NO20011293L - Faktor VIIa-inhibitorer - Google Patents

Faktor VIIa-inhibitorer

Info

Publication number
NO20011293L
NO20011293L NO20011293A NO20011293A NO20011293L NO 20011293 L NO20011293 L NO 20011293L NO 20011293 A NO20011293 A NO 20011293A NO 20011293 A NO20011293 A NO 20011293A NO 20011293 L NO20011293 L NO 20011293L
Authority
NO
Norway
Prior art keywords
factor viia
viia inhibitors
inhibitors
factor
viia
Prior art date
Application number
NO20011293A
Other languages
English (en)
Other versions
NO328523B1 (no
NO20011293D0 (no
Inventor
Pavel Safar
Alena Safarova
Peter Wildgoose
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20011293D0 publication Critical patent/NO20011293D0/no
Publication of NO20011293L publication Critical patent/NO20011293L/no
Publication of NO328523B1 publication Critical patent/NO328523B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20011293A 1998-09-15 2001-03-14 Faktor VIIa-inhibitorer, fremgangsmate for fremstilling av slike og farmasoytisk preparat omfattende slike, samt anvendelse av inhibitorene for fremstilling av farmasoytisk preparat. NO328523B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98117506A EP0987274A1 (en) 1998-09-15 1998-09-15 Factor VIIa Inhibitors
PCT/EP1999/006449 WO2000015658A1 (en) 1998-09-15 1999-09-02 FACTOR VIIa INHIBITORS

Publications (3)

Publication Number Publication Date
NO20011293D0 NO20011293D0 (no) 2001-03-14
NO20011293L true NO20011293L (no) 2001-05-04
NO328523B1 NO328523B1 (no) 2010-03-08

Family

ID=8232644

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20011293A NO328523B1 (no) 1998-09-15 2001-03-14 Faktor VIIa-inhibitorer, fremgangsmate for fremstilling av slike og farmasoytisk preparat omfattende slike, samt anvendelse av inhibitorene for fremstilling av farmasoytisk preparat.

Country Status (25)

Country Link
US (1) US6287794B1 (no)
EP (2) EP0987274A1 (no)
JP (1) JP4537581B2 (no)
KR (1) KR100665490B1 (no)
CN (1) CN1203087C (no)
AR (1) AR027814A1 (no)
AT (1) ATE460424T1 (no)
AU (1) AU760580B2 (no)
BR (1) BR9913742A (no)
CA (1) CA2344048A1 (no)
CZ (1) CZ300249B6 (no)
DE (1) DE69942123D1 (no)
HK (1) HK1040253B (no)
HU (1) HUP0103851A3 (no)
ID (1) ID28494A (no)
IL (2) IL141415A0 (no)
MY (1) MY125150A (no)
NO (1) NO328523B1 (no)
NZ (1) NZ510509A (no)
PL (1) PL203227B1 (no)
RU (1) RU2223967C2 (no)
TR (1) TR200100766T2 (no)
TW (1) TW576839B (no)
WO (1) WO2000015658A1 (no)
ZA (1) ZA200101861B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors
BR0008755A (pt) 1999-01-13 2007-05-29 Genentech Inc compostos inibidores de protease de serina, composição, método de inibição da atividade de tf/fator viia, fator xa, trombina ou calicreìna, método de tratamento de uma disfunção mediada por tf/fator viia, fator xa, trombina ou calicreìna e método de prevenção de trombose ou tratamento de trombose anormal
EP1059302A1 (en) * 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Factor VIIa inhibitors
MXPA02003278A (es) * 1999-10-01 2002-09-02 Chugai Pharmaceutical Co Ltd Prevencion y tratamiento de enfermedades relacionadas con la coagulacion sanguinea.
EP1095933A1 (en) 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
EP1162194A1 (en) * 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
GB0014134D0 (en) * 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
DK1383731T3 (da) 2000-10-20 2009-12-07 Biocryst Pharm Inc Biarylforbindelser som serinproteaseinhibitorer
KR20040015036A (ko) 2000-12-06 2004-02-18 아벤티스 파마 도이칠란트 게엠베하 인자 Ｘａ 억제제로서의 구아니딘 및 아미딘 유도체
JP4179878B2 (ja) * 2001-02-02 2008-11-12 中外製薬株式会社 ペプチド誘導体
EP1270551A1 (en) 2001-06-26 2003-01-02 Aventis Pharma Deutschland GmbH Urea derivatives with antiproteolytic activity
EP1314733A1 (en) 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
WO2004043991A2 (en) * 2002-11-13 2004-05-27 Haematologic Technologies, Inc. Assay for tissue factor and factor viia
US7358268B2 (en) 2002-12-04 2008-04-15 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives as factor Xa inhibitors
US7429581B2 (en) 2002-12-23 2008-09-30 Sanofi-Aventis Deutschland Gmbh Pyrazole-derivatives as factor Xa inhibitors
EP1479675A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Indazole-derivatives as factor Xa inhibitors
US7317027B2 (en) 2003-05-19 2008-01-08 Sanofi-Aventis Deutschland Gmbh Azaindole-derivatives as factor Xa inhibitors
US7223780B2 (en) 2003-05-19 2007-05-29 Sanofi-Aventis Deutschland Gmbh Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
EP1479677A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
US7741341B2 (en) 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
EP1479680A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Azaindole derivatives as Factor Xa inhibitors
US7250447B2 (en) 2003-05-20 2007-07-31 Genentech, Inc. Acylsulfamide inhibitors of factor VIIa
CA2525713A1 (en) 2003-05-20 2004-12-29 Genentech, Inc. Benzofuran inhibitors of factor viia
EP1568698A1 (en) 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Pyrrole-derivatives as factor Xa inhibitors
WO2008107362A2 (en) * 2007-03-07 2008-09-12 Novo Nordisk Health Care Ag Stabiliser and inhibitors of factor vii
BRPI0814627A2 (pt) 2007-07-10 2015-01-27 Sanofi Aventis Derivados de malonamida com atividade antitrombótica
CN101981050A (zh) * 2008-01-23 2011-02-23 诺沃-诺迪斯克保健股份有限公司 新的凝血因子抑制剂
CN103561758B (zh) 2011-02-04 2017-06-16 奥克塔法马股份有限公司 通过沉降灭活/去除凝血因子的方法
AU2019337806A1 (en) * 2018-09-11 2021-05-13 Anbition S.R.L. Peptides and medical uses thereof
AU2019340465A1 (en) * 2018-09-11 2021-05-13 Anbition S.R.L. Peptides and medical uses thereof
JP2022538674A (ja) 2019-07-01 2022-09-05 トニックス ファーマ リミテッド 抗ｃｄ１５４抗体およびその使用
EP4274587A1 (en) 2021-01-06 2023-11-15 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
GB202209228D0 (en) * 2022-06-23 2022-08-10 Univ Strathclyde Modified amino acids and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023236A (en) * 1988-04-07 1991-06-11 Corvas, Inc. Factor VII/VIIA active site inhibitors
EP0391999A4 (en) * 1988-09-23 1991-03-13 Corvas, Inc. Peptidyl inhibitors of the initiation of coagulation
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US5190919A (en) * 1989-11-13 1993-03-02 Board Of Regents, The University Of Texas System Antihemostatic factor vii peptides
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
SK156395A3 (en) * 1993-06-18 1996-06-05 Hafslund Nycomed As Peptid compounds, their manufacturing method and application
ZA953361B (en) * 1994-04-26 1996-01-12 Selectide Corp Factor Xa inhibitors
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
US5837684A (en) * 1995-06-07 1998-11-17 Nycomed Imaging As Peptides
ES2186874T3 (es) * 1996-02-22 2003-05-16 Bristol Myers Squibb Pharma Co Analogos de m-amidinofenilo como inhibidores del factor xa.
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors

Also Published As

Publication number Publication date
AU5972399A (en) 2000-04-03
RU2223967C2 (ru) 2004-02-20
AR027814A1 (es) 2003-04-16
NZ510509A (en) 2002-09-27
KR100665490B1 (ko) 2007-01-10
NO328523B1 (no) 2010-03-08
US6287794B1 (en) 2001-09-11
ZA200101861B (en) 2001-10-22
EP1114061B1 (en) 2010-03-10
AU760580B2 (en) 2003-05-15
ATE460424T1 (de) 2010-03-15
BR9913742A (pt) 2001-06-05
CA2344048A1 (en) 2000-03-23
HUP0103851A3 (en) 2002-05-28
PL346781A1 (en) 2002-02-25
TR200100766T2 (tr) 2001-10-22
HK1040253A1 (en) 2002-05-31
IL141415A0 (en) 2002-03-10
KR20010075130A (ko) 2001-08-09
CN1203087C (zh) 2005-05-25
NO20011293D0 (no) 2001-03-14
PL203227B1 (pl) 2009-09-30
MY125150A (en) 2006-07-31
JP2002524571A (ja) 2002-08-06
CN1318069A (zh) 2001-10-17
DE69942123D1 (de) 2010-04-22
CZ2001914A3 (en) 2001-06-13
CZ300249B6 (cs) 2009-04-01
EP0987274A1 (en) 2000-03-22
EP1114061A1 (en) 2001-07-11
HUP0103851A2 (hu) 2002-04-29
HK1040253B (zh) 2005-09-02
JP4537581B2 (ja) 2010-09-01
WO2000015658A1 (en) 2000-03-23
IL141415A (en) 2006-09-05
ID28494A (id) 2001-05-31
TW576839B (en) 2004-02-21

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