BR112022016695A2 - Anticorpo biespecífico ou fragmento de ligação do mesmo, polinucleotídeo, vetor, composição farmacêutica, molécula que se liga especificamente ao hla/ny-eso humano, seus usos, e métodos de produção de um anticorpo ou de uma molécula - Google Patents

Anticorpo biespecífico ou fragmento de ligação do mesmo, polinucleotídeo, vetor, composição farmacêutica, molécula que se liga especificamente ao hla/ny-eso humano, seus usos, e métodos de produção de um anticorpo ou de uma molécula

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Publication number
BR112022016695A2
BR112022016695A2 BR112022016695A BR112022016695A BR112022016695A2 BR 112022016695 A2 BR112022016695 A2 BR 112022016695A2 BR 112022016695 A BR112022016695 A BR 112022016695A BR 112022016695 A BR112022016695 A BR 112022016695A BR 112022016695 A2 BR112022016695 A2 BR 112022016695A2
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BR
Brazil
Prior art keywords
amino acid
antibody
molecule
acid sequence
seq
Prior art date
Application number
BR112022016695A
Other languages
English (en)
Inventor
Shiku Hiroshi
Akahori Yasushi
TANAKA Kento
Yatsu Ayaka
Ichikawa Junya
Ohtsuka Toshiaki
Kozuma Shiho
Hashimoto Ryuji
Nakayama Makiko
Shinozaki Naoya
Nakamura Kensuke
Watanabe Ichiro
Furuzono Shinji
Original Assignee
Univ Mie
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mie, Daiichi Sankyo Co Ltd filed Critical Univ Mie
Publication of BR112022016695A2 publication Critical patent/BR112022016695A2/pt

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ANTICORPO BIESPECÍFICO OU FRAGMENTO DE LIGAÇÃO DO MESMO, POLINUCLEOTÍDEO, VETOR, COMPOSIÇÃO FARMACÊUTICA, MOLÉCULA QUE SE LIGA ESPECIFICAMENTE AO HLA/NY-ESO HUMANO, SEUS USOS, E MÉTODOS DE PRODUÇÃO DE UM ANTICORPO OU DE UMA MOLÉCULA. A presente invenção refere-se a um anticorpo que pode ser usado como um agente antitumoral e um agente antitumoral que compreende uma molécula contendo o anticorpo, etc. como um ingrediente ativo. Um anticorpo que contém a CDRH1 de cadeia pesada que compreende a sequência de aminoácidos representada por SEQ ID NO: 54, CDRH2 de cadeia pesada que compreende a sequência de aminoácidos representada por SEQ ID NO: 55, uma CDRH3 de cadeia pesada que compreende a sequência de aminoácidos representada por SEQ ID NO: 56, CDRL1 de cadeia leve que compreende a sequência de aminoácidos representada por SEQ ID NO: 57 ou CDRL1 de cadeia leve que compreende uma sequência de aminoácidos que é idêntica à sequência de aminoácido representada por SEQ ID NO: 57 exceto que o sétimo o aminoácido é W e/ou o oitavo aminoácido é K, CDRL2 de cadeia leve que compreende a sequência de aminoácidos representada por SEQ ID NO: 58, e a CDRL3 de cadeia leve que compreende a sequência de aminoácidos representada por SEQ ID NO: 59 ou CDRL3 de cadeia leve que compreende uma sequência de aminoácidos que é idêntica à sequência de aminoácidos representada por SEQ ID NO: 57 exceto que o segundo aminoácido é A ou S; ou um fragmento de ligação do anticorpo.
BR112022016695A 2020-03-30 2021-03-29 Anticorpo biespecífico ou fragmento de ligação do mesmo, polinucleotídeo, vetor, composição farmacêutica, molécula que se liga especificamente ao hla/ny-eso humano, seus usos, e métodos de produção de um anticorpo ou de uma molécula BR112022016695A2 (pt)

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021003357A1 (en) * 2019-07-03 2021-01-07 Regeneron Pharmaceuticals, Inc. Anti-new york esophageal squamous cell carcinoma 1 (ny-eso-1) antigen-binding proteins and methods of use thereof
TW202400232A (zh) * 2022-03-16 2024-01-01 日商第一三共股份有限公司 多特異性分子與免疫檢查點抑制劑之組合
WO2023239736A1 (en) * 2022-06-09 2023-12-14 Amgen Inc. Methods of screening for peptide-hla class i alloreactivity
WO2024038193A1 (en) * 2022-08-18 2024-02-22 Immunocore Limited Multi-domain binding molecules
WO2024038183A1 (en) * 2022-08-18 2024-02-22 Immunocore Limited Multi-domain binding molecules

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DE69229477T2 (de) 1991-09-23 1999-12-09 Cambridge Antibody Tech Methoden zur Herstellung humanisierter Antikörper
US5885793A (en) 1991-12-02 1999-03-23 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
DE69333823T2 (de) 1992-03-24 2006-05-04 Cambridge Antibody Technology Ltd., Melbourn Verfahren zur herstellung von gliedern von spezifischen bindungspaaren
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
CA2177367A1 (en) 1993-12-03 1995-06-08 Andrew David Griffiths Recombinant binding proteins and peptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
DE69830901T2 (de) 1997-05-02 2006-05-24 Genentech Inc., San Francisco ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
ES2434961T5 (es) 1998-04-20 2018-01-18 Roche Glycart Ag Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
EP3031917A1 (en) 1999-04-09 2016-06-15 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
CN103333860B (zh) 2000-10-06 2015-07-08 协和发酵麒麟株式会社 产生抗体组合物的细胞
JP2003111595A (ja) * 2001-06-25 2003-04-15 Kyogo Ito 腫瘍抗原
WO2005113595A2 (en) 2004-05-19 2005-12-01 Avidex Ltd High affinity ny-eso t cell receptor
DK3050963T3 (da) 2005-03-31 2019-12-09 Chugai Pharmaceutical Co Ltd Fremgangsmåde til fremstilling af polypeptid ved regulering af arrangement
EP2235064B1 (en) 2008-01-07 2015-11-25 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
WO2010106431A2 (en) 2009-03-20 2010-09-23 Ludwig Institute For Cancer Research Ltd High affinity t-cell receptor-like ny-eso-1 peptide antibodies, methods, and uses thereof
CN103833855A (zh) 2009-06-26 2014-06-04 瑞泽恩制药公司 容易地分离的具有天然免疫球蛋白形式的双特异性抗体
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
CN110066339A (zh) 2010-04-20 2019-07-30 根马布股份公司 含异二聚体抗体fc的蛋白及其制备方法
CA2854233C (en) 2011-11-04 2020-05-12 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
JP6280031B2 (ja) 2012-03-29 2018-02-14 中外製薬株式会社 抗lamp5抗体およびその利用
MX354862B (es) 2012-06-27 2018-03-23 Hoffmann La Roche Método para la producción de entidades dirigidas altamente selectivas hechas a la medida y biespecíficas que contienen dos entidades de unión diferentes.
CA3211863A1 (en) 2013-01-14 2014-07-17 Xencor, Inc. Novel heterodimeric proteins
EP3004174B1 (en) 2013-05-31 2019-04-17 Zymeworks Inc. Heteromultimers with reduced or silenced effector function
WO2016210365A2 (en) 2015-06-24 2016-12-29 Eureka Therapeutics, Inc. Constructs targeting ny-eso-1 peptide/mhc complexes and uses thereof
GB201522592D0 (en) 2015-12-22 2016-02-03 Immunocore Ltd T cell receptors
TWI781108B (zh) * 2016-07-20 2022-10-21 比利時商健生藥品公司 抗gprc5d抗體、結合gprc5d與cd3之雙特異性抗原結合分子及其用途
SG10201912366YA (en) 2016-12-22 2020-02-27 Daiichi Sankyo Co Ltd Anti-cd3 antibody and molecules comprising the antibody
JP2020061476A (ja) 2018-10-11 2020-04-16 ソニーセミコンダクタソリューションズ株式会社 固体撮像装置及び電子機器
WO2021003357A1 (en) 2019-07-03 2021-01-07 Regeneron Pharmaceuticals, Inc. Anti-new york esophageal squamous cell carcinoma 1 (ny-eso-1) antigen-binding proteins and methods of use thereof

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