CO5251383A1 - Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentos - Google Patents
Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentosInfo
- Publication number
- CO5251383A1 CO5251383A1 CO00097385A CO00097385A CO5251383A1 CO 5251383 A1 CO5251383 A1 CO 5251383A1 CO 00097385 A CO00097385 A CO 00097385A CO 00097385 A CO00097385 A CO 00097385A CO 5251383 A1 CO5251383 A1 CO 5251383A1
- Authority
- CO
- Colombia
- Prior art keywords
- aryl
- alkyl
- phenyl
- represent
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Bases indólicas de Mannich sustituidas de la fórmula general I<EMI FILE="00097385_1" ID="1" IMF=JPEG >en la cualR1 representa H, un radical C1-10-alquilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno,R2 representa H, F, CI, Br, CF3, CN, NO2, NHR8, SR9, OR10, SO2NH2, SO2NHR21, CO(OR11), CH2CO(OR12), COR19, un radical C1-10-alquilo, arilo o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno,R3 representa CH(R13)N(R14)(R15),R4, R5, R6, R7 pueden ser iguales o distintos entre sí y representan H, F, CI, Br, CF3, CN, NO2, NHR8, SR9, OR10, SO2NH2, SO2NHR21, CO(OR11), CH2CO(OR12), COR19, C1-10-alquilo, arilo o heteroarilo o un radical arilo o heteroarilo ligado a través de C1-6-alquileno,R8 representa H, COR16, C1-10-alquilo o arilo y preferiblemente C1-6-alquilo,R9 representa H, C1-10-alquilo o arilo, preferiblemente C1-6-alquilo o fenilo,R10 representa H, COR17, C1-10-alquilo, arilo o un radical arilo o heteroarilo ligado a través de C1-6-alquileno,R11 representa H, C1-10 alquilo o arilo,R12 representa H, C1-10 alquilo o arilo,R13 representa un radical fenilo no sustituido o al menos monosustituido con C1-4-alquilo, C1-3-alcoxi, halógeno, CF3, CN, O-fenilo u OH,R14 y R15 pueden ser iguales o distintos entre sí y representan C-1-6-alquilo ramificado o no ramificado, saturado o insaturado, no sustituido o al menos - 2 -monosustituido, o fenilo, bencilo o fenetilo no sustituido o al menos monosustituido,o R14 y R15 en conjunto forman el radical (CH2)n siendo n un número entero de 3 a 6 o (CH2)2O(CH2)2,R16 representa C1-10-alquilo, arilo o heteroarilo,R17 representa C1-10-alquilo,R18 representa C1-10-alquilo, arilo, heteroarilo o naftiloR19 representa H, NHNH2, NHR20, C1-10-alquilo, arilo, heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno,R20 representa H, C1-10-alquilo, arilo o heteroarilo o un radical arilo o heteroarilo ligado a través de C1-6-alquileno R21 representa H, COR17, C1-10-alquilo, arilo o un radical arilo o heteroarilo ligado a través de C1-6-alquileno y/o sus racematos, enantiómeros, diastereómeros y/o las correspondientes bases y/o las correspondientes sales con ácidos fisiológicamente tolerables, estando excluidos los racematos de los compuestos en los cuales R3 representa CH(R13)N(R14)(R15) y se presentan algunas de las siguientes alternativas:R4 hasta R7 y R2 representan H, R13 representa fenilo, R14 y R15 en conjunto forman (CH2)5 y R1 representa H, CH3 o bencilo,oR4 a R7 y R2 representan H, R13 representa fenilo, R14, R15 representan sendos radicales CH3, y R1 representa H, CH3 o bencilo,oR4 hasta R7 y R1 representan H, R13 = 2-cloro-fenilo, R14 y R15 representan sendos radicales CH3 o R14 y R15 en conjunto representan (CH2)2O(CH2)2, R2 = COOR11 yR11 = C2H5 y los correspondientes clorhidratos,oR4 hasta R7 y R1 representan H, R13 = fenilo, R14 y R15 en conjunto forman (CH2)5,R2 representa COOR11 y R11 representa CH3 en forma de clorhidrato,oR4 hasta R7 y R2 representan H, R13 representa fenilo, R14 y R15 en conjunto forman (CH2)4, R1 representa H, CH3, CH2-CH=CH2 o 4-clorobencilo y para R1=CH3 también el correspondiente clorhidrato,oR4 hasta R7 y R1 y R2 representan H, R3 representa fenilo, R14 representa fenilo y R15 representa 4-etoxifenilo,oR4 hasta R7 representan H, R13 representa 2,4,6-trimetoxifenilo, R14 y R15 en conjunto forman (CH2)2O(CH2)2, R1 representa CH5 y R2 representa fenilo,oR4 hasta R7 y R1 representan H, R13 representa fenilo, 2-hidroxifenilo o 2-hidroxi-5-metilfenilo, R14 y R15 en conjunto forman (CH2)5 y R2 representa CH3 y para R13 = fenilo también el correspondiente bisulfato,oR4 hasta R7 y R1 representan H, R13 representa fenilo, R14 y R15 en conjunto forman (CH2)2O(CH2)2, y R2 representa CH3 y el correspondiente bisulfato del compuesto,oR4 hasta R7 y R1 representan H, R13 representa fenilo, R14 y R15 en conjunto forman (CH2)5, R2 representa COOR11 y R11 representa CH3 como clorhidrato,oR1, R4, R6 y R7 representan H, R2 representa COOR11, R11 representa C2H5, R14 y R15 representan sendos radicales CH3, R13 representa 2-clorofenilo y R5 representa 3-[(2-clorofenil)-dimetilaminometil]-5-metilen-1H-indol-2-carboxilato de etilo o 3-[(2-clorofenil)-dimetilaminometil]-5-hidroxato-1H-indol-2-carboxilato de etilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19963178A DE19963178A1 (de) | 1999-12-27 | 1999-12-27 | Substituierte Indol-Mannichbasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5251383A1 true CO5251383A1 (es) | 2003-02-28 |
Family
ID=7934622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00097385A CO5251383A1 (es) | 1999-12-27 | 2000-12-22 | Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentos |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7091220B2 (es) |
| EP (1) | EP1261585B1 (es) |
| JP (1) | JP2003519124A (es) |
| KR (1) | KR20020062314A (es) |
| CN (1) | CN1219763C (es) |
| AR (2) | AR027060A1 (es) |
| AT (1) | ATE374184T1 (es) |
| AU (1) | AU782585B2 (es) |
| BR (1) | BR0016747A (es) |
| CA (1) | CA2392866A1 (es) |
| CO (1) | CO5251383A1 (es) |
| CY (1) | CY1107080T1 (es) |
| CZ (1) | CZ20021708A3 (es) |
| DE (2) | DE19963178A1 (es) |
| DK (1) | DK1261585T3 (es) |
| ES (1) | ES2293935T3 (es) |
| HK (1) | HK1051367A1 (es) |
| HU (1) | HUP0203873A3 (es) |
| IL (1) | IL149426A0 (es) |
| NO (1) | NO20022803D0 (es) |
| NZ (1) | NZ518876A (es) |
| PE (1) | PE20010993A1 (es) |
| PL (1) | PL355446A1 (es) |
| PT (1) | PT1261585E (es) |
| RU (1) | RU2265594C2 (es) |
| SK (1) | SK8522002A3 (es) |
| UY (1) | UY26511A1 (es) |
| WO (1) | WO2001047885A1 (es) |
| ZA (1) | ZA200203444B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003000253A1 (en) | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| DE10153346A1 (de) | 2001-10-29 | 2004-04-22 | Grünenthal GmbH | Substituierte Indole |
| CA2509191A1 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| MXPA05006287A (es) * | 2002-12-10 | 2005-09-08 | Wyeth Corp | Derivados de acido indoloxo-acetilaminoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1). |
| CN1726190A (zh) | 2002-12-10 | 2006-01-25 | 惠氏公司 | 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－羰基－1h－吲哚－1－基乙酸衍生物 |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| WO2004052853A2 (en) * | 2002-12-10 | 2004-06-24 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7351726B2 (en) * | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| RU2007106868A (ru) * | 2004-08-23 | 2008-09-27 | Вайет (Us) | Оксазол-нафтиловые кислоты и их применение в качестве модуляторов ингибитора активатора плазминогена-1 (pai) для лечения тромбоза и сердечно-сосудистых заболеваний |
| CN101044127A (zh) * | 2004-08-23 | 2007-09-26 | 惠氏公司 | 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸 |
| BRPI0514549A (pt) * | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de pirrol-naftila como inibidores de pai-1 |
| EP1919866A2 (en) * | 2005-08-17 | 2008-05-14 | Wyeth a Corporation of the State of Delaware | Substituted indoles and use thereof |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| CA2760462C (en) * | 2009-05-01 | 2017-05-30 | Henkel Corporation | Cure accelerators for anaerobic curable compositions |
| US9416104B2 (en) | 2011-08-26 | 2016-08-16 | Uwm Research Foundation, Inc. | Vitamin D receptor-coregulator inhibitors |
| CN102687719A (zh) * | 2012-06-04 | 2012-09-26 | 陕西海安实业有限责任公司 | 一种新型高效油田用杀菌剂及其制备方法 |
| WO2015143020A1 (en) * | 2014-03-18 | 2015-09-24 | The Board Of Regents For Oklahoma State University | Systems and methods for production of artificial eumelanin |
| KR20180046531A (ko) * | 2016-10-28 | 2018-05-09 | 주식회사 대웅제약 | 3-아미노알킬레이티드 인돌 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3296072A (en) * | 1962-06-11 | 1967-01-03 | Upjohn Co | Method of treating mental depression |
| FR2181559A1 (en) | 1972-04-28 | 1973-12-07 | Aec Chimie Organique Bio | N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity |
| GB1374414A (en) | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| GB1456208A (en) * | 1972-12-28 | 1976-11-24 | Agfa Gevaert | Thermographic processes and recording material for use therein |
| DE2724809A1 (de) | 1977-06-02 | 1978-08-31 | Dieter P Philippen | Urinflaschen-spuelgeraet |
| US4341402A (en) * | 1980-03-06 | 1982-07-27 | Sterling Drug Inc. | Systems employing indole color formers |
| DE3209305A1 (de) | 1982-03-15 | 1983-09-22 | SIC AG, 4020 Basel | Verfahren zur automatischen entleerung und reinigung von hygienegefaessen unter optimaler zufuehrung des spuelwassers bei minimalem wasserverbrauch |
| SE8505715L (sv) * | 1984-12-04 | 1986-06-05 | Glaxo Group Ltd | Indolderivat |
| SE449483B (sv) | 1986-03-12 | 1987-05-04 | Juhani Jervinen | Anordning for att avlegsna urin fran en flexibel urinuppsamlingspase |
| US4855448A (en) * | 1986-08-26 | 1989-08-08 | A. H. Robins Company, Incorporated | 2-Amino-3-aroyl-γ-oxobenzenebutanoic acids and esters |
| GB9226537D0 (en) | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| CA2130294A1 (en) | 1994-08-17 | 1996-02-18 | F. W. Arthur Morrow | Method of cleaning an ostomy pouch |
| AU7261196A (en) | 1995-10-10 | 1997-04-30 | Eli Lilly And Company | N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists |
| US5735301A (en) * | 1996-02-22 | 1998-04-07 | Rower; Gary | Urostomy patient equipment irrigation system |
| CN1310706A (zh) | 1998-02-25 | 2001-08-29 | 遗传研究所有限公司 | 磷脂酶抑制剂 |
| DE19823326A1 (de) | 1998-05-26 | 1999-12-02 | Volker Fesser | Einrichtung zum Entleeren und Desinfizieren von Urin- und Sekretbeuteln |
| DE19963177A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substanzbibliothek |
| US6263887B1 (en) | 2000-01-14 | 2001-07-24 | Dornoch Medical Systems, Inc. | Liquid waste disposal and canister flushing system and method |
-
1999
- 1999-12-27 DE DE19963178A patent/DE19963178A1/de not_active Ceased
-
2000
- 2000-12-20 DE DE50014679T patent/DE50014679D1/de not_active Expired - Lifetime
- 2000-12-20 JP JP2001549357A patent/JP2003519124A/ja not_active Withdrawn
- 2000-12-20 CA CA002392866A patent/CA2392866A1/en not_active Abandoned
- 2000-12-20 WO PCT/EP2000/012974 patent/WO2001047885A1/de active Search and Examination
- 2000-12-20 PL PL00355446A patent/PL355446A1/xx not_active Application Discontinuation
- 2000-12-20 US US10/168,985 patent/US7091220B2/en not_active Expired - Fee Related
- 2000-12-20 EP EP00991219A patent/EP1261585B1/de not_active Expired - Lifetime
- 2000-12-20 KR KR1020027007032A patent/KR20020062314A/ko not_active Application Discontinuation
- 2000-12-20 AU AU31610/01A patent/AU782585B2/en not_active Ceased
- 2000-12-20 CZ CZ20021708A patent/CZ20021708A3/cs unknown
- 2000-12-20 RU RU2002120478/04A patent/RU2265594C2/ru not_active IP Right Cessation
- 2000-12-20 PT PT00991219T patent/PT1261585E/pt unknown
- 2000-12-20 CN CNB008177317A patent/CN1219763C/zh not_active Expired - Fee Related
- 2000-12-20 HU HU0203873A patent/HUP0203873A3/hu unknown
- 2000-12-20 SK SK852-2002A patent/SK8522002A3/sk unknown
- 2000-12-20 AT AT00991219T patent/ATE374184T1/de active
- 2000-12-20 NZ NZ518876A patent/NZ518876A/en unknown
- 2000-12-20 IL IL14942600A patent/IL149426A0/xx unknown
- 2000-12-20 BR BR0016747-9A patent/BR0016747A/pt not_active IP Right Cessation
- 2000-12-20 ES ES00991219T patent/ES2293935T3/es not_active Expired - Lifetime
- 2000-12-20 DK DK00991219T patent/DK1261585T3/da active
- 2000-12-21 AR ARP000106841A patent/AR027060A1/es unknown
- 2000-12-21 AR ARP000106840A patent/AR027059A1/es not_active Application Discontinuation
- 2000-12-22 CO CO00097385A patent/CO5251383A1/es not_active Application Discontinuation
- 2000-12-26 PE PE2000001397A patent/PE20010993A1/es not_active Application Discontinuation
- 2000-12-27 UY UY26511A patent/UY26511A1/es not_active Application Discontinuation
-
2002
- 2002-04-30 ZA ZA200203444A patent/ZA200203444B/xx unknown
- 2002-06-12 NO NO20022803A patent/NO20022803D0/no not_active Application Discontinuation
-
2003
- 2003-05-22 HK HK03103625A patent/HK1051367A1/xx not_active IP Right Cessation
-
2007
- 2007-12-10 CY CY20071101569T patent/CY1107080T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO5251383A1 (es) | Bases de mannich indolicas, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su uso para la preparacion de medicamentos | |
| CO5150159A1 (es) | Derivados de 4-arilquinolin-2-ona 3-substituida como moduladores de los canales de potasio | |
| KR960014121A (ko) | 아로일-피페리딘 유도체 | |
| AR035153A1 (es) | Derivados de carboxamidas y cetonas de dihidrobenzodioxina | |
| DE69208868D1 (de) | 5-heteroyl indol derivate | |
| JPS54151024A (en) | Photopolymerizable composition | |
| AR006640A1 (es) | Procedimiento para la preparacion de una sal de magnesio de un sulfinil-heterociclo substituido | |
| AR004219A1 (es) | Nuevos derivados de quinazolina, procedimientos para su preparacion, composiciones que los contienen y su uso en la preparacion de medicamentos,particularmente en el tratamiento de trastornos inflamatorios | |
| PE20020532A1 (es) | Derivados de naftaleno como agonistas del receptor canabinoide | |
| AR012244A1 (es) | Compuestos derivados de la 9-oxima eritomicina, composicion farmaceutica que los contiene, procedimiento para el tratamiento de una infeccion bacterianao protozoaria, procedimiento para su preparacion. | |
| CO5170512A1 (es) | Derivados de tetrahidroquinolin piperidina | |
| CO5271737A1 (es) | Tioamidas de oxazolidinona con substituyentes de piperazin-amida | |
| UY25987A1 (es) | Procedimiento para preparar complejo del inhibidor de ras-fa rnesiltransferasa y sulfobutileter-7-beta-ciclodextrina o 2- hidroxipropil-beta-ciclodextrina y método | |
| AR013153A1 (es) | Derivados de 2-arildihidropirimidina, proceso para su preparacion, composiciones farmaceuticas que contienen dichos derivados, y el uso de dichosderivados y composiciones como ligandos para canales de calcio neuronales de tipo n. | |
| CO5280081A1 (es) | Antibacterianos de piperidiniloxi oxazolidinona, composicion farmaceutica que los comprende y proceso para su preparacion | |
| MX9203019A (es) | Derivados heterociclicos y composiciones farmaceuticas que los contienen. | |
| AR006189A1 (es) | Aminoalquil-eteres y acilaminoalquil-eteres, procedimiento para su preparacion y su utilizacion como antagonistas de receptores de bradiquinina | |
| FI881640A0 (fi) | Foerfarande foer framstaellning av aromatiska foereningar med antimikrobiell aktivitet. | |
| EP0627426A1 (en) | Pyran derivative, photosensitive resin composition, and hologram recording medium using it | |
| PT81004B (pt) | Processo para a preparacao de oxindoles trigiclicos uteis como agentes anti-inflamatorios | |
| ATE262509T1 (de) | Indolinderivate als lichtschutzmittel | |
| CO5261489A1 (es) | Bases pirrolicas sustituidas de mannich, procedimiento para su preparacion, medicamentos que contienen estos compuestos, y uso del compuesto para la preparacion de medicamentos | |
| CO5200762A1 (es) | Preparacion de piperidin-4-onas sustituidas | |
| DK65780A (da) | Piperidinopropylderivater fremgangsmaader til deres fremstilling og laegemidler indeholdnde disse forbindelser | |
| DK0736012T3 (da) | Anellerede dihydropyridiner og deres anvendelse til fremstilling af farmaceutiske præparater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |