BR0016814A - Bases de mannich de pirrol substituìdas - Google Patents

Bases de mannich de pirrol substituìdas

Info

Publication number
BR0016814A
BR0016814A BR0016814-9A BR0016814A BR0016814A BR 0016814 A BR0016814 A BR 0016814A BR 0016814 A BR0016814 A BR 0016814A BR 0016814 A BR0016814 A BR 0016814A
Authority
BR
Brazil
Prior art keywords
radical
aryl
alkyl
heteroaryl radical
heteroaryl
Prior art date
Application number
BR0016814-9A
Other languages
English (en)
Inventor
Matthias Gerlach
Corinna Maul
Original Assignee
Gruenenthak Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthak Gmbh filed Critical Gruenenthak Gmbh
Publication of BR0016814A publication Critical patent/BR0016814A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"BASES DE MANNICH DE PIRROL SUBSTITUìDAS". A invenção refere-se a bases de Mannich de pirrol substituídas da fórmula geral I, na qual R^ 1^ representa H, um radical C~ 1-10~-alquila, um radical arila, um radical heteroarila ou um radical arila, heteroarila, CN-, Br-, CI- ou OH- ligado através de um grupo C~ 1-6~-alquileno, R^ 2^ representa CH(R^ 4^)N(R^ 5^)(R^ 6^), R^ 3^, R^ 3'^, R^ 3"^, iguais ou diferentes, representam H-, F, CI, Br, CF~ 3~, CN, NO~ 2~, SO~ 2~NH~ 2~, NHR^ 7^, SR^ 8^, OR^ 9^, CO(OR^ 10^), CH~ 2~CO(OR^ 11^), OCR^ 15^, um radical C~ 1-10~-alquila, um radical arila, um radical heteroarila ou um radical arila ou heteroarila ligado através de um grupo C~ 1-6~-alquileno, R^ 4^ representa um radical fenila não-substituído ou um radical fenila substituído pelo menos uma vez por C^ 1-4~-alquila, C~ 1-3~-alcóxi, halogênio, CF~ 3~, CN, O-fenila ou OH, processos para a sua preparação, medicamentos contendo estes compostos bem como o emprego destes compostos para a preparação de medicamentos. Estas substâncias ativas devem ser adequadas especialmente para a terapia da dor e para o tratamento de reações inflamatórias e alérgicas, abuso de drogas e/ou álcool, diarréias, gastrite, úlcera, doenças cardiovasculares, incontinência urinária, depressões, estados de choque, enxaqueca, narcolepsia, obesidade, asma, glaucoma, síndrome hipercinética, falta de coordenação, bulimia, anorexia, catalepsia, para a ansiólise, para o aumento da vigilância e/ou para o aumento da libido.
BR0016814-9A 1999-12-27 2000-12-20 Bases de mannich de pirrol substituìdas BR0016814A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19963174A DE19963174A1 (de) 1999-12-27 1999-12-27 Substituierte Pyrrol-Mannichbasen
PCT/EP2000/012976 WO2001047878A1 (de) 1999-12-27 2000-12-20 Substituierte pyrrol-mannichbasen zur bekämpfung von schmerzen und allergischen reaktionen

Publications (1)

Publication Number Publication Date
BR0016814A true BR0016814A (pt) 2002-09-10

Family

ID=7934619

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016814-9A BR0016814A (pt) 1999-12-27 2000-12-20 Bases de mannich de pirrol substituìdas

Country Status (29)

Country Link
US (1) US7034018B2 (pt)
EP (1) EP1246799B1 (pt)
JP (1) JP2003527350A (pt)
KR (1) KR20020067571A (pt)
CN (1) CN1247542C (pt)
AR (1) AR027058A1 (pt)
AT (1) ATE252077T1 (pt)
AU (1) AU782909B2 (pt)
BR (1) BR0016814A (pt)
CA (1) CA2396502A1 (pt)
CO (1) CO5261489A1 (pt)
CZ (1) CZ20022239A3 (pt)
DE (2) DE19963174A1 (pt)
DK (1) DK1246799T3 (pt)
ES (1) ES2208466T3 (pt)
HK (1) HK1051855A1 (pt)
HU (1) HUP0203695A3 (pt)
IL (2) IL149811A0 (pt)
MX (1) MXPA02005793A (pt)
NO (1) NO20023028L (pt)
NZ (1) NZ519975A (pt)
PE (1) PE20010988A1 (pt)
PL (1) PL355413A1 (pt)
PT (1) PT1246799E (pt)
RU (1) RU2002120468A (pt)
SK (1) SK286274B6 (pt)
TR (1) TR200302178T4 (pt)
WO (1) WO2001047878A1 (pt)
ZA (1) ZA200204199B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016453D0 (en) * 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
BR0306811A (pt) * 2002-01-11 2004-10-26 Sankyo Co Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero
DE10261130A1 (de) 2002-12-20 2004-07-01 Grünenthal GmbH Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole
EP1836390A2 (en) * 2004-11-09 2007-09-26 Hendrick Cornelius Van Harsleaar Electrical system
CN102221678A (zh) * 2011-05-17 2011-10-19 重庆长安汽车股份有限公司 一种电池系统在线寿命计算方法
TW201416348A (zh) * 2012-08-29 2014-05-01 Gruenenthal Chemie 以氟甲基取代之吡咯甲醯胺
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341402A (en) * 1980-03-06 1982-07-27 Sterling Drug Inc. Systems employing indole color formers
US4335136A (en) * 1980-04-18 1982-06-15 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines
US5523299A (en) * 1992-08-06 1996-06-04 Smithkline Beecham Plc 5-(2-oxyphenyl)-pyrrole derivatives as dopamine D3 receptor antagonists
GB9325827D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Plc Compounds
EP0946507B1 (en) * 1996-12-10 2003-09-24 G.D. SEARLE & CO. Substituted pyrrolyl compounds for the treatment of inflammation

Also Published As

Publication number Publication date
AU782909B2 (en) 2005-09-08
WO2001047878A8 (de) 2001-10-04
AR027058A1 (es) 2003-03-12
DE50004114D1 (de) 2003-11-20
MXPA02005793A (es) 2004-08-12
CN1414950A (zh) 2003-04-30
CO5261489A1 (es) 2003-03-31
SK286274B6 (sk) 2008-06-06
NZ519975A (en) 2004-02-27
JP2003527350A (ja) 2003-09-16
PE20010988A1 (es) 2001-10-06
WO2001047878A1 (de) 2001-07-05
NO20023028L (no) 2002-08-20
CZ20022239A3 (cs) 2003-04-16
ATE252077T1 (de) 2003-11-15
ES2208466T3 (es) 2004-06-16
HUP0203695A2 (hu) 2003-04-28
HUP0203695A3 (en) 2004-12-28
PL355413A1 (en) 2004-04-19
HK1051855A1 (en) 2003-08-22
KR20020067571A (ko) 2002-08-22
US7034018B2 (en) 2006-04-25
US20030023100A1 (en) 2003-01-30
TR200302178T4 (tr) 2004-01-21
CN1247542C (zh) 2006-03-29
IL149811A (en) 2006-07-05
IL149811A0 (en) 2002-11-10
PT1246799E (pt) 2004-03-31
EP1246799B1 (de) 2003-10-15
EP1246799A1 (de) 2002-10-09
ZA200204199B (en) 2004-02-10
SK7302002A3 (en) 2002-11-06
DE19963174A1 (de) 2001-07-12
NO20023028D0 (no) 2002-06-21
CA2396502A1 (en) 2001-07-05
DK1246799T3 (da) 2004-02-16
RU2002120468A (ru) 2004-01-10
AU3161101A (en) 2001-07-09

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