CO5200789A1 - Derivados i quinolin-4-il - Google Patents
Derivados i quinolin-4-ilInfo
- Publication number
- CO5200789A1 CO5200789A1 CO00073351A CO00073351A CO5200789A1 CO 5200789 A1 CO5200789 A1 CO 5200789A1 CO 00073351 A CO00073351 A CO 00073351A CO 00073351 A CO00073351 A CO 00073351A CO 5200789 A1 CO5200789 A1 CO 5200789A1
- Authority
- CO
- Colombia
- Prior art keywords
- lower alkyl
- phenyl
- amino
- hydrogen
- aminobutanol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Compuestos de la fórmula<EMI FILE="00073351_1" ID="1" IMF=JPEG >en dondeR1 es hidrógeno, alquilo inferior, alcoxilo inferior, hidroxilo, arnino, nitro, ciano, alquil-amino inferior, di-alquil-amino inferior o halógeno; R2 es fenilo, opcionalmente sustituido por alquilo inferior,alcoxilo inferior, halógeno, trifluorometilo, amino,alquil-amino inferior o di-alquil-amino inferior,2,3-dihidro-benzofuran-5-ilo, croman-6-ilo, naftalen-2-ilo, indan-5-ilo, alquilen-fenilo inferior, 5,6,7,8 tetrahidro - naftalenilo, 2,3-dihidro - isoindol-2-ilo, 1,2, 3, 4-tetrahidro-naftalenilo, benzofuran-2-ilo,benzo [b] tiofen-2-ilo, alquil-fenilo inferior, 3,4-dihidro-1H-isoquinolin-2-ilo o tiofen-3-ilo;R3 y R4 son, independientemente uno de otro hidrógeno o alquilo inferior;R3 es hidrógeno, alquilo inferior, -CH2OH o -CH2NR6R7;R6 y R7 son, independientemente uno de otro, hidrógeno, alquilo inferior -(CH2)n-fenilo, cicloalquilo, -(CH2)m-morfolinilo o forman junto con el átomo de N un anillo saturado con 4-6 átomos de C; n es 0-3;m es 2- 3;X es -NR8- u -O-; oX y R5 son, conjuntamente, ANDgt;N(CH2)2-; oX y R3 son, conjuntamente, ANDgt;N(CH2)3-; yR8 es hidrógeno o alquilo inferior;y sus sales de adición de ácido farmacéuticamente aceptables,con la excepción de los compuestos siguientes(6-cloro-2-fenil-4-quinolinil)-(+)-2-aminobutanol;(6-metil-2-fenil-4-quinolinil)-(+)-2-aminobutanol;(6-metoxi-2-fenil-4-quinolinil)-(+)-2-aminobutanol; y(8-metoxi-2-fenil-4-quinolinil)-(+)-2-aminobutanol.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99119539 | 1999-10-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5200789A1 true CO5200789A1 (es) | 2002-09-27 |
Family
ID=8239107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00073351A CO5200789A1 (es) | 1999-10-01 | 2000-09-27 | Derivados i quinolin-4-il |
Country Status (26)
Country | Link |
---|---|
US (1) | US6440995B1 (es) |
JP (1) | JP3523174B2 (es) |
KR (1) | KR100398561B1 (es) |
CN (1) | CN1181059C (es) |
AR (1) | AR025882A1 (es) |
AT (1) | ATE281436T1 (es) |
AU (1) | AU774363B2 (es) |
BR (1) | BR0004548A (es) |
CA (1) | CA2321324A1 (es) |
CO (1) | CO5200789A1 (es) |
CZ (1) | CZ20003575A3 (es) |
DE (1) | DE60015471T2 (es) |
ES (1) | ES2230017T3 (es) |
HR (1) | HRP20000639A2 (es) |
HU (1) | HUP0003861A3 (es) |
ID (1) | ID27525A (es) |
IL (1) | IL138777A0 (es) |
MA (1) | MA26752A1 (es) |
NO (1) | NO20004892L (es) |
NZ (1) | NZ507141A (es) |
PE (1) | PE20010648A1 (es) |
PL (1) | PL342876A1 (es) |
PT (1) | PT1088818E (es) |
SG (1) | SG164268A1 (es) |
TR (1) | TR200002831A3 (es) |
ZA (1) | ZA200005239B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6831087B2 (en) * | 2001-11-09 | 2004-12-14 | Hoffmann-La Roche Inc. | Pyridine substituted isoquinoline derivatives |
RU2285693C2 (ru) * | 2002-02-13 | 2006-10-20 | Ф.Хоффманн-Ля Рош Аг | Производные пиридина и хинолина, способ их получения, фармацевтическая композиция, применение соединений для лечения заболеваний, ассоциированных с dpp-iv |
US7648984B2 (en) * | 2004-07-13 | 2010-01-19 | Glaxo Group Limited | Antibacterial agents |
EP2573080A1 (en) * | 2007-09-27 | 2013-03-27 | The United States of America, as Represented by the Secretary, Department of Health and Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
US9840500B2 (en) * | 2014-06-16 | 2017-12-12 | Fundación Para La Investigación Médica Aplicada | Compounds as dual inhibitors of histone methyltransferases and DNA methyltransferases |
JP6899323B2 (ja) | 2014-10-14 | 2021-07-07 | ラ ホーヤ インスティテュート オブ アレルギー アンド イミュノロジー | 低分子量タンパク質チロシンホスファターゼの阻害剤、及びその使用 |
KR20170074178A (ko) * | 2015-12-21 | 2017-06-29 | 제이엔씨 주식회사 | 중합성 액정 화합물, 조성물, 그 액정 중합막류 및 이들의 용도 |
CN105646462B (zh) * | 2016-01-19 | 2019-04-05 | 河南大学 | 芸香宁碱衍生物、其制备方法及应用 |
EP3619210A4 (en) | 2017-05-01 | 2020-12-02 | Sanford Burnham Prebys Medical Discovery Institute | LOW MOLECULAR PROTEIN TYROSINE PHOSPHATASE (LMPTP) INHIBITORS AND USES THEREOF |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE440008C (de) | 1924-03-29 | 1927-05-04 | I G Farbenindustrie Akt Ges | Verfahren zur Darstellung von Chinolinderivaten |
US4560692A (en) | 1984-07-18 | 1985-12-24 | Hoffmann-La Roche Inc. | 4-Piperidino-2-phenylquinolines |
GB9125515D0 (en) | 1991-11-29 | 1992-01-29 | Merck Sharp & Dohme | Therapeutic agents |
US5441963A (en) | 1991-12-20 | 1995-08-15 | Merrell Dow Pharmaceuticals | Potentiation of NMDA antagonists |
-
2000
- 2000-09-11 US US09/658,934 patent/US6440995B1/en not_active Expired - Fee Related
- 2000-09-26 PT PT00120890T patent/PT1088818E/pt unknown
- 2000-09-26 NZ NZ507141A patent/NZ507141A/en unknown
- 2000-09-26 ES ES00120890T patent/ES2230017T3/es not_active Expired - Lifetime
- 2000-09-26 DE DE60015471T patent/DE60015471T2/de not_active Expired - Fee Related
- 2000-09-26 MA MA26068A patent/MA26752A1/fr unknown
- 2000-09-26 AT AT00120890T patent/ATE281436T1/de not_active IP Right Cessation
- 2000-09-27 AU AU61324/00A patent/AU774363B2/en not_active Ceased
- 2000-09-27 CA CA002321324A patent/CA2321324A1/en not_active Abandoned
- 2000-09-27 CO CO00073351A patent/CO5200789A1/es not_active Application Discontinuation
- 2000-09-27 SG SG200005551-7A patent/SG164268A1/en unknown
- 2000-09-27 CZ CZ20003575A patent/CZ20003575A3/cs unknown
- 2000-09-28 CN CNB001292013A patent/CN1181059C/zh not_active Expired - Fee Related
- 2000-09-28 PE PE2000001024A patent/PE20010648A1/es not_active Application Discontinuation
- 2000-09-28 AR ARP000105102A patent/AR025882A1/es not_active Application Discontinuation
- 2000-09-28 IL IL13877700A patent/IL138777A0/xx unknown
- 2000-09-28 ZA ZA200005239A patent/ZA200005239B/xx unknown
- 2000-09-28 HR HR20000639A patent/HRP20000639A2/hr not_active Application Discontinuation
- 2000-09-29 TR TR2000/02831A patent/TR200002831A3/tr unknown
- 2000-09-29 KR KR10-2000-0057259A patent/KR100398561B1/ko not_active IP Right Cessation
- 2000-09-29 ID IDP20000849D patent/ID27525A/id unknown
- 2000-09-29 NO NO20004892A patent/NO20004892L/no unknown
- 2000-09-29 BR BR0004548-9A patent/BR0004548A/pt not_active IP Right Cessation
- 2000-09-29 JP JP2000298078A patent/JP3523174B2/ja not_active Expired - Fee Related
- 2000-09-29 HU HU0003861A patent/HUP0003861A3/hu unknown
- 2000-09-29 PL PL00342876A patent/PL342876A1/xx not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0003861A3 (en) | 2002-09-30 |
CA2321324A1 (en) | 2001-04-01 |
NO20004892L (no) | 2001-04-02 |
NO20004892D0 (no) | 2000-09-29 |
NZ507141A (en) | 2002-05-31 |
ATE281436T1 (de) | 2004-11-15 |
BR0004548A (pt) | 2001-05-29 |
AU6132400A (en) | 2001-04-05 |
DE60015471D1 (de) | 2004-12-09 |
ID27525A (id) | 2001-04-12 |
TR200002831A2 (tr) | 2001-04-20 |
JP3523174B2 (ja) | 2004-04-26 |
HU0003861D0 (en) | 2000-12-28 |
DE60015471T2 (de) | 2005-10-27 |
JP2001097952A (ja) | 2001-04-10 |
MA26752A1 (fr) | 2004-12-20 |
IL138777A0 (en) | 2001-10-31 |
HRP20000639A2 (en) | 2001-06-30 |
ES2230017T3 (es) | 2005-05-01 |
US6440995B1 (en) | 2002-08-27 |
CZ20003575A3 (cs) | 2001-11-14 |
ZA200005239B (en) | 2001-04-16 |
AU774363B2 (en) | 2004-06-24 |
HUP0003861A2 (hu) | 2001-10-28 |
KR20010050738A (ko) | 2001-06-15 |
CN1290698A (zh) | 2001-04-11 |
PT1088818E (pt) | 2005-03-31 |
CN1181059C (zh) | 2004-12-22 |
AR025882A1 (es) | 2002-12-18 |
KR100398561B1 (ko) | 2003-09-19 |
TR200002831A3 (tr) | 2001-04-20 |
PE20010648A1 (es) | 2001-06-13 |
PL342876A1 (en) | 2001-04-09 |
SG164268A1 (en) | 2010-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |