BR0210432A - Formulações de lactona e processo de uso - Google Patents

Formulações de lactona e processo de uso

Info

Publication number
BR0210432A
BR0210432A BR0210432-6A BR0210432A BR0210432A BR 0210432 A BR0210432 A BR 0210432A BR 0210432 A BR0210432 A BR 0210432A BR 0210432 A BR0210432 A BR 0210432A
Authority
BR
Brazil
Prior art keywords
lactone
compounds
formulations
formula
usage process
Prior art date
Application number
BR0210432-6A
Other languages
English (en)
Inventor
David Terrero
Original Assignee
Magnachem Int Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magnachem Int Lab Inc filed Critical Magnachem Int Lab Inc
Publication of BR0210432A publication Critical patent/BR0210432A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"FORMULAçõES DE LACTONA E PROCESSO DE USO". Foram revelados os compostos das Fórmulas (Ia) e (Ic) possuindo uma estrutura de lactona e um grupo metileno na posição alfa da estrutura de lactona e processos para uso e fabricação dos compostos. Os compostos de lactona podem ser reagidos com um agente nucleófilo para abrir o anel de lactona para um composto da Fórmula (Ib). A lactona da Fórmula (Ia) e seus derivados funcionais foram isolados de Securidaca virgata. Os compostos purificados demonstraram atividade nos ensaios antibacterianos e antifungos e para tratamento de distúrbios de proliferação, tais como câncer.
BR0210432-6A 2001-06-13 2002-06-12 Formulações de lactona e processo de uso BR0210432A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29787501P 2001-06-13 2001-06-13
PCT/US2002/018602 WO2002100854A1 (en) 2001-06-13 2002-06-12 Lactone formulations and method of use

Publications (1)

Publication Number Publication Date
BR0210432A true BR0210432A (pt) 2004-08-03

Family

ID=23148076

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210432-6A BR0210432A (pt) 2001-06-13 2002-06-12 Formulações de lactona e processo de uso

Country Status (21)

Country Link
US (3) US6900242B2 (pt)
EP (1) EP1406895B1 (pt)
JP (1) JP2005500289A (pt)
KR (1) KR20040030676A (pt)
AR (1) AR036056A1 (pt)
AT (1) ATE406367T1 (pt)
AU (1) AU2002306150B2 (pt)
BR (1) BR0210432A (pt)
CA (1) CA2450660C (pt)
CO (1) CO5550429A2 (pt)
CY (1) CY1108590T1 (pt)
DE (1) DE60228576D1 (pt)
DK (1) DK1406895T3 (pt)
ES (1) ES2315365T3 (pt)
IL (3) IL159296A0 (pt)
MX (1) MXPA03011554A (pt)
PT (1) PT1406895E (pt)
RS (1) RS52139B (pt)
UY (1) UY27334A1 (pt)
WO (1) WO2002100854A1 (pt)
ZA (1) ZA200400208B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL159296A0 (en) * 2001-06-13 2004-06-01 Magnachem Int Lab Inc Lactone formulations and method of use
US8188145B2 (en) 2002-06-12 2012-05-29 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
EP1562930A4 (en) * 2002-11-05 2008-12-10 Magnachem Int Lab Inc SYNTHETIC LACTONE FORMULATIONS AND METHOD OF USE
US20050045197A1 (en) * 2003-08-28 2005-03-03 Gelder Steven K. Multiple drug delivery system & method
MX2011004331A (es) * 2008-10-24 2011-09-21 Magnachem Int Lab Inc Metodo para busqueda de compuestos que interactuan selectivamente con rad9.
CN103099901B (zh) * 2013-01-26 2014-07-30 张红 一种治疗子宫内膜移位症的中药灌肠剂
KR101988479B1 (ko) * 2017-10-11 2019-09-24 (주)휴럼 리트세노라이드를 유효성분으로 하는 헬리코박터 파이로리 균주로부터 유래되는 위장질환 예방 및 치료용 약학 조성물

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* Cited by examiner, † Cited by third party
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US3203953A (en) * 1963-01-18 1965-08-31 Ciba Geigy Corp Lactone obtained from helenium sp. and derivatives thereof
US3210377A (en) * 1963-06-05 1965-10-05 Olin Mathieson Gamma lactones
US4001425A (en) * 1974-04-17 1977-01-04 E. I. Du Pont De Nemours And Company Methods of treating hypertension and pharmaceutical compositions comprising 1-tertiary-alkyl-3-(substituted furyl)ureas as antihypertensive agents
JPS5111173B2 (pt) * 1974-04-25 1976-04-09
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JPS597713B2 (ja) 1977-12-19 1984-02-20 三井東圧化学株式会社 新規γ↓−ブチロラクトン誘導体とその製造法
JPS56128776A (en) 1980-03-14 1981-10-08 Otsuka Pharmaceut Factory Inc Alpha-methylene gamma-butyrolactone derivative
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JPS6058973A (ja) * 1983-09-13 1985-04-05 Mitsubishi Yuka Yakuhin Kk γ−プチロラクトン誘導体及びそれを有効成分とする免疫調節剤
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JP2524760B2 (ja) 1987-07-10 1996-08-14 テイカ株式会社 新規抗生物質
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ATE201397T1 (de) * 1994-06-07 2001-06-15 Teijin Ltd Vitamin d3 derivate und ein verfahren zu ihrer herstellung
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US6222048B1 (en) * 1995-12-18 2001-04-24 Merck Frosst Canada & Co. Diaryl-2-(5H)-furanones as Cox-2 inhibitors
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Also Published As

Publication number Publication date
US20050209316A1 (en) 2005-09-22
US20110092588A1 (en) 2011-04-21
US8536348B2 (en) 2013-09-17
KR20040030676A (ko) 2004-04-09
ATE406367T1 (de) 2008-09-15
RS98603A (en) 2006-12-15
US6900242B2 (en) 2005-05-31
US20030069393A1 (en) 2003-04-10
AR036056A1 (es) 2004-08-04
JP2005500289A (ja) 2005-01-06
PT1406895E (pt) 2008-11-04
AU2002306150B2 (en) 2008-02-14
CY1108590T1 (el) 2014-04-09
IL211958A0 (en) 2011-06-30
EP1406895A4 (en) 2004-11-17
IL159296A0 (en) 2004-06-01
UY27334A1 (es) 2003-02-28
DK1406895T3 (da) 2008-12-01
CO5550429A2 (es) 2005-08-31
EP1406895B1 (en) 2008-08-27
MXPA03011554A (es) 2004-10-28
WO2002100854A1 (en) 2002-12-19
RS52139B (en) 2012-08-31
EP1406895A1 (en) 2004-04-14
CA2450660A1 (en) 2002-12-19
IL159296A (en) 2011-06-30
ZA200400208B (en) 2005-06-29
DE60228576D1 (de) 2008-10-09
CA2450660C (en) 2011-08-16
ES2315365T3 (es) 2009-04-01

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07D 407/00, C07D 305/12

Ipc: C07D 407/00 (2011.01), C07D 305/12 (2011.01), A61P

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 13A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2310 DE 14-04-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.