CN1857694A - Epilepsy treating Xianyu tablet as one compound Chinese medicine preparation and its preparing process - Google Patents
Epilepsy treating Xianyu tablet as one compound Chinese medicine preparation and its preparing process Download PDFInfo
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- CN1857694A CN1857694A CNA2006100731002A CN200610073100A CN1857694A CN 1857694 A CN1857694 A CN 1857694A CN A2006100731002 A CNA2006100731002 A CN A2006100731002A CN 200610073100 A CN200610073100 A CN 200610073100A CN 1857694 A CN1857694 A CN 1857694A
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Abstract
The present invention belongs to the field of Chinese medicine technology, and especially a kind of compound Chinese medicine tablet for treating epilepsia, infantile convulsion and facial spasm and its preparation process.
Description
Technical field:
The present invention relates to a kind of epilepsy clonus that is used for due to the wind-phlegm impatency, infantile convulsion, compound Chinese medicinal preparation of facial spasm and preparation method thereof belongs to technical field of Chinese medicine.
Background technology:
The cause of disease of epilepsy is based on expectorant, and pathomechanism is the turbid liver-wind resistance of an expectorant key, causes brain gas not fallen ill along connecing mutually with visceral-qi.Compound Chinese medicinal preparation function provided by the invention is for eliminating phlegm for resuscitation, the arresting convulsion of calming the nerves, relieving spasm by calming endogenous wind.Be used for the epilepsy clonus due to the wind-phlegm impatency, infantile convulsion, facial spasm.Clinical practice has therapeutical effect preferably.
The dosage form of listing has capsule at present.This medicine is found its stable poor and easy moisture absorption in research process, thereby makes its bioavailability low, influences the curative effect of medicine.
Summary of the invention:
The invention provides a kind of epilepsy clonus that is used for due to the wind-phlegm impatency, infantile convulsion, facial spasm compound Chinese medicinal preparation and preparation method thereof.
Compound Chinese medicinal preparation provided by the invention, it is characterized in that, per 1000 dosage units, raw material of Chinese medicine by following weight parts is made: and adjuvant is made: 140 parts of the Radixs Astragali, 140 parts of Radix Codonopsis, 140 parts of Radix Salviae Miltiorrhizaes, 70 parts of Radix Bupleuri, 105 parts of Semen Ziziphi Spinosaes, 70 parts of Radix Polygalaes, 105 parts in Rhizoma Gastrodiae, 105 parts of Ramulus Uncariae Cum Uncis, 70 parts of Rhizoma Acori Graminei, 70 parts of Arisaema Cum Bile, 140 parts of Radix Angelicae Sinensis, 105 parts of Bombyx Batryticatus, 70 parts of Massa Medicata Fermentatas, 70 parts of Radix Curcumaes, 70 parts in Radix Glycyrrhizae, 35 parts of Rhizoma Typhoniis (system), 2 parts of magnesium stearate, 10 parts of carboxymethyl starch sodium.
Pharmaceutical preparation provided by the invention is tablet, is characterized in:
(1) dosage is accurate, and content is even, with the sheet number as dosage unit.
(2) chemical stability is better, because volume is little, fine and close.Be subjected to the influence of factors such as outside air, light, moisture less, more increased stability of drug by coating simultaneously.
(3) carry, transport, take more convenient.
Pharmaceutical preparation provided by the invention, its preparation method is: above ten Six-elements, 105 parts of Bombyx Batryticatus, Massa Medicata Fermentata is ground into fine powder for 70 parts, sieves, and is standby.140 parts of grades of all the other Radixs Astragali 14 flavor adds 11 times of amounts, 8 times of amounts, 8 times of water gagings respectively and decocts 2 hours first time, 1.5 hours second time three times, 1 hour for the third time, collecting decoction filtered, filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), adds above-mentioned medicated powder mixing, vacuum drying, be ground into fine powder, use 80% alcohol granulation, 70 ℃ of dryings, add 2 parts of magnesium stearate, 10 parts of carboxymethyl starch sodium, tabletting, coating, promptly.
Pharmaceutical preparation of the present invention can contain excipient commonly used, as filler, binding agent, disintegrating agent, lubricant, can carry out coating to tablet.
Wherein filler can be selected starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, mannitol, calcium hydrogen phosphate etc.
Wherein binding agent can be selected pure water solution, Different concentrations of alcohol solution, starch slurry, kollidon aqueous solution or alcoholic solution, gelling starch, sodium carboxymethyl cellulose solution etc.
Wherein disintegrating agent can be selected carboxymethyl starch sodium, XLPE ketopyrrolidine, hydroxypropyl cellulose etc.
Wherein lubricant can be selected magnesium stearate, Macrogol 4000 or 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The specific embodiment:
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment:
The preparation method of tablet of the present invention:
Radix Astragali 140g Radix Codonopsis 140g Radix Salviae Miltiorrhizae 140g Radix Bupleuri 70g Semen Ziziphi Spinosae 105g
Radix Polygalae 70g Rhizoma Gastrodiae 105g Ramulus Uncariae Cum Uncis 105g Rhizoma Acori Graminei 70g Arisaema Cum Bile 70g
Radix Angelicae Sinensis 140g Bombyx Batryticatus 105g Massa Medicata Fermentata 70g Radix Curcumae 70g Radix Glycyrrhizae 70g
Rhizoma Typhonii (system) 35g magnesium stearate 2.0g carboxymethyl starch sodium 10g
Make 1000
Preparation method: above ten Six-elements, Bombyx Batryticatus, Massa Medicata Fermentata is ground into fine powder, sieves, and is standby.All the other Radixs Astragali etc. 14 flavor adds 11 times of amounts, 8 times of amounts, 8 times of water gagings respectively and decocts 2 hours first time, 1.5 hours second time, 1 hour for the third time three times, collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), adds above-mentioned medicated powder mixing, vacuum drying is ground into fine powder, uses 80% alcohol granulation, 70 ℃ of dryings add magnesium stearate 2.0g, carboxymethylstach sodium 20g, mixing, tabletting is made 1000, coating, packing, promptly.
Claims (4)
1, a kind of epilepsy clonus that is used for due to the wind-phlegm impatency, infantile convulsion, the compound Chinese medicinal preparation of facial spasm, it is characterized in that: per 1000 dosage units, raw material of Chinese medicine and adjuvant by following weight parts are made: 140 parts of the Radixs Astragali, 140 parts of Radix Codonopsis, 140 parts of Radix Salviae Miltiorrhizaes, 70 parts of Radix Bupleuri, 105 parts of Semen Ziziphi Spinosaes, 70 parts of Radix Polygalaes, 105 parts in Rhizoma Gastrodiae, 105 parts of Ramulus Uncariae Cum Uncis, 70 parts of Rhizoma Acori Graminei, 70 parts of Arisaema Cum Bile, 140 parts of Radix Angelicae Sinensis, 105 parts of Bombyx Batryticatus, 70 parts of Massa Medicata Fermentatas, 70 parts of Radix Curcumaes, 70 parts in Radix Glycyrrhizae, 35 parts of Rhizoma Typhoniis (system), magnesium stearate 2-3 part, carboxymethyl starch sodium 8-15 part.
2, the compound Chinese medicinal preparation of claim 1, it is tablet, it is characterized in that: 140 parts of the Radixs Astragali, 140 parts of Radix Codonopsis, 140 parts of Radix Salviae Miltiorrhizaes, 70 parts of Radix Bupleuri, 105 parts of Semen Ziziphi Spinosaes, 70 parts of Radix Polygalaes, 105 parts in Rhizoma Gastrodiae, 105 parts of Ramulus Uncariae Cum Uncis, 70 parts of Rhizoma Acori Graminei, 70 parts of Arisaema Cum Bile, 140 parts of Radix Angelicae Sinensis, 105 parts of Bombyx Batryticatus, 70 parts of Massa Medicata Fermentatas, 70 parts of Radix Curcumaes, 70 parts in Radix Glycyrrhizae, 35 parts of Rhizoma Typhoniis (system), 2 parts of magnesium stearate, carboxymethyl starch sodium is prepared from for 10 parts.
3, the preparation method of the compound Chinese medicinal preparation of claim 1 is characterized in that: above ten Six-elements, and 105 parts of Bombyx Batryticatus, Massa Medicata Fermentata is ground into fine powder for 70 parts, sieves, and is standby.140 parts of grades of all the other Radixs Astragali, 14 flavors decoct with water three times, and amount of water is 5～15 times of amounts, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), adds above-mentioned medicated powder mixing, vacuum drying is ground into fine powder, uses 80% alcohol granulation, 70 ℃ of dryings add 2 parts of magnesium stearate, 10 parts of carboxymethyl starch sodium, tabletting, coating, promptly.
4, the preparation method of described ground of claim 3 compound Chinese medicinal preparation is characterized in that: above ten Six-elements, and Bombyx Batryticatus 105g, Massa Medicata Fermentata 70g is ground into fine powder, sieves, and is standby.All the other Radix Astragali 140g etc. 14 flavor adds 11 times of amounts, 8 times of amounts, 8 times of water gagings decoctions three times respectively, and decocting boils three times, 2 hours first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), adds above-mentioned medicated powder mixing, vacuum drying is ground into fine powder, uses 80% alcohol granulation, 70 ℃ of dryings add magnesium stearate 2g, carboxymethyl starch sodium 10g, tabletting, coating, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100731002A CN1857694A (en) | 2006-04-13 | 2006-04-13 | Epilepsy treating Xianyu tablet as one compound Chinese medicine preparation and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006100731002A CN1857694A (en) | 2006-04-13 | 2006-04-13 | Epilepsy treating Xianyu tablet as one compound Chinese medicine preparation and its preparing process |
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| CN1857694A true CN1857694A (en) | 2006-11-08 |
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| CNA2006100731002A Pending CN1857694A (en) | 2006-04-13 | 2006-04-13 | Epilepsy treating Xianyu tablet as one compound Chinese medicine preparation and its preparing process |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240384A (en) * | 2010-08-23 | 2011-11-16 | 陈锐 | Medicament for treating phlegm-stasis accumulating type epilepsy and preparation method thereof |
| CN102861283A (en) * | 2011-07-04 | 2013-01-09 | 西安千禾药业有限责任公司 | Pharmaceutical composition used for treating epilepsy, preparation method and application |
| CN103830669A (en) * | 2014-02-17 | 2014-06-04 | 刘禾青 | Chinese medicinal composition for treating infantile convulsion |
| CN104547883A (en) * | 2013-10-16 | 2015-04-29 | 西安千禾药业有限责任公司 | Traditional Chinese medicine composition for treating facial spasms and facial paralysis as well as preparation method and application of composition |
| JP2016113444A (en) * | 2014-12-12 | 2016-06-23 | 大正製薬株式会社 | Solid composition |
| WO2019205959A1 (en) * | 2018-04-26 | 2019-10-31 | 西安千禾药业股份有限公司 | Pharmaceutical composition for treating epilepsy and convulsions, infantile convulsions and facial spasms and preparation method therefor |
-
2006
- 2006-04-13 CN CNA2006100731002A patent/CN1857694A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240384A (en) * | 2010-08-23 | 2011-11-16 | 陈锐 | Medicament for treating phlegm-stasis accumulating type epilepsy and preparation method thereof |
| CN102240384B (en) * | 2010-08-23 | 2013-03-27 | 陈锐 | Medicament for treating phlegm-stasis accumulating type epilepsy and preparation method thereof |
| CN102861283A (en) * | 2011-07-04 | 2013-01-09 | 西安千禾药业有限责任公司 | Pharmaceutical composition used for treating epilepsy, preparation method and application |
| CN102861283B (en) * | 2011-07-04 | 2014-08-20 | 西安千禾药业有限责任公司 | Pharmaceutical composition used for treating epilepsy, preparation method and application |
| CN104547883A (en) * | 2013-10-16 | 2015-04-29 | 西安千禾药业有限责任公司 | Traditional Chinese medicine composition for treating facial spasms and facial paralysis as well as preparation method and application of composition |
| CN104547883B (en) * | 2013-10-16 | 2017-12-15 | 西安千禾药业有限责任公司 | A kind of Chinese medicine composition for treating facial spasm, facial paralysis and its preparation method and application |
| CN103830669A (en) * | 2014-02-17 | 2014-06-04 | 刘禾青 | Chinese medicinal composition for treating infantile convulsion |
| JP2016113444A (en) * | 2014-12-12 | 2016-06-23 | 大正製薬株式会社 | Solid composition |
| WO2019205959A1 (en) * | 2018-04-26 | 2019-10-31 | 西安千禾药业股份有限公司 | Pharmaceutical composition for treating epilepsy and convulsions, infantile convulsions and facial spasms and preparation method therefor |
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