HUP0103851A2 - VIIa Faktor inhibitorai, eljárás előállításukra, alkalmazásuk és azokat tartalmazó gyógyászati készítmények - Google Patents

VIIa Faktor inhibitorai, eljárás előállításukra, alkalmazásuk és azokat tartalmazó gyógyászati készítmények

Info

Publication number
HUP0103851A2
HUP0103851A2 HU0103851A HUP0103851A HUP0103851A2 HU P0103851 A2 HUP0103851 A2 HU P0103851A2 HU 0103851 A HU0103851 A HU 0103851A HU P0103851 A HUP0103851 A HU P0103851A HU P0103851 A2 HUP0103851 A2 HU P0103851A2
Authority
HU
Hungary
Prior art keywords
factor viia
preparation
pharmaceutical compositions
viia inhibitors
formula
Prior art date
Application number
HU0103851A
Other languages
English (en)
Inventor
Pavel Safar
Alena Safarova
Peter Wildgoose
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of HUP0103851A2 publication Critical patent/HUP0103851A2/hu
Publication of HUP0103851A3 publication Critical patent/HUP0103851A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A tal lm ny szerinti R1-A-B-D-En-R2 (I) ltal nos képletű új vegyületek- a képletben R1 jelentése R13, R12C(O) vagy N-termin lis n adottesetben szubsztitu lt 1-3 aminosavat tartalmazó peptidmaradék, Ajelentése NH-CHR93-C(O), B jelentése NR95-CHR97-C(O), D jelentése NH-CR81R82-C(O), En jelentése (NR70-CR71R72-C(O)n, ahol n értéke 0, 1, 2vagy 3, és R2 jelentése NR21R22, OR23 vagy R24 - a VIIa véralvad sifaktor reverzíbilis g tl sa révén erős antitrombotikus hat ssalrendelkeznek. A tal lm ny t rgy t képezi a fenti vegyületek elő llítsa, alkalmaz sa és az ezeket tartalmazó gyógy szati készítmények is. Ó
HU0103851A 1998-09-15 1999-09-02 Factor viia inhibitors, process for their preparation, their use and pharmaceutical compositions comprising thereof HUP0103851A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98117506A EP0987274A1 (en) 1998-09-15 1998-09-15 Factor VIIa Inhibitors
PCT/EP1999/006449 WO2000015658A1 (en) 1998-09-15 1999-09-02 FACTOR VIIa INHIBITORS

Publications (2)

Publication Number Publication Date
HUP0103851A2 true HUP0103851A2 (hu) 2002-04-29
HUP0103851A3 HUP0103851A3 (en) 2002-05-28

Family

ID=8232644

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103851A HUP0103851A3 (en) 1998-09-15 1999-09-02 Factor viia inhibitors, process for their preparation, their use and pharmaceutical compositions comprising thereof

Country Status (25)

Country Link
US (1) US6287794B1 (hu)
EP (2) EP0987274A1 (hu)
JP (1) JP4537581B2 (hu)
KR (1) KR100665490B1 (hu)
CN (1) CN1203087C (hu)
AR (1) AR027814A1 (hu)
AT (1) ATE460424T1 (hu)
AU (1) AU760580B2 (hu)
BR (1) BR9913742A (hu)
CA (1) CA2344048A1 (hu)
CZ (1) CZ300249B6 (hu)
DE (1) DE69942123D1 (hu)
HK (1) HK1040253B (hu)
HU (1) HUP0103851A3 (hu)
ID (1) ID28494A (hu)
IL (2) IL141415A0 (hu)
MY (1) MY125150A (hu)
NO (1) NO328523B1 (hu)
NZ (1) NZ510509A (hu)
PL (1) PL203227B1 (hu)
RU (1) RU2223967C2 (hu)
TR (1) TR200100766T2 (hu)
TW (1) TW576839B (hu)
WO (1) WO2000015658A1 (hu)
ZA (1) ZA200101861B (hu)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
WO2000041531A2 (en) 1999-01-13 2000-07-20 Genentech, Inc. Serine protease inhibitors
EP1059302A1 (en) * 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Factor VIIa inhibitors
WO2001024626A1 (fr) * 1999-10-01 2001-04-12 Chugai Seiyaku Kabushiki Kaisha Prevention et traitement de maladies associees a la coagulation sanguine
EP1095933A1 (en) 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
EP1162194A1 (en) * 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
GB0014134D0 (en) * 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
AU1339302A (en) 2000-10-20 2002-05-06 Biocryst Pharm Inc Biaryl compounds as serine protease inhibitors
CZ20031554A3 (cs) 2000-12-06 2003-08-13 Aventis Pharma Deutschland Gmbh Guanidinové a amidinové deriváty jako inhibitory faktoru XA
US7001887B2 (en) 2001-02-02 2006-02-21 Chugai Seiyaku Kabushiki Kaisha Peptide derivatives
EP1270551A1 (en) * 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Urea derivatives with antiproteolytic activity
EP1314733A1 (en) 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
US7604932B2 (en) * 2002-11-13 2009-10-20 Haematologic Technologies, Inc. Assay for tissue factor in a sample
US7358268B2 (en) 2002-12-04 2008-04-15 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives as factor Xa inhibitors
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
US7317027B2 (en) 2003-05-19 2008-01-08 Sanofi-Aventis Deutschland Gmbh Azaindole-derivatives as factor Xa inhibitors
US7223780B2 (en) 2003-05-19 2007-05-29 Sanofi-Aventis Deutschland Gmbh Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
EP1479680A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Azaindole derivatives as Factor Xa inhibitors
EP1479675A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
EP1479677A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
US7741341B2 (en) 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
WO2004113278A2 (en) 2003-05-20 2004-12-29 Genentech, Inc. Acylsulfamide inhibitors of factor viia
EP1626966A1 (en) 2003-05-20 2006-02-22 Genentech, Inc. Benzofuran inhibitors of factor viia
EP1568698A1 (en) 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Pyrrole-derivatives as factor Xa inhibitors
WO2008107362A2 (en) * 2007-03-07 2008-09-12 Novo Nordisk Health Care Ag Stabiliser and inhibitors of factor vii
CA2693396A1 (en) 2007-07-10 2009-01-15 Sanofi-Aventis Malonamide derivatives with antithrombotic activity
WO2009092758A1 (en) * 2008-01-23 2009-07-30 Novo Nordisk Health Care Ag New blood coagulation factor inhibitors
US9901597B2 (en) 2011-02-04 2018-02-27 Octapharma Ag Method for inactivation/removal of coagulation factors by precipitation
KR20210062650A (ko) * 2018-09-11 2021-05-31 앤비션 에스.알.엘. 펩티드 및 이의 의학적 용도
KR20210062649A (ko) * 2018-09-11 2021-05-31 앤비션 에스.알.엘. 펩티드 및 이의 의학적 용도
CN114423785A (zh) 2019-07-01 2022-04-29 通尼克斯制药有限公司 抗-cd154抗体及其用途
MX2023008055A (es) 2021-01-06 2023-08-22 Tonix Pharma Ltd Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados.
GB202209228D0 (en) * 2022-06-23 2022-08-10 Univ Strathclyde Modified amino acids and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023236A (en) * 1988-04-07 1991-06-11 Corvas, Inc. Factor VII/VIIA active site inhibitors
EP0391999A4 (en) * 1988-09-23 1991-03-13 Corvas, Inc. Peptidyl inhibitors of the initiation of coagulation
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US5190919A (en) * 1989-11-13 1993-03-02 Board Of Regents, The University Of Texas System Antihemostatic factor vii peptides
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
JPH08511794A (ja) * 1993-06-18 1996-12-10 ハフスルント ニコムド エイ／エス ▲ｖｉｉ▼因子由来ペプチド
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
EP1384725A3 (en) * 1994-04-26 2007-02-21 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
US5837684A (en) * 1995-06-07 1998-11-17 Nycomed Imaging As Peptides
DE69717268T2 (de) * 1996-02-22 2003-09-04 Bristol Myers Squibb Pharma Co M-amidinophenyl-analoga als faktor-xa-inhibitoren
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors

Also Published As

Publication number Publication date
BR9913742A (pt) 2001-06-05
AR027814A1 (es) 2003-04-16
EP1114061A1 (en) 2001-07-11
US6287794B1 (en) 2001-09-11
ID28494A (id) 2001-05-31
CN1203087C (zh) 2005-05-25
IL141415A0 (en) 2002-03-10
HK1040253B (zh) 2005-09-02
AU760580B2 (en) 2003-05-15
TW576839B (en) 2004-02-21
KR20010075130A (ko) 2001-08-09
AU5972399A (en) 2000-04-03
MY125150A (en) 2006-07-31
RU2223967C2 (ru) 2004-02-20
DE69942123D1 (de) 2010-04-22
NO20011293D0 (no) 2001-03-14
IL141415A (en) 2006-09-05
JP2002524571A (ja) 2002-08-06
HK1040253A1 (en) 2002-05-31
NZ510509A (en) 2002-09-27
PL203227B1 (pl) 2009-09-30
ZA200101861B (en) 2001-10-22
NO328523B1 (no) 2010-03-08
EP0987274A1 (en) 2000-03-22
JP4537581B2 (ja) 2010-09-01
EP1114061B1 (en) 2010-03-10
CN1318069A (zh) 2001-10-17
CZ300249B6 (cs) 2009-04-01
NO20011293L (no) 2001-05-04
HUP0103851A3 (en) 2002-05-28
CZ2001914A3 (en) 2001-06-13
CA2344048A1 (en) 2000-03-23
KR100665490B1 (ko) 2007-01-10
PL346781A1 (en) 2002-02-25
TR200100766T2 (tr) 2001-10-22
WO2000015658A1 (en) 2000-03-23
ATE460424T1 (de) 2010-03-15

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees