CN1976923B - (s)-奥美拉唑镁盐的固体形式及其制备方法 - Google Patents

(s)-奥美拉唑镁盐的固体形式及其制备方法 Download PDF

Info

Publication number
CN1976923B
CN1976923B CN2005800215619A CN200580021561A CN1976923B CN 1976923 B CN1976923 B CN 1976923B CN 2005800215619 A CN2005800215619 A CN 2005800215619A CN 200580021561 A CN200580021561 A CN 200580021561A CN 1976923 B CN1976923 B CN 1976923B
Authority
CN
China
Prior art keywords
magnesium salt
omeprazole
water
solvent
omeprazole magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800215619A
Other languages
English (en)
Chinese (zh)
Other versions
CN1976923A (zh
Inventor
R·伯伦格尔麦莫
L·考皮
Y·加桑斯古伦
J·梅德拉诺鲁佩雷斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Publication of CN1976923A publication Critical patent/CN1976923A/zh
Application granted granted Critical
Publication of CN1976923B publication Critical patent/CN1976923B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2005800215619A 2004-07-02 2005-06-29 (s)-奥美拉唑镁盐的固体形式及其制备方法 Expired - Fee Related CN1976923B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP200401729 2004-07-02
ES200401729A ES2246149B1 (es) 2004-07-02 2004-07-02 Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
PCT/EP2005/053062 WO2006003163A1 (en) 2004-07-02 2005-06-29 Solid forms of the magnesium salt of (s)-omeprazole and processes for their preparation

Publications (2)

Publication Number Publication Date
CN1976923A CN1976923A (zh) 2007-06-06
CN1976923B true CN1976923B (zh) 2011-08-24

Family

ID=34972307

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800215619A Expired - Fee Related CN1976923B (zh) 2004-07-02 2005-06-29 (s)-奥美拉唑镁盐的固体形式及其制备方法

Country Status (19)

Country Link
US (1) US7902370B2 (enExample)
EP (1) EP1765807B1 (enExample)
JP (2) JP5575366B2 (enExample)
KR (1) KR101290035B1 (enExample)
CN (1) CN1976923B (enExample)
AT (1) ATE425975T1 (enExample)
AU (1) AU2005259205B2 (enExample)
CA (1) CA2570559C (enExample)
CY (1) CY1109048T1 (enExample)
DE (1) DE602005013382D1 (enExample)
DK (1) DK1765807T3 (enExample)
ES (2) ES2246149B1 (enExample)
HR (1) HRP20090211T1 (enExample)
MX (1) MXPA06014736A (enExample)
NO (1) NO20070635L (enExample)
NZ (1) NZ552458A (enExample)
PT (1) PT1765807E (enExample)
WO (1) WO2006003163A1 (enExample)
ZA (1) ZA200700865B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
FR2920428B1 (fr) * 2007-08-29 2012-06-15 Univ Rouen Procede de dedoublement de sels de l'omeprazole
EP2147918A1 (en) * 2008-07-21 2010-01-27 LEK Pharmaceuticals D.D. Process for the preparation of S-omeprazole magnesium in a stable form
CN103044400A (zh) * 2012-12-21 2013-04-17 北京华禧联合科技发展有限公司 埃索美拉唑镁盐及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
PT1078628E (pt) * 1994-07-08 2009-01-27 Astrazeneca Ab Forma de dosagem em comprimidos com unidades múltiplas
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
SE510666C2 (sv) * 1996-12-20 1999-06-14 Astra Ab Nya Kristallmodifikationer
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
ATE306483T1 (de) * 1999-08-26 2005-10-15 Aaipharma Inc Alkoxy-substituierte benzimidazolverbindungen , diese enthaltende arzneimittel und ihre verwendung
US6312712B1 (en) * 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6326384B1 (en) * 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
CA2409258A1 (en) * 2000-05-15 2001-11-22 Ranbaxy Laboratories Limited Novel amorphous form of omeprazole salts
CA2386716C (en) * 2002-05-17 2012-07-24 Bernard Charles Sherman Magnesium salt of s-omeprazole
ATE342263T1 (de) * 2000-08-04 2006-11-15 Takeda Pharmaceutical Salze von benzimidazol-derivaten und deren verwendung
SI20875A (sl) * 2001-04-25 2002-10-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristalna oblika omeprazola
AU2003262375A1 (en) * 2002-04-22 2003-11-03 Sun Pharmaceutical Industries Limited Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts
US6894066B2 (en) * 2002-05-09 2005-05-17 Bernard Charles Sherman Magnesium salt of S-omeprazole
EP1546131A1 (en) * 2002-08-30 2005-06-29 Dr. Reddy's Laboratories Ltd. Amorphous hydrates of esomeprazole magnesium and process for the preparation thereof
EP1556043A1 (en) 2002-10-22 2005-07-27 Ranbaxy Laboratories, Ltd. Amorphous form of esomeprazole salts
US20040242642A1 (en) * 2002-11-18 2004-12-02 Dr. Reddy's Laboratories Limited Crystalline esomeprazole compounds and process for the preparation thereof
WO2004089935A1 (en) * 2003-04-10 2004-10-21 Hetero Drugs Limitd Novel crystalline forms of s-omeprazole magnesium
ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
崔名全等.S-奥美拉唑镁的水相法合成研究.《合成化学》.2002,第10卷193-194. *

Also Published As

Publication number Publication date
JP5575366B2 (ja) 2014-08-20
ES2246149A1 (es) 2006-02-01
KR101290035B1 (ko) 2013-07-30
WO2006003163A1 (en) 2006-01-12
JP2014169302A (ja) 2014-09-18
US20070249684A1 (en) 2007-10-25
CY1109048T1 (enExample) 2014-07-02
ZA200700865B (en) 2009-09-30
CA2570559A1 (en) 2006-01-12
ES2323319T3 (es) 2009-07-13
EP1765807B1 (en) 2009-03-18
NO20070635L (no) 2007-03-20
AU2005259205A1 (en) 2006-01-12
CA2570559C (en) 2012-08-28
EP1765807A1 (en) 2007-03-28
CN1976923A (zh) 2007-06-06
DK1765807T3 (da) 2009-06-08
JP2008505160A (ja) 2008-02-21
NZ552458A (en) 2010-07-30
HRP20090211T1 (en) 2009-05-31
DE602005013382D1 (de) 2009-04-30
PT1765807E (pt) 2009-04-13
ATE425975T1 (de) 2009-04-15
US7902370B2 (en) 2011-03-08
ES2246149B1 (es) 2007-06-01
MXPA06014736A (es) 2007-06-25
KR20070031992A (ko) 2007-03-20
AU2005259205B2 (en) 2011-01-27

Similar Documents

Publication Publication Date Title
US6162816A (en) Crystalline form of the S-enantiomer of omeprazole
EP2262790B1 (en) Crystal of benzimidazole compound
WO2002044167A1 (en) Process for the crystallization of (r)- or (s)-lansoprazole
CN1258295A (zh) 新型s－奥美拉唑
JP2002522537A (ja) 改良されたオメプラゾールの方法および組成物
EP2227462A1 (en) Crystalline solvated forms of (r) -2- [[[3-methyl-4- (2, 2, 2-trifluoroethoxy) -2-pyridinyl]methyl]sulfinyl]-1h-benz imidazole
US20100280077A1 (en) Process for Preparation of Stable Amorphous R-Lansoprazole
JP2003516985A (ja) 改良されたオメプラゾール工程および該化合物の組成物
CN1976923B (zh) (s)-奥美拉唑镁盐的固体形式及其制备方法
CN102241668B (zh) S-奥美拉唑盐
WO2005082888A1 (en) Process for the preparation of magnesium salt of omeprazole
US8247567B2 (en) Process for solvent removal from omeprazole salts
CN109111430B (zh) 一种右兰索拉唑晶型a及其制备方法
HK1107093A (en) Solid forms of the magnesium salt of(s)-omeprazole and processes for their preparation
KR20100101405A (ko) 비결정형의 (+)-란소프라졸 제조방법 및 이에 사용되는 (+)-란소프라졸 알코올레이트
JPWO2001002389A1 (ja) ベンズイミダゾール化合物の結晶

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1107093

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1107093

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110824

Termination date: 20170629