CO2019009221A2 - Composición farmacéutica que comprende selexipag - Google Patents

Composición farmacéutica que comprende selexipag

Info

Publication number
CO2019009221A2
CO2019009221A2 CONC2019/0009221A CO2019009221A CO2019009221A2 CO 2019009221 A2 CO2019009221 A2 CO 2019009221A2 CO 2019009221 A CO2019009221 A CO 2019009221A CO 2019009221 A2 CO2019009221 A2 CO 2019009221A2
Authority
CO
Colombia
Prior art keywords
compositions
aqueous
pharmaceutical composition
selexipag
relates
Prior art date
Application number
CONC2019/0009221A
Other languages
English (en)
Inventor
Klaus Hellerbrand
Alexandra Schlicker-Spain
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61655736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2019009221(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of CO2019009221A2 publication Critical patent/CO2019009221A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La invención se relaciona con composiciones farmacéuticas acuosas que comprenden el compuesto 2-{4-[N-(5,6-difenilpirazin-2-il)-N-isopropilamino]butiloxi}-N-(metilsulfonil) acetamida; glicina; polisorbato 20; y un regulador de fosfato acuoso, en donde las cantidades relativas son como se describió en la descripción, en donde el pH de dicha composición farmacéutica está entre aproximadamente 7 y 8; con composiciones farmacéuticas liofilizadas preparadas a partir de dichas composiciones acuosas, y con composiciones acuosas reconstituidas de estas que son adecuadas para administración i.v. La invención se relaciona, además, con procesos para la preparación de dichas composiciones, y con su uso para el tratamiento de enfermedades y trastornos relacionados con el receptor IP.
CONC2019/0009221A 2017-03-08 2019-08-27 Composición farmacéutica que comprende selexipag CO2019009221A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017055406 2017-03-08
PCT/EP2018/055551 WO2018162527A1 (en) 2017-03-08 2018-03-07 Pharmaceutical composition comprising selexipag

Publications (1)

Publication Number Publication Date
CO2019009221A2 true CO2019009221A2 (es) 2019-08-30

Family

ID=61655736

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0009221A CO2019009221A2 (es) 2017-03-08 2019-08-27 Composición farmacéutica que comprende selexipag

Country Status (27)

Country Link
US (1) US20200129506A1 (es)
EP (1) EP3592391B1 (es)
JP (1) JP6964679B2 (es)
KR (1) KR102593075B1 (es)
CN (1) CN110430900B (es)
AR (1) AR111570A1 (es)
AU (1) AU2018229750B2 (es)
BR (1) BR112019018420A2 (es)
CA (1) CA3055010A1 (es)
CL (1) CL2019002511A1 (es)
CO (1) CO2019009221A2 (es)
CR (1) CR20190455A (es)
DO (1) DOP2019000250A (es)
EA (1) EA201992074A1 (es)
EC (1) ECSP19072294A (es)
ES (1) ES2880009T3 (es)
IL (1) IL269061A (es)
JO (1) JOP20190204A1 (es)
MA (1) MA47816A (es)
MX (1) MX2019010598A (es)
NI (1) NI201900090A (es)
PE (1) PE20191492A1 (es)
PH (1) PH12019502033A1 (es)
PL (1) PL3592391T3 (es)
SG (1) SG11201907804QA (es)
TW (1) TWI764996B (es)
WO (1) WO2018162527A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3965767A1 (en) * 2019-05-06 2022-03-16 Actelion Pharmaceuticals Ltd Methods for treating sarcoidosis-associated pulmonary hypertension
JP2022536623A (ja) * 2019-06-11 2022-08-18 アクテリオン ファーマシューティカルズ リミテッド 肺動脈性肺高血圧症の治療方法
IL292354A (en) * 2019-10-23 2022-06-01 Actelion Pharmaceuticals Ltd A pharmaceutical preparation containing Selexifag
JP2023512273A (ja) 2020-01-31 2023-03-24 アクテリオン ファーマシューティカルズ リミテッド 制御放出セレキシパグ組成物
TW202239408A (zh) 2021-01-29 2022-10-16 瑞士商艾克泰聯製藥有限公司 包含二苯基吡𠯤衍生物的醫藥組成物
WO2022215045A1 (en) * 2021-04-08 2022-10-13 Glenmark Pharmaceutical Limited Lyophilized composition comprising selexipag
WO2023131608A1 (en) 2022-01-04 2023-07-13 Actelion Pharmaceuticals Ltd Controlled release compositions
WO2023209731A1 (en) * 2022-04-25 2023-11-02 Msn Laboratories Private Limited, R&D Center Injectable liquid or lyophilized powder dosage forms of selexipag and their method of preparation
WO2023214059A1 (en) 2022-05-06 2023-11-09 Actelion Pharmaceuticals Ltd Diphenylpyrazine compounds as prodrugs
TW202404594A (zh) * 2022-06-10 2024-02-01 日商日本新藥股份有限公司 醫藥組合物
WO2024017964A1 (en) 2022-07-20 2024-01-25 Actelion Pharmaceuticals Ltd Injectable pharmaceutical composition comprising a diphenylpyrazine derivative

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI316055B (es) 2001-04-26 2009-10-21 Nippon Shinyaku Co Ltd
DK1478339T3 (da) * 2002-02-22 2008-08-25 Schering Corp Farmaceutiske formuleringer af antineoplastiske midler, specielt temozolomid, fremgangsmåder til fremstilling og anvendelse heraf
CN104761509A (zh) 2008-02-28 2015-07-08 日本新药株式会社 纤维化抑制剂
WO2009154246A1 (ja) 2008-06-19 2009-12-23 日本新薬株式会社 勃起不全治療剤
WO2009157397A1 (ja) 2008-06-23 2009-12-30 日本新薬株式会社 非ステロイド性抗炎症剤投与に伴う腸管傷害治療剤
PT2292231E (pt) 2008-06-23 2015-12-31 Nippon Shinyaku Co Ltd Agente terapêutico para a estenose do canal espinal
DK2289518T3 (en) 2008-06-23 2017-01-16 Nippon Shinyaku Co Ltd Therapeutic agent for inflammatory bowel diseases
PT2447254T (pt) * 2009-06-26 2018-01-04 Nippon Shinyaku Co Ltd Cristais
WO2011024874A1 (ja) 2009-08-26 2011-03-03 日本新薬株式会社 塩基付加塩
BR112013027009A2 (pt) * 2011-04-19 2016-12-27 Rigshospitalet prostaciclina e análogos da mesa administrada durante cirurgia para prevenção e tratamento de derrame capilar
KR20140082649A (ko) 2011-08-12 2014-07-02 아센디스 파마 에이에스 프로스타사이클린의 서방형 조성물
ES2733998T3 (es) 2012-10-29 2019-12-03 Cardio Incorporated Agente terapéutico específico de enfermedad pulmonar
EP3043774B1 (en) * 2013-09-11 2020-11-04 Eagle Biologics, Inc. Liquid protein formulations containing ionic liquids
GB201400412D0 (en) * 2014-01-10 2014-02-26 Heart Biotech Ltd Pharmaceutical formulations for the treatment of pulmonary arterial hypertension
WO2017029594A1 (en) 2015-08-17 2017-02-23 Dr. Reddy's Laboratories Limited Processes for preparation of selexipag and its amorphous form
EP3192502A1 (en) * 2016-01-15 2017-07-19 Sandoz Ag Pharmaceutical composition of selexipag

Also Published As

Publication number Publication date
ES2880009T3 (es) 2021-11-23
IL269061A (en) 2019-11-28
BR112019018420A2 (pt) 2020-04-14
AU2018229750A1 (en) 2019-09-12
CR20190455A (es) 2019-11-12
JP2020509070A (ja) 2020-03-26
US20200129506A1 (en) 2020-04-30
NI201900090A (es) 2020-03-11
DOP2019000250A (es) 2020-09-15
MA47816A (fr) 2020-01-15
CL2019002511A1 (es) 2020-01-17
CN110430900A (zh) 2019-11-08
EP3592391A1 (en) 2020-01-15
SG11201907804QA (en) 2019-09-27
PE20191492A1 (es) 2019-10-21
AU2018229750B2 (en) 2023-11-23
WO2018162527A1 (en) 2018-09-13
JOP20190204A1 (ar) 2019-09-05
JP6964679B2 (ja) 2021-11-10
ECSP19072294A (es) 2019-11-30
KR20190122803A (ko) 2019-10-30
MX2019010598A (es) 2019-10-15
EA201992074A1 (ru) 2020-02-27
EP3592391B1 (en) 2021-04-21
CN110430900B (zh) 2023-09-19
PH12019502033A1 (en) 2020-06-15
CA3055010A1 (en) 2018-09-13
TWI764996B (zh) 2022-05-21
PL3592391T3 (pl) 2021-11-02
TW201842910A (zh) 2018-12-16
AR111570A1 (es) 2019-07-31
KR102593075B1 (ko) 2023-10-23

Similar Documents

Publication Publication Date Title
CO2019009221A2 (es) Composición farmacéutica que comprende selexipag
ECSP19030002A (es) 1,2,4-triazolonas 2,4,5-trisustituidas
CL2020001762A1 (es) Formas cristalinas del derivado de 4-pirimidinsulfamida de aprocitentán. (divisional solicitud 201902464)
BR112018017172A2 (pt) anticorpos monoclonais anti-alfa-sinucleína para prevenção da agregação de tau
CO2020001244A2 (es) Derivados de quinolina para tratar infecciones con helmintos
EA201691242A1 (ru) Фармацевтические композиции, содержащие azd9291
CL2009000349A1 (es) Compuestos derivados de 4,5-dihidro-oxazol-2-ilamina; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la enfermedad de alzheimer.
EA202090890A1 (ru) Состав растительного и синтетического каннабиноида быстрого начала действия и пролонгированного действия
EA201100691A1 (ru) Антагонисты рецепторов лизофосфатидной кислоты
BR112015018087A8 (pt) composto, composição farmacêutica e uso
EA201990820A1 (ru) Способы лечения митохондриальных и метаболических нарушений
CL2022000998A1 (es) Inhibidores de las cinasas raf
BR112018013979A2 (pt) composições em gel para liberação transdérmica para maximizar as concentrações de fármacos no estrato córneo e no soro e métodos de uso dos mesmos
UY37971A (es) Derivados de indol macrocíclicos sustituidos
CO6400235A2 (es) Tensiactivos reconstituidos que tienen propiedades mejoradas
CO2020013876A2 (es) Nuevos derivados de quinolina
BR112019005318A2 (pt) compostos de aza-indazol para uso em lesões no tendão e/ou ligamento
ECSP22040921A (es) Composición farmacéutica que comprende selexipag
ECSP21003171A (es) Dinucleótidos cíclicos como agonistas de sting
BR112012026509A2 (pt) "novos derivados de benzamida"
BR112017019431A2 (pt) material de implante de compósito
EA201892529A1 (ru) Комбинация чистых антагонистов 5-htрецепторов с ингибиторами ацетилхолинэстеразы
CL2008002060A1 (es) Compuestos derivados de sulfonamida, inhibidores de la produccion de beta amiloide; metodo de preparacion; composicion farmaceutica; kit farmaceutico; y uso en el tratamiento de enfermedades tales como alzheimer, angiopatia amiloide, sindrome de down, entre otras.
EA201990766A1 (ru) Индазольные соединения для применения при повреждениях сухожилий и/или связок
DOP2023000170A (es) Formas cristalinas de (4s)–24–cloro–4–etil–73–fluoro–35–metoxi–32,5–dioxo–14–(trifluoro–metil)–32h–6–aza–3(4,1)–piridina–1(1)–[1,2,3]triazola–2(1,2),7(1)–dibencenaheptafano–74–carboxamida