BR112022016695A2 - Anticorpo biespecífico ou fragmento de ligação do mesmo, polinucleotídeo, vetor, composição farmacêutica, molécula que se liga especificamente ao hla/ny-eso humano, seus usos, e métodos de produção de um anticorpo ou de uma molécula - Google Patents

Anticorpo biespecífico ou fragmento de ligação do mesmo, polinucleotídeo, vetor, composição farmacêutica, molécula que se liga especificamente ao hla/ny-eso humano, seus usos, e métodos de produção de um anticorpo ou de uma molécula

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Publication number
BR112022016695A2
BR112022016695A2 BR112022016695A BR112022016695A BR112022016695A2 BR 112022016695 A2 BR112022016695 A2 BR 112022016695A2 BR 112022016695 A BR112022016695 A BR 112022016695A BR 112022016695 A BR112022016695 A BR 112022016695A BR 112022016695 A2 BR112022016695 A2 BR 112022016695A2
Authority
BR
Brazil
Prior art keywords
amino acid
antibody
molecule
acid sequence
seq
Prior art date
Application number
BR112022016695A
Other languages
English (en)
Inventor
Shiku Hiroshi
Akahori Yasushi
TANAKA Kento
Yatsu Ayaka
Ichikawa Junya
Ohtsuka Toshiaki
Kozuma Shiho
Hashimoto Ryuji
Nakayama Makiko
Shinozaki Naoya
Nakamura Kensuke
Watanabe Ichiro
Furuzono Shinji
Original Assignee
Univ Mie
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mie, Daiichi Sankyo Co Ltd filed Critical Univ Mie
Publication of BR112022016695A2 publication Critical patent/BR112022016695A2/pt

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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ANTICORPO BIESPECÍFICO OU FRAGMENTO DE LIGAÇÃO DO MESMO, POLINUCLEOTÍDEO, VETOR, COMPOSIÇÃO FARMACÊUTICA, MOLÉCULA QUE SE LIGA ESPECIFICAMENTE AO HLA/NY-ESO HUMANO, SEUS USOS, E MÉTODOS DE PRODUÇÃO DE UM ANTICORPO OU DE UMA MOLÉCULA. A presente invenção refere-se a um anticorpo que pode ser usado como um agente antitumoral e um agente antitumoral que compreende uma molécula contendo o anticorpo, etc. como um ingrediente ativo. Um anticorpo que contém a CDRH1 de cadeia pesada que compreende a sequência de aminoácidos representada por SEQ ID NO: 54, CDRH2 de cadeia pesada que compreende a sequência de aminoácidos representada por SEQ ID NO: 55, uma CDRH3 de cadeia pesada que compreende a sequência de aminoácidos representada por SEQ ID NO: 56, CDRL1 de cadeia leve que compreende a sequência de aminoácidos representada por SEQ ID NO: 57 ou CDRL1 de cadeia leve que compreende uma sequência de aminoácidos que é idêntica à sequência de aminoácido representada por SEQ ID NO: 57 exceto que o sétimo o aminoácido é W e/ou o oitavo aminoácido é K, CDRL2 de cadeia leve que compreende a sequência de aminoácidos representada por SEQ ID NO: 58, e a CDRL3 de cadeia leve que compreende a sequência de aminoácidos representada por SEQ ID NO: 59 ou CDRL3 de cadeia leve que compreende uma sequência de aminoácidos que é idêntica à sequência de aminoácidos representada por SEQ ID NO: 57 exceto que o segundo aminoácido é A ou S; ou um fragmento de ligação do anticorpo.
BR112022016695A 2020-03-30 2021-03-29 Anticorpo biespecífico ou fragmento de ligação do mesmo, polinucleotídeo, vetor, composição farmacêutica, molécula que se liga especificamente ao hla/ny-eso humano, seus usos, e métodos de produção de um anticorpo ou de uma molécula BR112022016695A2 (pt)

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