ES2138212T3 - Derivado de la vitamina d3 y procedimiento para producirlo. - Google Patents

Derivado de la vitamina d3 y procedimiento para producirlo.

Info

Publication number
ES2138212T3
ES2138212T3 ES95921131T ES95921131T ES2138212T3 ES 2138212 T3 ES2138212 T3 ES 2138212T3 ES 95921131 T ES95921131 T ES 95921131T ES 95921131 T ES95921131 T ES 95921131T ES 2138212 T3 ES2138212 T3 ES 2138212T3
Authority
ES
Spain
Prior art keywords
sub
vitamin
derived
procedure
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921131T
Other languages
English (en)
Inventor
Masayasu Tabe
Atsuo Hazato
Kenji Manabe
Qingzhi Gao
Hiroko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of ES2138212T3 publication Critical patent/ES2138212T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PRESENTA UN DERIVADO DE LA VITAMINA D 3 REPRESENTADO POR LA FORMULA (I) EN DONDE R ES INDEPENDIENTEMENTE, UN ATOMO DE HIDROGENO, UN GRUPO DE TRI(HIDROCARBONO C{SUB,1-7})SILIL, UN GRUPO DE ACIL C{SUB,2-8}, O UN GRUPO QUE FORMA UN ENLACE DE ACETAL JUNTO CON UN ATOMO DE OXIGENO DEL GRUPO DE HIDROXIL, A ES LA FORMULA (II) O LA FORMULA (III) EN DONDE R1 ES UN GRUPO DE METILO, O UN GRUPO DE METILENO, Y CUANDO R1 ES UN GRUPO DE METILENO, EL ENLACE ENTRE R1 Y LA POSICION 3 DEL ANILLO DE LACTONA ES UN DOBLE ENLACE, R2 ES UN ATOMO DE HIDROGENO O UN GRUPO DE ALQUILO C{SUB,1-3}, R3 ES UN ATOMO DE HIDROGENO, O R2 Y R3 JUNTAS INDICAN UN GRUPO DE METILENO SIMPLE SUSTITUIBLE.
ES95921131T 1994-06-07 1995-06-07 Derivado de la vitamina d3 y procedimiento para producirlo. Expired - Lifetime ES2138212T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12514494 1994-06-07
JP22018594 1994-09-14
JP22322994 1994-09-19

Publications (1)

Publication Number Publication Date
ES2138212T3 true ES2138212T3 (es) 2000-01-01

Family

ID=27315056

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921131T Expired - Lifetime ES2138212T3 (es) 1994-06-07 1995-06-07 Derivado de la vitamina d3 y procedimiento para producirlo.

Country Status (6)

Country Link
US (3) US5719297A (es)
EP (3) EP0712843B1 (es)
AT (3) ATE205190T1 (es)
DE (3) DE69513367T2 (es)
ES (1) ES2138212T3 (es)
WO (1) WO1995033716A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69513367T2 (de) * 1994-06-07 2000-06-08 Teijin Ltd., Osaka Vitamin d3 derivat und verfahren zu dessen herstellung
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
GB2321244B (en) * 1997-01-20 2000-11-22 Pharmacia & Upjohn Spa Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents
CN1090180C (zh) * 1997-06-25 2002-09-04 帝人株式会社 维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
KR100676106B1 (ko) 1998-10-23 2007-02-28 데이진 가부시키가이샤 비타민 ｄ3 유도체 및 그것을 사용하는 염증성 호흡기질환 치료제
DE19935771A1 (de) 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US20020137731A1 (en) 2000-05-30 2002-09-26 Gewirtz David A. Combination of radiation and vitamin D3 analogs for the treatment of cancer
WO2002017911A1 (fr) * 2000-08-30 2002-03-07 Teijin Limited Inhibiteurs de la production de parathormone contenant des derives de vitamine d3
AU2008202109B2 (en) * 2001-06-13 2012-02-02 Magnachem International Laboratories, Inc Lactone formulations and method of use
EP1406895B1 (en) * 2001-06-13 2008-08-27 Magnachem International Laboratories, Inc. Lactone formulations and method of use
KR20040096589A (ko) * 2002-02-20 2004-11-16 데이진 가부시키가이샤 비타민 ｄ3 유도체 및 이것을 사용하는 치료제
EP1342796A3 (en) * 2002-02-22 2004-01-02 Teijin Limited Compound for the treatment of paget's disease of bone
US8188145B2 (en) 2002-06-12 2012-05-29 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
CA2504886C (en) 2002-11-05 2011-07-05 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
BRPI0407104A (pt) * 2003-01-30 2006-01-24 Teijin Pharma Ltd Composto, agente terapêutico, composição farmacêutica, e, processo para sintetizar um composto
EP1593678A1 (en) * 2003-01-31 2005-11-09 Teijin Pharma Limited Crystal of (23s)-1alpha-hydroxy-27-nor-25-methylenevitamin d3-26,23-lactone and process for producing the same
KR20110128785A (ko) 2008-10-24 2011-11-30 매그나켐 인터내셔널 레버러토리즈 아이엔씨 Ｒａｄ9와 선택적으로 상호작용하는 화합물들의 스크리닝방법
US20110207944A1 (en) 2008-11-04 2011-08-25 Teijin Pharma Limited Vitamin d3 lactam derivative
KR101666255B1 (ko) * 2013-01-08 2016-10-13 삼성에스디아이 주식회사 이차 전지

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58118516A (ja) * 1981-12-29 1983-07-14 Teijin Ltd １α，２５−ジヒドロキシビタミンＤ↓３−２６，２３−ラクトンを含有するカルシユウム調節剤
JPS58210011A (ja) * 1982-05-31 1983-12-07 Kureha Chem Ind Co Ltd 抗腫瘍剤
JPS60185715A (ja) * 1984-03-05 1985-09-21 Teijin Ltd 骨形成促進剤
CA2114830C (en) * 1993-02-05 2000-06-06 Masayasu Tabe Lactone compound and process of production thereof
DE69513367T2 (de) * 1994-06-07 2000-06-08 Teijin Ltd., Osaka Vitamin d3 derivat und verfahren zu dessen herstellung

Also Published As

Publication number Publication date
DE69521065T2 (de) 2001-10-25
EP0854138A3 (en) 1998-09-23
EP0854139A3 (en) 1998-09-23
EP0712843A4 (en) 1996-11-13
US6177586B1 (en) 2001-01-23
ATE205190T1 (de) 2001-09-15
DE69513367D1 (de) 1999-12-23
EP0712843B1 (en) 1999-11-17
DE69522589D1 (de) 2001-10-11
DE69521065D1 (de) 2001-06-28
EP0712843A1 (en) 1996-05-22
DE69513367T2 (de) 2000-06-08
US5986112A (en) 1999-11-16
EP0854138B1 (en) 2001-05-23
US5719297A (en) 1998-02-17
WO1995033716A1 (fr) 1995-12-14
ATE201397T1 (de) 2001-06-15
ATE186721T1 (de) 1999-12-15
EP0854139A2 (en) 1998-07-22
EP0854139B1 (en) 2001-09-05
EP0854138A2 (en) 1998-07-22
DE69522589T2 (de) 2002-04-18

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