CO5261489A1 - Bases pirrolicas sustituidas de mannich, procedimiento para su preparacion, medicamentos que contienen estos compuestos, y uso del compuesto para la preparacion de medicamentos - Google Patents
Bases pirrolicas sustituidas de mannich, procedimiento para su preparacion, medicamentos que contienen estos compuestos, y uso del compuesto para la preparacion de medicamentosInfo
- Publication number
- CO5261489A1 CO5261489A1 CO00097382A CO00097382A CO5261489A1 CO 5261489 A1 CO5261489 A1 CO 5261489A1 CO 00097382 A CO00097382 A CO 00097382A CO 00097382 A CO00097382 A CO 00097382A CO 5261489 A1 CO5261489 A1 CO 5261489A1
- Authority
- CO
- Colombia
- Prior art keywords
- radical
- aryl
- heteroaryl
- alkyl
- linked
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Bases pirrólicas de Mannich sustituidas de la fórmula general I,<EMI FILE="00097382_1" ID="1" IMF=JPEG >en la cual R1 representa H, C1-10-alquilo, arilo, heteroarilo, o CN-, Br-, CI- u OH- o arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R2 representa CH(R4)N(R5)(R6), R3, R3AND#39, R3", pueden ser iguales o distintos entre sí y representan H, F, CI, Br, CF3, CN, NO2, SO2NH2, NHR7, SR8, OR9, CO(OR10), CH2CO(OR11), COR15, un radical C1-10-alquilo, arilo, o heteroarilo, o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R4 representa un radical fenilo no sustituido o al menos monosustituido con C1-4-alquilo, C1-3-alcoxi, halógeno, CF3, CN, O-fenilo u OH; R5, R6, pueden ser iguales o distintos entre sí y representan un radical C1-6-alquilo, ramificado o no ramificado, saturado o insaturado, no sustituido o al menos monosustituido o un radical fenilo, bencilo o fenetilo no sustituido o al menos monosustituido, o R5 y R6 conjuntamente forman (CH2)n siendo n un número entero de 3 a 6 o (CH2)2O(CH2)2, R7 representa H, COR12, un radical C1-10; alquilo, arilo, heteroarilo, o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R8 representa H, o un radical C1-10-alquilo, arilo o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R9 representa H, COR13, un radical C1-10-alquilo, arilo, o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R10 representa H, un radical C1-10-alquilo, arilo, o heteroarilo - 2 -o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R11 representa H, un radical C1-10-alquilo, arilo, o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R12 representa un radical C1-10-alquilo, arilo, o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R13 representa un radical C1-10-alquilo, arilo, o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R14 representa H, un radical C1-10-alquilo, arilo, o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, R15 representa NHNH2, NHR14, un radical C1-10-alquilo, arilo, o heteroarilo o un radical arilo o heteroarilo ligado a través de un radical C1-6-alquileno, y/o sus racematos, enantiómeros o diastereómeros, y/o las bases correspondientes y/o sales correspondientes con ácidos fisiológicamente tolerables,exceptuando el racemato del compuesto de la fórmula general I, en la cual R1, R3, R3AND#39 y R3" respectivamente representan H, el radical R2 = CH(R4)N(R5)(R6), el radical R4 representa fenilo y cada uno de los radicales R5 y R6 representan CH3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19963174A DE19963174A1 (de) | 1999-12-27 | 1999-12-27 | Substituierte Pyrrol-Mannichbasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5261489A1 true CO5261489A1 (es) | 2003-03-31 |
Family
ID=7934619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00097382A CO5261489A1 (es) | 1999-12-27 | 2000-12-22 | Bases pirrolicas sustituidas de mannich, procedimiento para su preparacion, medicamentos que contienen estos compuestos, y uso del compuesto para la preparacion de medicamentos |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7034018B2 (es) |
| EP (1) | EP1246799B1 (es) |
| JP (1) | JP2003527350A (es) |
| KR (1) | KR20020067571A (es) |
| CN (1) | CN1247542C (es) |
| AR (1) | AR027058A1 (es) |
| AT (1) | ATE252077T1 (es) |
| AU (1) | AU782909B2 (es) |
| BR (1) | BR0016814A (es) |
| CA (1) | CA2396502A1 (es) |
| CO (1) | CO5261489A1 (es) |
| CZ (1) | CZ20022239A3 (es) |
| DE (2) | DE19963174A1 (es) |
| DK (1) | DK1246799T3 (es) |
| ES (1) | ES2208466T3 (es) |
| HK (1) | HK1051855A1 (es) |
| HU (1) | HUP0203695A3 (es) |
| IL (2) | IL149811A0 (es) |
| MX (1) | MXPA02005793A (es) |
| NO (1) | NO20023028L (es) |
| NZ (1) | NZ519975A (es) |
| PE (1) | PE20010988A1 (es) |
| PL (1) | PL355413A1 (es) |
| PT (1) | PT1246799E (es) |
| RU (1) | RU2002120468A (es) |
| SK (1) | SK286274B6 (es) |
| TR (1) | TR200302178T4 (es) |
| WO (1) | WO2001047878A1 (es) |
| ZA (1) | ZA200204199B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0016453D0 (en) * | 2000-07-04 | 2000-08-23 | Hoffmann La Roche | Pyrrole derivatives |
| BR0306811A (pt) * | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
| DE10261130A1 (de) | 2002-12-20 | 2004-07-01 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole |
| EP1836390A2 (en) * | 2004-11-09 | 2007-09-26 | Hendrick Cornelius Van Harsleaar | Electrical system |
| CN102221678A (zh) * | 2011-05-17 | 2011-10-19 | 重庆长安汽车股份有限公司 | 一种电池系统在线寿命计算方法 |
| TW201416348A (zh) * | 2012-08-29 | 2014-05-01 | Gruenenthal Chemie | 以氟甲基取代之吡咯甲醯胺 |
| KR102084185B1 (ko) * | 2013-08-29 | 2020-03-04 | 주식회사 대웅제약 | 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4341402A (en) * | 1980-03-06 | 1982-07-27 | Sterling Drug Inc. | Systems employing indole color formers |
| US4335136A (en) * | 1980-04-18 | 1982-06-15 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines |
| US5523299A (en) * | 1992-08-06 | 1996-06-04 | Smithkline Beecham Plc | 5-(2-oxyphenyl)-pyrrole derivatives as dopamine D3 receptor antagonists |
| GB9325827D0 (en) * | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
| EP0946507B1 (en) * | 1996-12-10 | 2003-09-24 | G.D. SEARLE & CO. | Substituted pyrrolyl compounds for the treatment of inflammation |
-
1999
- 1999-12-27 DE DE19963174A patent/DE19963174A1/de not_active Ceased
-
2000
- 2000-12-20 PL PL00355413A patent/PL355413A1/xx unknown
- 2000-12-20 DE DE50004114T patent/DE50004114D1/de not_active Expired - Lifetime
- 2000-12-20 AU AU31611/01A patent/AU782909B2/en not_active Ceased
- 2000-12-20 AT AT00991220T patent/ATE252077T1/de active
- 2000-12-20 HU HU0203695A patent/HUP0203695A3/hu unknown
- 2000-12-20 PT PT00991220T patent/PT1246799E/pt unknown
- 2000-12-20 BR BR0016814-9A patent/BR0016814A/pt not_active Application Discontinuation
- 2000-12-20 WO PCT/EP2000/012976 patent/WO2001047878A1/de active Search and Examination
- 2000-12-20 NZ NZ519975A patent/NZ519975A/en unknown
- 2000-12-20 CA CA002396502A patent/CA2396502A1/en not_active Abandoned
- 2000-12-20 MX MXPA02005793A patent/MXPA02005793A/es active IP Right Grant
- 2000-12-20 SK SK730-2002A patent/SK286274B6/sk not_active IP Right Cessation
- 2000-12-20 RU RU2002120468/04A patent/RU2002120468A/ru unknown
- 2000-12-20 CN CNB008178739A patent/CN1247542C/zh not_active Expired - Fee Related
- 2000-12-20 CZ CZ20022239A patent/CZ20022239A3/cs unknown
- 2000-12-20 JP JP2001549351A patent/JP2003527350A/ja not_active Withdrawn
- 2000-12-20 KR KR1020027008185A patent/KR20020067571A/ko not_active Application Discontinuation
- 2000-12-20 IL IL14981100A patent/IL149811A0/xx active IP Right Grant
- 2000-12-20 US US10/168,964 patent/US7034018B2/en not_active Expired - Fee Related
- 2000-12-20 EP EP00991220A patent/EP1246799B1/de not_active Expired - Lifetime
- 2000-12-20 DK DK00991220T patent/DK1246799T3/da active
- 2000-12-20 ES ES00991220T patent/ES2208466T3/es not_active Expired - Lifetime
- 2000-12-20 TR TR2003/02178T patent/TR200302178T4/xx unknown
- 2000-12-21 AR ARP000106837A patent/AR027058A1/es unknown
- 2000-12-22 CO CO00097382A patent/CO5261489A1/es not_active Application Discontinuation
- 2000-12-26 PE PE2000001398A patent/PE20010988A1/es not_active Application Discontinuation
-
2002
- 2002-05-27 ZA ZA200204199A patent/ZA200204199B/en unknown
- 2002-06-21 NO NO20023028A patent/NO20023028L/no not_active Application Discontinuation
-
2003
- 2003-04-09 HK HK03102525A patent/HK1051855A1/xx not_active IP Right Cessation
-
2004
- 2004-01-01 IL IL149811A patent/IL149811A/en not_active IP Right Cessation
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