HK1040253B - 因子viia抑制劑 - Google Patents

因子viia抑制劑

Info

Publication number
HK1040253B
HK1040253B HK02101586.6A HK02101586A HK1040253B HK 1040253 B HK1040253 B HK 1040253B HK 02101586 A HK02101586 A HK 02101586A HK 1040253 B HK1040253 B HK 1040253B
Authority
HK
Hong Kong
Prior art keywords
factor viia
viia inhibitors
inhibitors
factor
viia
Prior art date
Application number
HK02101586.6A
Other languages
English (en)
Other versions
HK1040253A1 (en
Inventor
P‧薩法
A‧薩法羅瓦
P‧維爾德古斯
Original Assignee
薩諾費-阿文蒂斯德國有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 薩諾費-阿文蒂斯德國有限公司 filed Critical 薩諾費-阿文蒂斯德國有限公司
Publication of HK1040253A1 publication Critical patent/HK1040253A1/xx
Publication of HK1040253B publication Critical patent/HK1040253B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK02101586.6A 1998-09-15 2002-03-01 因子viia抑制劑 HK1040253B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98117506A EP0987274A1 (en) 1998-09-15 1998-09-15 Factor VIIa Inhibitors
PCT/EP1999/006449 WO2000015658A1 (en) 1998-09-15 1999-09-02 FACTOR VIIa INHIBITORS

Publications (2)

Publication Number Publication Date
HK1040253A1 HK1040253A1 (en) 2002-05-31
HK1040253B true HK1040253B (zh) 2005-09-02

Family

ID=8232644

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02101586.6A HK1040253B (zh) 1998-09-15 2002-03-01 因子viia抑制劑

Country Status (25)

Country Link
US (1) US6287794B1 (zh)
EP (2) EP0987274A1 (zh)
JP (1) JP4537581B2 (zh)
KR (1) KR100665490B1 (zh)
CN (1) CN1203087C (zh)
AR (1) AR027814A1 (zh)
AT (1) ATE460424T1 (zh)
AU (1) AU760580B2 (zh)
BR (1) BR9913742A (zh)
CA (1) CA2344048A1 (zh)
CZ (1) CZ300249B6 (zh)
DE (1) DE69942123D1 (zh)
HK (1) HK1040253B (zh)
HU (1) HUP0103851A3 (zh)
ID (1) ID28494A (zh)
IL (2) IL141415A0 (zh)
MY (1) MY125150A (zh)
NO (1) NO328523B1 (zh)
NZ (1) NZ510509A (zh)
PL (1) PL203227B1 (zh)
RU (1) RU2223967C2 (zh)
TR (1) TR200100766T2 (zh)
TW (1) TW576839B (zh)
WO (1) WO2000015658A1 (zh)
ZA (1) ZA200101861B (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
ATE307111T1 (de) 1999-01-13 2005-11-15 Genentech Inc Serinprotease-inhibitoren
EP1059302A1 (en) * 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Factor VIIa inhibitors
HUP0203486A2 (hu) * 1999-10-01 2003-02-28 Chugai Seiyaku Kabushiki Kaisha Véralvadással összefüggő betegségek megelőzése és kezelése
EP1095933A1 (en) 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
EP1162194A1 (en) * 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
GB0014134D0 (en) * 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
NZ526003A (en) 2000-10-20 2005-09-30 Biocryst Pharm Inc Biaryl compounds as serine protease inhibitors
NZ526269A (en) 2000-12-06 2004-11-26 Aventis Pharma Gmbh Guanidine and amidine derivatives as factor Xa inhibitors having antithrombotic effect
WO2002062829A1 (fr) * 2001-02-02 2002-08-15 Chugai Seiyaku Kabushiki Kaisha Derives de peptide
EP1270551A1 (en) * 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Urea derivatives with antiproteolytic activity
EP1314733A1 (en) 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
WO2004043991A2 (en) * 2002-11-13 2004-05-27 Haematologic Technologies, Inc. Assay for tissue factor and factor viia
US7358268B2 (en) 2002-12-04 2008-04-15 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives as factor Xa inhibitors
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
EP1479675A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
EP1479677A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
US7223780B2 (en) 2003-05-19 2007-05-29 Sanofi-Aventis Deutschland Gmbh Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
US7317027B2 (en) 2003-05-19 2008-01-08 Sanofi-Aventis Deutschland Gmbh Azaindole-derivatives as factor Xa inhibitors
EP1479680A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Azaindole derivatives as Factor Xa inhibitors
US7741341B2 (en) 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
AU2004249671A1 (en) 2003-05-20 2004-12-29 Genentech, Inc. Benzofuran inhibitors of factor VIIa
CA2525854C (en) 2003-05-20 2009-12-15 Genentech, Inc. Acylsulfamide inhibitors of factor viia
EP1568698A1 (en) 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Pyrrole-derivatives as factor Xa inhibitors
WO2008107362A2 (en) * 2007-03-07 2008-09-12 Novo Nordisk Health Care Ag Stabiliser and inhibitors of factor vii
WO2009007015A1 (en) 2007-07-10 2009-01-15 Sanofi-Aventis Malonamide derivatives with antithrombotic activity
JP2011510043A (ja) * 2008-01-23 2011-03-31 ノボ ノルディスク ヘルス ケア アーゲー 新規血液凝固因子インヒビター
EP2670429B1 (en) 2011-02-04 2018-04-04 Octapharma AG Method for inactivation/removal of coagulation factors by precipitation
AU2019337806A1 (en) * 2018-09-11 2021-05-13 Anbition S.R.L. Peptides and medical uses thereof
CN113015539A (zh) * 2018-09-11 2021-06-22 安必圣有限责任公司 肽及其医学用途
WO2021001458A1 (en) 2019-07-01 2021-01-07 Tonix Pharma Holdings Limited Anti-cd154 antibodies and uses thereof
CA3207098A1 (en) 2021-01-06 2022-07-14 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
GB202209228D0 (en) * 2022-06-23 2022-08-10 Univ Strathclyde Modified amino acids and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023236A (en) * 1988-04-07 1991-06-11 Corvas, Inc. Factor VII/VIIA active site inhibitors
EP0391999A4 (en) * 1988-09-23 1991-03-13 Corvas, Inc. Peptidyl inhibitors of the initiation of coagulation
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US5190919A (en) * 1989-11-13 1993-03-02 Board Of Regents, The University Of Texas System Antihemostatic factor vii peptides
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
JPH08511794A (ja) * 1993-06-18 1996-12-10 ハフスルント ニコムド エイ／エス ▲ｖｉｉ▼因子由来ペプチド
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
CA2186497C (en) * 1994-04-26 2008-06-17 Fahad Al-Obeidi Factor xa inhibitors
US5837684A (en) * 1995-06-07 1998-11-17 Nycomed Imaging As Peptides
DE69717268T2 (de) * 1996-02-22 2003-09-04 Bristol-Myers Squibb Pharma Co., Wilmington M-amidinophenyl-analoga als faktor-xa-inhibitoren
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors

Also Published As

Publication number Publication date
ZA200101861B (en) 2001-10-22
CZ2001914A3 (en) 2001-06-13
ATE460424T1 (de) 2010-03-15
EP1114061A1 (en) 2001-07-11
CN1203087C (zh) 2005-05-25
EP0987274A1 (en) 2000-03-22
ID28494A (id) 2001-05-31
CA2344048A1 (en) 2000-03-23
CZ300249B6 (cs) 2009-04-01
WO2000015658A1 (en) 2000-03-23
TR200100766T2 (tr) 2001-10-22
KR20010075130A (ko) 2001-08-09
NO20011293L (no) 2001-05-04
PL346781A1 (en) 2002-02-25
BR9913742A (pt) 2001-06-05
PL203227B1 (pl) 2009-09-30
HUP0103851A3 (en) 2002-05-28
NZ510509A (en) 2002-09-27
JP4537581B2 (ja) 2010-09-01
AU5972399A (en) 2000-04-03
CN1318069A (zh) 2001-10-17
AU760580B2 (en) 2003-05-15
HK1040253A1 (en) 2002-05-31
JP2002524571A (ja) 2002-08-06
RU2223967C2 (ru) 2004-02-20
EP1114061B1 (en) 2010-03-10
NO20011293D0 (no) 2001-03-14
US6287794B1 (en) 2001-09-11
HUP0103851A2 (hu) 2002-04-29
TW576839B (en) 2004-02-21
IL141415A0 (en) 2002-03-10
DE69942123D1 (de) 2010-04-22
KR100665490B1 (ko) 2007-01-10
AR027814A1 (es) 2003-04-16
MY125150A (en) 2006-07-31
IL141415A (en) 2006-09-05
NO328523B1 (no) 2010-03-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100902