSRAM)
DE (1) DE60025317T2 (OSRAM)
DK (1) DK1125929T3 (OSRAM)
DZ (1) DZ3079A1 (OSRAM)
EA (1) EA003668B1 (OSRAM)
EE (1) EE200000659A (OSRAM)
ES (1) ES2254109T3 (OSRAM)
GE (1) GEP20022798B (OSRAM)
GT (1) GT200000190A (OSRAM)
HN (1) HN2000000203A (OSRAM)
HR (1) HRP20000804A2 (OSRAM)
HU (1) HUP0004747A3 (OSRAM)
ID (1) ID28489A (OSRAM)
IL (1) IL139849A (OSRAM)
IS (1) IS5715A (OSRAM)
MA (1) MA25223A1 (OSRAM)
NO (1) NO20006039L (OSRAM)
NZ (1) NZ508509A (OSRAM)
OA (1) OA11494A (OSRAM)
PA (1) PA8503801A1 (OSRAM)
PE (1) PE20010913A1 (OSRAM)
PL (1) PL344208A1 (OSRAM)
SG (1) SG102603A1 (OSRAM)
SK (1) SK17792000A3 (OSRAM)
TN (1) TNSN00230A1 (OSRAM)
TW (1) TW591016B (OSRAM)
UA (1) UA65615C2 (OSRAM)
UY (1) UY26451A1 (OSRAM)
YU (1) YU71500A (OSRAM)
ZA (1) ZA200006947B (OSRAM)

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HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
CA2470931A1 (en) * 2001-12-19 2003-07-03 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
AU2002361811A1 (en) 2001-12-19 2003-07-09 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
CA2480439C (en) * 2002-04-11 2012-08-21 Roar Holding Llc Ex vivo method for determination of cetp activity and efficacy of heart disease treatment
KR20050055747A (ko) * 2002-10-04 2005-06-13 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료용의 ｐｇｄ2 수용체 길항제
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) * 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
AU2003303239A1 (en) * 2002-12-19 2004-07-14 Atherogenics, Inc. Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
MXPA05005813A (es) 2002-12-20 2005-12-12 Pfizer Prod Inc Formas de dosificacion que comprenden un inhibidor de la cetp y un inhibidor de la hmg-coa reductasa.
WO2004078730A2 (en) * 2003-03-04 2004-09-16 Takasago International Corporation Method for producing optically active amines
EP1603554A1 (en) * 2003-03-17 2005-12-14 Japan Tobacco Inc. Method for increasing the oral bioavailability of s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanethioate
SI1603553T1 (sl) * 2003-03-17 2012-03-30 Japan Tobacco Inc Farmacevtski sestavki CETP inhibitorjev
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
CA2537942A1 (en) * 2003-10-08 2005-04-28 Eli Lilly And Company Compounds and methods for treating dyslipidemia
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
US20080269284A1 (en) * 2004-06-24 2008-10-30 Eli Lilly And Company Compounds and Methods for Treating Dyslipidemia
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
RU2007135224A (ru) * 2005-02-24 2009-03-27 Милленниум Фармасьютикалз, Инк. (Us) Антагонисты рецептора pgd2 для лечения воспалительных заболеваний
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
TW200901959A (en) 2007-03-09 2009-01-16 Indigene Pharmaceuticals Inc Combination of metformin R-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
AR077208A1 (es) * 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
KR20250049276A (ko) 2022-07-05 2025-04-11 뉴암스테르담 파마 비.브이. 오비세트라피브(obicetrapib)의 염 및 그의 제조 방법 및 그의 중간체

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US3971789A (en) 1972-10-21 1976-07-27 John Wyeth & Brother Limited O-(4-Quinolylamino)benzamides
GB8432091D0 (en) 1984-12-19 1985-01-30 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
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PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
UA65615C2 (uk) 2004-04-15
DK1125929T3 (da) 2006-04-03
AP2000002011A0 (en) 2000-12-31
KR100408177B1 (ko) 2003-12-01
IS5715A (is) 2001-05-31
HN2000000203A (es) 2001-06-13
DZ3079A1 (fr) 2004-10-24
UY26451A1 (es) 2001-06-29
GEP20022798B (en) 2002-09-25
EA003668B1 (ru) 2003-08-28
YU71500A (sh) 2003-02-28
DE60025317T2 (de) 2006-08-03
AR029775A1 (es) 2003-07-16
AU784694B2 (en) 2006-06-01
EP1125929A1 (en) 2001-08-22
NO20006039L (no) 2001-05-31
US6313142B1 (en) 2001-11-06
ID28489A (id) 2001-05-31
HU0004747D0 (OSRAM) 2001-02-28
JP2001163859A (ja) 2001-06-19
DE60025317D1 (de) 2006-03-30
JP3579345B2 (ja) 2004-10-20
OA11494A (en) 2004-05-07
GT200000190A (es) 2002-04-27
SG102603A1 (en) 2004-03-26
CN1173953C (zh) 2004-11-03
ZA200006947B (en) 2002-05-27
CA2327029C (en) 2005-08-09
BR0005636A (pt) 2001-07-17
PL344208A1 (en) 2001-06-04
PE20010913A1 (es) 2001-09-10
ES2254109T3 (es) 2006-06-16
CZ20004407A3 (cs) 2002-06-12
NZ508509A (en) 2001-06-29
NO20006039D0 (no) 2000-11-29
BG105009A (en) 2001-11-30
HRP20000804A2 (en) 2001-06-30
CY1104989T1 (el) 2010-03-03
EA200001129A2 (ru) 2001-06-25
ATE315028T1 (de) 2006-02-15
TW591016B (en) 2004-06-11
IL139849A (en) 2006-10-31
IL139849A0 (en) 2002-02-10
SK17792000A3 (sk) 2002-10-08
CN1302800A (zh) 2001-07-11
EE200000659A (et) 2001-08-15
PA8503801A1 (es) 2002-07-30
HUP0004747A2 (hu) 2001-10-28
EA200001129A3 (ru) 2001-10-22
HUP0004747A3 (en) 2002-12-28
CA2327029A1 (en) 2001-05-30
AU7178900A (en) 2001-05-31
MA25223A1 (fr) 2001-07-02
KR20010052012A (ko) 2001-06-25
TNSN00230A1 (fr) 2005-11-10
EP1125929B1 (en) 2006-01-04
HK1038007A1 (en) 2002-03-01

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