CO4900054A1 - Pirroles sustituidos - Google Patents
Pirroles sustituidosInfo
- Publication number
- CO4900054A1 CO4900054A1 CO97042636A CO97042636A CO4900054A1 CO 4900054 A1 CO4900054 A1 CO 4900054A1 CO 97042636 A CO97042636 A CO 97042636A CO 97042636 A CO97042636 A CO 97042636A CO 4900054 A1 CO4900054 A1 CO 4900054A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- aryl
- hydrogen
- independently
- formula
- Prior art date
Links
- 150000003233 pyrroles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- -1 O 1⁄2CH2 OCR8 Inorganic materials 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2207896P | 1996-07-29 | 1996-07-29 | |
| US4849697P | 1997-06-03 | 1997-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900054A1 true CO4900054A1 (es) | 2000-03-27 |
Family
ID=26695475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97042636A CO4900054A1 (es) | 1996-07-29 | 1997-07-25 | Pirroles sustituidos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6228877B1 (enExample) |
| EP (1) | EP0915870B1 (enExample) |
| JP (1) | JP2000516588A (enExample) |
| KR (1) | KR20000029640A (enExample) |
| CN (1) | CN1077571C (enExample) |
| AR (1) | AR007969A1 (enExample) |
| AT (1) | ATE224889T1 (enExample) |
| AU (1) | AU740011B2 (enExample) |
| BR (1) | BR9711607A (enExample) |
| CA (1) | CA2262089A1 (enExample) |
| CO (1) | CO4900054A1 (enExample) |
| DE (1) | DE69715870T2 (enExample) |
| DK (1) | DK0915870T3 (enExample) |
| ES (1) | ES2183163T3 (enExample) |
| HR (1) | HRP970415A2 (enExample) |
| MA (1) | MA24354A1 (enExample) |
| PE (1) | PE91598A1 (enExample) |
| PT (1) | PT915870E (enExample) |
| TR (1) | TR199900186T2 (enExample) |
| WO (1) | WO1998004551A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2208612C2 (ru) * | 1998-03-17 | 2003-07-20 | Ф.Хоффманн-Ля Рош Аг | Замещенные бисиндолималеимиды, предназначенные для ингибирования пролиферации клеток |
| US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| US6559164B1 (en) | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
| CN1155595C (zh) * | 1999-10-12 | 2004-06-30 | 霍夫曼-拉罗奇有限公司 | 作为用于治疗癌症的抗增殖剂的取代的吡咯类化合物 |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| EP1441772A2 (en) * | 2001-10-29 | 2004-08-04 | Nektar Therapeutics Al, Corporation | Polymer conjugates of protein kinase c inhibitors |
| CA2393720C (en) * | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
| WO2006086484A1 (en) | 2005-02-09 | 2006-08-17 | Arqule, Inc. | Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
| MX2009006533A (es) * | 2006-12-19 | 2009-06-26 | Novartis Ag | Derivados de indolil-maleimida como inhibidores de cinasa. |
| EP2170870B1 (en) * | 2007-06-22 | 2014-03-05 | ArQule, Inc. | Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| WO2009002808A2 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| JP5490688B2 (ja) | 2007-06-22 | 2014-05-14 | アークル インコーポレイテッド | 癌の治療のためのインドリルピロリジン |
| GB201111427D0 (en) * | 2011-07-05 | 2011-08-17 | Amakem Nv | Novel bisindolylmaleimides, pan-pkc inhibitors |
| EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| CN109535158B (zh) * | 2016-04-26 | 2021-04-23 | 浙江工业大学 | 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用 |
| CN107973785B (zh) * | 2017-11-27 | 2019-12-31 | 浙江工业大学上虞研究院有限公司 | 一种用于检测银离子的荧光探针及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| PT93947B (pt) * | 1989-05-05 | 1996-11-29 | Goedecke Ag | Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem |
| US5380746A (en) | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| JPH0539289A (ja) | 1991-02-15 | 1993-02-19 | Masahiro Irie | 無水マレイン酸誘導体およびその製造方法 |
| EP0630241A1 (en) | 1992-03-20 | 1994-12-28 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
| DE4217964A1 (de) | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
-
1997
- 1997-07-15 PE PE1997000629A patent/PE91598A1/es not_active Application Discontinuation
- 1997-07-19 CN CN97196783A patent/CN1077571C/zh not_active Expired - Fee Related
- 1997-07-19 KR KR1019997000711A patent/KR20000029640A/ko not_active Abandoned
- 1997-07-19 ES ES97918934T patent/ES2183163T3/es not_active Expired - Lifetime
- 1997-07-19 DE DE69715870T patent/DE69715870T2/de not_active Expired - Fee Related
- 1997-07-19 AU AU42963/97A patent/AU740011B2/en not_active Ceased
- 1997-07-19 TR TR1999/00186T patent/TR199900186T2/xx unknown
- 1997-07-19 CA CA002262089A patent/CA2262089A1/en not_active Abandoned
- 1997-07-19 PT PT97918934T patent/PT915870E/pt unknown
- 1997-07-19 JP JP10508452A patent/JP2000516588A/ja not_active Ceased
- 1997-07-19 WO PCT/EP1997/003888 patent/WO1998004551A1/en not_active Ceased
- 1997-07-19 BR BR9711607A patent/BR9711607A/pt not_active IP Right Cessation
- 1997-07-19 EP EP97918934A patent/EP0915870B1/en not_active Expired - Lifetime
- 1997-07-19 DK DK97918934T patent/DK0915870T3/da active
- 1997-07-19 AT AT97918934T patent/ATE224889T1/de not_active IP Right Cessation
- 1997-07-22 AR ARP970103308A patent/AR007969A1/es unknown
- 1997-07-25 CO CO97042636A patent/CO4900054A1/es unknown
- 1997-07-25 HR HR60/048,496A patent/HRP970415A2/hr not_active Application Discontinuation
- 1997-07-29 MA MA24743A patent/MA24354A1/fr unknown
-
1998
- 1998-12-22 US US09/218,404 patent/US6228877B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2262089A1 (en) | 1998-02-05 |
| TR199900186T2 (xx) | 1999-03-22 |
| MA24354A1 (fr) | 1998-07-01 |
| EP0915870A1 (en) | 1999-05-19 |
| WO1998004551A1 (en) | 1998-02-05 |
| PE91598A1 (es) | 1998-12-24 |
| CN1077571C (zh) | 2002-01-09 |
| DK0915870T3 (da) | 2003-02-03 |
| HRP970415A2 (en) | 1998-08-31 |
| US6228877B1 (en) | 2001-05-08 |
| JP2000516588A (ja) | 2000-12-12 |
| KR20000029640A (ko) | 2000-05-25 |
| ATE224889T1 (de) | 2002-10-15 |
| BR9711607A (pt) | 1999-08-24 |
| ES2183163T3 (es) | 2003-03-16 |
| AU740011B2 (en) | 2001-10-25 |
| AR007969A1 (es) | 1999-11-24 |
| PT915870E (pt) | 2003-01-31 |
| DE69715870D1 (de) | 2002-10-31 |
| DE69715870T2 (de) | 2003-06-18 |
| AU4296397A (en) | 1998-02-20 |
| CN1226248A (zh) | 1999-08-18 |
| EP0915870B1 (en) | 2002-09-25 |
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