CN1954880A - 安神补脑颗粒剂及其制备方法 - Google Patents
安神补脑颗粒剂及其制备方法 Download PDFInfo
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Abstract
Description
工艺 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | ||
五味药提取 | 五味药煎煮 | 加水量(kg)时间(hr)次数浓缩后相对密度 | 8.5531.20--1.25 | 35151.30--1.32 | 20241.28 | 25321.3 |
醇沉 | 醇含量(第一次)醇含量(第二次) | 50%65% | 52%64% | 55%63% | 54%62% | |
鹿茸提取 | 煎煮时间 | 第一、二次第三、四次第五次第六次第七、八次相对密度 | 5hr4hr3hr2hr2hr1.3 | 4hr3hr2hr1.25 | 4hr3hr1hr1.22 | 1hr2hr3hr1.2 |
醇沉 | 醇用量第一次)相对密度醇用量(第二次)相对密度 | 50ml1.2570ml1.12 | 70ml1.3050ml1.18 | 60ml1.2160ml1.20 | 60ml1.2865ml1.10 | |
颗粒剂 | 糊精(g)甘露醇(g)甜菊素(g) | 23062050 | 24060020 | 25057030 | 26058040 |
实施例 | 干膏得率(%) |
123 | 27.4129.5629.98 |
45 | 28.9528.44 |
实施例 | 水提浸膏粉(g) | 65%醇沉浸膏粉(g) |
123均值 | 27.4129.5629.9828.98 | 10.119.939.809.95 |
处方 | 1 | 2 | 3 | 4 | 5 | 6 | |
稠膏混合物 | 处方量提取物 | 处方量提取物 | 处方量提取物 | 处方量提取物 | 处方量提取物 | 处方量提取物 | |
糊精甘露醇蔗糖甜菊素 | 240g600g | 240g600g | 240g600g25g | 240g600g25g | 240g600g50g | 240g600g100g | |
质量评价 | 溶化性粒度口感 | 合格合格一般 | 合格合格差 | 合格合格一般 | 合格合格较好 | 合格合格优 | 合格合格优 |
处方 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | |
提取物稠膏混合物糊精甘露醇甜菊素 | 350g260g550g50g | 200g200g620g50g | 250g220g600g40g | 300g280g550g40g | 200g200g650g40g. | 340200550100 | 26020058080 | |
质量评价 | 溶化性口感粒度 | 合格优合格 | 合格优合格 | 合格优合格 | 合格优合格 | 合格优合格 | 合格优合格 |
样品编号 | 时间(月) | 性状 | 鉴别 | 水分 | 溶化性 | 标示含量(mg/粒) |
实施例1 | 0123 | 棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒 | 符合规定符合规定符合规定符合规定 | 3.65%3.75%3.86%3.75% | 符合规定符合规定符合规定符合规定 | 2.162.162.172.17 |
样品编号 | 时间(月) | 性状 | 鉴别 | 水分 | 溶化性 | 标示含量(mg/粒) |
实施例2 | 0123 | 棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒 | 符合规定符合规定符合规定符合规定 | 3.54%3.64%3.59%3.48% | 符合规定符合规定符合规定符合规定 | 2.192.182.182.19 |
样品编号 | 时间(月) | 性状 | 鉴别 | 水分 | 溶化性 | 标示含量(mg/粒) |
实施例3 | 0 | 棕黄色颗粒 | 符合规定 | 3.47% | 符合规定 | 2.16 |
123 | 棕黄色颗粒棕黄色颗粒棕黄色颗粒 | 符合规定符合规定符合规定 | 3.47%3.57%3.39% | 符合规定符合规定符合规定 | 2.152.172.18 |
样品编批号 | 时间(月) | 性状 | 鉴别 | 水分 | 溶化性 | 标示含量(mg/粒) |
实施例1 | 036121824 | 棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒 | 符合规定符合规定符合规定符合规定符合规定符合规定 | 3.65%3.84%3.79%3.91%3.86%3.84% | 符合规定符合规定符合规定符合规定符合规定符合规定 | 2.162.172.172.172.162.15 |
样品编号 | 时间(月) | 性状 | 鉴别 | 水分 | 溶化性 | 标示含量(mg/粒) |
实施例2 | 036121824 | 棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒 | 符合规定符合规定符合规定符合规定符合规定符合规定 | 3.54%3.54%3.64%3.74%3.67%3.65% | 符合规定符合规定符合规定符合规定符合规定符合规定 | 2.192.192.192.192.182.18 |
样品 | 时间(月) | 性状 | 鉴别 | 水分 | 溶化性 | 标示含量(mg/粒) |
实施例3 | 03 | 棕黄色颗粒棕黄色颗粒 | 符合规定符合规定 | 3.47%3.46% | 符合规定符合规定 | 2.162.17 |
6121824 | 棕黄色颗粒棕黄色颗粒棕黄色颗粒棕黄色颗粒 | 符合规定符合规定符合规定符合规定 | 3.43%3.56%3.62%3.64% | 符合规定符合规定符合规定符合规定 | 2.182.172.172.15 |
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CN1954880A true CN1954880A (zh) | 2007-05-02 |
CN100443113C CN100443113C (zh) | 2008-12-17 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107582947A (zh) * | 2017-09-30 | 2018-01-16 | 莱芜房干康复医院 | 一种益智补脑的中药组合物及其制备方法 |
CN107789596A (zh) * | 2016-08-31 | 2018-03-13 | 浙江康恩贝制药股份有限公司 | 一种安神补脑颗粒制备工艺 |
CN115089685A (zh) * | 2022-03-01 | 2022-09-23 | 江苏聚荣制药集团有限公司 | 一种无糖型安神补脑液及其制备方法 |
CN116098962A (zh) * | 2022-12-16 | 2023-05-12 | 无锡济煜山禾药业股份有限公司 | 一种益寿强身颗粒的制备方法 |
-
2005
- 2005-10-28 CN CNB200510116707XA patent/CN100443113C/zh active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107789596A (zh) * | 2016-08-31 | 2018-03-13 | 浙江康恩贝制药股份有限公司 | 一种安神补脑颗粒制备工艺 |
CN107582947A (zh) * | 2017-09-30 | 2018-01-16 | 莱芜房干康复医院 | 一种益智补脑的中药组合物及其制备方法 |
CN115089685A (zh) * | 2022-03-01 | 2022-09-23 | 江苏聚荣制药集团有限公司 | 一种无糖型安神补脑液及其制备方法 |
CN116098962A (zh) * | 2022-12-16 | 2023-05-12 | 无锡济煜山禾药业股份有限公司 | 一种益寿强身颗粒的制备方法 |
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