CO2021001375A2 - Compuestos heterocíclicos antihelmínticos - Google Patents

Compuestos heterocíclicos antihelmínticos

Info

Publication number
CO2021001375A2
CO2021001375A2 CONC2021/0001375A CO2021001375A CO2021001375A2 CO 2021001375 A2 CO2021001375 A2 CO 2021001375A2 CO 2021001375 A CO2021001375 A CO 2021001375A CO 2021001375 A2 CO2021001375 A2 CO 2021001375A2
Authority
CO
Colombia
Prior art keywords
heterocyclic
anthelmintic compounds
formula
anthelmintic
compounds
Prior art date
Application number
CONC2021/0001375A
Other languages
English (en)
Inventor
Alan Long
Hyoung Lee
Hannes Fiepko Koolman
Original Assignee
Boehringer Ingelheim Pharma Gmbh [&] Co Kg
Boehringer Ingelheim Animal Health Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh [&] Co Kg, Boehringer Ingelheim Animal Health Usa Inc filed Critical Boehringer Ingelheim Pharma Gmbh [&] Co Kg
Publication of CO2021001375A2 publication Critical patent/CO2021001375A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

RESUMEN DE LA INVENCIÓN Se describen un compuesto de la fórmula (I), (IA) o fórmula (II) o una composición que comprende el compuesto de la fórmula (I), (IA) o fórmula (II) en asociación con un portador veterinariamente aceptable. Se describe un método para controlar helmintos utilizando los mismos.
CONC2021/0001375A 2018-07-09 2021-02-08 Compuestos heterocíclicos antihelmínticos CO2021001375A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862695656P 2018-07-09 2018-07-09
PCT/US2019/040509 WO2020014068A1 (en) 2018-07-09 2019-07-03 Anthelminthic heterocyclic compounds

Publications (1)

Publication Number Publication Date
CO2021001375A2 true CO2021001375A2 (es) 2021-04-08

Family

ID=67470666

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0001375A CO2021001375A2 (es) 2018-07-09 2021-02-08 Compuestos heterocíclicos antihelmínticos

Country Status (17)

Country Link
US (1) US20220048903A1 (es)
EP (1) EP3820870A1 (es)
JP (1) JP7289349B2 (es)
KR (1) KR20210032416A (es)
CN (1) CN112996788A (es)
AU (1) AU2019301510B2 (es)
BR (1) BR112021000257A2 (es)
CA (1) CA3106092A1 (es)
CL (1) CL2021000031A1 (es)
CO (1) CO2021001375A2 (es)
EC (1) ECSP21001265A (es)
IL (1) IL279977B2 (es)
MX (1) MX2021000293A (es)
PE (1) PE20211275A1 (es)
PH (1) PH12021550024A1 (es)
SG (1) SG11202012922VA (es)
WO (1) WO2020014068A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3643711A1 (en) 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
CR20210477A (es) 2019-03-19 2022-01-06 Boehringer Ingelheim Animal Health Usa Inc Compuestos de aza-benzotiofeno y aza-benzofurano como antihelmínticos
BR112022024156A2 (pt) 2020-05-29 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Compostos heterocílicos antelmínticos
AU2021384833A1 (en) 2020-11-18 2023-06-15 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
CA3236894A1 (en) 2021-11-01 2023-05-04 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic pyrrolopyridazine compounds

Family Cites Families (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
JPS4914624A (es) 1972-06-08 1974-02-08
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (es) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4451356A (en) 1980-12-22 1984-05-29 Exxon Research And Engineering Co. Catalytic dehydroxylation of phenols
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
DE3580444D1 (en) 1984-10-18 1990-12-13 Ciba Geigy Ag Benzoylphenylharnstoffe.
DE3681465D1 (es) 1985-02-04 1991-10-24 Nihon Bayer Agrochem K.K., Tokio/Tokyo, Jp
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
RU2024527C1 (ru) 1986-03-25 1994-12-15 Санкио Компани Лимитед Способ получения макролидных соединений
EP0252879B1 (de) 1986-07-02 1992-05-06 Ciba-Geigy Ag Pestizide
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0319142B1 (en) 1987-11-03 1994-04-06 Beecham Group Plc Intermediates for the preparation of anthelmintic macrolide antibiotics
MA21697A1 (fr) 1988-12-19 1990-07-01 Dow Agrosciences Llc Composes de macrolides.
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5202242A (en) 1991-11-08 1993-04-13 Dowelanco A83543 compounds and processes for production thereof
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
US5591606A (en) 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
BR9406587A (pt) 1993-03-12 1996-01-02 Dowelanco Novos compostos a83543 e processo para a produção dos mesmos
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
US5750548A (en) 1994-01-24 1998-05-12 Novartis Corp. 1- N-(halo-3-pyridylmethyl)!-N-methylamino-1-alklamino-2-nitroethylene derivatives for controlling fleas in domestic animals
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
TW334436B (en) 1995-07-21 1998-06-21 Upjohn Co Antiparasitic marcfortines and paraherquamides
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US6001981A (en) 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
US20040151759A1 (en) 2002-08-16 2004-08-05 Douglas Cleverly Non-animal product containing veterinary formulations
AR042420A1 (es) 2002-09-11 2005-06-22 Novartis Ag Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica
TWI366442B (en) 2003-07-30 2012-06-21 Novartis Ag Palatable ductile chewable veterinary composition
ZA200607637B (en) 2004-03-05 2008-05-28 Nissan Chemical Ind Ltd Isoxazoline-substituted benzamide compound and noxious organism control agent
ES2387927T3 (es) * 2004-12-17 2012-10-04 Devgen Nv Composiciones nematicidas
ES2443690T3 (es) 2005-09-02 2014-02-20 Nissan Chemical Industries, Ltd. Compuesto de benzamida sustituido con isoxazolina y agente controlador de organismos dañinos
US7955632B2 (en) 2005-12-07 2011-06-07 Bayer B.V. Process for manufacturing chewable dosage forms for drug delivery and products thereof
EP1965645A2 (en) 2005-12-14 2008-09-10 E.I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
WO2007105814A1 (ja) 2006-03-10 2007-09-20 Nissan Chemical Industries, Ltd. 置換イソキサゾリン化合物及び有害生物防除剤
KR20090005201A (ko) 2006-04-20 2009-01-12 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제용 피라졸린
WO2007125984A1 (ja) 2006-04-28 2007-11-08 Nihon Nohyaku Co., Ltd. イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法
KR101437704B1 (ko) 2006-07-05 2014-09-04 아벤티스 애그리컬쳐 1-아릴-5-알킬 피라졸 유도체 화합물, 이의 제조 방법 및 이의 사용 방법
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
JP5206993B2 (ja) 2007-03-07 2013-06-12 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
KR101538176B1 (ko) 2007-03-16 2015-07-20 구미아이 가가쿠 고교 가부시키가이샤 제초제 조성물
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
AU2008235089B8 (en) 2007-04-10 2014-04-10 Bayer Intellectual Property Gmbh Insecticidal aryl isoxazoline derivatives
ES2825198T3 (es) 2007-05-15 2021-05-14 Boehringer Ingelheim Animal Health Usa Inc Compuestos de ariloazol-2-il cianoetilamino, procedimiento de fabricación y procedimiento de utilización de los mismos
US8623875B2 (en) 2007-06-13 2014-01-07 E.I. Du Pont De Nemours And Company Isoxazoline insecticides
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
US8952175B2 (en) 2007-06-27 2015-02-10 Nissan Chemical Industries, Ltd. Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound
ES2423505T3 (es) 2007-06-29 2013-09-20 Zoetis Llc Combinación antihelmíntica
JP5316808B2 (ja) 2007-06-29 2013-10-16 日産化学工業株式会社 置換イソキサゾリン又はエノンオキシム化合物および有害生物防除剤
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
EP2199287A4 (en) 2007-09-10 2011-04-27 Nissan Chemical Ind Ltd SUBSTITUTED ISOXAZOLINE COMPOUND AND AGENT FOR CONTROLLING PESTS
AU2008308907B2 (en) 2007-10-03 2014-08-14 Corteva Agriscience Llc Naphthalene isoxazoline compounds for control of invertebrate pests
JP2009209125A (ja) * 2008-02-07 2009-09-17 Bayer Cropscience Ag 殺虫性アリールピロリン類
US8563474B2 (en) 2008-07-09 2013-10-22 Basf Se Pestcidal active mixtures comprising isoxazoline compounds I
WO2010005048A1 (ja) 2008-07-09 2010-01-14 日産化学工業株式会社 イソキサゾリン置換安息香酸アミド化合物の製造方法
CN102088857A (zh) 2008-07-09 2011-06-08 巴斯夫欧洲公司 包含异噁唑啉化合物的杀虫活性混合物ⅱ
EP2320737B1 (en) * 2008-08-05 2013-07-17 Merck Sharp & Dohme Corp. Pyrazolo-[1,5-a]-pyridines as mark inhibitors
EP2331535B1 (en) 2008-09-04 2015-07-22 Syngenta Participations AG Insecticidal compounds
US9820977B2 (en) 2008-10-03 2017-11-21 Bayer Healthcare Llc Systemic treatment of blood-sucking and blood-consuming parasites by oral administration of a parasiticidal agent
NZ592382A (en) 2008-10-21 2013-03-28 Merial Ltd Thioamide compounds, method of making and method of using thereof
WO2010079077A1 (en) 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
PL2379537T3 (pl) 2008-12-19 2013-03-29 Elanco Tiergesundheit Ag Pochodne izooksazoliny i ich zastosowanie jako pestycydów
CN102325759A (zh) 2008-12-23 2012-01-18 巴斯夫欧洲公司 用于防治动物害虫的取代脒化合物
WO2010108733A1 (en) 2009-03-26 2010-09-30 Syngenta Participations Ag Insecticidal compounds
WO2010112545A1 (en) 2009-04-01 2010-10-07 Basf Se Isoxazoline compounds for combating invertebrate pests
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
EP3560923B1 (en) 2009-12-17 2021-05-05 Boehringer Ingelheim Animal Health USA Inc. Anti parasitic dihydroazole compounds and compositions comprising same
ES2546417T3 (es) 2010-02-01 2015-09-23 Basf Se Compuestos de isoxazolina cetónica sustituidos y derivados para combatir plagas animales
MA34071B1 (fr) 2010-02-25 2013-03-05 Syngenta Participations Ag Mélanges pesticides comprenant des dérivés d'isoxazoline et un agent biologique insecticide ou nématicide
CN102822168B (zh) 2010-02-25 2016-10-26 先正达参股股份有限公司 制备异恶唑啉衍生物的方法
WO2011104088A1 (en) 2010-02-25 2011-09-01 Syngenta Participations Ag Pesticidal mixtures containing isoxazoline derivatives and a fungicide
CN102933563A (zh) 2010-04-08 2013-02-13 Ah美国42有限责任公司 作为杀虫剂和杀螨剂的取代的3,5-二苯基异噁唑啉衍生物
EP2579724A2 (en) 2010-06-09 2013-04-17 Syngenta Participations AG Pesticidal mixtures including isoxazoline derivatives
AR081843A1 (es) 2010-06-09 2012-10-24 Syngenta Participations Ag Mezclas pesticidas incluyendo derivados isoxazolina
UY33403A (es) 2010-06-17 2011-12-30 Novartis Ag Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales
CN103270036B (zh) 2010-08-05 2015-11-25 佐蒂斯有限责任公司 作为抗寄生物剂的异噁唑啉衍生物
AU2011306489B2 (en) 2010-09-24 2015-11-05 Zoetis Services Llc Isoxazoline oximes as antiparasitic agents
WO2012086462A1 (ja) 2010-12-20 2012-06-28 日本曹達株式会社 イソオキサゾリン化合物および有害生物防除剤
MX356926B (es) 2010-12-27 2018-06-19 Intervet Int Bv Formulación de isoxazolina tópica localizada.
EP2658541B1 (en) 2010-12-27 2022-01-26 Intervet International B.V. Topical localized isoxazoline formulation comprising glycofurol
WO2012100342A1 (en) * 2011-01-27 2012-08-02 Université de Montréal Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
JP2014505089A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー 無脊椎有害動物を防除するためのイソオキサゾリン誘導体
RU2013145304A (ru) 2011-03-10 2015-04-20 Новартис Аг Производные изоксазола
CN103517907B (zh) 2011-03-10 2016-07-06 硕腾服务有限责任公司 作为抗寄生物剂的螺环异噁唑啉衍生物
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
HUE041514T2 (hu) 2012-02-06 2019-05-28 Merial Inc Szisztémásan ható hatóanyagokat tartalmazó, parazitaellenes, szájon át adagolt állatgyógyászati készítmények, eljárások és alkalmazásuk
BR112015004826A2 (pt) 2012-09-07 2017-07-04 Zoetis Llc derivados espirocíclicos como agentes antiparasíticos
CN105164124B (zh) * 2012-11-19 2017-03-15 诺华股份有限公司 用于治疗寄生虫疾病的化合物和组合物
US9404206B2 (en) 2013-02-28 2016-08-02 Nike, Inc. Feeder for knitting machine having pushing member
AR096393A1 (es) * 2013-05-23 2015-12-30 Bayer Cropscience Ag Compuestos heterocíclicos pesticidas
TWI652014B (zh) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
ES2905848T3 (es) 2013-11-01 2022-04-12 Boehringer Ingelheim Animal Health Usa Inc Compuestos de isoxazolina antiparasitarios y plaguicidas
RU2018130069A (ru) * 2016-01-21 2020-02-21 Новартис Аг Соединения и композиции для лечения криптоспоридиоза
ES2953467T3 (es) * 2016-04-15 2023-11-13 Elanco Animal Health Gmbh Derivados de pirazolopirimidina
MX2019015895A (es) * 2017-06-30 2020-02-07 Bayer Animal Health Gmbh Nuevos derivados de azaquinolina.

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KR20210032416A (ko) 2021-03-24
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