ATE201397T1 - Vitamin d3 derivate und ein verfahren zu ihrer herstellung - Google Patents
Vitamin d3 derivate und ein verfahren zu ihrer herstellungInfo
- Publication number
- ATE201397T1 ATE201397T1 AT98101653T AT98101653T ATE201397T1 AT E201397 T1 ATE201397 T1 AT E201397T1 AT 98101653 T AT98101653 T AT 98101653T AT 98101653 T AT98101653 T AT 98101653T AT E201397 T1 ATE201397 T1 AT E201397T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- vitamin
- derivatives
- production
- group
- Prior art date
Links
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12514494 | 1994-06-07 | ||
| JP22018594 | 1994-09-14 | ||
| JP22322994 | 1994-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE201397T1 true ATE201397T1 (de) | 2001-06-15 |
Family
ID=27315056
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98101653T ATE201397T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3 derivate und ein verfahren zu ihrer herstellung |
| AT95921131T ATE186721T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3 derivat und verfahren zu dessen herstellung |
| AT98101654T ATE205190T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3-derivate und ein verfahren zu ihrer herstellung |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95921131T ATE186721T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3 derivat und verfahren zu dessen herstellung |
| AT98101654T ATE205190T1 (de) | 1994-06-07 | 1995-06-07 | Vitamin d3-derivate und ein verfahren zu ihrer herstellung |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US5719297A (de) |
| EP (3) | EP0854139B1 (de) |
| AT (3) | ATE201397T1 (de) |
| DE (3) | DE69521065T2 (de) |
| ES (1) | ES2138212T3 (de) |
| WO (1) | WO1995033716A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0854139B1 (de) * | 1994-06-07 | 2001-09-05 | Teijin Limited | Vitamin D3-Derivate und ein Verfahren zu ihrer Herstellung |
| DE19619036A1 (de) * | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| GB2321244B (en) * | 1997-01-20 | 2000-11-22 | Pharmacia & Upjohn Spa | Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents |
| US6028208A (en) * | 1997-06-25 | 2000-02-22 | Teijin Limited | Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same |
| EP1123921A4 (de) | 1998-10-23 | 2003-08-20 | Teijin Ltd | Vitamin d 3 derivate und diese enthaltende heilmittel für entzündliche erkrankungen der atemwege |
| DE19935771A1 (de) | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| WO2001091794A2 (en) | 2000-05-30 | 2001-12-06 | Virginia Commonwealth University | Vitamin d3 analogs as radiosensitizers for the treatment of cancer |
| WO2002017911A1 (fr) * | 2000-08-30 | 2002-03-07 | Teijin Limited | Inhibiteurs de la production de parathormone contenant des derives de vitamine d3 |
| AU2008202109B2 (en) * | 2001-06-13 | 2012-02-02 | Magnachem International Laboratories, Inc | Lactone formulations and method of use |
| AU2002306150B2 (en) | 2001-06-13 | 2008-02-14 | Magnachem International Laboratories, Inc. | Lactone formulations and method of use |
| CN1636003A (zh) * | 2002-02-20 | 2005-07-06 | 帝人株式会社 | 维生素d3衍生物及使用其的治疗剂 |
| EP1342796A3 (de) * | 2002-02-22 | 2004-01-02 | Teijin Limited | Verbindung zur Behandlung der Paget Knochenkrankheit |
| JP4869597B2 (ja) | 2002-11-05 | 2012-02-08 | マグナケム インターナショナル ラボラトリーズ， インコーポレイテッド | 合成ラクトン処方物ならびに使用方法 |
| CN1771239B (zh) * | 2003-01-30 | 2010-06-09 | 帝人制药株式会社 | 维生素d3内酯衍生物 |
| JPWO2004067526A1 (ja) * | 2003-01-31 | 2006-05-18 | 帝人ファーマ株式会社 | （２３Ｓ）−１α−ヒドロキシ−２７−ノル−２５−メチレンビタミンＤ３−２６，２３−ラクトンの結晶およびその製造方法 |
| WO2005102315A1 (en) | 2004-04-23 | 2005-11-03 | Magnachem International Laboratories, Inc. | Synthetic lactone formulations for pain control |
| EP2350645A2 (de) | 2008-10-24 | 2011-08-03 | Magnachem International Laboratories, Inc. | Verfahren zur suche nach mit rad9 selektiv wechselwirkenden verbindungen |
| WO2010053165A1 (ja) | 2008-11-04 | 2010-05-14 | 帝人ファーマ株式会社 | ビタミンｄ３ラクタム誘導体 |
| KR101666255B1 (ko) * | 2013-01-08 | 2016-10-13 | 삼성에스디아이 주식회사 | 이차 전지 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58118516A (ja) * | 1981-12-29 | 1983-07-14 | Teijin Ltd | １α，２５−ジヒドロキシビタミンＤ↓３−２６，２３−ラクトンを含有するカルシユウム調節剤 |
| JPS58210011A (ja) * | 1982-05-31 | 1983-12-07 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
| JPS60185715A (ja) * | 1984-03-05 | 1985-09-21 | Teijin Ltd | 骨形成促進剤 |
| DE69403541T2 (de) * | 1993-02-05 | 1997-09-25 | Teijin Ltd | Lacton-Verbindung und Verfahren zu ihrer Herstellung |
| EP0854139B1 (de) * | 1994-06-07 | 2001-09-05 | Teijin Limited | Vitamin D3-Derivate und ein Verfahren zu ihrer Herstellung |
-
1995
- 1995-06-07 EP EP98101654A patent/EP0854139B1/de not_active Expired - Lifetime
- 1995-06-07 EP EP98101653A patent/EP0854138B1/de not_active Expired - Lifetime
- 1995-06-07 US US08/591,547 patent/US5719297A/en not_active Expired - Lifetime
- 1995-06-07 DE DE69521065T patent/DE69521065T2/de not_active Expired - Lifetime
- 1995-06-07 AT AT98101653T patent/ATE201397T1/de active
- 1995-06-07 DE DE69513367T patent/DE69513367T2/de not_active Expired - Lifetime
- 1995-06-07 DE DE69522589T patent/DE69522589T2/de not_active Expired - Lifetime
- 1995-06-07 ES ES95921131T patent/ES2138212T3/es not_active Expired - Lifetime
- 1995-06-07 WO PCT/JP1995/001145 patent/WO1995033716A1/ja active IP Right Grant
- 1995-06-07 AT AT95921131T patent/ATE186721T1/de active
- 1995-06-07 EP EP95921131A patent/EP0712843B1/de not_active Expired - Lifetime
- 1995-06-07 AT AT98101654T patent/ATE205190T1/de active
-
1997
- 1997-11-14 US US08/971,201 patent/US5986112A/en not_active Expired - Lifetime
-
1999
- 1999-06-08 US US09/327,489 patent/US6177586B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69521065T2 (de) | 2001-10-25 |
| ATE186721T1 (de) | 1999-12-15 |
| US6177586B1 (en) | 2001-01-23 |
| US5719297A (en) | 1998-02-17 |
| EP0854138A3 (de) | 1998-09-23 |
| ES2138212T3 (es) | 2000-01-01 |
| WO1995033716A1 (fr) | 1995-12-14 |
| EP0854138B1 (de) | 2001-05-23 |
| DE69513367T2 (de) | 2000-06-08 |
| US5986112A (en) | 1999-11-16 |
| EP0854138A2 (de) | 1998-07-22 |
| DE69521065D1 (de) | 2001-06-28 |
| EP0712843A1 (de) | 1996-05-22 |
| EP0712843A4 (de) | 1996-11-13 |
| EP0854139A2 (de) | 1998-07-22 |
| EP0854139A3 (de) | 1998-09-23 |
| DE69513367D1 (de) | 1999-12-23 |
| ATE205190T1 (de) | 2001-09-15 |
| DE69522589T2 (de) | 2002-04-18 |
| EP0854139B1 (de) | 2001-09-05 |
| EP0712843B1 (de) | 1999-11-17 |
| DE69522589D1 (de) | 2001-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE201397T1 (de) | Vitamin d3 derivate und ein verfahren zu ihrer herstellung | |
| ATE229960T1 (de) | Verfahren zur herstellung von 13-ether-derivaten von milbemycinen und zwischenprodukte | |
| ATE365171T1 (de) | Verfahren zur herstellung einer epoxyverbindung | |
| ATE229527T1 (de) | Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung | |
| DE69527400D1 (de) | Wasserlösliche camptothecin-derivate, verfahren zu deren herstellung und deren verwendung als antitumor-mittel | |
| CA2053820A1 (en) | Method of Inhibiting Metabolism of Cholesterol | |
| KR960029336A (ko) | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 | |
| ATE157973T1 (de) | Carbazolon - derivate und verfahren zu ihrer herstellung | |
| ATE239701T1 (de) | Polyethoxylierte retinamid-derivate und verfahren zu ihrer herstellung | |
| DE3888563D1 (de) | Tylosin- und 10,11,12,13-Tetrahydrotylosin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zusammensetzungen und bei deren Herstellung. | |
| ATE9469T1 (de) | Reaktive derivate des 3-oxa-bicyclo(4.3.0)-non-1- en-9-ons, verfahren zu ihrer herstellung und deren verwendung. | |
| DE69606411D1 (de) | Verfahren zur herstellung von liponsaeure | |
| ATE199706T1 (de) | Vitamin d analoga und verfahren zu ihrer herstellung | |
| DE69327906D1 (de) | Vitamin-d-derivat und verfahren zu seiner herstellung | |
| HUP0001654A2 (hu) | Eljárás szubsztituált antrakinon-származékok előállítására | |
| DE68907857D1 (de) | Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
| ATE94548T1 (de) | Prostaglandin-vorlaeufer und ihre herstellung. | |
| DE69719673T2 (de) | D-pentofuranose-derivate und verfahren zu ihrer herstellung | |
| DE69302007D1 (de) | Androst-4-en[4,5-b]-pyrrol-derivate und ein verfahren zu ihrer herstellung | |
| DE3683073D1 (de) | 3-oxo-2-azabicyclohexan-derivate, verfahren zu ihrer herstellung und verwendung dieser derivate als zwischenverbindungen fuer antibakterielle wirkstoffe. | |
| SE9502876D0 (sv) | New process |