CN1157200C - Syrup and granules for treating laryngopharyngitis and preparation process thereof - Google Patents
Syrup and granules for treating laryngopharyngitis and preparation process thereof Download PDFInfo
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- CN1157200C CN1157200C CNB991225287A CN99122528A CN1157200C CN 1157200 C CN1157200 C CN 1157200C CN B991225287 A CNB991225287 A CN B991225287A CN 99122528 A CN99122528 A CN 99122528A CN 1157200 C CN1157200 C CN 1157200C
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Abstract
The present invention relates to pharyngolaryngitis syrup and granules, and a preparation method thereof, and the pharyngolaryngitis syrup and granules are used for treating swelling and pain in throats, eliminating phlegm and relieving inflammation, and are prepared from 30g of common anemarrhena rhizome, 10g of ophiopogon root, 15g of blackberrylily rhizome, 20g of vietnamese sophora root, 10g of honeysuckle, 20g of balloonflower root and 10g of scutellaria. The method for preparing the pharyngolaryngitis syrup comprises the steps that the materials are decocted by water for twice, 8 times of water is added at the first time, and 4 times of water is added at the second time; each time of the decoction is carried out for 2 hours; decocted solutions are combined and are filtered, and the filtered solution is mixed with a proper quantity of sucrose; the pharyngolaryngitis syrup is prepared through concentration and subpackage. The method for preparing the granules is identical to the method for preparing the water decocted solution, which is characterized in that the filtered solution is made into paste with the relative density of 1.33 to 1.35(50 to 60 DEG C) through depressurization and concentration, and an excipient is added; granulation is carried out by alcohol in the concentration of 75%, and the granules are sieved by a screen with 80 meshes; the granules are prepared through boiled bed drying, granulation, quality detection and subpackage.
Description
The present invention relates to A61K 9/00 pharmaceutical dosage form class, pharyngolaryngitis syrup and granule and preparation method thereof.
Pharyngolaryngitis belongs to the frequently-occurring disease of respiratory system, treat this disease in, the western drug curative effect relatively, Chinese medicine is better relatively.That generally uses at present has the spirit of pharynx disease, Calculus Bovis laryngalgia capsule, LIUSHEN WAN, a contribution sheet etc. that reduces internal heat, and dosage form is sheet, ball or capsule.After said medicine was taken, what have was hard to bear because of the oral cavity delay sense of taste, and the patient is reluctant to take; More main cause be dosage form institute extremely, need through the gastric disintegrate, the efficacy of a drug slows down release time relatively.
The purpose of this invention is to provide that a kind of produce effects is fast, effective percentage is high, the pharyngolaryngitis syrup of taking convenience and granule and preparation method thereof.
Pharyngolaryngitis syrup and granule are used for the treatment of laryngopharynx swelling and pain, the antiinflammatory of eliminating the phlegm, and it is characterized in that proportioning raw materials is: Rhizoma Anemarrhenae 30g, Radix Ophiopogonis 10g, Rhizoma Belamcandae 15g, Radix Sophorae Tonkinensis 20g, Flos Lonicerae 10g, Radix Platycodonis 2g, Radix Scutellariae 10g.
The syrupy method of preparation pharyngolaryngitis is got the raw materials ready the controlling the water circulation decocting liquid by right 1 proportioning raw materials, it is characterized in that decocting twice: add 8 times of amounts of water for the first time, add 4 times of amounts of water for the second time, each decocted 2 hours, collecting decoction, filtration, survey medicinal liquid proportion 1.08-1.16, filtrate is mixed with an amount of sucrose, packing.
The method for preparing the pharyngolaryngitis granule is identical with above-mentioned controlling the water circulation decocting liquid method, it is characterized in that it is 1.33-1.35 that the filtrate decompression after filtering is concentrated into relative density, 50-60 ℃ clear paste, with starch and dextrin mix homogeneously, be 75% alcohol granulation, drying, granulate, packing with concentration.
Pharyngolaryngitis belongs to traditional Chinese medical science pharyngalgia category, and pathogenesis is many by sense in the exopathogen, YIN-deficiency of the lung and kidney, hyperactivity of deficient fire, or causes laryngopharynx swelling and pain by dryness-heat impairing the lung.The rule of treatment is worked as clearing heat, purging intense-heat, and nourshing Yin and drynsessmoistening prescription is main.But Rhizoma Anemarrhenae clearing away heat-fire in the side, nourshing Yin and drynsessmoistening prescription be monarch drug, be used for deficiency of YIN cough caused by dryness and fire-toxin and cause laryngopharynx swelling and pain.Radix Ophiopogonis sweet Han Zhirun, can lung-yin nourishing, lung moistening is dry, so can control dryness-heat impairing the lung, the dry cough disease of expectorant less, and YIN nourishing is not loved heresy.The Radix Scutellariae bitter cold, the fire of the kind clear part of the body cavity above the diaphragm housing the heart and lungs and is combined into ministerial drug Radix Ophiopogonis.Radix Platycodonis is opened lung qi dispersing gas, the chest stuffiness relieving sore-throat relieving, and expelling phlegm for arresting cough, detumescence and apocenosis, and be making of ships, the medicine carrying come-up is until throat.All medicines share the effect that can receive clearing away heat-fire, nourishing YIN and moistening the lung, detumescence sore-throat relieving, expelling phlegm for arresting cough, so can be used for the laryngopharynx swelling and pain of hyperactivity of deficient fire or dryness-heat impairing the lung, the disease of dry pharynx cough caused by dryness.
Decoction pharyngolaryngitis syrup is in two more than ten years of clinical practice, and is evident in efficacy.But have that dose is big, dosage is forbidden, carry inconvenience and sugar content, defective such as limited that diabetics is taken than higher (30-50%).On this side basis, improve dosage form, make granule, and use modern pharmaceutical technology and check and analysis technology, it is carried out qualitative, quantitative, set up quality control standard.The pharyngolaryngitis granule has not only kept the characteristic part of syrup through the clinical confirmation of fraction, also makes dosage more accurate, and curative effect is more definite.Pharyngolaryngitis syrup and granule have kept Chinese medicine compound decoction compatibility equilibrium, the efficacy of a drug produces the advantage fast, that produce effects is fast, the efficacy of a drug is strong, and granule adds the mixing in water for oral taking medicine, have overcome the shortcoming portable, not apt to deteriorate of syrup.
Pharyngolaryngitis syrup and granule are used for the treatment of laryngopharynx swelling and pain, the antiinflammatory of eliminating the phlegm, it is characterized in that proportioning raw materials be Rhizoma Anemarrhenae 30g, Radix Ophiopogonis 10g, Rhizoma Belamcandae 15g, Radix Sophorae Tonkinensis 20g, Flos Lonicerae 10g, Radix Platycodonis 20g, Radix Scutellariae 10g.
The syrupy method of preparation pharyngolaryngitis is got the raw materials ready the controlling the water circulation decocting liquid by the above-mentioned raw materials proportioning, it is characterized in that decocting twice: add 8 times of amounts of water for the first time, add 4 times of amounts of water for the second time, each decocted 2 hours, collecting decoction, filtration, survey medicinal liquid proportion 1.08-1.16, filtrate is mixed with an amount of sucrose, packing.
Consumption: sooner or later respectively once, 50ml/ time.
The method for preparing the pharyngolaryngitis granule is identical with above-mentioned controlling the water circulation decocting liquid method, it is characterized in that it is 1.33-1.35 that the filtrate decompression after filtering is concentrated into relative density, the clear paste of (50-60 ℃), add excipient, with starch and dextrin mix homogeneously, drying under reduced pressure, be 75% alcohol granulation, cross 80 mesh sieves with concentration, through boiled bed drying, granulate, quality inspection packing, pouch 5 gram dresses.
Consumption: sooner or later respectively once, each 1-2 bag/5 grams, seven days is a course of treatment.
Comparison of therapeutic: with the spirit of larynx disease is contrast, compares test with granule:
Group two courses of treatment an of course of treatment
The observation side is counted the effective percentage cure rate and is observed routine number effective percentage cure rate
Pharyngolaryngitis
Granule group 200 87% 62% 100 94% 71%
The spirit of larynx disease
Contrast 200 80% 53% 100 88% 60%
Curative effect judging standard:
With red and swollen degree of larynx and mucosa degree of drying is index
1. larynx diffusivity redness is two degree, and larynx pink had been for once, spends by two once to transfer to, or is effective by alleviator once; Red and swollen disappearance person is for curing.
2. conscious dry laryngopharynx shape alleviator is effectively, and the transference cure person is for curing.
Claims (4)
- One kind be used for the treatment of laryngopharynx swelling and pain, the pharyngolaryngitis syrup of the antiinflammatory of eliminating the phlegm, it is characterized in that effective ingredient made by following raw materials according: Rhizoma Anemarrhenae 30g, Radix Ophiopogonis 10g, Rhizoma Belamcandae 15g, Radix Sophorae Tonkinensis 20g, Flos Lonicerae 10g, Radix Platycodonis 20g, Radix Scutellariae 10g.
- 2. as claimed in claim 1ly a kind ofly be used for the treatment of laryngopharynx swelling and pain, the pharyngolaryngitis granule of the antiinflammatory of eliminating the phlegm, it is characterized in that effective ingredient made by following raw materials according: Rhizoma Anemarrhenae 30g, Radix Ophiopogonis 10g, Rhizoma Belamcandae 15g, Radix Sophorae Tonkinensis 20g, Flos Lonicerae 10g, Radix Platycodonis 20g, Radix Scutellariae 10g.
- 3. the syrupy method of pharyngolaryngitis as claimed in claim 1, the controlling the water circulation decocting liquid is characterized in that decocting twice: add 8 times of amounts of water for the first time, add 4 times of amounts of water for the second time, each decocted 2 hours, medicinal liquid proportion 1.08-1.16 is surveyed in collecting decoction, filtration, and filtrate is mixed with an amount of sucrose.
- 4. the method for pharyngolaryngitis granule as claimed in claim 2, the method for controlling the water circulation decocting liquid is identical with claim 2; It is characterized in that the filtrate after filtering being evaporated to the clear paste that relative density is 1.33-1.35 when temperature is 50-60 ℃, with starch and dextrin mix homogeneously, is 75% alcohol granulation, drying, granulate with concentration, makes finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991225287A CN1157200C (en) | 1999-11-15 | 1999-11-15 | Syrup and granules for treating laryngopharyngitis and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991225287A CN1157200C (en) | 1999-11-15 | 1999-11-15 | Syrup and granules for treating laryngopharyngitis and preparation process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1295856A CN1295856A (en) | 2001-05-23 |
| CN1157200C true CN1157200C (en) | 2004-07-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB991225287A Expired - Fee Related CN1157200C (en) | 1999-11-15 | 1999-11-15 | Syrup and granules for treating laryngopharyngitis and preparation process thereof |
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| Country | Link |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330344C (en) * | 2003-08-25 | 2007-08-08 | 成都三明药物研究所 | Medicinal composition for treating acute, chronic pharyngolaryngitis and its preparation method |
| CN102416095B (en) * | 2011-11-21 | 2013-02-06 | 湖南时代阳光药业股份有限公司 | Chinese medicine composition for treating amygdalitis and pharyngitis |
| CN103933326A (en) * | 2013-09-22 | 2014-07-23 | 李修奇 | Traditional Chinese medicine formula tea drink for treating chronic pharyngolaryngitis |
| CN104815304A (en) * | 2015-04-15 | 2015-08-05 | 苏州市天灵中药饮片有限公司 | Swollen sore throat tablet and preparing method thereof |
| CN105663649A (en) * | 2016-01-19 | 2016-06-15 | 宁夏金太阳药业有限公司 | Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof |
| CN105596714A (en) * | 2016-01-19 | 2016-05-25 | 宁夏金太阳药业有限公司 | Pharyngitis treatment traditional Chinese medicine and preparation method and application thereof |
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1999
- 1999-11-15 CN CNB991225287A patent/CN1157200C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1295856A (en) | 2001-05-23 |
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