PE20010988A1 - Bases pirrolicas sustituidas de mannich, con actividad analgesica - Google Patents

Bases pirrolicas sustituidas de mannich, con actividad analgesica

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Publication number
PE20010988A1
PE20010988A1 PE2000001398A PE0013982000A PE20010988A1 PE 20010988 A1 PE20010988 A1 PE 20010988A1 PE 2000001398 A PE2000001398 A PE 2000001398A PE 0013982000 A PE0013982000 A PE 0013982000A PE 20010988 A1 PE20010988 A1 PE 20010988A1
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PE
Peru
Prior art keywords
alkyl
aryl
heteroaryl
pyrrolic
mannich
Prior art date
Application number
PE2000001398A
Other languages
English (en)
Inventor
Matthias Gerlach
Corinna Maul
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20010988A1 publication Critical patent/PE20010988A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE REFIERE A BASES PIRROLICAS DE MANNICH SUSTITUIDAS DE FORMULA I; R1 ES H, ALQUILO C1-C10, ARILO, HETEROARILO; R2 ES CH(R4)N(R5)(R6), R3, R3', R3" SON H, F, Cl, Br, CF3, CN, NO2, SO2NH2, NHR7, SR8, OR9, COOR10, CH2COOR11, COR15, ENTRE OTROS; R4 ES FENILO; R5 Y R6 SON ALQUILO C1-C6; R5 Y R6 FORMAN (CH2)n, (CH2)2O(CH2)2; n ES 3-6; R7 ES H, COR12, ALQUILO C1-C10, ARILO, HETEROARILO; R8 Y R11 SON H, ALQUILO C1-C10, ARILO, HETEROARILO; R9 ES H, COR13, ALQUILO C1-C10, ENTRE OTROS; R12 ES ALQUILO C1-C10, ARILO, HETEROARILO; R13 ES ALQUILO C1-C10, ARILO, ENTRE OTROS; R14 ES H, ALQUILO C1-C10, ARILO, HETEROARILO; R15 ES NHNH2, NHR14, ALQUILO C1-C10, ARILO, ENTRE OTROS; EXCEPTO LOS COMPUESTOS CUANDO R1, R3, R3' Y R3" SON H; R2 ES CH(R4)N(R5)(R6); R4 ES FENILO; R5 Y R6 SON CH3. SON COMPUESTOS PREFERIDOS 4-[(2-METOXIFENIL)-(1-FENIL-1H-PIRROL-2-IL)-METIL]-MORFOLINA, 4-[[1-(2-FLUOROFENIL)-1H-PIRROL-2-IL](2-METOXIFENIL)-METIL]-MORFOLINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE DOLOR, REACCIONES INFLAMATORIAS, ALERGIAS, ABUSO DE DROGAS, ALCOHOL, DIARREA, GASTRITIS, DEPRESION, MIGRANA, SOBREPESO, GLAUCOMA
PE2000001398A 1999-12-27 2000-12-26 Bases pirrolicas sustituidas de mannich, con actividad analgesica PE20010988A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19963174A DE19963174A1 (de) 1999-12-27 1999-12-27 Substituierte Pyrrol-Mannichbasen

Publications (1)

Publication Number Publication Date
PE20010988A1 true PE20010988A1 (es) 2001-10-06

Family

ID=7934619

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001398A PE20010988A1 (es) 1999-12-27 2000-12-26 Bases pirrolicas sustituidas de mannich, con actividad analgesica

Country Status (29)

Country Link
US (1) US7034018B2 (es)
EP (1) EP1246799B1 (es)
JP (1) JP2003527350A (es)
KR (1) KR20020067571A (es)
CN (1) CN1247542C (es)
AR (1) AR027058A1 (es)
AT (1) ATE252077T1 (es)
AU (1) AU782909B2 (es)
BR (1) BR0016814A (es)
CA (1) CA2396502A1 (es)
CO (1) CO5261489A1 (es)
CZ (1) CZ20022239A3 (es)
DE (2) DE19963174A1 (es)
DK (1) DK1246799T3 (es)
ES (1) ES2208466T3 (es)
HK (1) HK1051855A1 (es)
HU (1) HUP0203695A3 (es)
IL (2) IL149811A0 (es)
MX (1) MXPA02005793A (es)
NO (1) NO20023028L (es)
NZ (1) NZ519975A (es)
PE (1) PE20010988A1 (es)
PL (1) PL355413A1 (es)
PT (1) PT1246799E (es)
RU (1) RU2002120468A (es)
SK (1) SK286274B6 (es)
TR (1) TR200302178T4 (es)
WO (1) WO2001047878A1 (es)
ZA (1) ZA200204199B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016453D0 (en) * 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
PT1471054E (pt) * 2002-01-11 2009-09-23 Daiichi Sankyo Co Ltd Derivado de aminoálcool ou derivado de ácido fosfónico e composição medicinal que os contém
DE10261130A1 (de) * 2002-12-20 2004-07-01 Grünenthal GmbH Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole
CN101099041A (zh) * 2004-11-09 2008-01-02 亨卓克·康尼里尔斯·范哈尔斯丽尔 空气动力风扇发电系统
CN102221678A (zh) * 2011-05-17 2011-10-19 重庆长安汽车股份有限公司 一种电池系统在线寿命计算方法
TW201416348A (zh) * 2012-08-29 2014-05-01 Gruenenthal Chemie 以氟甲基取代之吡咯甲醯胺
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341402A (en) * 1980-03-06 1982-07-27 Sterling Drug Inc. Systems employing indole color formers
US4335136A (en) * 1980-04-18 1982-06-15 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines
NZ254784A (en) * 1992-08-06 1996-11-26 Smithkline Beecham Plc Substituted 5-phenyl pyrrole derivatives and medicaments
GB9325827D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Plc Compounds
CA2273836A1 (en) * 1996-12-10 1998-06-18 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation

Also Published As

Publication number Publication date
EP1246799A1 (de) 2002-10-09
EP1246799B1 (de) 2003-10-15
CA2396502A1 (en) 2001-07-05
DE50004114D1 (de) 2003-11-20
HUP0203695A3 (en) 2004-12-28
MXPA02005793A (es) 2004-08-12
WO2001047878A8 (de) 2001-10-04
DE19963174A1 (de) 2001-07-12
HUP0203695A2 (hu) 2003-04-28
KR20020067571A (ko) 2002-08-22
ZA200204199B (en) 2004-02-10
CZ20022239A3 (cs) 2003-04-16
WO2001047878A1 (de) 2001-07-05
ATE252077T1 (de) 2003-11-15
CN1414950A (zh) 2003-04-30
CO5261489A1 (es) 2003-03-31
TR200302178T4 (tr) 2004-01-21
DK1246799T3 (da) 2004-02-16
HK1051855A1 (en) 2003-08-22
US20030023100A1 (en) 2003-01-30
SK7302002A3 (en) 2002-11-06
AU3161101A (en) 2001-07-09
AR027058A1 (es) 2003-03-12
NZ519975A (en) 2004-02-27
PL355413A1 (en) 2004-04-19
ES2208466T3 (es) 2004-06-16
PT1246799E (pt) 2004-03-31
IL149811A0 (en) 2002-11-10
JP2003527350A (ja) 2003-09-16
NO20023028D0 (no) 2002-06-21
CN1247542C (zh) 2006-03-29
IL149811A (en) 2006-07-05
RU2002120468A (ru) 2004-01-10
SK286274B6 (sk) 2008-06-06
US7034018B2 (en) 2006-04-25
AU782909B2 (en) 2005-09-08
BR0016814A (pt) 2002-09-10
NO20023028L (no) 2002-08-20

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