CN1943672A - A Chinese traditional medicinal composition for treatment of dermatosis and its preparation method - Google Patents
A Chinese traditional medicinal composition for treatment of dermatosis and its preparation method Download PDFInfo
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- CN1943672A CN1943672A CNA2005101059501A CN200510105950A CN1943672A CN 1943672 A CN1943672 A CN 1943672A CN A2005101059501 A CNA2005101059501 A CN A2005101059501A CN 200510105950 A CN200510105950 A CN 200510105950A CN 1943672 A CN1943672 A CN 1943672A
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Abstract
This invention provides a Chinese traditional medicinal composition for treatment of dermatosis which comes under the field of the Chinese traditional medicine. The medicine is prepared by a certain ratio of honeysuckle, astragalus root, radix scutellariaee, fructus cnidi, kuhseng, Chinese corktree bark, angelica. It has obvious curative efficiency for treating Itch of skin, hives. The invention also reveals its' preparing method.
Description
Technical field
The present invention relates to dermopathic Chinese medicine composition of a kind of treatment and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Pruritus be the most painful in the dermatosis also be one of modal symptom because it shows effect repeatedly, longer duration has had a strong impact on patient's physical and mental health.The dermopathic medicine of treatment mostly is external at present, and pollution clothes uses inconvenient.
The invention provides the caused papular urticaria of a kind of treatment retention of damp-heat in the interior, the oral Chinese medicine of skin pruritus symptoms such as dermatitis aestivale greatly facilitates the patient, has served society.
Summary of the invention
One of purpose of the present invention provides a kind of Chinese medicine composition.
Two of purpose of the present invention provides the preparation method of this Chinese medicine composition.
The present invention seeks to be achieved through the following technical solutions:
Medicine of the present invention is made by following bulk drugs:
Flos Lonicerae 62-186 weight portion Fructus Gardeniae 62-186 weight portion Radix Scutellariae 62-186 weight portion
Radix Sophorae Flavescentis 62-186 weight portion Cortex Phellodendri 46-139 weight portion Radix Gentianae 46-139 weight portion
Radix Angelicae Dahuricae 62-186 weight portion Cortex Dictamni 62-186 weight portion Fructus Cnidii 62-186 weight portion
Periostracum Cicadae 31-93 weight portion Fructus Forsythiae 62-186 weight portion Fructus Kochiae 62-186 weight portion
Radix Rehmanniae 93-279 weight portion Herba Artemisiae Annuae 93-279 weight portion Herba Pogostemonis 62-186 weight portion
Radix Glycyrrhizae 31-93 weight portion
Medicine optimum weight part proportioning of the present invention is:
The Flos Lonicerae 124 weight portion Fructus Gardeniaes 124 weight portion Radix Scutellariaes 124 weight portion Radix Sophorae Flavescentiss 124 weight portion Cortex Phellodendris 93 weight portion Radix Gentianae 93 weight portion Radixs Angelicae Dahuricae 124 weight portion Cortex Dictamni 124 weight portion Fructus Cnidiis 124 weight portion Periostracum Cicadaes 62 weight portion Fructus Forsythiaes 124 weight portion Fructus Kochiae 124 weight portion Radix Rehmanniae 186 weight portion Herba Artemisiae Annuaes 186 weight portion Herba Pogostemonis 124 weight portion Radix Glycyrrhizaes 62 weight portions
Above crude drug can be made multiple oral formulations, comprises tablet, capsule, granule, soft capsule, pill etc., and the common preparation process of these preparations is:
More than ten Six-elements, get Herba Pogostemonis, Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Herba Artemisiae Annuae and extract volatile oil, the aqueous solution after distillation device is in addition collected; Medicinal residues and all the other Radix Scutellariaes etc. ten decocts with water two～four times simply, and collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, and are condensed into clear paste, and be standby, makes required dosage form.
Common dosage form and preparation method are:
Add adjuvant in clear paste, granulate, add volatile oil, mixing is made granule.
Clear paste is concentrated, dry, pulverize, add adjuvant, volatile oil is prepared into pill.
Clear paste is added volatile oil, add water and adjust total amount, filter, be prepared into oral liquid.
Best preparation method is:
More than ten Six-elements, get Herba Pogostemonis, Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Herba Artemisiae Annuae and extract volatile oil, the aqueous solution after distillation device is in addition collected; Medicinal residues and all the other Radix Scutellariaes etc. ten decocts with water three times simply, adds 8 times of amounts for the first time and decocts 2 hours, add for the second time 6 times of amounts and decocted 1 hour, add 5 times of amounts for the third time and decocted collecting decoction 1 hour, filter, filtrate and above-mentioned aqueous solution merge, and are concentrated into the clear paste of relative density 1.20～1.22 (80 ℃).1 part of qinghuo reagent, 0.81 part of sucrose, 0.5 part in dextrin, stevioside is 0.5% of a sucrose amount, makes granule with marumerization, drying adds volatile oil and Oleum menthae 0.5ml such as above-mentioned Herba Pogostemonis, mixing, promptly.
This product can be used for treating dermatosis, for determining drug effect, this product has been carried out pharmacodynamics test research, and particles used dose is by best proportioning of the present invention and optimum process preparation and get in the test.Concrete test is as follows:
1, to the influence of drug-induced skin pruritus
Test method: get 40 of Cavia porcelluss, body weight 350～450g, male and female half and half, be divided into 4 groups at random, cut off right back breech in preceding 1 hour and use sand paper scratch mark, the about 2cm2 of area in test, each group gavages through stomach, itch-stopping cicada granule high and low dose group is administration 32g/kg, 16g/kg respectively, matched group chlorphenamine 4mg/kg, and the blank group is given the normal saline with volume.Behind the 30min, with the 50 μ l of 0.05% hydrochloric acid histamine, smear scratch mark, the scratch mark action does not appear licking in Cavia porcellus in the 30min, and repaste is smeared histamine 1 time, and so repeatable operation till occurring, writes down and smears histamine's number of times and accumulative total consumption.The results are shown in Table 1.
The influence of table 1 guinea pig skin pruritus
| Group | Dosage | Smear histamine's situation | |
| Number of times (X ± SD) | Consumption (μ l) (X ± SD) | ||
| Blank group chlorphenamine group this product high dose group this product low dose group | With volume normal saline 4mg/kg 8g/kg 2g/kg | 5.0±1.6 9.3±2.1** 8.5±1.4** 7.4±1.7* | 125.0±39.0 232.5±53.0** 212.5±34.9** 185.0±43.0* |
Show that this product has itching-relieving action.
2, to the effect of non-immunity contact urticaria
Get 40 of Cavia porcelluss, body weight 350～450g, male and female half and half, be divided into 4 groups at random, grouping administration or normal saline, dosage is the same, each group is made into 5% cinnamic aldehyde (CA) with dehydrated alcohol and smears Cavia porcellus auricle two sides, in 15 after stomach gavages corresponding medicine or normal saline 30min, 30,45,60,120, the 180min thickness of four points of kind of calliper auricle, income value is a Cavia porcellus ear swelling value, the results are shown in Table 2.
| Group | Dosage | Ear swelling value (10 -3)mm( X±s) | |||||
| 15 | 30 | 45 | 60 | 120 | 180(min) | ||
| Blank group chlorphenamine group this product high dose group this product low dose group | With volume normal saline 4mg/kg 8g/k39g 2g/kg | 39±13 37±10** 39±13** 38±7 | 54±11 47±11** 48±13** 60±13 | 375±95 240±45** 264±50** 358±72 | 274±56 120±43** 136±53** 161±6 | 128±56 49±29** 58±35** 72±36 | 87±55 10±5** 18±12** 21±9** |
Show that this product has the effect that suppresses mice ear.
Below by implementing to further specify technical scheme of the present invention, but this applies for that claimed scope is not limited in
The described content of embodiment.
The specific embodiment:
Embodiment 1
[prescription] Flos Lonicerae 124g Fructus Gardeniae 124g Radix Scutellariae 124g Radix Sophorae Flavescentis 124g
Cortex Phellodendri 93g Radix Gentianae 93g Radix Angelicae Dahuricae 124g Cortex Dictamni 124g
Fructus Cnidii 124g Periostracum Cicadae 62g Fructus Forsythiae 124g Fructus Kochiae 124g
Radix Rehmanniae 186g Herba Artemisiae Annuae 186g Herba Pogostemonis 124g Radix Glycyrrhizae 62g
[method for making] above ten Six-elements are got Herba Pogostemonis, Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Herba Artemisiae Annuae extraction volatile oil, and the aqueous solution after distillation device is in addition collected; Medicinal residues and all the other Radix Scutellariaes etc. ten decocts with water three times simply, adds 8 times of amounts for the first time and decocts 2 hours, add for the second time 6 times of amounts and decocted 1 hour, add 5 times of amounts for the third time and decocted collecting decoction 1 hour, filter, filtrate and above-mentioned aqueous solution merge, and are concentrated into the clear paste of relative density 1.20～1.22 (80 ℃).1 part of qinghuo reagent, 0.81 part of sucrose, 0.5 part in dextrin, stevioside is 0.5% of a sucrose amount, makes granule with marumerization, and drying adds volatile oil and Oleum menthae 0.5ml such as above-mentioned Herba Pogostemonis, and mixing makes 1000g, promptly altogether.
Embodiment 2
[prescription] Flos Lonicerae 62g Fructus Gardeniae 62g Radix Scutellariae 62g Radix Sophorae Flavescentis 62g
Cortex Phellodendri 46.5g Radix Gentianae 46.5g Radix Angelicae Dahuricae 62g Cortex Dictamni 62g
Fructus Cnidii 62g Periostracum Cicadae 31g Fructus Forsythiae 62g Fructus Kochiae 62g
Radix Rehmanniae 93g Herba Artemisiae Annuae 93g Herba Pogostemonis 62g Radix Glycyrrhizae 31g
[method for making] above ten Six-elements are got Herba Pogostemonis, Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Herba Artemisiae Annuae extraction volatile oil, and the aqueous solution after distillation device is in addition collected; Medicinal residues and all the other Radix Scutellariaes etc. ten decocts with water three times simply, adds 8 times of amounts for the first time and decocts 2 hours, add for the second time 6 times of amounts and decocted 1 hour, add 5 times of amounts for the third time and decocted collecting decoction 1 hour, filter, filtrate and above-mentioned aqueous solution merge, and are concentrated into the clear paste of relative density 1.20～1.22 (80 ℃).And the continuation drying under reduced pressure, pulverize, add 3% carboxymethyl starch sodium, and add microcrystalline Cellulose adjustment total amount to 200g, granulate, add volatile oil, mixing, tabletting is made 500.
Embodiment 3:
[prescription] Flos Lonicerae 248g Fructus Gardeniae 248g Radix Scutellariae 248g Radix Sophorae Flavescentis 248g
Cortex Phellodendri 186g Radix Gentianae 186g Radix Angelicae Dahuricae 248g Cortex Dictamni 248g
Fructus Cnidii 248g Periostracum Cicadae 124g Fructus Forsythiae 248g Fructus Kochiae 248g
Radix Rehmanniae 372g Herba Artemisiae Annuae 372g Herba Pogostemonis 248g Radix Glycyrrhizae 124g
[method for making] above ten Six-elements are got Herba Pogostemonis, Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Herba Artemisiae Annuae extraction volatile oil, and the aqueous solution after distillation device is in addition collected; Medicinal residues and all the other Radix Scutellariaes etc. ten decocts with water three times simply, adds 8 times of amounts for the first time and decocts 2 hours, add for the second time 6 times of amounts and decocted 1 hour, add 5 times of amounts for the third time and decocted collecting decoction 1 hour, filter, filtrate and above-mentioned aqueous solution merge, and are concentrated into the clear paste of relative density 1.20～1.22 (80 ℃).The qinghuo reagent concentrating under reduced pressure is also dry, pulverizes, and adds carboxymethyl starch sodium 60g, adds microcrystalline Cellulose and adjusts total amount to 2000g, adds volatile oil and Oleum menthae 1.0ml such as above-mentioned Herba Pogostemonis, mixing, and pill, promptly.
Claims (6)
1, the dermopathic Chinese medicine composition of a kind of treatment is characterized in that this Chinese medicine composition made by following raw material medicaments:
Flos Lonicerae 62-186 weight portion Fructus Gardeniae 62-186 weight portion Radix Scutellariae 62-186 weight portion
Radix Sophorae Flavescentis 62-186 weight portion Cortex Phellodendri 46-139 weight portion Radix Gentianae 46-139 weight portion
Radix Angelicae Dahuricae 62-186 weight portion Cortex Dictamni 62-186 weight portion Fructus Cnidii 62-186 weight portion
Periostracum Cicadae 31-93 weight portion Fructus Forsythiae 62-186 weight portion Fructus Kochiae 62-186 weight portion
Radix Rehmanniae 93-279 weight portion Herba Artemisiae Annuae 93-279 weight portion Herba Pogostemonis 62-186 weight portion
Radix Glycyrrhizae 31-93 weight portion.
2, Chinese medicine composition according to claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Flos Lonicerae 124 weight portion Fructus Gardeniaes 124 weight portion Radix Scutellariaes 124 weight portion Radix Sophorae Flavescentiss 124 weight portion Huangs
The cypress 93 weight portion Radix Gentianae 93 weight portion Radixs Angelicae Dahuricae 124 weight portion Cortex Dictamni 124 weight portion Serpentiss
The machine tool 124 weight portion Periostracum Cicadaes 62 weight portion Fructus Forsythiaes 124 weight portion Fructus Kochiae 124 weight portions
Radix Rehmanniae 186 weight portion Herba Artemisiae Annuaes 186 weight portion Herba Pogostemonis 124 weight portion Radix Glycyrrhizaes 62 weight portions.
3, Chinese medicine composition according to claim 1 and 2 is characterized in that making multiple oral formulations, comprises granule, oral liquid, pill etc.
4, according to the preparation method of the described Chinese medicine composition of claim 3, the preparation method that it is characterized in that this Chinese medicine composition is passed through following steps: above ten Six-elements, get Herba Pogostemonis, Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Herba Artemisiae Annuae extraction volatile oil, the aqueous solution after distillation device is in addition collected; Medicinal residues and all the other Radix Scutellariaes etc. ten decocts with water two～four times simply, and collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, and are condensed into clear paste, and be standby, makes required dosage form.
5, according to the preparation method of the described Chinese medicine composition of claim 4, the preparation method that it is characterized in that this Chinese medicine composition is passed through following steps: above ten Six-elements, get Herba Pogostemonis, Flos Lonicerae, Fructus Forsythiae, the Radix Angelicae Dahuricae, Herba Artemisiae Annuae extraction volatile oil, the aqueous solution after distillation device is in addition collected; Medicinal residues and all the other Radix Scutellariaes etc. ten decocts with water three times simply, adds 8 times of amounts for the first time and decocts 2 hours, add for the second time 6 times of amounts and decocted 1 hour, add 5 times of amounts for the third time and decocted collecting decoction 1 hour, filter, filtrate and above-mentioned aqueous solution merge, the clear paste of relative density 1.20～1.22 when being concentrated into 80 ℃.1 part of qinghuo reagent, 0.81 part of sucrose, 0.5 part in dextrin, stevioside is 0.5% of a sucrose amount, makes granule with marumerization, and drying adds volatile oil and Oleum menthae 0.5ml such as above-mentioned Herba Pogostemonis, and mixing makes 1000g, promptly altogether.
6, Chinese medicine composition is used for the treatment of application in the dermopathic medicine in preparation as claimed in claim 1 or 2.
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| CN2005101059501A CN1943672B (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition for treatment of dermatosis and its preparation method and uses |
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| CN1943672A true CN1943672A (en) | 2007-04-11 |
| CN1943672B CN1943672B (en) | 2011-05-04 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554424B (en) * | 2009-05-18 | 2011-06-22 | 高全旺 | Traditional Chinese medicine for treating skin diseases and preparation method thereof |
| CN102160888A (en) * | 2011-02-24 | 2011-08-24 | 李金多 | Medicine for treating mycotic vaginitis |
| CN104013903A (en) * | 2014-07-02 | 2014-09-03 | 济南高达信息技术有限公司 | Traditional Chinese medicine unguent for treating infantile eczema |
| CN106822352A (en) * | 2017-02-15 | 2017-06-13 | 成都市飞龙水处理技术研究所青白江第分所 | A kind of Chinese medicine composition of the papular urticaria treated caused by retention of damp-heat in the interior |
| CN112494537A (en) * | 2020-12-16 | 2021-03-16 | 宁乡市人民医院 | Compound lithospermum itching relieving ointment, preparation method and application |
| CN115581669A (en) * | 2022-10-28 | 2023-01-10 | 贵州省湿缠身中医研究院 | Wrinkle powder and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1457834A (en) * | 2003-04-12 | 2003-11-26 | 张华贵 | Detoxicating pill |
-
2005
- 2005-10-08 CN CN2005101059501A patent/CN1943672B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554424B (en) * | 2009-05-18 | 2011-06-22 | 高全旺 | Traditional Chinese medicine for treating skin diseases and preparation method thereof |
| CN102160888A (en) * | 2011-02-24 | 2011-08-24 | 李金多 | Medicine for treating mycotic vaginitis |
| CN104013903A (en) * | 2014-07-02 | 2014-09-03 | 济南高达信息技术有限公司 | Traditional Chinese medicine unguent for treating infantile eczema |
| CN106822352A (en) * | 2017-02-15 | 2017-06-13 | 成都市飞龙水处理技术研究所青白江第分所 | A kind of Chinese medicine composition of the papular urticaria treated caused by retention of damp-heat in the interior |
| CN112494537A (en) * | 2020-12-16 | 2021-03-16 | 宁乡市人民医院 | Compound lithospermum itching relieving ointment, preparation method and application |
| CN115581669A (en) * | 2022-10-28 | 2023-01-10 | 贵州省湿缠身中医研究院 | Wrinkle powder and preparation method thereof |
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| CN1943672B (en) | 2011-05-04 |
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