CO2019002159A2 - Análogos de amilina - Google Patents
Análogos de amilinaInfo
- Publication number
- CO2019002159A2 CO2019002159A2 CONC2019/0002159A CO2019002159A CO2019002159A2 CO 2019002159 A2 CO2019002159 A2 CO 2019002159A2 CO 2019002159 A CO2019002159 A CO 2019002159A CO 2019002159 A2 CO2019002159 A2 CO 2019002159A2
- Authority
- CO
- Colombia
- Prior art keywords
- amylin analogues
- analogs
- diabetes
- disorders
- treat
- Prior art date
Links
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 title abstract 2
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 235000012631 food intake Nutrition 0.000 abstract 1
- 239000012669 liquid formulation Substances 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
Abstract
La presente invención se refiere a análogos de amilina y su uso para tratar o prevenir varias enfermedades, afecciones o trastornos, que incluyen obesidad, ingesta excesiva de alimentos y enfermedades metabólicas asociadas tal como la diabetes. Los análogos pueden tener una buena estabilidad física y química, una buena solubilidad y una duración de acción prolongada y son muy adecuados para usar en forma de formulación líquida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16188024 | 2016-09-09 | ||
PCT/EP2017/072718 WO2018046719A1 (en) | 2016-09-09 | 2017-09-11 | Amylin analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019002159A2 true CO2019002159A2 (es) | 2019-07-31 |
Family
ID=56990230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0002159A CO2019002159A2 (es) | 2016-09-09 | 2019-03-07 | Análogos de amilina |
Country Status (26)
Country | Link |
---|---|
US (4) | US10071140B2 (es) |
EP (2) | EP3510044B1 (es) |
JP (1) | JP7064103B2 (es) |
KR (1) | KR102498393B1 (es) |
CN (1) | CN109863168B (es) |
AR (1) | AR109514A1 (es) |
AU (1) | AU2017322277B2 (es) |
BR (1) | BR112019004534A2 (es) |
CA (1) | CA3035958A1 (es) |
CL (1) | CL2019000575A1 (es) |
CO (1) | CO2019002159A2 (es) |
DK (1) | DK3510044T3 (es) |
EA (1) | EA201990360A1 (es) |
ES (1) | ES2901386T3 (es) |
IL (1) | IL264864B2 (es) |
MA (1) | MA46180A (es) |
MX (1) | MX2019002599A (es) |
MY (1) | MY197024A (es) |
PE (1) | PE20190963A1 (es) |
PH (1) | PH12019500474A1 (es) |
SA (1) | SA519401239B1 (es) |
SG (1) | SG11201901423XA (es) |
TW (1) | TWI784968B (es) |
UA (1) | UA123369C2 (es) |
WO (1) | WO2018046719A1 (es) |
ZA (1) | ZA201901253B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016232218B2 (en) | 2015-03-18 | 2020-09-10 | Boehringer Ingelheim International Gmbh | Amylin analogues |
TWI784968B (zh) | 2016-09-09 | 2022-12-01 | 丹麥商西蘭製藥公司 | 澱粉素類似物 |
MX2022005661A (es) | 2019-11-11 | 2022-09-07 | Boehringer Ingelheim Int | Agonistas del receptor npy2. |
IL300239A (en) | 2020-08-07 | 2023-03-01 | Boehringer Ingelheim Int | Soluble NPY2 receptor agonists |
WO2022248419A2 (en) | 2021-05-22 | 2022-12-01 | Adocia | Compositions comprising short-acting hormones for treating or preventing obesity and pumps comprising said composition |
EP4144362A1 (en) | 2021-09-06 | 2023-03-08 | Adocia | Compositions comprising short-acting hormones for treating or preventing obesity and pumps comprising said composition |
EP4129324A1 (en) | 2021-08-02 | 2023-02-08 | Adocia | Compositions comprising at least an amylin receptor agonist and a glp-1 receptor agonist |
TW202346323A (zh) | 2022-02-07 | 2023-12-01 | 英商梅迪繆思有限公司 | 具有改善的生物穩定性的glp—1及升糖素雙重激動肽 |
WO2023227133A1 (zh) * | 2022-05-27 | 2023-11-30 | 杭州先为达生物科技股份有限公司 | 人胰淀素类似物、其衍生物及用途 |
EP4319798A1 (en) | 2022-05-30 | 2024-02-14 | Zealand Pharma A/S | Liquid formulations of amylin analogues |
WO2024022465A1 (zh) * | 2022-07-29 | 2024-02-01 | 杭州九源基因工程有限公司 | 一种人胰淀素多肽衍生物及其用途 |
WO2024061919A1 (en) | 2022-09-19 | 2024-03-28 | Zealand Pharma A/S | Combination therapy |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5175146A (en) | 1989-12-05 | 1992-12-29 | Vical, Inc. | Synthetic calcitonin peptides |
US5234906A (en) | 1991-01-10 | 1993-08-10 | Amylin Pharmaceuticals, Inc. | Hyperglycemic compositions |
HU222249B1 (hu) | 1991-03-08 | 2003-05-28 | Amylin Pharmaceuticals Inc. | Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
DK0567626T3 (da) | 1991-11-19 | 2001-12-17 | Amylin Pharmaceuticals Inc | Amylin-agonist-peptider og anvendelse deraf |
EP0717635B1 (en) | 1993-09-07 | 2000-11-15 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
HU227021B1 (en) | 1996-08-30 | 2010-05-28 | Novo Nordisk As | Glp-1 derivatives |
EP0929567B1 (en) | 1996-09-09 | 2005-03-02 | Zealand Pharma A/S | Solid-phase peptide synthesis |
US5677279A (en) | 1996-12-16 | 1997-10-14 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating pain with amylin or agonists thereof |
US7101853B2 (en) | 1997-05-06 | 2006-09-05 | Amylin Pharmaceuticals, Inc. | Method for treating or preventing gastritis using amylin or amylin agonists |
CA2206028C (en) | 1997-06-04 | 2006-10-03 | Frantisek Ziak | Fitness-balance board |
US7910548B2 (en) | 1997-06-06 | 2011-03-22 | Amylin Pharmaceuticals, Inc. | Methods for treating obesity |
WO1999034764A2 (en) * | 1998-01-09 | 1999-07-15 | Amylin Pharmaceuticals, Inc. | Amylin agonist pharmaceutical compositions containing insulin |
US6451987B1 (en) | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
WO2000055119A1 (en) | 1999-03-17 | 2000-09-21 | Novo Nordisk A/S | Method for acylating peptides and novel acylating agents |
WO2005000222A2 (en) | 2003-05-30 | 2005-01-06 | Amylin Pharmaceuticals, Inc. | Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins |
ATE471340T1 (de) * | 2004-02-11 | 2010-07-15 | Amylin Pharmaceuticals Inc | Peptide der amylin familie, verfahren zu deren herstellung und verwendung |
CN102174115B (zh) | 2004-02-11 | 2014-05-14 | 安米林药品有限责任公司 | 具有可选择特性的杂合多肽 |
DE102004051014A1 (de) | 2004-10-20 | 2006-04-27 | Rwth Aachen | Chemisch modifizierte Peptidanaloga |
EP1922336B1 (en) | 2005-08-11 | 2012-11-21 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
WO2007104789A2 (en) | 2006-03-15 | 2007-09-20 | Novo Nordisk A/S | Amylin derivatives |
NZ578948A (en) | 2007-02-15 | 2012-03-30 | Univ Indiana Res & Tech Corp | Glucagon/glp-1 receptor co-agonists |
DK2158214T3 (da) | 2007-06-15 | 2011-12-05 | Zealand Pharma As | Glukagonanaloger |
EP2036539A1 (en) | 2007-09-11 | 2009-03-18 | Novo Nordisk A/S | Stable formulations of amylin and its analogues |
EP2036923A1 (en) | 2007-09-11 | 2009-03-18 | Novo Nordisk A/S | Improved derivates of amylin |
JP5703226B2 (ja) | 2008-10-21 | 2015-04-15 | ノヴォ ノルディスク アー/エス | アミリン誘導体 |
ES2477880T3 (es) | 2008-12-15 | 2014-07-18 | Zealand Pharma A/S | Análogos del glucagón |
EA020537B1 (ru) | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
BRPI0823379A2 (pt) | 2008-12-15 | 2015-07-14 | Zealand Pharma As | Análogos de glucagon |
AU2008365559B2 (en) | 2008-12-15 | 2016-02-25 | Zealand Pharma A/S | Glucagon analogues |
US8748375B2 (en) | 2009-03-17 | 2014-06-10 | Amylin Pharmaceuticals, Llc | Methods for affecting body composition using amylin agonists |
US9156901B2 (en) | 2009-07-13 | 2015-10-13 | Ditte Riber | Acylated glucagon analogues |
US8815541B2 (en) | 2009-11-25 | 2014-08-26 | Novo Nordisk A/S | Method for making polypeptides |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
CN103068841A (zh) | 2010-06-24 | 2013-04-24 | 西兰制药公司 | 胰高血糖素类似物 |
EP2718315B1 (en) * | 2011-06-10 | 2017-12-27 | Novo Nordisk A/S | Pramlintide derivatives |
PE20142113A1 (es) | 2011-12-23 | 2014-12-03 | Zealand Pharma As | Analogos de glucagon |
JP6227629B2 (ja) | 2012-04-19 | 2017-11-08 | ノヴォ ノルディスク アー/エス | ヒトアミリン類似体 |
US8575091B1 (en) | 2012-04-19 | 2013-11-05 | Novo Nordisk A/S | Amylin analogues and pharmaceutical compositions thereof |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
AR097701A1 (es) | 2013-09-19 | 2016-04-13 | Zealand Pharma As | Análogos de amilina |
BR112016008115B1 (pt) | 2013-10-17 | 2024-03-12 | Boehringer Ingelheim International Gmbh | Análogos de glucagon acilados |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
CA2947587C (en) | 2014-05-02 | 2022-10-18 | The Research Foundation For The State University Of New York | Islet amyloid polypeptides with improved solubility |
AR101742A1 (es) | 2014-09-04 | 2017-01-11 | Novo Nordisk As | Agonista del receptor de calcitonina y amilina |
AU2016232218B2 (en) * | 2015-03-18 | 2020-09-10 | Boehringer Ingelheim International Gmbh | Amylin analogues |
TWI784968B (zh) | 2016-09-09 | 2022-12-01 | 丹麥商西蘭製藥公司 | 澱粉素類似物 |
WO2018144671A1 (en) | 2017-02-01 | 2018-08-09 | The Research Foundation For The State University Of New York | Mutant islet amyloid polypeptides with improved solubility and methods for using the same |
-
2017
- 2017-09-08 TW TW106130880A patent/TWI784968B/zh active
- 2017-09-08 AR ARP170102485A patent/AR109514A1/es unknown
- 2017-09-08 US US15/698,743 patent/US10071140B2/en active Active
- 2017-09-11 MY MYPI2019000878A patent/MY197024A/en unknown
- 2017-09-11 PE PE2019000488A patent/PE20190963A1/es unknown
- 2017-09-11 KR KR1020197010080A patent/KR102498393B1/ko active IP Right Grant
- 2017-09-11 IL IL264864A patent/IL264864B2/en unknown
- 2017-09-11 MX MX2019002599A patent/MX2019002599A/es unknown
- 2017-09-11 CA CA3035958A patent/CA3035958A1/en active Pending
- 2017-09-11 SG SG11201901423XA patent/SG11201901423XA/en unknown
- 2017-09-11 DK DK17761907.9T patent/DK3510044T3/da active
- 2017-09-11 JP JP2019513043A patent/JP7064103B2/ja active Active
- 2017-09-11 BR BR112019004534A patent/BR112019004534A2/pt unknown
- 2017-09-11 EP EP17761907.9A patent/EP3510044B1/en active Active
- 2017-09-11 MA MA046180A patent/MA46180A/fr unknown
- 2017-09-11 WO PCT/EP2017/072718 patent/WO2018046719A1/en active Application Filing
- 2017-09-11 CN CN201780055088.9A patent/CN109863168B/zh active Active
- 2017-09-11 AU AU2017322277A patent/AU2017322277B2/en active Active
- 2017-09-11 EA EA201990360A patent/EA201990360A1/ru unknown
- 2017-09-11 UA UAA201901786A patent/UA123369C2/uk unknown
- 2017-09-11 EP EP21209103.7A patent/EP4074729A1/en active Pending
- 2017-09-11 ES ES17761907T patent/ES2901386T3/es active Active
-
2018
- 2018-07-31 US US16/050,102 patent/US20190134159A1/en not_active Abandoned
-
2019
- 2019-02-27 ZA ZA2019/01253A patent/ZA201901253B/en unknown
- 2019-03-04 PH PH12019500474A patent/PH12019500474A1/en unknown
- 2019-03-05 SA SA519401239A patent/SA519401239B1/ar unknown
- 2019-03-07 CL CL2019000575A patent/CL2019000575A1/es unknown
- 2019-03-07 CO CONC2019/0002159A patent/CO2019002159A2/es unknown
- 2019-10-25 US US16/664,168 patent/US11382956B2/en active Active
-
2021
- 2021-07-21 US US17/381,373 patent/US20210346468A1/en active Pending
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