AR057898A1 - Derivados de 3- acilindol, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de 3- acilindol, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR057898A1 AR057898A1 ARP060105044A ARP060105044A AR057898A1 AR 057898 A1 AR057898 A1 AR 057898A1 AR P060105044 A ARP060105044 A AR P060105044A AR P060105044 A ARP060105044 A AR P060105044A AR 057898 A1 AR057898 A1 AR 057898A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- unsubstituted
- several times
- group
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Proceso de preparacion y aplicacion en terapéutica. Reivindicacion 1: Compuesto que responde a la formula (1), en la que: X representa un átomo de oxígeno o un grupo =N-O-R6; R1 representa un grupo elegido entre -N(R7)SO2R8, -N(R7)SO2NR9R10, - SR8, -SOR8, -SO2R8, -SO2NR9R10; R2 representa un átomo de hidrogeno o un alquilo C1-4; R3 representa: un alquilo C1-6 no sustituido o sustituido con: a) uno o varios átomos de halogeno; b) un carbociclo no aromático de C3-12, saturado o insaturado, no sustituido o sustituido una o varias veces con un alquilo C1-4; c) un fenilo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halogeno, un grupo Alk, un grupo OAlk, un grupo -S(O)nAlk, un nitro, un ciano; d) un naftilo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halogeno, un alquilo C1-4, un alcoxi C1-4, un radical trifluorometilo; un carbociclo no aromático en C3-12 saturado o insaturado, sustituido con un fenilo, el mismo no sustituido o sustituido una o varias veces con sustituyentes elegidos independientemente entre un átomo de halogeno, un alquilo C1-4, un alcoxi C1-4, un radical trifluorometilo; un bencidrilmetilo; R4 y R5 representan cada uno independientemente un átomo de hidrogeno, un átomo de halogeno, un alquilo C1-4, un alcoxi C1-4, un radical trifluorometilo, un nitro; R6 representa un átomo de hidrogeno o un alquilo C1-4; R7 representa un átomo de hidrogeno o un alquilo C1-4; R8 representa un alquilo C1-4o un radical trifluorometilo; R9 y R10 representan cada uno independientemente un átomo de hidrogeno o un alquilo C1-4; n representa 0, 1 o 2; Alk representa un alquilo C1-4 no sustituido o sustituido una o varias veces con un átomo de fluor; así como sus hidratos o sus solvatos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0511740A FR2893615B1 (fr) | 2005-11-18 | 2005-11-18 | Derives de 3-acylindole, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057898A1 true AR057898A1 (es) | 2007-12-26 |
Family
ID=36619225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105044A AR057898A1 (es) | 2005-11-18 | 2006-11-17 | Derivados de 3- acilindol, su preparacion y su aplicacion en terapeutica |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7741363B2 (es) |
| EP (1) | EP1951225B1 (es) |
| JP (1) | JP5106410B2 (es) |
| AR (1) | AR057898A1 (es) |
| AT (1) | ATE543496T1 (es) |
| FR (1) | FR2893615B1 (es) |
| TW (1) | TW200738628A (es) |
| UY (1) | UY29921A1 (es) |
| WO (1) | WO2007057571A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2950055A1 (fr) | 2009-09-17 | 2011-03-18 | Sanofi Aventis | Derives de 3-amino-cinnolin-4(1h)-one substitues, leur preparation et leur application en therapeutique |
| FR2983859B1 (fr) | 2011-12-12 | 2014-01-17 | Sanofi Sa | Derives de 1,3,5-triazine-2-amine, leur preparation et leur application en diagnostique et en therapeutique |
| WO2022114105A1 (ja) * | 2020-11-27 | 2022-06-02 | ミライラボバイオサイエンス株式会社 | 高純度βニコチンアミドモノヌクレオチド（ＮＭＮ）及びその製造方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4581354A (en) | 1984-08-06 | 1986-04-08 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use |
| CA2036307C (en) * | 1990-03-08 | 2002-07-09 | Susan Jean Ward | 3-arylcarbonyl-1-aminoalkyl-1h-indole-containing antiglaucoma compositions and method |
| GB9115951D0 (en) * | 1991-07-24 | 1991-09-11 | Pfizer Ltd | Indoles |
| US5532237A (en) * | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| FR2735774B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
| FR2816938B1 (fr) * | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
| WO2002060447A1 (en) * | 2001-01-29 | 2002-08-08 | University Of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
| FR2839718B1 (fr) * | 2002-05-17 | 2004-06-25 | Sanofi Synthelabo | Derives d'indole, leur procede de preparation et les compositions pharmaceutiques en contenant |
| FR2847899B1 (fr) * | 2002-11-29 | 2006-04-28 | Sanofi Synthelabo | Derives d'indole-3-carboxamide, leur preparation et leur application en therapeutique |
| CN1886133B (zh) * | 2003-12-04 | 2010-12-01 | 财团法人卫生研究院 | 吲哚化合物 |
| TW200522944A (en) * | 2003-12-23 | 2005-07-16 | Lilly Co Eli | CB1 modulator compounds |
| JP4922946B2 (ja) * | 2004-12-21 | 2012-04-25 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしての３−シクロアルキルカルボニルインドール類 |
-
2005
- 2005-11-18 FR FR0511740A patent/FR2893615B1/fr not_active Expired - Fee Related
-
2006
- 2006-11-17 EP EP06841810A patent/EP1951225B1/fr active Active
- 2006-11-17 WO PCT/FR2006/002535 patent/WO2007057571A2/fr active Application Filing
- 2006-11-17 UY UY29921A patent/UY29921A1/es unknown
- 2006-11-17 JP JP2008540656A patent/JP5106410B2/ja not_active Expired - Fee Related
- 2006-11-17 AT AT06841810T patent/ATE543496T1/de active
- 2006-11-17 AR ARP060105044A patent/AR057898A1/es not_active Application Discontinuation
- 2006-11-17 TW TW095142655A patent/TW200738628A/zh unknown
-
2008
- 2008-05-14 US US12/120,509 patent/US7741363B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE543496T1 (de) | 2012-02-15 |
| UY29921A1 (es) | 2007-06-29 |
| TW200738628A (en) | 2007-10-16 |
| FR2893615B1 (fr) | 2008-03-07 |
| JP5106410B2 (ja) | 2012-12-26 |
| WO2007057571A2 (fr) | 2007-05-24 |
| EP1951225A2 (fr) | 2008-08-06 |
| JP2009515935A (ja) | 2009-04-16 |
| FR2893615A1 (fr) | 2007-05-25 |
| EP1951225B1 (fr) | 2012-02-01 |
| US7741363B2 (en) | 2010-06-22 |
| WO2007057571A3 (fr) | 2007-07-12 |
| US20080275102A1 (en) | 2008-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |