CO5200758A1 - Derivados de 1,5-dihidropirrol-2-ona sustituida, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de estos compuestos para la preparacion de medicamentos - Google Patents
Derivados de 1,5-dihidropirrol-2-ona sustituida, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de estos compuestos para la preparacion de medicamentosInfo
- Publication number
- CO5200758A1 CO5200758A1 CO00058413A CO00058413A CO5200758A1 CO 5200758 A1 CO5200758 A1 CO 5200758A1 CO 00058413 A CO00058413 A CO 00058413A CO 00058413 A CO00058413 A CO 00058413A CO 5200758 A1 CO5200758 A1 CO 5200758A1
- Authority
- CO
- Colombia
- Prior art keywords
- radical
- aryl
- heteroaryl
- linked
- alkylene
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
Abstract
Derivados de 1,5-dihidropirrol-2-ona sustituidos de la fórmula general I<EMI FILE="00058413_1" ID="1" IMF=JPEG >en la cualX representa O, S o NR7,R1 representa H, OR11, SR11, COR8, CSR8, NR9R10, COOR8, CONR9R10, CSNR9R10, COCOR8, un radical alquilo C1-10, un radical arilo, heteroarilo o arilo ligado a través de un grupo C1-6-alquileno,R2, R3, son iguales o distintos entre sí y representan H, F, CI, Br, CF3, OR11, SR11, NR9R10, un radical alquilo C1-10, un radical arilo o heteroarilo, o arilo ligado a través de un radical C1-6-alquileno, R4 representa H, OH, OR11, SR11, COR8, COOR8, COCOR8, CONR9R10, CSNR9R10, un radical C1-10-alquilo, un radical arilo, heteroarilo o arilo ligado a través de un radical C1-6-alquileno,R5, R6, pueden ser iguales o distintos entre sí y representan H, O, OH, OR11, SR11, COR8, CSR8, COOR8, COCOR8, CONR9R10, CSNR9R10, un radical C1-10-alquilo, un radical arilo o heteroarilo o arilo ligado a través de un radical C1-6-alquileno, oR5 y R6 en conjunto representan el radical=O,R7 representa H, OR11, SR11, COR8, COOR8, COCOR8, CONR9R10, CSNR9R10, un radical C1-10-alquilo, un radical arilo o heteroarilo o arilo ligado a través de un radical C1-6-alquileno,R8 representa H, OR11, SR11, NR9R10, un radical C1-10-alquilo, preferiblemente C1-6-alquilo, un radical arilo, o heteroarilo o arilo ligado a través de un radical C1-6-alquileno,R9 representa un radical C1-10-alquilo, o un radical arilo o heteroarilo, o arilo ligado a través de un radical C1-6-alquileno,R10 representa un radical C1-10 alquilo, un radical arilo, o heteroarilo o arilo ligado a través de un radical C1-6-alquileno,R11 representa un radical C1-10-alquilo, un radical arilo, o heteroarilo, o arilo ligado a través de un radical C1-6-alquileno,en forma de racematos, enantiómeros, diastereómeros o una base correspondiente o una sal correspondiente con un ácido fisiológicamente tolerable, exceptuando los racematosde ácido 1-metil-3-acetamino-5-etoximetilentetrámico, ....
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19936719A DE19936719A1 (de) | 1999-08-06 | 1999-08-06 | Substituierte 1,5-Dihydropyrrol-2-on-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5200758A1 true CO5200758A1 (es) | 2002-09-27 |
Family
ID=7917172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00058413A CO5200758A1 (es) | 1999-08-06 | 2000-08-03 | Derivados de 1,5-dihidropirrol-2-ona sustituida, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de estos compuestos para la preparacion de medicamentos |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6642267B2 (es) |
| EP (1) | EP1200402B1 (es) |
| JP (1) | JP2003506437A (es) |
| KR (1) | KR20020025214A (es) |
| CN (1) | CN1378532A (es) |
| AR (1) | AR028848A1 (es) |
| AT (1) | ATE304530T1 (es) |
| AU (1) | AU782435B2 (es) |
| BR (1) | BR0013311A (es) |
| CA (1) | CA2381033A1 (es) |
| CO (1) | CO5200758A1 (es) |
| CZ (1) | CZ2002441A3 (es) |
| DE (2) | DE19936719A1 (es) |
| ES (1) | ES2248104T3 (es) |
| HK (1) | HK1046405A1 (es) |
| HU (1) | HUP0201937A3 (es) |
| IL (1) | IL147977A0 (es) |
| MX (1) | MXPA02001212A (es) |
| NO (1) | NO20020574L (es) |
| NZ (1) | NZ516988A (es) |
| PE (1) | PE20010402A1 (es) |
| PL (1) | PL353854A1 (es) |
| SK (1) | SK1702002A3 (es) |
| WO (1) | WO2001010833A1 (es) |
| ZA (1) | ZA200201788B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269482C (zh) * | 2001-05-18 | 2006-08-16 | 威克斯医药有限公司 | 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用 |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| EP2425846A1 (en) * | 2004-12-23 | 2012-03-07 | Voyager Pharmaceutical Corporation | Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease |
| ES2524994T3 (es) * | 2005-09-28 | 2014-12-16 | Auris Medical Ag | Composiciones farmacéuticas para el tratamiento de trastornos del oído interno. |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
| ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| US8815508B2 (en) | 2008-08-12 | 2014-08-26 | Zinfandel Pharmaceuticals, Inc. | Method of identifying disease risk factors |
| US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| JP5688745B2 (ja) | 2010-03-10 | 2015-03-25 | プロビオドルグ エージー | グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤 |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| SG191399A1 (en) | 2011-01-10 | 2013-08-30 | Zinfandel Pharmaceuticals Inc | Methods and drug products for treating alzheimer's disease |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| KR102084185B1 (ko) | 2013-08-29 | 2020-03-04 | 주식회사 대웅제약 | 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법 |
| US10708389B2 (en) * | 2016-12-06 | 2020-07-07 | Intelligrated Headquarters, Llc | Phased deployment of scalable real time web applications for material handling system |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL258360A (es) * | 1960-11-25 | |||
| GB2170498A (en) * | 1985-02-04 | 1986-08-06 | Ici Plc | Processes for making fungicidal dithiolopyrrolones |
| GB2173499A (en) * | 1985-02-04 | 1986-10-15 | Ici Plc | Fungicidal dithiolopyrrolones |
| GB9210393D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
-
1999
- 1999-08-06 DE DE19936719A patent/DE19936719A1/de not_active Ceased
-
2000
- 2000-07-25 AT AT00956273T patent/ATE304530T1/de active
- 2000-07-25 MX MXPA02001212A patent/MXPA02001212A/es active IP Right Grant
- 2000-07-25 CA CA002381033A patent/CA2381033A1/en not_active Abandoned
- 2000-07-25 ES ES00956273T patent/ES2248104T3/es not_active Expired - Lifetime
- 2000-07-25 NZ NZ516988A patent/NZ516988A/en unknown
- 2000-07-25 CN CN00813944A patent/CN1378532A/zh active Pending
- 2000-07-25 DE DE50011178T patent/DE50011178D1/de not_active Expired - Lifetime
- 2000-07-25 PL PL00353854A patent/PL353854A1/xx not_active Application Discontinuation
- 2000-07-25 WO PCT/EP2000/007100 patent/WO2001010833A1/de active IP Right Grant
- 2000-07-25 AU AU68279/00A patent/AU782435B2/en not_active Ceased
- 2000-07-25 JP JP2001515300A patent/JP2003506437A/ja not_active Withdrawn
- 2000-07-25 SK SK170-2002A patent/SK1702002A3/sk not_active Application Discontinuation
- 2000-07-25 KR KR1020027001608A patent/KR20020025214A/ko not_active Application Discontinuation
- 2000-07-25 CZ CZ2002441A patent/CZ2002441A3/cs unknown
- 2000-07-25 BR BR0013311-6A patent/BR0013311A/pt not_active IP Right Cessation
- 2000-07-25 EP EP00956273A patent/EP1200402B1/de not_active Expired - Lifetime
- 2000-07-25 HU HU0201937A patent/HUP0201937A3/hu unknown
- 2000-07-25 IL IL14797700A patent/IL147977A0/xx unknown
- 2000-07-31 AR ARP000103963A patent/AR028848A1/es not_active Application Discontinuation
- 2000-08-01 PE PE2000000761A patent/PE20010402A1/es not_active Application Discontinuation
- 2000-08-03 CO CO00058413A patent/CO5200758A1/es not_active Application Discontinuation
-
2002
- 2002-02-05 NO NO20020574A patent/NO20020574L/no not_active Application Discontinuation
- 2002-02-06 US US10/066,800 patent/US6642267B2/en not_active Expired - Fee Related
- 2002-03-04 ZA ZA200201788A patent/ZA200201788B/xx unknown
- 2002-10-28 HK HK02107776.3A patent/HK1046405A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20020161033A1 (en) | 2002-10-31 |
| AU6827900A (en) | 2001-03-05 |
| PL353854A1 (en) | 2003-12-01 |
| ZA200201788B (en) | 2003-08-27 |
| HUP0201937A3 (en) | 2002-12-28 |
| SK1702002A3 (en) | 2002-07-02 |
| US6642267B2 (en) | 2003-11-04 |
| DE19936719A1 (de) | 2001-02-15 |
| EP1200402B1 (de) | 2005-09-14 |
| ES2248104T3 (es) | 2006-03-16 |
| DE50011178D1 (de) | 2005-10-20 |
| IL147977A0 (en) | 2002-09-12 |
| NZ516988A (en) | 2004-11-26 |
| CA2381033A1 (en) | 2001-02-15 |
| NO20020574L (no) | 2002-03-25 |
| WO2001010833A1 (de) | 2001-02-15 |
| AR028848A1 (es) | 2003-05-28 |
| NO20020574D0 (no) | 2002-02-05 |
| AU782435B2 (en) | 2005-07-28 |
| EP1200402A1 (de) | 2002-05-02 |
| CZ2002441A3 (cs) | 2002-05-15 |
| CN1378532A (zh) | 2002-11-06 |
| ATE304530T1 (de) | 2005-09-15 |
| PE20010402A1 (es) | 2001-05-05 |
| KR20020025214A (ko) | 2002-04-03 |
| HK1046405A1 (zh) | 2003-01-10 |
| JP2003506437A (ja) | 2003-02-18 |
| HUP0201937A2 (en) | 2002-10-28 |
| MXPA02001212A (es) | 2002-07-02 |
| BR0013311A (pt) | 2003-01-28 |
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