CN1970590A - 由聚合物水凝胶与溶剂接触得到的固体聚合物 - Google Patents
由聚合物水凝胶与溶剂接触得到的固体聚合物 Download PDFInfo
- Publication number
- CN1970590A CN1970590A CNA2006101494752A CN200610149475A CN1970590A CN 1970590 A CN1970590 A CN 1970590A CN A2006101494752 A CNA2006101494752 A CN A2006101494752A CN 200610149475 A CN200610149475 A CN 200610149475A CN 1970590 A CN1970590 A CN 1970590A
- Authority
- CN
- China
- Prior art keywords
- hydrogel
- temperature
- gel
- solid polymer
- polyacrylamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 153
- 229920000642 polymer Polymers 0.000 title claims abstract description 88
- 239000007787 solid Substances 0.000 title claims abstract description 47
- 239000002904 solvent Substances 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 185
- 239000000178 monomer Substances 0.000 claims abstract description 93
- 230000008569 process Effects 0.000 claims abstract description 50
- 239000007864 aqueous solution Substances 0.000 claims abstract description 11
- 239000000499 gel Substances 0.000 claims description 120
- 239000000203 mixture Substances 0.000 claims description 113
- 229920002401 polyacrylamide Polymers 0.000 claims description 60
- 239000000126 substance Substances 0.000 claims description 51
- 150000005846 sugar alcohols Polymers 0.000 claims description 44
- 238000005406 washing Methods 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 41
- 239000000463 material Substances 0.000 claims description 37
- XXQBGBUZLWZPKT-UHFFFAOYSA-N n-prop-2-enoylbuta-2,3-dienamide Chemical compound C=CC(=O)NC(=O)C=C=C XXQBGBUZLWZPKT-UHFFFAOYSA-N 0.000 claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 230000005540 biological transmission Effects 0.000 claims description 18
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- -1 polysiloxane Polymers 0.000 claims description 10
- 239000002019 doping agent Substances 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 7
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000008472 epithelial growth Effects 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 3
- 229920002955 Art silk Polymers 0.000 claims description 2
- 102000018997 Growth Hormone Human genes 0.000 claims description 2
- 108010051696 Growth Hormone Proteins 0.000 claims description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 2
- 239000004642 Polyimide Substances 0.000 claims description 2
- 102000013275 Somatomedins Human genes 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000003429 antifungal agent Substances 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 230000003327 cancerostatic effect Effects 0.000 claims description 2
- 239000000824 cytostatic agent Substances 0.000 claims description 2
- MHCLJIVVJQQNKQ-UHFFFAOYSA-N ethyl carbamate;2-methylprop-2-enoic acid Chemical compound CCOC(N)=O.CC(=C)C(O)=O MHCLJIVVJQQNKQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000122 growth hormone Substances 0.000 claims description 2
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 claims description 2
- 229960003988 indigo carmine Drugs 0.000 claims description 2
- 235000012738 indigotine Nutrition 0.000 claims description 2
- 239000004179 indigotine Substances 0.000 claims description 2
- 239000003410 keratolytic agent Substances 0.000 claims description 2
- 229960000907 methylthioninium chloride Drugs 0.000 claims description 2
- 230000003533 narcotic effect Effects 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920001721 polyimide Polymers 0.000 claims description 2
- 229920001470 polyketone Polymers 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 230000001568 sexual effect Effects 0.000 claims description 2
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 description 79
- 238000002156 mixing Methods 0.000 description 67
- 239000000243 solution Substances 0.000 description 44
- 239000003999 initiator Substances 0.000 description 40
- 238000006243 chemical reaction Methods 0.000 description 39
- 230000015572 biosynthetic process Effects 0.000 description 34
- 239000000047 product Substances 0.000 description 33
- 238000001879 gelation Methods 0.000 description 22
- 238000002360 preparation method Methods 0.000 description 22
- 230000003068 static effect Effects 0.000 description 22
- 239000007788 liquid Substances 0.000 description 18
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 16
- 230000002028 premature Effects 0.000 description 16
- 239000011541 reaction mixture Substances 0.000 description 16
- 238000004132 cross linking Methods 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 15
- IRLPACMLTUPBCL-KQYNXXCUSA-N 5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O IRLPACMLTUPBCL-KQYNXXCUSA-N 0.000 description 14
- 230000008859 change Effects 0.000 description 12
- 238000009826 distribution Methods 0.000 description 11
- 238000010438 heat treatment Methods 0.000 description 11
- 150000003254 radicals Chemical class 0.000 description 10
- 230000008961 swelling Effects 0.000 description 10
- 241000699700 Ondatra zibethicus Species 0.000 description 9
- 238000013461 design Methods 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000012530 fluid Substances 0.000 description 7
- 229910000831 Steel Inorganic materials 0.000 description 6
- 239000010410 layer Substances 0.000 description 6
- 239000010959 steel Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000003292 glue Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 238000006068 polycondensation reaction Methods 0.000 description 5
- 238000010526 radical polymerization reaction Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 241000209094 Oryza Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 4
- 235000019395 ammonium persulphate Nutrition 0.000 description 4
- 239000012267 brine Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 230000004907 flux Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 238000000265 homogenisation Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000001746 injection moulding Methods 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- 239000012429 reaction media Substances 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000007872 degassing Methods 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 238000002386 leaching Methods 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 238000012643 polycondensation polymerization Methods 0.000 description 3
- 239000002265 redox agent Substances 0.000 description 3
- 238000000518 rheometry Methods 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 150000001336 alkenes Chemical group 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000003637 basic solution Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000006258 conductive agent Substances 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000002939 deleterious effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000001502 gel electrophoresis Methods 0.000 description 2
- 229920000140 heteropolymer Polymers 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000000710 polymer precipitation Methods 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000007447 staining method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- JHPBZFOKBAGZBL-UHFFFAOYSA-N (3-hydroxy-2,2,4-trimethylpentyl) 2-methylprop-2-enoate Chemical compound CC(C)C(O)C(C)(C)COC(=O)C(C)=C JHPBZFOKBAGZBL-UHFFFAOYSA-N 0.000 description 1
- SCMVPOVMOHQFKU-UHFFFAOYSA-N 1-(aziridin-1-yl)prop-2-en-1-one Chemical compound C=CC(=O)N1CC1 SCMVPOVMOHQFKU-UHFFFAOYSA-N 0.000 description 1
- IUVCFHHAEHNCFT-INIZCTEOSA-N 2-[(1s)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one Chemical compound C1=C(F)C(OC(C)C)=CC=C1C(C1=C(N)N=CN=C11)=NN1[C@@H](C)C1=C(C=2C=C(F)C=CC=2)C(=O)C2=CC(F)=CC=C2O1 IUVCFHHAEHNCFT-INIZCTEOSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- YXYJVFYWCLAXHO-UHFFFAOYSA-N 2-methoxyethyl 2-methylprop-2-enoate Chemical compound COCCOC(=O)C(C)=C YXYJVFYWCLAXHO-UHFFFAOYSA-N 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 239000004160 Ammonium persulphate Substances 0.000 description 1
- 229920001823 Aquamid® Polymers 0.000 description 1
- GIEIXQWYSAYJDM-UHFFFAOYSA-N C=C=CC(=O)NC(=O)C=C.C(C=C)(=O)N Chemical compound C=C=CC(=O)NC(=O)C=C.C(C=C)(=O)N GIEIXQWYSAYJDM-UHFFFAOYSA-N 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 150000003926 acrylamides Chemical class 0.000 description 1
- 150000001266 acyl halides Chemical class 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001345 alkine derivatives Chemical class 0.000 description 1
- VAZSKTXWXKYQJF-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)OOS([O-])=O VAZSKTXWXKYQJF-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 239000012986 chain transfer agent Substances 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000011243 crosslinked material Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N ethyl acetate Substances CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
- FPVGTPBMTFTMRT-NSKUCRDLSA-L fast yellow Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(N)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 FPVGTPBMTFTMRT-NSKUCRDLSA-L 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229950007687 macrogol ester Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical compound COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 238000010094 polymer processing Methods 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/02—Polymerisation in bulk
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
- C08F20/52—Amides or imides
- C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F20/56—Acrylamide; Methacrylamide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polymerisation Methods In General (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101266 | 2001-08-25 | ||
| DKPA200101266 | 2001-08-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028166914A Division CN1296393C (zh) | 2001-08-25 | 2002-08-26 | 均质聚合物制备的温度控制方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1970590A true CN1970590A (zh) | 2007-05-30 |
Family
ID=8160682
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101494752A Pending CN1970590A (zh) | 2001-08-25 | 2002-08-26 | 由聚合物水凝胶与溶剂接触得到的固体聚合物 |
| CNB028166914A Expired - Lifetime CN1296393C (zh) | 2001-08-25 | 2002-08-26 | 均质聚合物制备的温度控制方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028166914A Expired - Lifetime CN1296393C (zh) | 2001-08-25 | 2002-08-26 | 均质聚合物制备的温度控制方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20030176602A1 (https=) |
| JP (1) | JP4015618B2 (https=) |
| KR (1) | KR100502135B1 (https=) |
| CN (2) | CN1970590A (https=) |
| WO (1) | WO2003018641A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY130475A (en) * | 2000-08-25 | 2007-06-29 | Contura As | Polyacrylamide hydrogel and its use as an endoprosthesis |
| US7824711B2 (en) | 2003-12-11 | 2010-11-02 | Isto Technologies, Inc. | Particulate cartilage system |
| EP1589040B1 (en) * | 2004-03-24 | 2008-09-10 | Nippon Shokubai Co., Ltd. | Method for continuous production of water absorbent resin |
| EP1750769B1 (en) * | 2004-05-20 | 2013-01-23 | Mentor Worldwide LLC | Methods for making injectable polymer hydrogels |
| US20060222596A1 (en) * | 2005-04-01 | 2006-10-05 | Trivascular, Inc. | Non-degradable, low swelling, water soluble radiopaque hydrogel polymer |
| US9476123B2 (en) | 2005-05-31 | 2016-10-25 | Aspen Aerogels, Inc. | Solvent management methods for gel production |
| US20060270248A1 (en) * | 2005-05-31 | 2006-11-30 | Gould George L | Solvent Management Methods for Gel Production |
| JP5292533B2 (ja) | 2005-08-26 | 2013-09-18 | ジンマー・インコーポレイテッド | インプラントおよび関節疾患の治療、置換および治療方法 |
| US7720533B2 (en) * | 2006-12-20 | 2010-05-18 | Zimmer Orthobiologicals, Inc. | Apparatus and method for delivering a biocompatible material to a surgical site |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| AU2008240191B2 (en) | 2007-04-12 | 2013-09-19 | Zimmer, Inc. | Compositions and methods for tissue repair |
| CN101161689B (zh) * | 2007-09-21 | 2010-05-19 | 东华大学 | 一种快速响应和高力学性能水凝胶的制备方法 |
| CN101293942B (zh) * | 2008-04-22 | 2011-06-01 | 东华大学 | 紫外引发法制备快速响应的互穿网络复合水凝胶的方法 |
| EP2192409B1 (en) * | 2008-11-26 | 2014-04-23 | Corning Incorporated | Label independent detection biosensor composition and methods thereof |
| CN103864986B (zh) * | 2012-12-07 | 2016-05-25 | 中国石油化工股份有限公司 | 一种丙烯酰胺聚合物及其制备方法和应用 |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| WO2019202981A1 (ja) * | 2018-04-17 | 2019-10-24 | 国立大学法人東京海洋大学 | スケール厚さ推定システム、スケール厚さ推定方法、およびスケール厚さ推定プログラム |
| CN110054727B (zh) * | 2019-04-25 | 2022-12-20 | 西安万德能源化学股份有限公司 | 一种聚丙烯酰胺纳米微球的制备方法及装置 |
| CN111171227B (zh) * | 2020-01-07 | 2021-03-02 | 北京理工大学 | 水下柔性施罗德散射体复合结构及其制备方法 |
| CN111269354B (zh) * | 2020-02-29 | 2021-02-02 | 湖南大学 | 一种光固化3d打印用抗冻导电水凝胶及其制备方法 |
| CN111978102B (zh) * | 2020-08-17 | 2022-02-18 | 绍兴职业技术学院 | 一种海绵城市节能触变媒可降解砂浆 |
| CN114752007B (zh) * | 2022-04-08 | 2023-08-01 | 青岛科技大学 | 一种聚丙烯酰胺水溶液聚合的生产工艺及生产系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH592896A5 (https=) * | 1974-04-04 | 1977-11-15 | Lonza Ag | |
| CH669387A5 (en) * | 1986-07-23 | 1989-03-15 | Clinique Medicale Hopital Cant | Cylindrical polyacrylamide gels immobilised pH gradient - used in one-dimensional electrophoresis |
| SU1797612A1 (ru) * | 1987-08-10 | 1993-02-23 | Nippon Catalytic Chem Ind | Cпocoб пoлучehия boдoпoглoщaющeй cmoлы |
| US5658329A (en) * | 1995-02-14 | 1997-08-19 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
| US5700289A (en) * | 1995-10-20 | 1997-12-23 | North Shore University Hospital Research Corporation | Tissue-engineered bone repair using cultured periosteal cells |
| CN1068612C (zh) * | 1999-01-15 | 2001-07-18 | 吉林富华医用高分子材料有限公司 | 医用交联聚丙烯酰胺水凝胶的制备方法 |
-
2002
- 2002-08-26 CN CNA2006101494752A patent/CN1970590A/zh active Pending
- 2002-08-26 WO PCT/IB2002/003441 patent/WO2003018641A1/en not_active Ceased
- 2002-08-26 CN CNB028166914A patent/CN1296393C/zh not_active Expired - Lifetime
- 2002-08-26 US US10/227,265 patent/US20030176602A1/en not_active Abandoned
- 2002-08-26 JP JP2003523500A patent/JP4015618B2/ja not_active Expired - Lifetime
- 2002-08-26 KR KR10-2004-7002730A patent/KR100502135B1/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040068110A (ko) | 2004-07-30 |
| CN1547592A (zh) | 2004-11-17 |
| JP4015618B2 (ja) | 2007-11-28 |
| CN1296393C (zh) | 2007-01-24 |
| KR100502135B1 (ko) | 2005-07-20 |
| WO2003018641A1 (en) | 2003-03-06 |
| JP2005501141A (ja) | 2005-01-13 |
| US20030176602A1 (en) | 2003-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1970590A (zh) | 由聚合物水凝胶与溶剂接触得到的固体聚合物 | |
| CN112694610A (zh) | 一种改性对位芳纶聚合液、涂覆浆料、锂电池隔膜及其制备方法 | |
| Afroz et al. | Synthesis and characterization of polyethylene oxide (PEO)—N, N-dimethylacrylamide (DMA) hydrogel by gamma radiation | |
| CN113527666A (zh) | 一种连续化尼龙聚合方法 | |
| KR101290886B1 (ko) | 폴리머 섬유를 제조하기 위한 방사용액의 제조방법 및 시스템 | |
| EP1948734B1 (en) | Fluoropolymer composition | |
| CN101570603B (zh) | 一种改善疏水聚合物材料表面亲水性的方法 | |
| CN108047386A (zh) | 一种用于3d打印的柔性光敏树脂及其制备方法 | |
| CN113980267A (zh) | 一种高粘度的本征阻燃聚酰胺及其制备方法 | |
| CN106267366A (zh) | 一种利用3d打印制备高强高韧聚离子水凝胶支架的方法 | |
| US6080282A (en) | Electrolytic solution for use as gel electrolyte and process for making the same | |
| Hu et al. | Suppressing syneresis in poly (N-isopropylacrylamide) hydrogels by incorporating poly (ethylene glycol) | |
| DE2127840B2 (de) | Härtbare Formpulver | |
| CN111617311B (zh) | 一种基于碱基自组装的强韧性自修复组织黏附水凝胶材料的制备方法及应用 | |
| CN119060272B (zh) | 一种3d打印辅助水相前端聚合构筑水凝胶基芯片的方法 | |
| Daengmankhong et al. | Water-soluble macromers based on 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (Na-AMPS) for rapid in situ hydrogel film formation | |
| CN118652554A (zh) | 一种通孔结构聚丙烯疏水泡沫、制备方法及其应用 | |
| HK1107361A (en) | A solid polymer obtainable by contacting a polymer hydrogel with a solvent | |
| Nakatani | Scale‐up theory for twin‐screw extruder, keeping the resin temperature unchanged | |
| CN114380956B (zh) | 一种非对称吸水树脂的制备方法及制备所用的液滴成型器 | |
| CN116043362A (zh) | 一种具有表面凹凸结构的聚合物纤维及其制备方法 | |
| Kubilay et al. | Synthesis and characterization of p (N-isopropylacrylamide) hydrogels with tunable swelling behavior using different crosslinkers | |
| CN116606519A (zh) | 一种高附着力pvdf复合材料及其制备方法 | |
| CN100513656C (zh) | 一种含有蛋白质的纤维纺丝原液及其制造方法 | |
| CN104420373A (zh) | 一种聚季铵盐固色剂及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1107361 Country of ref document: HK |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1107361 Country of ref document: HK |