CO2022013885A2 - Anticuerpo biespecífico - Google Patents

Anticuerpo biespecífico

Info

Publication number
CO2022013885A2
CO2022013885A2 CONC2022/0013885A CO2022013885A CO2022013885A2 CO 2022013885 A2 CO2022013885 A2 CO 2022013885A2 CO 2022013885 A CO2022013885 A CO 2022013885A CO 2022013885 A2 CO2022013885 A2 CO 2022013885A2
Authority
CO
Colombia
Prior art keywords
amino acid
acid sequence
seq
sequence represented
light chain
Prior art date
Application number
CONC2022/0013885A
Other languages
English (en)
Inventor
Hiroshi Shiku
Yasushi Akahori
Kento Tanaka
Ayaka YATSU
Junya Ichikawa
Toshiaki Ohtsuka
Shiho Kozuma
Ryuji Hashimoto
Makiko Nakayama
Naoya Shinozaki
Kensuke Nakamura
Ichiro Watanabe
Shinji Furuzono
Original Assignee
Daiichi Sankyo Co Ltd
Univ Mie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd, Univ Mie filed Critical Daiichi Sankyo Co Ltd
Publication of CO2022013885A2 publication Critical patent/CO2022013885A2/es

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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se proporcionan un nuevo anticuerpo que puede usarse como agente antitumoral y un agente antitumoral que comprende una molécula que contiene el anticuerpo, etc, como ingrediente activo. Un anticuerpo que contiene CDRH1 de cadena pesada que comprende la secuencia de aminoácidos representada por SEC ID NO: 54, CDRH2 de cadena pesada que comprende la secuencia de aminoácidos representada por SEC ID NO: 55, CDRH3 de cadena pesada que comprende la secuencia de aminoácidos representada por SEC ID NO: 56, CDRL1 de cadena ligera que comprende la secuencia de aminoácidos representada por SEC ID NO: 57 o CDRL1 de cadena ligera que comprende una secuencia de aminoácidos que es idéntica a la secuencia de aminoácidos representada por SEC ID NO: 57 excepto que el séptimo aminoácido es W y/o el octavo aminoácido es K, CDRL2 de cadena ligera que comprende la secuencia de aminoácidos representada por SEC ID NO: 58, y CDRL3 de cadena ligera que comprende la secuencia de aminoácidos representada por SEC ID NO: 59 o CDRL3 de cadena ligera que comprende una secuencia de aminoácidos que es idéntica a la secuencia de aminoácidos representada por SEC ID NO: 57 excepto que el segundo aminoácido es A o S; o un fragmento de unión del anticuerpo.
CONC2022/0013885A 2020-03-30 2022-09-28 Anticuerpo biespecífico CO2022013885A2 (es)

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