CO4480103A1 - Compuestos heterociclicos su preparacion y uso - Google Patents
Compuestos heterociclicos su preparacion y usoInfo
- Publication number
- CO4480103A1 CO4480103A1 CO95049689A CO95049689A CO4480103A1 CO 4480103 A1 CO4480103 A1 CO 4480103A1 CO 95049689 A CO95049689 A CO 95049689A CO 95049689 A CO95049689 A CO 95049689A CO 4480103 A1 CO4480103 A1 CO 4480103A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- halogen
- alkyl
- independently selected
- alkynil
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
REIVINDICACION NUMERO UN COMPUESTO DE FORMULA I O UNA FORMA CUATERNIZADA DE EL SELECCIONADA DE LOS SIGUIENTES COMPUESTOS QUE TIENE LA FORMULA: FIGURA 1 EN DONDE W ES OXIGENO O AZUFRE; R4 SE SELECCIONA DEL GRUPO CONFORMADO POR HIDROGE- NO, AMINO, HALOGENO NHR6, NR6R7, R4, -OR4, -SR4, -SOR4, -SO2R4, CICLOALQUILO C3-10, CICLOALQUILAL- QUILO C4-12, CICLOALQUIL-Z-C3-10 Y CICLOALQUIAL- QUILO-Z-C4-12; R4 SE SELECCIONA DEL GRUPO CONFORMADO POR ALQUILO C1-15, ALQUENILO C2-15, ALQUINILO C2-15, CADA UNO DE LOS CUALES ESTA OPCIONALMENTE SUSTITUIDO CON UNO O MAS INDEPENDIENTEMENTE SELECCIONADO DEL GRU- PO CONFORMADO POR HALOGENO, -CN, Y, FENIL O FENOXI EN DONE EL FENILO O FENOXI ESTA OPCIONALMENTE SUS- TITUIDO CON UNO O MAS INDEPENDIENTEMENTE SELECCIO- NADO DEL GRUPO CONFORMADO POR HALOGENO, -CN, AL- QUIL C1-4, ALCOXI C1-4, -OCF3, -CF3, -CONH2 o -CSNH2; o R ES FENIL O BENCILOXICARBONILO, CADA UNO DE LOS CUALES ESTA OPCIONALMENTE SUSTITUIDO CON UNO O MAS INDEPENDIENTEMENTE SELECCIONADO DEL GRUPO CONFOR- MADO POR HALOGENO, -CN, ALQUIL C1-4, ALCOXI C1-4, OCF3, -CF3, -CONH2 o -CSNH2; o R SE SELECCIONA DEL GRUPO CONFORMADO POR OR5Y, -SR5Y, OR5-Z-Y, -SR5ZY, -O-R5-Z-R4 y -S-R5-Z-R4; Z ES OXIGENO O AZUFRE; HOJA 2 DEL RESUMEN****** R5 ES ALQUILO C1-15, ALQUENILO C2-15, ALQUINILO C2-15; Y ES UN GRUPO HETEROCICLICO DE 5 O 6 MIEMBROS; G SE SELECCIONA ENTRE UNO DE LOS SIGUIENTES SISTE- MAS DE ANILLOS AZACICLICO O AZABICICLICO; FIGURA 2 O G ESTA OPCIONALMENTE SUSTITUIDO POR CICLOALQUILO C3-C8 EN DONDE LOS SUSTITUYENTES CICLOALQUILO SE SELECCIONAN ENTRE R1 Y R2; U OPCIONALMENTE CON ALQUILO C1-6 EN DONDE LA SUSTITUCION ES -NR6R7; R6 Y R7 SON INDEPENDIENTEMENTE SELECCIONADOS DEL GRUPO CONFORMADO POR HIDROGENO, ALQUILO (C1-C15), ALQUENILO (C2-C5), ALQUINILO (C2-C5), ALCOXI C1-10 Y ALQUILO (C1-C5) SUSTITUIDO CON UNO O MAS INDE- PENDIENTEMENTE SELECCIONADOS DEL GRUPO CONFORMADO POR -OH, -COR6´, -CH2-OH, HALOGENO, -NH2, CARBOXI Y FENILO; R6´ ES HIDROGENO O ALQUILO C1-C6;....
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32776694A | 1994-10-24 | 1994-10-24 | |
US44367395A | 1995-06-01 | 1995-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4480103A1 true CO4480103A1 (es) | 1997-07-09 |
Family
ID=26986055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO95049689A CO4480103A1 (es) | 1994-10-24 | 1995-10-23 | Compuestos heterociclicos su preparacion y uso |
Country Status (21)
Country | Link |
---|---|
US (6) | US5821370A (es) |
EP (1) | EP0709381A1 (es) |
JP (1) | JPH08225575A (es) |
KR (1) | KR960014125A (es) |
CN (1) | CN1048986C (es) |
AU (1) | AU705047B2 (es) |
BR (1) | BR9504509A (es) |
CA (1) | CA2161176A1 (es) |
CO (1) | CO4480103A1 (es) |
CZ (1) | CZ275995A3 (es) |
FI (1) | FI955051A (es) |
HU (1) | HUT76347A (es) |
IL (1) | IL115717A0 (es) |
NO (1) | NO306949B1 (es) |
NZ (1) | NZ280300A (es) |
PE (1) | PE12697A1 (es) |
PL (1) | PL311077A1 (es) |
RU (1) | RU2158262C2 (es) |
TR (1) | TR199501305A2 (es) |
TW (1) | TW420680B (es) |
YU (1) | YU66895A (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
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US5998404A (en) * | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
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US5767280A (en) * | 1995-06-01 | 1998-06-16 | Eli Lilly And Company | Process for making heterocyclic compounds |
US5852037A (en) * | 1995-11-13 | 1998-12-22 | Eli Lilly And Company | Method for treating anxiety |
US5998434A (en) * | 1995-12-06 | 1999-12-07 | Eli Lilly And Company | Composition for treating pain |
AU2152497A (en) * | 1996-03-19 | 1997-10-10 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
WO1997040016A1 (en) * | 1996-04-23 | 1997-10-30 | Eli Lilly And Company | Heterocyclic compounds |
JP2000509043A (ja) * | 1996-04-23 | 2000-07-18 | イーライ・リリー・アンド・カンパニー | ヘテロサイクリック化合物群 |
AU3203297A (en) | 1996-04-23 | 1997-11-12 | Eli Lilly And Company | Heterocyclic compounds |
ES2180998T3 (es) * | 1996-04-23 | 2003-02-16 | Lilly Co Eli | Compuestos heterociclicos. |
CA2251974A1 (en) * | 1996-04-23 | 1997-10-30 | Lone Jeppesen | Heterocyclic compounds |
US6069159A (en) * | 1996-05-10 | 2000-05-30 | Eli Lilly And Company | Heterocyclic compounds |
DE69710526T2 (de) * | 1996-08-01 | 2002-10-02 | Eli Lilly And Co., Indianapolis | Verwendung von 3-(4-Hexyloxy-1,2,5-Thiadiazol-3-yl)-1,2,5,6-Tetrahydro-1-Methylpyridin (Xanomelin) zur Behandlung von bipolaren Störungen |
AU7871498A (en) * | 1996-12-20 | 1998-07-17 | Novo Nordisk A/S | A method of treating hypercholesterolemia and related disorders |
US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
US6620940B1 (en) | 1998-08-20 | 2003-09-16 | Eli Lilly And Company | Palladium-catalyzed cross-coupling chemistry on 3-chloro-4-halo-1,2,5-thiadiazole |
EP1189902B1 (en) * | 1999-06-04 | 2003-08-27 | Eli Lilly And Company | 7-oxo-2-azabicyclo[2.2.1]heptanes as selective muscarinic receptor antagonist |
US6392329B1 (en) * | 1999-10-12 | 2002-05-21 | Face International Corp. | Piezoelectric vibrating apparatus |
WO2004016608A1 (en) * | 2002-08-14 | 2004-02-26 | Neurosearch A/S | Novel quinuclidine derivatives and their use |
EA008767B1 (ru) * | 2002-10-08 | 2007-08-31 | Зе Скрипс Ресеч Инститьют | Ингибиторы гидролазы амидов жирных кислот |
US20070021404A1 (en) * | 2003-06-24 | 2007-01-25 | Dan Peters | Novel aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP1656375B1 (en) * | 2003-08-13 | 2011-01-19 | NeuroSearch A/S | Novel quinuclidine derivatives and their pharmaceutical use |
US7309699B2 (en) | 2003-12-22 | 2007-12-18 | Abbott Laboratories | 3-Quinuclidinyl amino-substituted biaryl derivatives |
US20050137203A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-quinuclidinyl amino-substituted biaryl derivatives |
US20050137398A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-Quinuclidinyl heteroatom bridged biaryl derivatives |
US7241773B2 (en) | 2003-12-22 | 2007-07-10 | Abbott Laboratories | 3-quinuclidinyl heteroatom bridged biaryl derivatives |
US7674899B2 (en) | 2004-02-04 | 2010-03-09 | Neurosearch A/S | Dimeric azacyclic compounds and their use |
EP1831220A2 (en) * | 2004-12-20 | 2007-09-12 | Eli Lilly & Company | Processes for the preparation of 3,4-substituted-1,2,5-thiadiazoles and intermediates thereof |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
JP2009506069A (ja) * | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス,インコーポレイティド | 4−アシルアミノピリジン誘導体を含む組み合わせ |
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US7849599B2 (en) * | 2006-09-28 | 2010-12-14 | Hydril Usa Manufacturing Llc | Imputing strength gradient in pressure vessels |
US20080078081A1 (en) * | 2006-09-28 | 2008-04-03 | Huff Philip A | High pressure-rated ram blowout preventer and method of manufacture |
US20080105340A1 (en) * | 2006-11-02 | 2008-05-08 | Huff Philip A | Heat Treatment Method of Inlaid Pressure Vessels |
US7721401B2 (en) * | 2006-09-28 | 2010-05-25 | Hydril Usa Manufacturing Llc | Reinforcement of irregular pressure vessels |
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
AU2008326360A1 (en) * | 2007-11-21 | 2009-05-28 | Abbott Laboratories | Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators |
US9464078B2 (en) | 2010-09-23 | 2016-10-11 | Abbvie Inc. | Monohydrate of azaadamantane derivatives |
CA2857969A1 (en) * | 2012-01-25 | 2013-08-01 | Demerx, Inc. | (1r,4r) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof |
CA2991099A1 (en) | 2015-07-02 | 2017-01-05 | Horizon Orphan Llc | Ado-resistant cysteamine analogs and uses thereof |
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CA2042336A1 (en) * | 1990-05-11 | 1991-11-12 | Mitsuo Nagano | Piperidyloxy-and quinuclidinyloxy-isoxazole, derivatives, their preparation and their therapeutic use |
US5418240A (en) * | 1990-08-21 | 1995-05-23 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
DK198590D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
US5376668A (en) * | 1990-08-21 | 1994-12-27 | Novo Nordisk A/S | Heterocyclic compounds |
DK198390D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
DK198490D0 (da) * | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
JPH04182403A (ja) * | 1990-11-16 | 1992-06-30 | Tosoh Corp | チアジアゾール誘導体を有効成分として含有する殺菌剤 |
US5051420A (en) * | 1991-03-04 | 1991-09-24 | A. H. Robins Company, Incorporated | 4-substituted-3-1H-imidazol-1-,2,5-thiadiazoles as antiarrhythmic agents |
GB2258652A (en) * | 1991-08-15 | 1993-02-17 | Merck Sharp & Dohme | Pharmaceutically useful azabicyclic oxime ethers |
EP0591486A1 (de) * | 1992-04-22 | 1994-04-13 | PEUSCHEL, Karin, Elisabeth | Immunaktivierende und damit antivirale wirking von 4- 3-(subst.-amino)-2-hydroxypropoxy]-1,2,5-thiadiazolverbindungen |
DK154092D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
AU6010594A (en) * | 1993-02-12 | 1994-08-29 | Sankyo Company Limited | Isoxazoleoxy derivative |
DE69406836T2 (de) * | 1993-04-21 | 1998-06-25 | Tosoh Corp | Teilweise als Fungizide verwendbare 3,4-Dioxy-1,2,5-thiadiazole |
DK60493D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
CZ285030B6 (cs) * | 1993-08-19 | 1999-05-12 | Novo Nordisk A/S | Použití thiadiazolových a oxadiazolových sloučenin pro výrobu farmaceutického prostředku a farmacetický prostředek pro léčení schizofrenie nebo schizofrenních nemocí |
ES2160127T3 (es) * | 1993-08-19 | 2001-11-01 | Novo Nordisk As | Metodo antipsicotico con derivados de tiadiazol y oxadiazol. |
-
1995
- 1995-06-06 US US08/470,787 patent/US5821370A/en not_active Expired - Fee Related
- 1995-06-06 US US08/470,789 patent/US5672709A/en not_active Expired - Fee Related
- 1995-06-06 US US08/470,788 patent/US5821371A/en not_active Expired - Fee Related
- 1995-06-06 US US08/470,790 patent/US5929247A/en not_active Expired - Fee Related
- 1995-06-06 US US08/470,791 patent/US5665745A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,481 patent/US5646289A/en not_active Expired - Fee Related
- 1995-10-20 HU HU9503045A patent/HUT76347A/hu unknown
- 1995-10-20 NZ NZ280300A patent/NZ280300A/en unknown
- 1995-10-23 RU RU95118133/04A patent/RU2158262C2/ru active
- 1995-10-23 EP EP95307513A patent/EP0709381A1/en not_active Withdrawn
- 1995-10-23 IL IL11571795A patent/IL115717A0/xx unknown
- 1995-10-23 CZ CZ952759A patent/CZ275995A3/cs unknown
- 1995-10-23 JP JP7274104A patent/JPH08225575A/ja not_active Withdrawn
- 1995-10-23 PL PL95311077A patent/PL311077A1/xx unknown
- 1995-10-23 CA CA002161176A patent/CA2161176A1/en not_active Abandoned
- 1995-10-23 AU AU34396/95A patent/AU705047B2/en not_active Ceased
- 1995-10-23 BR BR9504509A patent/BR9504509A/pt not_active Application Discontinuation
- 1995-10-23 NO NO954239A patent/NO306949B1/no not_active IP Right Cessation
- 1995-10-23 PE PE1995282695A patent/PE12697A1/es not_active Application Discontinuation
- 1995-10-23 CO CO95049689A patent/CO4480103A1/es unknown
- 1995-10-23 FI FI955051A patent/FI955051A/fi unknown
- 1995-10-23 YU YU66895A patent/YU66895A/sh unknown
- 1995-10-23 CN CN95120382A patent/CN1048986C/zh not_active Expired - Fee Related
- 1995-10-23 KR KR1019950036595A patent/KR960014125A/ko active IP Right Grant
- 1995-10-24 TR TR95/01305A patent/TR199501305A2/xx unknown
- 1995-10-27 TW TW084111356A patent/TW420680B/zh active
Also Published As
Publication number | Publication date |
---|---|
PE12697A1 (es) | 1997-04-24 |
CZ275995A3 (en) | 1996-08-14 |
RU2158262C2 (ru) | 2000-10-27 |
NO954239L (no) | 1996-04-25 |
IL115717A0 (en) | 1996-01-19 |
CN1145364A (zh) | 1997-03-19 |
FI955051A (fi) | 1996-04-25 |
EP0709381A1 (en) | 1996-05-01 |
AU3439695A (en) | 1996-05-02 |
BR9504509A (pt) | 1997-05-27 |
PL311077A1 (en) | 1996-04-29 |
TW420680B (en) | 2001-02-01 |
AU705047B2 (en) | 1999-05-13 |
NO954239D0 (no) | 1995-10-23 |
US5672709A (en) | 1997-09-30 |
US5665745A (en) | 1997-09-09 |
US5821371A (en) | 1998-10-13 |
CA2161176A1 (en) | 1996-04-25 |
JPH08225575A (ja) | 1996-09-03 |
HUT76347A (en) | 1997-08-28 |
US5646289A (en) | 1997-07-08 |
CN1048986C (zh) | 2000-02-02 |
HU9503045D0 (en) | 1995-12-28 |
TR199501305A2 (tr) | 1996-06-21 |
NO306949B1 (no) | 2000-01-17 |
US5929247A (en) | 1999-07-27 |
KR960014125A (ko) | 1996-05-22 |
FI955051A0 (fi) | 1995-10-23 |
US5821370A (en) | 1998-10-13 |
YU66895A (sh) | 1998-09-18 |
NZ280300A (en) | 1997-11-24 |
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