CN1745837A - Funing preparation and its making method theref - Google Patents
Funing preparation and its making method theref Download PDFInfo
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- CN1745837A CN1745837A CN 200410046741 CN200410046741A CN1745837A CN 1745837 A CN1745837 A CN 1745837A CN 200410046741 CN200410046741 CN 200410046741 CN 200410046741 A CN200410046741 A CN 200410046741A CN 1745837 A CN1745837 A CN 1745837A
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Abstract
A Chinese medicine 'Funing' in the form of tablet, disintegrating tablet, or soft-gel suppository for treating vaginitis, vaginal ulcer, cervicitis, cervical erosion, etc is prepared from 11 Chinese-medicinal materials including flavescent sophora root, phellodendron bark, scutellaria root, etc. Its advantages are high curative effect, broad spectrum and no irritation.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, peaceful preparation of specifically a kind of woman and preparation method thereof.
Background technology
By Radix Sophorae Flavescentis, Cortex Phellodendri, Radix Scutellariae etc. ten simply the peaceful vagina administration preparation of woman formed of Chinese medicine have the function of heat-clearing and toxic substances removing, removing dampness and killing parasites, removing the necrotic tissue and promoting granulation, blood-activating analgetic, be used for vaginitis that antibacterial, virus, mycete, infusorian etc. cause, ulcer of vagina, cervicitis, cervical erosion etc. and have significant curative effect.FUNINGSHUAN (recording for the 20 of the Sanitation Ministry medicine standard " Chinese traditional patent formulation preparation ") is arranged at present.But suppository storage inconvenience requires preserving below 30 ℃, uses at some high temperature severe cold areas to be subjected to certain restriction.Simultaneously, this pharmaceutically dosage form is single, can not satisfy the medication demand of vast female patient.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, a kind of scalable, good effect that has is provided, the peaceful preparation of the woman of nonirritant, compliance advantages of higher, the standard of improving the quality of products simultaneously further satisfies and ensures the medication demand of vast female patient.
Purpose of the present invention can take following method to realize:
The peaceful preparation of a kind of woman, it is characterized in that it is that component is formed or made other various vagina administration preparations except that ordinary suppository that active component and pharmaceutically acceptable additives are formed by the extract of following main materials by following main materials, as ordinary tablet, fast disintegrating tablet, effervescent tablet, capsule, type of effervescent suppository, soft capsule suppository, gel, foam, ointment, membrane etc.
Radix Sophorae Flavescentis 300-3000 weight portion, Cortex Phellodendri 200-2000 weight portion, Radix Scutellariae 150-1500 weight portion, Rhizoma Curcumae 100-1000 weight portion, Concha Meretricis Seu Cyclinae powder 40-400 weight portion, Plumbum preparatium 6-60 weight portion, catechu 6-60 weight portion, Olibanum 3-30 weight portion, Myrrha 3-30 weight portion, Pulvis Fellis Suis 9-90 weight portion, Borneolum Syntheticum 1-10 weight portion.
Its formula optimization is:
Radix Sophorae Flavescentis 1370 weight portions, Cortex Phellodendri 820 weight portions, Radix Scutellariae 682 weight portions, Rhizoma Curcumae 410 weight portions, Concha Meretricis Seu Cyclinae powder 182 weight portions, Plumbum preparatium 27.3 weight portions, catechu 27.3 weight portions, Olibanum 13.6 weight portions, Myrrha 13.6 weight portions, Pulvis Fellis Suis 36.4 weight portions, Borneolum Syntheticum 5.5 weight portions.
Described pharmaceutically acceptable additives are following one or more:
Beta-schardinger dextrin-, hydroxypropyl, vaseline, liquid Paraffin, tween 80, lecithin, sodium lauryl sulphate, dimethyl sulfoxine, azone, glycerol, gelatin, Polyethylene Glycol, Polyethylene Glycol-32 glycerol monolaurate (gelucire44/14), carbomer, micropowder silica gel, dextrin, starch, methylcellulose, pregelatinized Starch, sodium alginate, citric acid, tartaric acid, sodium bicarbonate, magnesium stearate, 30 POVIDONE K 30 BP/USP
30, microcrystalline Cellulose, hydroxypropyl cellulose, carboxymethyl starch sodium, sodium carboxymethyl cellulose, carboxymethylcellulose calcium, ethylparaben, Oleum Sesami, soybean oil, Semen arachidis hypogaeae wet goods.
Described tablet can be ordinary tablet, fast disintegrating tablet, effervescent tablet or other various suitable tablets, and available suitable coating material coating is coating not also.
Described capsule can be soft capsule, hard capsule or other various suitable capsules.
The preparation method of the peaceful preparation of a kind of woman is characterized in that it may further comprise the steps:
(1) in the prescription Radix Sophorae Flavescentis, Cortex Phellodendri pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after medicinal residues again water carry or acid extraction or other suitable method are extracted;
(2) in the prescription Radix Scutellariae pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after the medicinal residues method that water is carried or other is suitable again extract;
(3) in the prescription Rhizoma Curcumae pulverize or superfine powder be broken into fine powder directly use adopt alcohol extraction or water carry or extract behind the volatile oil that medicinal residues water is carried or alcohol extraction after the medicinal residues method that water is carried or other is suitable again extract;
(4) Concha Meretricis Seu Cyclinae powder is pulverized or superfine powder is broken into that fine powder is directly used or part is ground into fine powder and partly adopts suitable method to extract or all adopt the method that alcohol extraction or water are carried or other is suitable to extract in the prescription;
(5) Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis pulverizing or superfine powder are broken into fine powder or other suitable method processing in the prescription;
(6) Borneolum Syntheticum is ground into or is ground into that fine powder is used or add or handle with other suitable method with The suitable solvent dissolving back in the prescription;
(7) fine powder that is ground into described in the step was a 100-160 purpose fine powder, and the best is broken into 200-300 purpose fine powder for superfine powder;
(8) condition of the alcohol extraction described in the step is: with 50-95% ethanol is solvent, can adopt heating reflux method or percolation or other suitable method to extract;
(9) condition carried of the water described in the step is: decoct with water/extract 1-3 time at 90-98 ℃ 1-3 hour at every turn;
(10) extracting gained water extract in the step (9) can adopt precipitate with ethanol or acid precipitation or add the flocculating agent sedimentation or method that other is suitable is further handled;
(11) extraction of the volatile oil described in the step can be extracted or extract with supercritical process with the way of distillation, extracts the volatile oil of gained and can directly use or use or make clathrate with an amount of medicated powder absorption and use;
(12) concentrate, adopt concentrating under reduced pressure or thin film concentration or vacuum film to concentrate or other proper method;
(13) drying can adopt vacuum drying or spray drying or lyophilization or other suitable method;
(14) add described additives as required, adopt suitable moulding process, be prepared into other the various vagina administration preparations except that ordinary suppository, as ordinary tablet, fast disintegrating tablet, effervescent tablet, capsule, type of effervescent suppository, soft capsule suppository, foam, ointment, membrane etc.
The specific embodiment
Embodiment 1:
Get Radix Sophorae Flavescentis 1370 grams, Cortex Phellodendri 820 grams, Radix Scutellariae 682 grams, Rhizoma Curcumae 410 grams, Concha Meretricis Seu Cyclinae powder 182 grams, Plumbum preparatium 27.3 grams, catechu 27.3 grams, Olibanum 13.6 grams, Myrrha 13.6 grams, Pulvis Fellis Suis 36.4 grams, Borneolum Syntheticum 5.5 grams.
Ten Herba indigoferae Pseudotinctoriae are up to the standards standby respectively in will filling a prescription; Rhizoma Curcumae extracts volatile oil, and 1/2 Concha Meretricis Seu Cyclinae powder decocts secondary in aqueous solution after the distillation and medicinal residues and Radix Sophorae Flavescentis, Cortex Phellodendri and the prescription, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is condensed into thick paste, and drying is pulverized, and is standby; Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and being concentrated into relative density is the clear paste of 1.05-1.08 (80 ℃ of surveys), in the time of 80 ℃, add hydrochloric acid (2mol/L) and transfer pH value 1.0-1.2,80 ℃ are incubated 1 hour, leave standstill 24 hours, filter, get precipitation, dry below 80 ℃, pulverize, standby; With above-mentioned medicated powder and remaining Concha Meretricis Seu Cyclinae powder, Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis mixing, be ground into fine powder, standby with the Borneolum Syntheticum facing-up; It is an amount of to get vaseline, and heat fused, temperature are reduced to about 50 ℃, adds liquid Paraffin, tween 80 is an amount of, is mixed with substrate, adds above-mentioned fine powder and Rhizoma Curcumae volatile oil, fully stirs evenly, and is pressed into 1000 of soft capsules, and packing promptly gets the peaceful soft capsule suppository of woman.
Embodiment 2:
Get Radix Sophorae Flavescentis 300 grams, Cortex Phellodendri 200 grams, Radix Scutellariae 150 grams, Rhizoma Curcumae 100 grams, Concha Meretricis Seu Cyclinae powder 40 grams, Plumbum preparatium 6 grams, catechu 6 grams, Olibanum 3 grams, Myrrha 3 grams, Pulvis Fellis Suis 9 grams, Borneolum Syntheticum 1 gram.
Ten Herba indigoferae Pseudotinctoriae are up to the standards standby respectively in will filling a prescription; Rhizoma Curcumae extracts volatile oil, and 1/2 Concha Meretricis Seu Cyclinae powder decocts secondary in aqueous solution after the distillation and medicinal residues and Radix Sophorae Flavescentis, Cortex Phellodendri and the prescription, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is condensed into thick paste, and drying is pulverized, and is standby; Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and is concentrated in right amount, and drying under reduced pressure below 80 ℃ is pulverized, and is standby; With above-mentioned medicated powder and remaining Concha Meretricis Seu Cyclinae powder, Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis mixing, be ground into fine powder, behind the Borneolum Syntheticum facing-up, add liquid Paraffin and stir evenly standby in right amount; Other gets vaseline, lecithin is an amount of, and heat fused, temperature are reduced to about 50 ℃, add above-mentioned spares and Rhizoma Curcumae volatile oil, fully stir evenly, and is pressed into 1000 of soft capsules, and packing promptly gets the peaceful soft capsule suppository of woman.
Embodiment 3:
Get Radix Sophorae Flavescentis 3000 grams, Cortex Phellodendri 2000 grams, Radix Scutellariae 1500 grams, Rhizoma Curcumae 1000 grams, Concha Meretricis Seu Cyclinae powder 400 grams, Plumbum preparatium 60 grams, catechu 60 grams, Olibanum 30 grams, Myrrha 30 grams, Pulvis Fellis Suis 90 grams, Borneolum Syntheticum 10 grams.
Ten Herba indigoferae Pseudotinctoriae are up to the standards standby respectively in will filling a prescription; Rhizoma Curcumae extracts volatile oil, and 1/2 Concha Meretricis Seu Cyclinae powder decocts secondary in aqueous solution after the distillation and medicinal residues and Radix Sophorae Flavescentis, Cortex Phellodendri and the prescription, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is condensed into thick paste, and drying is pulverized, and is standby; Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and being concentrated into relative density is the clear paste of 1.05-1.08 (80 ℃ of surveys), in the time of 80 ℃, add hydrochloric acid (2mol/L) and transfer pH value 1.0-1.2,80 ℃ are incubated 1 hour, leave standstill 24 hours, filter, get precipitation, dry below 80 ℃, pulverize, standby; With above-mentioned medicated powder and remaining Concha Meretricis Seu Cyclinae powder, Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis mixing, be ground into fine powder,, granulate with the appropriate amount of auxiliary materials mixing, dry, spray adds the ethanol solution of Borneolum Syntheticum, Rhizoma Curcumae volatile oil, mixes airtight 24 hours thoroughly, 1000 of tablettings, coating, packing promptly gets the peaceful vaginal tablet of woman.
Embodiment 4:
Get Radix Sophorae Flavescentis 1000 grams, Cortex Phellodendri 2000 grams, Radix Scutellariae 150 grams, Rhizoma Curcumae 300 grams, Concha Meretricis Seu Cyclinae powder 400 grams, Plumbum preparatium 20 grams, catechu 20 grams, Olibanum 10 grams, Myrrha 10 grams, Pulvis Fellis Suis 30 grams, Borneolum Syntheticum 3 grams.
Ten Herba indigoferae Pseudotinctoriae are up to the standards standby respectively in will filling a prescription; Rhizoma Curcumae extracts volatile oil, and it is standby to make volatile oil clathrate compound with cyclodextrin inclusion compound; 1/2 Concha Meretricis Seu Cyclinae powder decocts secondary in aqueous solution after the distillation and medicinal residues and Radix Sophorae Flavescentis, Cortex Phellodendri and the prescription, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is condensed into thick paste, and drying is pulverized, and is standby; Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and being concentrated into relative density is the clear paste of 1.05-1.08 (80 ℃ of surveys), in the time of 80 ℃, add hydrochloric acid (2mol/L) and transfer pH value 1.0-1.2,80 ℃ are incubated 1 hour, leave standstill 24 hours, filter, get precipitation, dry below 80 ℃, pulverize, standby; With above-mentioned medicated powder and remaining Concha Meretricis Seu Cyclinae powder, Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis mixing, be ground into fine powder,, granulate with the appropriate amount of auxiliary materials mixing, dry, add the ethanol solution of Borneolum Syntheticum, mix airtight 24 hours thoroughly, add the volatile oil clathrate compound mixing, 1000 of tablettings, packing promptly gets the peaceful vaginal tablet of woman.
Embodiment 5:
Get Radix Sophorae Flavescentis 1650 grams, Cortex Phellodendri 1100 grams, Radix Scutellariae 825 grams, Rhizoma Curcumae 550 grams, Concha Meretricis Seu Cyclinae powder 220 grams, Plumbum preparatium 33 grams, catechu 33 grams, Olibanum 16.5 grams, Myrrha 16.5 grams, Pulvis Fellis Suis 49.5 grams, Borneolum Syntheticum 5.5 grams.
Ten Herba indigoferae Pseudotinctoriae are up to the standards standby respectively in will filling a prescription; Rhizoma Curcumae extracts volatile oil, and 1/2 Concha Meretricis Seu Cyclinae powder decocts secondary in aqueous solution after the distillation and medicinal residues and Radix Sophorae Flavescentis, Cortex Phellodendri and the prescription, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is condensed into thick paste, and drying is pulverized, and is standby; Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and is concentrated in right amount, and drying under reduced pressure below 80 ℃ is pulverized, and is standby; With above-mentioned medicated powder and remaining Concha Meretricis Seu Cyclinae powder, Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis mixing, be ground into fine powder,, granulate with the auxiliary materials and mixing of an amount of fast disintegrating tablet, dry, add the ethanol solution of Borneolum Syntheticum, Rhizoma Curcumae volatile oil, mix airtight 24 hours thoroughly, 1000 of tablettings, coating, packing promptly gets the peaceful vagina speed of woman disintegrating tablet.
Embodiment 6:
Get Radix Sophorae Flavescentis 300 grams, Cortex Phellodendri 2000 grams, Radix Scutellariae 1500 grams, Rhizoma Curcumae 100 grams, Concha Meretricis Seu Cyclinae powder 40 grams, Plumbum preparatium 60 grams, catechu 60 grams, Olibanum 3 grams, Myrrha 3 grams, Pulvis Fellis Suis 90 grams, Borneolum Syntheticum 1 gram.
Ten Herba indigoferae Pseudotinctoriae are up to the standards standby respectively in will filling a prescription; Rhizoma Curcumae extracts volatile oil, and 1/2 Concha Meretricis Seu Cyclinae powder decocts secondary in aqueous solution after the distillation and medicinal residues and Radix Sophorae Flavescentis, Cortex Phellodendri and the prescription, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is condensed into thick paste, and drying is pulverized, and is standby; Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and is concentrated in right amount, at drying under reduced pressure below 80 ℃, pulverizes, and is standby; With above-mentioned medicated powder and remaining Concha Meretricis Seu Cyclinae powder, Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis mixing, be ground into fine powder, with an amount of effervescent tablet auxiliary materials and mixing, dehydrated alcohol is granulated, dry, add the ethanol solution of Borneolum Syntheticum, Rhizoma Curcumae volatile oil, mix airtight 24 hours thoroughly, 1000 of tablettings, coating, packing promptly gets gynecologic vaginal effervescent tablets.
Embodiment 7:
Get Radix Sophorae Flavescentis 3000 grams, Cortex Phellodendri 2000 grams, Radix Scutellariae 150 grams, Rhizoma Curcumae 100 grams, Concha Meretricis Seu Cyclinae powder 400 grams, Plumbum preparatium 6 grams, catechu 60 grams, Olibanum 30 grams, Myrrha 3 grams, Pulvis Fellis Suis 19 grams, Borneolum Syntheticum 1 gram.
Ten Herba indigoferae Pseudotinctoriae are up to the standards standby respectively in will filling a prescription; Rhizoma Curcumae extracts volatile oil, and it is standby to make volatile oil clathrate compound with cyclodextrin inclusion compound; 1/2 Concha Meretricis Seu Cyclinae powder decocts secondary in aqueous solution after the distillation and medicinal residues and Radix Sophorae Flavescentis, Cortex Phellodendri and the prescription, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is condensed into thick paste, and drying is pulverized, and is standby; Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and being concentrated into relative density is the clear paste of 1.05-1.08 (80 ℃ of surveys), in the time of 80 ℃, add hydrochloric acid (2mol/L) and transfer pH value 1.0-1.2,80 ℃ are incubated 1 hour, leave standstill 24 hours, filter, get precipitation, dry below 80 ℃, pulverize, standby; With above-mentioned medicated powder and remaining Concha Meretricis Seu Cyclinae powder, Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis mixing, be ground into fine powder, with the Borneolum Syntheticum facing-up, add the volatile oil clathrate compound mixing, encapsulated 1000, packing promptly gets the peaceful vaginal capsule of woman.
Embodiment 8:
Get Radix Sophorae Flavescentis 2000 grams, Cortex Phellodendri 400 grams, Radix Scutellariae 150 grams, Rhizoma Curcumae 1000 grams, Concha Meretricis Seu Cyclinae powder 80 grams, Plumbum preparatium 60 grams, catechu 60 grams, Olibanum 15 grams, Myrrha 15 grams, Pulvis Fellis Suis 20 grams, Borneolum Syntheticum 4 grams.
Ten Herba indigoferae Pseudotinctoriae are up to the standards standby respectively in will filling a prescription; Rhizoma Curcumae extracts volatile oil, and 1/2 Concha Meretricis Seu Cyclinae powder decocts secondary in aqueous solution after the distillation and medicinal residues and Radix Sophorae Flavescentis, Cortex Phellodendri and the prescription, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, and filtrate is condensed into thick paste, and drying is pulverized, and is standby; Radix Scutellariae decocts with water three times, and 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and is concentrated in right amount, at drying under reduced pressure below 80 ℃, pulverizes, and is standby; With above-mentioned medicated powder and remaining Concha Meretricis Seu Cyclinae powder, Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis mixing, be ground into fine powder, with the appropriate amount of auxiliary materials mixing, granulate drying, the ethanol solution that adds Borneolum Syntheticum, Rhizoma Curcumae volatile oil, mix thoroughly, airtight 24 hours, encapsulated 1000, packing promptly gets the peaceful vaginal capsule of woman.
Claims (6)
1, the peaceful preparation of a kind of woman is characterized in that it is that component is formed or made other various vagina administration preparations except that ordinary suppository that active component and pharmaceutically acceptable additives are formed by the extract of following main materials by following main materials, as ordinary tablet, fast disintegrating tablet, effervescent tablet, capsule, type of effervescent suppository, soft capsule suppository, gel, foam, ointment, membrane;
Radix Sophorae Flavescentis 300-3000 weight portion, Cortex Phellodendri 200-2000 weight portion, Radix Scutellariae 150-1500 weight portion, Rhizoma Curcumae 100-1000 weight portion, Concha Meretricis Seu Cyclinae powder 40-400 weight portion, Plumbum preparatium 6-60 weight portion, catechu 6-60 weight portion, Olibanum 3-30 weight portion, Myrrha 3-30 weight portion, Pulvis Fellis Suis 9-90 weight portion, Borneolum Syntheticum 1-10 weight portion.
2, the peaceful preparation of a kind of woman according to claim 1 is characterized in that its formula optimization is:
Radix Sophorae Flavescentis 1370 weight portions, Cortex Phellodendri 820 weight portions, Radix Scutellariae 682 weight portions, Rhizoma Curcumae 410 weight portions, Concha Meretricis Seu Cyclinae powder 182 weight portions, Plumbum preparatium 27.3 weight portions, catechu 27.3 weight portions, Olibanum 13.6 weight portions, Myrrha 13.6 weight portions, Pulvis Fellis Suis 36.4 weight portions, Borneolum Syntheticum 5.5 weight portions.
3, the peaceful preparation of a kind of woman according to claim 1 is characterized in that described pharmaceutically acceptable additives are following one or more:
Beta-schardinger dextrin-, hydroxypropyl, vaseline, liquid Paraffin, tween 80, lecithin, sodium lauryl sulphate, dimethyl sulfoxine, azone, glycerol, gelatin, Polyethylene Glycol, Polyethylene Glycol-32 glycerol monolaurate (gelucire44/14), carbomer, micropowder silica gel, dextrin, starch, methylcellulose, pregelatinized Starch, sodium alginate, citric acid, tartaric acid, sodium bicarbonate, magnesium stearate, 30 POVIDONE K 30 BP/USP
30, microcrystalline Cellulose, hydroxypropyl cellulose, carboxymethyl starch sodium, sodium carboxymethyl cellulose, carboxymethylcellulose calcium, ethylparaben, Oleum Sesami, soybean oil, Oleum Arachidis hypogaeae semen.
4, the peaceful preparation of a kind of woman according to claim 1 is characterized in that: described tablet can be ordinary tablet, fast disintegrating tablet, effervescent tablet or other various suitable tablets.Available suitable coating material coating is coating not also.
5, the peaceful preparation of a kind of woman according to claim 1 is characterized in that: described capsule can be soft capsule, hard capsule or other various suitable capsules.
6, the preparation method of the peaceful preparation of a kind of woman is characterized in that it may further comprise the steps:
(1) in the prescription Radix Sophorae Flavescentis, Cortex Phellodendri pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after medicinal residues again water carry or acid extraction or other suitable method are extracted;
(2) in the prescription Radix Scutellariae pulverize superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or alcohol extraction after the medicinal residues method that water is carried or other is suitable again extract;
(3) in the prescription Rhizoma Curcumae pulverize or superfine powder be broken into fine powder directly use adopt alcohol extraction or water carry or extract behind the volatile oil that medicinal residues water is carried or alcohol extraction after the medicinal residues method that water is carried or other is suitable again extract;
(4) Concha Meretricis Seu Cyclinae powder is pulverized or superfine powder is broken into that fine powder is directly used or part is ground into fine powder and partly adopts suitable method to extract or all adopt the method that alcohol extraction or water are carried or other is suitable to extract in the prescription;
(5) Plumbum preparatium, catechu, Olibanum, Myrrha, Pulvis Fellis Suis pulverizing or superfine powder are broken into fine powder or other suitable method processing in the prescription;
(6) Borneolum Syntheticum is ground into or is ground into that fine powder is used or add or handle with other suitable method with The suitable solvent dissolving back in the prescription;
(7) fine powder that is ground into described in the step was a 100-160 purpose fine powder, and the best is broken into 200-300 purpose fine powder for superfine powder;
(8) condition of the alcohol extraction described in the step is: with 50-95% ethanol is solvent, can adopt heating reflux method or percolation or other suitable method to extract;
(9) condition carried of the water described in the step is: decoct with water/extract 1-3 time at 90-98 ℃ 1-3 hour at every turn;
(10) extracting gained water extract in the step (9) can adopt precipitate with ethanol or acid precipitation or add the flocculating agent sedimentation or method that other is suitable is further handled;
(11) extraction of the volatile oil described in the step can be extracted or extract with supercritical process with the way of distillation, extracts the volatile oil of gained and can directly use or use or make clathrate with an amount of medicated powder absorption and use;
(12) concentrate, adopt concentrating under reduced pressure or thin film concentration or vacuum film to concentrate or other proper method;
(13) drying can adopt vacuum drying or spray drying or lyophilization or other suitable method;
(14) add described additives as required, adopt suitable moulding process, be prepared into other the various vagina administration preparations except that ordinary suppository, as ordinary tablet, fast disintegrating tablet, effervescent tablet, capsule, type of effervescent suppository, soft capsule suppository, foam, ointment, membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046741 CN1745837A (en) | 2004-09-06 | 2004-09-06 | Funing preparation and its making method theref |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046741 CN1745837A (en) | 2004-09-06 | 2004-09-06 | Funing preparation and its making method theref |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1745837A true CN1745837A (en) | 2006-03-15 |
Family
ID=36165655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410046741 Pending CN1745837A (en) | 2004-09-06 | 2004-09-06 | Funing preparation and its making method theref |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1745837A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450528C (en) * | 2006-08-16 | 2009-01-14 | 北京科信必成医药科技发展有限公司 | Funing gel prepn. and its prepn. method |
| CN1899392B (en) * | 2006-07-03 | 2010-05-12 | 株洲千金药业股份有限公司 | Chinese medicine composition for treating gynecological inflammation and its preparing method and use |
| US20120237621A1 (en) * | 2011-03-17 | 2012-09-20 | Sonia Pharma Gmbh | Treatment of Menopausal Symptoms as Novel Indication for Myrrh |
-
2004
- 2004-09-06 CN CN 200410046741 patent/CN1745837A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899392B (en) * | 2006-07-03 | 2010-05-12 | 株洲千金药业股份有限公司 | Chinese medicine composition for treating gynecological inflammation and its preparing method and use |
| CN100450528C (en) * | 2006-08-16 | 2009-01-14 | 北京科信必成医药科技发展有限公司 | Funing gel prepn. and its prepn. method |
| US20120237621A1 (en) * | 2011-03-17 | 2012-09-20 | Sonia Pharma Gmbh | Treatment of Menopausal Symptoms as Novel Indication for Myrrh |
| US8287924B2 (en) * | 2011-03-17 | 2012-10-16 | Sonia Pharma Gmbh | Treatment of menopausal symptoms as novel indication for myrrh |
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