CO5160349A1 - Proteinas y amino acidos de sitio especifico, marcados isotopicamnete y precursores bioquimicos resultantes dos para preparar dichas proteinas, amino acidos y precurso- res bioquimicos resultantes - Google Patents

Proteinas y amino acidos de sitio especifico, marcados isotopicamnete y precursores bioquimicos resultantes dos para preparar dichas proteinas, amino acidos y precurso- res bioquimicos resultantes

Info

Publication number
CO5160349A1
CO5160349A1 CO00025250A CO00025250A CO5160349A1 CO 5160349 A1 CO5160349 A1 CO 5160349A1 CO 00025250 A CO00025250 A CO 00025250A CO 00025250 A CO00025250 A CO 00025250A CO 5160349 A1 CO5160349 A1 CO 5160349A1
Authority
CO
Colombia
Prior art keywords
amino acids
results
biochemical
precurse
isotopicamnete
Prior art date
Application number
CO00025250A
Other languages
English (en)
Inventor
Stephen W Fesik
David J Augeri
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CO5160349A1 publication Critical patent/CO5160349A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Un compuesto de la fórmula I:<EMI FILE="00025250_1" ID="1" IMF=JPEG >o la sal resultante, donde:R1 es oxigeno o NH2;R2 es seleccionada entre un grupo consistente en:<EMI FILE="00025250_2" ID="2" IMF=JPEG >donde R3 es hidrógeno o nCH3 ;el enlace de línea punteada representa un segundo enlace de valencia;m es cero o uno;y n, en cada ocurrencia es 13 ó 14;con las condiciones de que:i) cuando R1 es NH2, el segundo enlace de valencia representado por el enlace de línea punteada a R1 está ausente y el hidrógeno unido al enlace de línea punteada está presente;ii) cuando R1 es oxigeno, el segundo enlace de valencia, representado por el enlace de línea punteada a R1 está presente y el átomo de hidrógeno unido al enlace de línea punteada está ausente.iii) cuando R1 es oxigeno, R2 es B y m es cero; yiv) cuando R1 es NH2, R3 es hidrógeno o nCH3.
CO00025250A 1999-04-09 2000-04-06 Proteinas y amino acidos de sitio especifico, marcados isotopicamnete y precursores bioquimicos resultantes dos para preparar dichas proteinas, amino acidos y precurso- res bioquimicos resultantes CO5160349A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28951799A 1999-04-09 1999-04-09

Publications (1)

Publication Number Publication Date
CO5160349A1 true CO5160349A1 (es) 2002-05-30

Family

ID=23111884

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00025250A CO5160349A1 (es) 1999-04-09 2000-04-06 Proteinas y amino acidos de sitio especifico, marcados isotopicamnete y precursores bioquimicos resultantes dos para preparar dichas proteinas, amino acidos y precurso- res bioquimicos resultantes

Country Status (29)

Country Link
EP (1) EP1169282B1 (es)
JP (1) JP2002541228A (es)
KR (1) KR100708225B1 (es)
CN (1) CN1244521C (es)
AR (1) AR029747A1 (es)
AT (1) ATE296789T1 (es)
AU (1) AU777749B2 (es)
BG (1) BG106043A (es)
BR (1) BR0009664A (es)
CA (1) CA2368652C (es)
CO (1) CO5160349A1 (es)
CZ (1) CZ20013616A3 (es)
DE (1) DE60020547T2 (es)
DK (1) DK1169282T3 (es)
ES (1) ES2243251T3 (es)
HK (1) HK1044753B (es)
HU (1) HUP0200809A3 (es)
IL (2) IL145536A0 (es)
MX (1) MXPA01010183A (es)
NO (1) NO20014691L (es)
NZ (1) NZ514518A (es)
PL (1) PL350889A1 (es)
PT (1) PT1169282E (es)
SI (1) SI1169282T1 (es)
SK (1) SK14322001A3 (es)
TR (1) TR200102842T2 (es)
TW (1) TWI283659B (es)
WO (1) WO2000061525A1 (es)
ZA (1) ZA200107919B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9708228B2 (en) 2010-01-06 2017-07-18 Commissariat A L'energie Atomique Et Aux Energies Alternatives Process for the specific isotopic labeling of methyl groups of Val, Leu and Ile
US10053396B2 (en) 2010-01-06 2018-08-21 Commissariat A L'energie Atomique Et Aux Energies Alternatives Process for the specific isotopic labeling of methyl groups of Val, Leu and Ile
KR101219684B1 (ko) * 2012-04-27 2013-01-10 건국대학교 산학협력단 정량적 질량분석기법을 이용한 만성골수성 백혈병의 발병 진단방법과 약제 내성 진단방법
EP2695873B1 (en) * 2012-08-08 2016-10-26 Commissariat A L'energie Atomique Et Aux Energies Alternatives Labeled chiral alpha-hydroxy ketoacid derivatives, a process for preparing said derivatives and their use
CN107793209A (zh) * 2016-08-30 2018-03-13 泰生科技香港有限公司 稳定性同位素标记植物的专用培养基、其制备方法及用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698401A (en) * 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules

Also Published As

Publication number Publication date
NO20014691L (no) 2001-12-10
CN1353678A (zh) 2002-06-12
PT1169282E (pt) 2005-10-31
CN1244521C (zh) 2006-03-08
AR029747A1 (es) 2003-07-16
EP1169282A1 (en) 2002-01-09
DE60020547D1 (de) 2005-07-07
BR0009664A (pt) 2002-01-08
TWI283659B (en) 2007-07-11
KR20010108475A (ko) 2001-12-07
CA2368652C (en) 2009-11-10
IL145536A0 (en) 2002-06-30
TR200102842T2 (tr) 2002-03-21
IL145536A (en) 2010-05-31
SK14322001A3 (sk) 2002-02-05
ZA200107919B (en) 2003-03-26
HK1044753B (zh) 2006-03-24
KR100708225B1 (ko) 2007-04-17
SI1169282T1 (en) 2005-10-31
WO2000061525A1 (en) 2000-10-19
CZ20013616A3 (cs) 2002-04-17
HUP0200809A2 (en) 2002-06-29
CA2368652A1 (en) 2000-10-19
HK1044753A1 (en) 2002-11-01
AU777749B2 (en) 2004-10-28
PL350889A1 (en) 2003-02-10
HUP0200809A3 (en) 2004-11-29
DE60020547T2 (de) 2006-05-04
NO20014691D0 (no) 2001-09-27
NZ514518A (en) 2003-10-31
EP1169282B1 (en) 2005-06-01
BG106043A (en) 2002-05-31
MXPA01010183A (es) 2003-07-21
ES2243251T3 (es) 2005-12-01
AU4212100A (en) 2000-11-14
DK1169282T3 (da) 2005-10-03
JP2002541228A (ja) 2002-12-03
ATE296789T1 (de) 2005-06-15

Similar Documents

Publication Publication Date Title
KR900002799A (ko) 뉴로펩티드 y 애고니스트
DE59406570D1 (de) Phenylsulfonylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als herbizide und pflanzenwachstumsregulatoren
DE69316367D1 (de) Natürliche aminosäurederivate als metalloproteinase-inhibitoren
PT888349E (pt) Pirrolopirimidinas e processos para a sua preparacao
DE69026980D1 (de) Schwefel enthaltende kondensierte Pyrimidinderivate, ihre Herstellung und Verwendung
DE69837346D1 (de) Anilidderivate, deren herstellung und verwendung
CY1105091T1 (el) Αντικατεστημενες ενωσεις 2-αρυλοβενζαζολιου και η χρηση τους σαν παραγοντες κατα των ογκων
HUP0103851A2 (hu) VIIa Faktor inhibitorai, eljárás előállításukra, alkalmazásuk és azokat tartalmazó gyógyászati készítmények
DE69705930D1 (de) Neue n-(arylsulfonyl)aminosäurederivate mit einer affinität für bradykininrezeptoren
IT1214920B (it) Agenti disperdenti polimerici migliorati;la loro costituzione chimica teorica e i metodi per realizzarli;prodotti e dispersioni che contengono i suddetti agenti disperdenti e le loro innovazioni strutturali
ATE81854T1 (de) Aminoluciferine, verfahren zu deren herstellung und ihre verwendung.
BR0012514B1 (pt) composição de fluido de transferência térmica e uso de uma composição compreendendo uma mistura de sais de ácido carboxìlico.
AR018159A1 (es) Compuestos derivados de amidin-amino-acidos halogenados utiles como inhibidores de la oxido-nitrico-sintetasa, composicion farmaceutica que los contiene ymetodo de tratamiento
KR960031466A (ko) 테트라하이드로나프탈렌 유도체
BR0004535A (pt) Compostos, e, uso dos mesmos.
CO5160349A1 (es) Proteinas y amino acidos de sitio especifico, marcados isotopicamnete y precursores bioquimicos resultantes dos para preparar dichas proteinas, amino acidos y precurso- res bioquimicos resultantes
SE8901552D0 (sv) Acid addition salts of amidated or glycine, their preparation and use
DE69703878T2 (de) Guanidinium-verbindungen, pharmazeutische präparate davon und ihre verwendungen
TR200100504T2 (tr) Seramikten üretilmiş eşyaları renklendirmeye uygun altın bileşiklerine dayalı formüller
CO5140099A1 (es) Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores
BR9811483A (pt) Derivados do ácido amino-etil-fenóxi-acético e fármacos para a remissão da dor e promover a remoção de cálculos na litìase urinária
DE3769910D1 (de) Verwendung von n, n&#39;-bis-l-aminosaeure-l-cystinpeptiden in aminosaeure-praeparaten fuer orale und parenterale ernaehrung.
ATE342062T1 (de) Angiotensin ii zur verbesserung der befruchtung
CO5180541A1 (es) Inhibidores de proteasa del tipo de 1,3-diaminocetonas con anillo de 8-14 miembros
AR043037A1 (es) Benzo [1,2,5] tiadiazoles y su uso farmaceutico