CO5251383A1 - Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentos - Google Patents
Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentosInfo
- Publication number
- CO5251383A1 CO5251383A1 CO00097385A CO00097385A CO5251383A1 CO 5251383 A1 CO5251383 A1 CO 5251383A1 CO 00097385 A CO00097385 A CO 00097385A CO 00097385 A CO00097385 A CO 00097385A CO 5251383 A1 CO5251383 A1 CO 5251383A1
- Authority
- CO
- Colombia
- Prior art keywords
- aryl
- alkyl
- phenyl
- represent
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bases indólicas de Mannich sustituidas de la fórmula general I<EMI FILE="00097385_1" ID="1" IMF=JPEG >en la cualR1 representa H, un radical C1-10-alquilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno,R2 representa H, F, CI, Br, CF3, CN, NO2, NHR8, SR9, OR10, SO2NH2, SO2NHR21, CO(OR11), CH2CO(OR12), COR19, un radical C1-10-alquilo, arilo o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno,R3 representa CH(R13)N(R14)(R15),R4, R5, R6, R7 pueden ser iguales o distintos entre sí y representan H, F, CI, Br, CF3, CN, NO2, NHR8, SR9, OR10, SO2NH2, SO2NHR21, CO(OR11), CH2CO(OR12), COR19, C1-10-alquilo, arilo o heteroarilo o un radical arilo o heteroarilo ligado a través de C1-6-alquileno,R8 representa H, COR16, C1-10-alquilo o arilo y preferiblemente C1-6-alquilo,R9 representa H, C1-10-alquilo o arilo, preferiblemente C1-6-alquilo o fenilo,R10 representa H, COR17, C1-10-alquilo, arilo o un radical arilo o heteroarilo ligado a través de C1-6-alquileno,R11 representa H, C1-10 alquilo o arilo,R12 representa H, C1-10 alquilo o arilo,R13 representa un radical fenilo no sustituido o al menos monosustituido con C1-4-alquilo, C1-3-alcoxi, halógeno, CF3, CN, O-fenilo u OH,R14 y R15 pueden ser iguales o distintos entre sí y representan C-1-6-alquilo ramificado o no ramificado, saturado o insaturado, no sustituido o al menos - 2 -monosustituido, o fenilo, bencilo o fenetilo no sustituido o al menos monosustituido,o R14 y R15 en conjunto forman el radical (CH2)n siendo n un número entero de 3 a 6 o (CH2)2O(CH2)2,R16 representa C1-10-alquilo, arilo o heteroarilo,R17 representa C1-10-alquilo,R18 representa C1-10-alquilo, arilo, heteroarilo o naftiloR19 representa H, NHNH2, NHR20, C1-10-alquilo, arilo, heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno,R20 representa H, C1-10-alquilo, arilo o heteroarilo o un radical arilo o heteroarilo ligado a través de C1-6-alquileno R21 representa H, COR17, C1-10-alquilo, arilo o un radical arilo o heteroarilo ligado a través de C1-6-alquileno y/o sus racematos, enantiómeros, diastereómeros y/o las correspondientes bases y/o las correspondientes sales con ácidos fisiológicamente tolerables, estando excluidos los racematos de los compuestos en los cuales R3 representa CH(R13)N(R14)(R15) y se presentan algunas de las siguientes alternativas:R4 hasta R7 y R2 representan H, R13 representa fenilo, R14 y R15 en conjunto forman (CH2)5 y R1 representa H, CH3 o bencilo,oR4 a R7 y R2 representan H, R13 representa fenilo, R14, R15 representan sendos radicales CH3, y R1 representa H, CH3 o bencilo,oR4 hasta R7 y R1 representan H, R13 = 2-cloro-fenilo, R14 y R15 representan sendos radicales CH3 o R14 y R15 en conjunto representan (CH2)2O(CH2)2, R2 = COOR11 yR11 = C2H5 y los correspondientes clorhidratos,oR4 hasta R7 y R1 representan H, R13 = fenilo, R14 y R15 en conjunto forman (CH2)5,R2 representa COOR11 y R11 representa CH3 en forma de clorhidrato,oR4 hasta R7 y R2 representan H, R13 representa fenilo, R14 y R15 en conjunto forman (CH2)4, R1 representa H, CH3, CH2-CH=CH2 o 4-clorobencilo y para R1=CH3 también el correspondiente clorhidrato,oR4 hasta R7 y R1 y R2 representan H, R3 representa fenilo, R14 representa fenilo y R15 representa 4-etoxifenilo,oR4 hasta R7 representan H, R13 representa 2,4,6-trimetoxifenilo, R14 y R15 en conjunto forman (CH2)2O(CH2)2, R1 representa CH5 y R2 representa fenilo,oR4 hasta R7 y R1 representan H, R13 representa fenilo, 2-hidroxifenilo o 2-hidroxi-5-metilfenilo, R14 y R15 en conjunto forman (CH2)5 y R2 representa CH3 y para R13 = fenilo también el correspondiente bisulfato,oR4 hasta R7 y R1 representan H, R13 representa fenilo, R14 y R15 en conjunto forman (CH2)2O(CH2)2, y R2 representa CH3 y el correspondiente bisulfato del compuesto,oR4 hasta R7 y R1 representan H, R13 representa fenilo, R14 y R15 en conjunto forman (CH2)5, R2 representa COOR11 y R11 representa CH3 como clorhidrato,oR1, R4, R6 y R7 representan H, R2 representa COOR11, R11 representa C2H5, R14 y R15 representan sendos radicales CH3, R13 representa 2-clorofenilo y R5 representa 3-[(2-clorofenil)-dimetilaminometil]-5-metilen-1H-indol-2-carboxilato de etilo o 3-[(2-clorofenil)-dimetilaminometil]-5-hidroxato-1H-indol-2-carboxilato de etilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19963178A DE19963178A1 (de) | 1999-12-27 | 1999-12-27 | Substituierte Indol-Mannichbasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5251383A1 true CO5251383A1 (es) | 2003-02-28 |
Family
ID=7934622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00097385A CO5251383A1 (es) | 1999-12-27 | 2000-12-22 | Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentos |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7091220B2 (es) |
| EP (1) | EP1261585B1 (es) |
| JP (1) | JP2003519124A (es) |
| KR (1) | KR20020062314A (es) |
| CN (1) | CN1219763C (es) |
| AR (2) | AR027059A1 (es) |
| AT (1) | ATE374184T1 (es) |
| AU (1) | AU782585B2 (es) |
| BR (1) | BR0016747A (es) |
| CA (1) | CA2392866A1 (es) |
| CO (1) | CO5251383A1 (es) |
| CY (1) | CY1107080T1 (es) |
| CZ (1) | CZ20021708A3 (es) |
| DE (2) | DE19963178A1 (es) |
| DK (1) | DK1261585T3 (es) |
| ES (1) | ES2293935T3 (es) |
| HK (1) | HK1051367A1 (es) |
| HU (1) | HUP0203873A3 (es) |
| IL (1) | IL149426A0 (es) |
| NO (1) | NO20022803L (es) |
| NZ (1) | NZ518876A (es) |
| PE (1) | PE20010993A1 (es) |
| PL (1) | PL355446A1 (es) |
| PT (1) | PT1261585E (es) |
| RU (1) | RU2265594C2 (es) |
| SK (1) | SK8522002A3 (es) |
| UY (1) | UY26511A1 (es) |
| WO (1) | WO2001047885A1 (es) |
| ZA (1) | ZA200203444B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| JP4399253B2 (ja) * | 2001-06-20 | 2010-01-13 | ワイス | プラスミノゲンアクチベーターインヒビター−１（ｐａｉ−１）のインヒビターとしての、置換されたインドール酸誘導体 |
| US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| DE10153346A1 (de) * | 2001-10-29 | 2004-04-22 | Grünenthal GmbH | Substituierte Indole |
| JP2006514640A (ja) * | 2002-12-10 | 2006-05-11 | ワイス | プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体 |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| CA2509222A1 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| WO2004052855A2 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| DK1569901T3 (da) * | 2002-12-10 | 2009-02-16 | Wyeth Corp | Aryl-, aryloxy- og alkoxysubstituerede 1H-indol-3-yl-glyoxylsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) |
| US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7351726B2 (en) * | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7411083B2 (en) * | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7186749B2 (en) * | 2004-08-23 | 2007-03-06 | Wyeth | Pyrrolo-naphthyl acids and methods for using them |
| RU2007106869A (ru) | 2004-08-23 | 2008-09-27 | Вайет (Us) | Тиазол-нафтиловые кислоты как ингибиторы ингибитора активации плазминогена-1 |
| WO2006023865A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases |
| JP2009504762A (ja) * | 2005-08-17 | 2009-02-05 | ワイス | 置換インドール類およびそれらの使用方法 |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| EP2424918A4 (en) * | 2009-05-01 | 2013-03-27 | Henkel Corp | HARDENING ACCELERATOR FOR ANAEROBIC HARDENABLE COMPOSITIONS |
| WO2013032960A2 (en) | 2011-08-26 | 2013-03-07 | Uwm Research Foundation, Inc. | Vitamin d receptor - coregulator inhibitors |
| CN102687719A (zh) * | 2012-06-04 | 2012-09-26 | 陕西海安实业有限责任公司 | 一种新型高效油田用杀菌剂及其制备方法 |
| US20170174825A1 (en) * | 2014-03-18 | 2017-06-22 | The Board Of Regents For Oklahoma State University | Systems and methods for production of artificial eumelanin |
| KR20180046531A (ko) * | 2016-10-28 | 2018-05-09 | 주식회사 대웅제약 | 3-아미노알킬레이티드 인돌 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3296072A (en) * | 1962-06-11 | 1967-01-03 | Upjohn Co | Method of treating mental depression |
| FR2181559A1 (en) | 1972-04-28 | 1973-12-07 | Aec Chimie Organique Bio | N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity |
| GB1374414A (en) | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| GB1456208A (en) * | 1972-12-28 | 1976-11-24 | Agfa Gevaert | Thermographic processes and recording material for use therein |
| DE2724809A1 (de) | 1977-06-02 | 1978-08-31 | Dieter P Philippen | Urinflaschen-spuelgeraet |
| US4341402A (en) * | 1980-03-06 | 1982-07-27 | Sterling Drug Inc. | Systems employing indole color formers |
| DE3209305A1 (de) | 1982-03-15 | 1983-09-22 | SIC AG, 4020 Basel | Verfahren zur automatischen entleerung und reinigung von hygienegefaessen unter optimaler zufuehrung des spuelwassers bei minimalem wasserverbrauch |
| GB2168973B (en) * | 1984-12-04 | 1988-02-03 | Glaxo Group Ltd | Indole derivatives |
| SE449483B (sv) | 1986-03-12 | 1987-05-04 | Juhani Jervinen | Anordning for att avlegsna urin fran en flexibel urinuppsamlingspase |
| US4855448A (en) | 1986-08-26 | 1989-08-08 | A. H. Robins Company, Incorporated | 2-Amino-3-aroyl-γ-oxobenzenebutanoic acids and esters |
| GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GB9226537D0 (en) | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| CA2130294A1 (en) | 1994-08-17 | 1996-02-18 | F. W. Arthur Morrow | Method of cleaning an ostomy pouch |
| US5942536A (en) | 1995-10-10 | 1999-08-24 | Eli Lilly And Company | N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists |
| US5735301A (en) | 1996-02-22 | 1998-04-07 | Rower; Gary | Urostomy patient equipment irrigation system |
| EA003876B1 (ru) | 1998-02-25 | 2003-10-30 | Дженетикс Инститьют, Ллс | Ингибиторы фосфолипазных ферментов |
| DE19823326A1 (de) | 1998-05-26 | 1999-12-02 | Volker Fesser | Einrichtung zum Entleeren und Desinfizieren von Urin- und Sekretbeuteln |
| DE19963177A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substanzbibliothek |
| US6263887B1 (en) | 2000-01-14 | 2001-07-24 | Dornoch Medical Systems, Inc. | Liquid waste disposal and canister flushing system and method |
-
1999
- 1999-12-27 DE DE19963178A patent/DE19963178A1/de not_active Ceased
-
2000
- 2000-12-20 DK DK00991219T patent/DK1261585T3/da active
- 2000-12-20 PT PT00991219T patent/PT1261585E/pt unknown
- 2000-12-20 US US10/168,985 patent/US7091220B2/en not_active Expired - Fee Related
- 2000-12-20 PL PL00355446A patent/PL355446A1/xx not_active Application Discontinuation
- 2000-12-20 CZ CZ20021708A patent/CZ20021708A3/cs unknown
- 2000-12-20 WO PCT/EP2000/012974 patent/WO2001047885A1/de active Search and Examination
- 2000-12-20 KR KR1020027007032A patent/KR20020062314A/ko not_active Application Discontinuation
- 2000-12-20 EP EP00991219A patent/EP1261585B1/de not_active Expired - Lifetime
- 2000-12-20 RU RU2002120478/04A patent/RU2265594C2/ru not_active IP Right Cessation
- 2000-12-20 HU HU0203873A patent/HUP0203873A3/hu unknown
- 2000-12-20 CA CA002392866A patent/CA2392866A1/en not_active Abandoned
- 2000-12-20 NZ NZ518876A patent/NZ518876A/en unknown
- 2000-12-20 IL IL14942600A patent/IL149426A0/xx unknown
- 2000-12-20 CN CNB008177317A patent/CN1219763C/zh not_active Expired - Fee Related
- 2000-12-20 ES ES00991219T patent/ES2293935T3/es not_active Expired - Lifetime
- 2000-12-20 AT AT00991219T patent/ATE374184T1/de active
- 2000-12-20 DE DE50014679T patent/DE50014679D1/de not_active Expired - Lifetime
- 2000-12-20 JP JP2001549357A patent/JP2003519124A/ja not_active Withdrawn
- 2000-12-20 BR BR0016747-9A patent/BR0016747A/pt not_active IP Right Cessation
- 2000-12-20 SK SK852-2002A patent/SK8522002A3/sk unknown
- 2000-12-20 AU AU31610/01A patent/AU782585B2/en not_active Ceased
- 2000-12-21 AR ARP000106840A patent/AR027059A1/es not_active Application Discontinuation
- 2000-12-21 AR ARP000106841A patent/AR027060A1/es unknown
- 2000-12-22 CO CO00097385A patent/CO5251383A1/es not_active Application Discontinuation
- 2000-12-26 PE PE2000001397A patent/PE20010993A1/es not_active Application Discontinuation
- 2000-12-27 UY UY26511A patent/UY26511A1/es not_active Application Discontinuation
-
2002
- 2002-04-30 ZA ZA200203444A patent/ZA200203444B/xx unknown
- 2002-06-12 NO NO20022803A patent/NO20022803L/no not_active Application Discontinuation
-
2003
- 2003-05-22 HK HK03103625A patent/HK1051367A1/xx not_active IP Right Cessation
-
2007
- 2007-12-10 CY CY20071101569T patent/CY1107080T1/el unknown
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