CO2021000188A2 - Anticuerpos anti-bcma x anti-cd3 biespecíficos y usos de estos - Google Patents
Anticuerpos anti-bcma x anti-cd3 biespecíficos y usos de estosInfo
- Publication number
- CO2021000188A2 CO2021000188A2 CONC2021/0000188A CO2021000188A CO2021000188A2 CO 2021000188 A2 CO2021000188 A2 CO 2021000188A2 CO 2021000188 A CO2021000188 A CO 2021000188A CO 2021000188 A2 CO2021000188 A2 CO 2021000188A2
- Authority
- CO
- Colombia
- Prior art keywords
- bcma
- bispecific
- antibodies
- cells
- useful
- Prior art date
Links
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 abstract 5
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 208000034578 Multiple myelomas Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 210000004180 plasmocyte Anatomy 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464429—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
RESUMEN El antígeno de maduración de células B (BCMA) se expresa en células plasmáticas malignas. La presente invención proporciona anticuerpos biespecíficos (bsAbs) novedosos que se unen a BCMA y CD3 y activan las células T a través del complejo CD3 en presencia de células tumorales que expresan BCMA. En determinadas modalidades, las moléculas de unión a antígeno biespecíficas de la presente invención pueden inhibir el crecimiento de tumores que expresan BCMA. Las moléculas de unión a antígeno biespecíficas de la invención son útiles para el tratamiento de enfermedades y trastornos en los que se desea y/o es terapéuticamente beneficiosa una respuesta inmunitaria dirigida a BCMA inducida o regulada de manera ascendente. Por ejemplo, los anticuerpos biespecíficos de la invención son útiles para el tratamiento de diversos tipos de cáncer, que incluyen mieloma múltiple.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862700596P | 2018-07-19 | 2018-07-19 | |
US201862750968P | 2018-10-26 | 2018-10-26 | |
US201962793645P | 2019-01-17 | 2019-01-17 | |
PCT/US2019/042447 WO2020018820A1 (en) | 2018-07-19 | 2019-07-18 | BISPECIFIC ANTI-BCMA x ANTI-CD3 ANTIBODIES AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021000188A2 true CO2021000188A2 (es) | 2021-01-18 |
Family
ID=67515169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0000188A CO2021000188A2 (es) | 2018-07-19 | 2021-01-13 | Anticuerpos anti-bcma x anti-cd3 biespecíficos y usos de estos |
Country Status (16)
Country | Link |
---|---|
US (2) | US11384153B2 (es) |
EP (1) | EP3823664A1 (es) |
JP (2) | JP7319348B2 (es) |
KR (1) | KR20210034032A (es) |
CN (1) | CN112423785A (es) |
AU (1) | AU2019307928A1 (es) |
BR (1) | BR112021000186A2 (es) |
CA (1) | CA3107126A1 (es) |
CL (1) | CL2021000131A1 (es) |
CO (1) | CO2021000188A2 (es) |
IL (1) | IL279974A (es) |
MA (1) | MA53168A (es) |
MX (1) | MX2021000488A (es) |
PH (1) | PH12021550031A1 (es) |
SG (1) | SG11202100252SA (es) |
WO (1) | WO2020018820A1 (es) |
Families Citing this family (18)
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NZ759513A (en) | 2017-06-01 | 2022-01-28 | Regeneron Pharma | Human antibodies to bet v 1 and methods of use thereof |
EP4069373A1 (en) | 2019-12-06 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Methods of treating multiple myeloma with bispecific anti-bcma x anti-cd3 antibodies |
TW202144425A (zh) * | 2020-04-17 | 2021-12-01 | 大陸商上海翰森生物醫藥科技有限公司 | 特異性抗原結合分子,其製備方法及醫藥用途 |
KR20230030573A (ko) | 2020-07-01 | 2023-03-06 | 리제너론 파마슈티칼스 인코포레이티드 | 항-bet v1 항체를 사용하여 알러지를 치료하는 방법 |
US20230398147A1 (en) | 2020-09-16 | 2023-12-14 | Amgen Inc. | Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer |
JP2023543152A (ja) | 2020-09-18 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Cd38及び/又はcd28を結合する抗原結合分子及びその使用 |
CN114524878A (zh) | 2020-11-23 | 2022-05-24 | 康诺亚生物医药科技(成都)有限公司 | 一种双特异性抗体及其用途 |
CN114573703A (zh) | 2020-12-02 | 2022-06-03 | 康诺亚生物医药科技(成都)有限公司 | 一种t细胞衔接器治疗剂的开发和应用 |
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-
2019
- 2019-07-18 MA MA053168A patent/MA53168A/fr unknown
- 2019-07-18 BR BR112021000186-7A patent/BR112021000186A2/pt unknown
- 2019-07-18 KR KR1020217004615A patent/KR20210034032A/ko unknown
- 2019-07-18 MX MX2021000488A patent/MX2021000488A/es unknown
- 2019-07-18 CN CN201980047976.5A patent/CN112423785A/zh active Pending
- 2019-07-18 AU AU2019307928A patent/AU2019307928A1/en active Pending
- 2019-07-18 SG SG11202100252SA patent/SG11202100252SA/en unknown
- 2019-07-18 WO PCT/US2019/042447 patent/WO2020018820A1/en active Application Filing
- 2019-07-18 JP JP2021502831A patent/JP7319348B2/ja active Active
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- 2019-07-18 US US16/516,028 patent/US11384153B2/en active Active
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2021
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US20200024356A1 (en) | 2020-01-23 |
US11384153B2 (en) | 2022-07-12 |
JP2023134728A (ja) | 2023-09-27 |
CN112423785A (zh) | 2021-02-26 |
JP7319348B2 (ja) | 2023-08-01 |
EP3823664A1 (en) | 2021-05-26 |
WO2020018820A1 (en) | 2020-01-23 |
JP2021531005A (ja) | 2021-11-18 |
MX2021000488A (es) | 2021-04-12 |
MA53168A (fr) | 2021-05-26 |
IL279974A (en) | 2021-03-01 |
US20220306758A1 (en) | 2022-09-29 |
BR112021000186A2 (pt) | 2021-08-10 |
CL2021000131A1 (es) | 2021-07-02 |
CA3107126A1 (en) | 2020-01-23 |
SG11202100252SA (en) | 2021-02-25 |
AU2019307928A1 (en) | 2021-02-11 |
TW202019966A (zh) | 2020-06-01 |
KR20210034032A (ko) | 2021-03-29 |
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