CN1879803A - A cough-stopping granule and method for preparing same - Google Patents
A cough-stopping granule and method for preparing same Download PDFInfo
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- CN1879803A CN1879803A CN 200610020947 CN200610020947A CN1879803A CN 1879803 A CN1879803 A CN 1879803A CN 200610020947 CN200610020947 CN 200610020947 CN 200610020947 A CN200610020947 A CN 200610020947A CN 1879803 A CN1879803 A CN 1879803A
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Abstract
Disclosed is a cough-relieving granule and its preparation process, wherein the granule is prepared from the following raw materials (by weight ratio): luckiness grass 3.5-4.5, Siberian solomonseal rhizome 3.1-4.1, Codonopsis convolvulacea Kurz 2.5-3.5, saxfrage 1.5-2.5, loquat leaves 2.5-3.5, Chinese ephedra 1.1-2.1, poppy capsule 0.50-1.5. The preparation process includes the steps of medicinal materials grilling and boiling, merging the grilling liquid, filtrating, stewing and concentrating the filtrate, drying and making powder, charging sucrose and starch gum, mixing homogenously, obtaining granules and drying.
Description
(1) technical field: a kind of cough-stopping granule and preparation method thereof, relate to pharmaceutical composition, relating in particular to the vegetable Chinese herbal medicine is the medicament that raw material is made, and its preparation method.
(2) background technology: cough is the most common in the internal disease, and the sickness rate height is an example with the chronic bronchitis, and prevalence is 3%-5%, and prevalence can sharply rise to 10%-15% more than 59 years old, and is higher with the cold district sickness rate especially.It is relevant with the invasion and attack and the lungs functional disorder of exopathogen to cough.Lung controlling breathing and identical with atmosphere, the cold and heat of extraneous weather, the dampness of air all will directly influence the ascending, descending, exiting and entering of lung qi, body fluid be full of the empty cloth that relaxes.At present, doctor trained in Western medicine adopts mainly to treatment flu, acute/chronic bronchitis that antibiotic carries out antitussive, eliminates the phlegm, antiinflammatory.The effective speed of coughing of treatment cough is at present stopped syrup, cough quick-relieving capsule.But there is following shortcoming in they: 1, syrup, capsule are unsuitable for clinical different use, can not satisfy the different demand of patient; 2, syrup transportation, carry, use inconvenience, the taste of adverse drug is arranged, the patient is glad to take; 3, syrup and capsule manufacture complex process, the production cost height.
(3) summary of the invention: the problem to be solved in the present invention be exactly provide at above deficiency that a kind of cough suppressing effect is good, ingredient is stable, can be suitable for clinical difference uses and the cough-stopping granule that satisfies the different demands of patient, and its preparation method.Its technical scheme is as follows:
It mainly is by comprising that following raw medicaments in portion by weight makes:
Herba Reineckeae Carneae 3.5～4.5, Rhizoma Polygonati 3.1～4.1, Herba Aletridis Khasianae 2.5～3.5, Herba Saxifragae 1.5～2.5,
Folium Eriobotryae 2.5～3.5, Herba Ephedrae 1.1～2.1, Pericarpium Papaveris 0.50～1.5
In order to reach better therapeutic, medicine material medicine of the present invention also comprises Radix Platycodonis 3.5～4.5.
In order to obtain optimum curative effect, medicine material medicine of the present invention further comprises Cortex Mori 1.1～2.1.
Herba Reineckeae Carneae is the dry herb of liliaceous plant Herba Reineckeae Carneae Reineckia camea (Andr.) Kunth among the present invention.Have another name called and be Herba Pratiae Nummulariae.
Rhizoma Polygonati is the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.
Herba Aletridis Khasianae is the dry root and rhizome of the precious tongued bell grass of liliaceous plant cantonese fairy bells Disporum cantoniense (Lour.) Merr. Disporum sessile (Thunb.) D.Don.
Herba Saxifragae is the dry herb of saxifragaceae plant Herba Saxifragae Saxifraga stolonifera Meerb.
Pericarpium Papaveris is the drying and ripening shell of bloodroot Papaver somniferum L..
Preparation method of the present invention is:
Get crude drug, decoct with water 2～3 times, collecting decoction filters, and filtrate was left standstill 24～36 hours, and filtrate is concentrated into the thick paste that relative density is 1.30 (80 ℃), and drying is beaten powder, adds 5～6 portions of sucrose and 2～3 parts of dextrin, and mixing is made granule, drying, promptly.
Product boosting qi and nourishing yin of the present invention, nourishing the lung to arrest cough, reinforcing stomach reg fluid.Be used to catch a cold and cough that acute and chronic bronchitis causes, dry pharynx, expectoration, asthma etc.Usage and dosage: three times on the one, one time 1～2 bag (5g/ bag).
Compared with prior art the present invention has following beneficial effect: 1, medicine disperses rapidly, so the drug release stripping is fast, has kept decoction to absorb characteristics such as fast, that produce effects is rapid, and the drug bioavailability height can be covered uncomfortable bitterness, is convenient to take; 2, lighttight packaging material can make medicine not be subjected to the influence of dampness and air, light, thereby improve stability of drug; 3, can simplify technology, reduce cost, transportation stores, and carries, easy to use, has enriched this product dosage form simultaneously, applies to clinical different use, has satisfied the different demands in market.
Product practicality of the present invention proves: because of exopathogen is violated lung, and impairment of purifying function of the lung and cause cough.The lung being damaged by lasted cough, lung qi lose empty, and then undermine spleen, kidney and cardiac function. insufficiency of the spleen can not transmitting and distributing the fluids, then long-pending humidogene expectorant, on do in lung, because of expectorant is coughed, the turbid straight lung of expectorant or failure of the kidney in receiving QI are then breathed heavily.It is relevant with the invasion and attack and the visceral dysfunction of exopathogen to cough.Said as " three-character medical verses ": " lung is the canopy of internal organs, and that exhales is then empty, suctions then completely ... ".Reuse Herba Reineckeae Carneae, Rhizoma Polygonati in the prescription, the nourishing the lung to arrest cough QI invigorating is supported lung, spleen invigorating lung moistening; The Folium Eriobotryae bitter in the mouth attaches to the lung and stomach meridians, and clearing away lung-heat to relieve cough reduces phlegm, and is shared with Herba Reineckeae Carneae, Rhizoma Polygonati, and one clear one mends, and forms monarch drug.The Herba Aletridis Khasianae nourishing the lung to arrest cough, the spleen invigorating removing food stagnancy.Radix Platycodonis, Herba Saxifragae bitter in the mouth, the property suffering, lung qi dispersing eliminates the phlegm, eliminating inflammation and expelling toxin.Herba Ephedrae diaphoresis cold expelling, depressed lung-energy dispersing, the merit that helps the Folium Eriobotryae lung qi dispersing is a ministerial drug.Cortex Mori, Pericarpium Papaveris are shared, detoxify, astringe the lung, pain relieving, are adjuvant.All medicines share, and gather boosting qi and nourishing yin altogether, nourishing the lung to arrest cough, the merit of reinforcing stomach reg fluid.It has following characteristics: 1, fully medical herbs and the potent detoxifcation of tool, antiinflammatory, antitussive effect; Eliminate respiratory tract and pneumonia fast, the tense situation of distinguishing in the rapid relieving cough in clothes back.2, discharge rapidly with back respiratory tract and pulmonary's secretions, make respiratory smooth without hindrance, gas stops along coughing.3, fast cough-relieving the time, have concurrently and support lung and protect pulmonary function.Therefore, this granular preparation is considered to a kind of omnidistance inflammation-diminishing and cough-controlling good medicine from the respiratory tract to the pulmonary.
Product Safety of the present invention proves: the applicant has carried out acute toxicity testing to this granular preparation, and the maximum dosage-feeding of mouse stomach administration is 332.1g crude drug/kg/24h, and maximum administration multiple is 437 times of 60kg body weight adult clinical oral administration day dosage.Observed 7 days the no abnormal performance of animal behavior activity, defecation, fur, breathing and circulation behind the gastric infusion.Viewing duration, the body weight Non Apparent Abnormality of animal.After putting to death animal, perusal vitals (heart, liver, spleen, lung, kidney etc.) there is no unusually.
(4) drawing explanation:
Accompanying drawing is a process chart of the present invention.
(5) specific embodiment:
Embodiment one:
Press following weight weighting raw materials:
Herba Reineckeae Carneae 400g, Rhizoma Polygonati 360g, Herba Aletridis Khasianae 300g, Herba Saxifragae 200g, Folium Eriobotryae 300g, Herba Ephedrae 160g,
Pericarpium Papaveris 100g, sucrose 480g, dextrin 180g
Its preparation method is:
Get crude drug, decoct with water 2 times, add 10 times of water gagings for the first time, for the second time add 8 times of water gagings, decocted collecting decoction at every turn 2 hours, filter with 200 order filter clothes, filtrate was left standstill 24 hours, and filtrate is 80 ℃ in temperature, vacuum is to be concentrated into the thick paste that relative density is 1.30 (80 ℃) under the condition of 0.08～0.1Mpa, and drying is beaten powder, add sucrose and dextrin, mixing is made granule with 80% ethanol, drying, promptly.
Embodiment two:
Press following weight weighting raw materials:
Herba Reineckeae Carneae 400g, Rhizoma Polygonati 360g, Herba Aletridis Khasianae 300g, Radix Platycodonis 300g, Herba Saxifragae 200g, Folium Eriobotryae 300g,
Herba Ephedrae 160g, Pericarpium Papaveris 100g, sucrose 490g, dextrin 190g
Its preparation method is:
Get crude drug, decoct with water 3 times, add 8 times of water gagings for the first time, for the second time and add 6 times of water gagings for the third time, decocted collecting decoction 1.5 hours at every turn, filter with 200 order filter clothes, filtrate was left standstill 30 hours, and filtrate is 75 ℃ in temperature, vacuum is to be concentrated into the thick paste that relative density is 1.30 (80 ℃) under the condition of 0.08～0.1Mpa, and drying is beaten powder, add sucrose and dextrin, mixing is made granule with 75% ethanol, drying, promptly.
Embodiment three:
Press following weight weighting raw materials:
Herba Reineckeae Carneae 400g, Rhizoma Polygonati 360g, Herba Aletridis Khasianae 300g, Radix Platycodonis 300g, Herba Saxifragae 200g, Folium Eriobotryae 300g,
Herba Ephedrae 160g, Cortex Mori 160g, Pericarpium Papaveris 100g, sucrose 500g, dextrin 200g
Its preparation method is:
Get crude drug, decoct with water 2 times, add 10 times of water gagings for the first time, for the second time add 8 times of water gagings, decocted collecting decoction at every turn 2 hours, filter with 200 order filter clothes, filtrate was left standstill 24 hours, and filtrate is 80 ℃ in temperature, vacuum is to be concentrated into the thick paste that relative density is 1.30 (80 ℃) under the condition of 0.08～0.1Mpa, and drying is beaten powder, add sucrose and dextrin, mixing is made granule with 80% ethanol, drying promptly gets the 1000g cough-stopping granule.
Embodiment four:
Press following weight weighting raw materials:
Herba Reineckeae Carneae 350g, Rhizoma Polygonati 310g, Herba Aletridis Khasianae 250g, Radix Platycodonis 350g, Herba Saxifragae 150g, Folium Eriobotryae 250g,
Herba Ephedrae 110g, Cortex Mori 110g, Pericarpium Papaveris 50g, sucrose 490g, dextrin 190g
Its preparation method is:
Get crude drug, decoct with water 2 times, add 9 times of water gagings for the first time, for the second time add 7 times of water gagings, decocted collecting decoction at every turn 2.5 hours, filter with 200 order filter clothes, filtrate was left standstill 36 hours, and filtrate is 85 ℃ in temperature, vacuum is to be concentrated into the thick paste that relative density is 1.30 (80 ℃) under the condition of 0.08～0.1Mpa, and drying is beaten powder, add sucrose and dextrin, mixing is made granule with 85% ethanol, drying, promptly.
Embodiment five:
Press following weight weighting raw materials:
Herba Reineckeae Carneae 450g, Rhizoma Polygonati 410g, Herba Aletridis Khasianae 350g, Radix Platycodonis 450g, Herba Saxifragae 250g, Folium Eriobotryae 350g,
Herba Ephedrae 210g, Cortex Mori 210g, Pericarpium Papaveris 150g, sucrose 520g, dextrin 220g
Its preparation method is:
Get crude drug, decoct with water 2 times, add 10 times of water gagings for the first time, for the second time add 8 times of water gagings, decocted collecting decoction at every turn 2 hours, filter with 200 order filter clothes, filtrate was left standstill 24 hours, and filtrate is 80 ℃ in temperature, vacuum is to be concentrated into the thick paste that relative density is 1.30 (80 ℃) under the condition of 0.08～0.1Mpa, and drying is beaten powder, add sucrose and dextrin, mixing is made granule with 80% ethanol, drying, promptly.
Product of the present invention carries out packing in 300,000 grades of clean areas, relative humidity is controlled at below 60%.
By the above-mentioned technology of working out, carried out many batches of pilot scale researches, wherein the three batches of pilot plant tests and check result thereof see Table one, table two.
Table one three batch samples trial-production data
| Lot number | 20030901 | 20030902 | 20030903 | |
| Heavily (kg) feeds intake | 22.80 | 22.80 | 22.80 | |
| Extractum heavy (kg) | 2.98 | 3.05 | 3.10 | |
| Granulate | Sucrose heavy (kg) | 5.0 | 5.0 | 5.0 |
| Dextrin heavy (kg) | 2.0 | 2.0 | 2.0 | |
| Granule heavy (kg) | 9.75 | 9.63 | 9.78 | |
| Deserved bag number (bag) | 2000 | 2000 | 2000 | |
| The real bag number (bag) that gets | 1820 | 1812 | 1835 | |
| Recovery rate (%) | 91.0 | 90.6 | 91.8 | |
Table two sample survey result
| Lot number | 20030901 | 20030902 | 20030903 |
| Character | Brown yellow granule, sweet, little hardship of distinguishing the flavor of | Brown yellow granule, sweet, little hardship of distinguishing the flavor of | Brown yellow granule, sweet, little hardship of distinguishing the flavor of |
| Granularity | Qualified | Qualified | Qualified |
| Moisture (%) | 2.7 | 2.5 | 2.3 |
| Melting | Qualified | Qualified | Qualified |
| Content uniformity (%) | ＜±5.2 | ＜±4.7 | ＜±5.5 |
| Microbial limit | Qualified | Qualified | Qualified |
| Ephedrine hydrochloride content (mg/ bag) | 1.625 | 1.725 | 1.550 |
Pilot-scale experiment shows that gained preparation technology is reasonable, feasible.
Claims (10)
1, a kind of cough-stopping granule is characterized in that it mainly is by comprising that following raw medicaments in portion by weight makes:
Herba Reineckeae Carneae 3.5～4.5, Rhizoma Polygonati 3.1～4.1, Herba Aletridis Khasianae 2.5～3.5, Herba Saxifragae 1.5～2.5,
Folium Eriobotryae 2.5～3.5, Herba Ephedrae 1.1～2.1, Pericarpium Papaveris 0.50～1.5
2, cough-stopping granule according to claim 1 is characterized in that the weight proportion of each crude drug is:
Herba Reineckeae Carneae 4, Rhizoma Polygonati 3.6, Herba Aletridis Khasianae 3, Herba Saxifragae 2, Folium Eriobotryae 3, Herba Ephedrae 1.6,
Pericarpium Papaveris 1
3,, it is characterized in that wherein crude drug also has Radix Platycodonis 3.5～4.5 according to the described cough-stopping granule of claim 1.
4, cough-stopping granule according to claim 3 is characterized in that the weight proportion of each crude drug is:
Herba Reineckeae Carneae 4, Rhizoma Polygonati 3.6, Herba Aletridis Khasianae 3, Radix Platycodonis 3, Herba Saxifragae 2, Folium Eriobotryae 3, Herba Ephedrae 1.6,
Pericarpium Papaveris 1
5,, it is characterized in that wherein crude drug also has Cortex Mori 1.1～2.1 according to the described cough-stopping granule of claim 3.
6, cough-stopping granule according to claim 5 is characterized in that the weight proportion of each crude drug is:
Herba Reineckeae Carneae 4, Rhizoma Polygonati 3.6, Herba Aletridis Khasianae 3, Radix Platycodonis 3, Herba Saxifragae 2, Folium Eriobotryae 3, Herba Ephedrae 1.6, Cortex Mori 1.6, Pericarpium Papaveris 1
7, the preparation method of any described cough-stopping granule of claim of claim 1～6 is characterized in that getting crude drug, decocts with water 2～3 times, collecting decoction filters, and filtrate was left standstill 24～36 hours, it is 1.30 thick paste that filtrate is concentrated into relative density, drying is beaten powder, adds 5～6 portions of sucrose and 2～3 parts of dextrin, mixing, make granule, drying, promptly.
8, the preparation method of cough-stopping granule according to claim 7 is characterized in that decocting herbs add 8～10 times of water gagings for the first time, for the second time or add 6～8 times of water gagings for the third time, decocts 1.5～2.5 hours at every turn.
9, according to the preparation method of claim 7 or 8 described cough-stopping granules, it is characterized in that the condition that concentrates thick paste is: temperature is 75～85 ℃, and vacuum is 0.08～0.1Mpa.
10, the preparation method of cough-stopping granule according to claim 9 is characterized in that granulating and adopts 75～85% alcohol granulation.
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| CN 200610020947 CN1879803A (en) | 2006-04-30 | 2006-04-30 | A cough-stopping granule and method for preparing same |
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| CN 200610020947 CN1879803A (en) | 2006-04-30 | 2006-04-30 | A cough-stopping granule and method for preparing same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520444A (en) * | 2013-10-23 | 2014-01-22 | 冯伟 | Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine |
| CN107468964A (en) * | 2017-08-11 | 2017-12-15 | 裴然 | A kind of Chinese medicine and boiling method of effectively treatment respiratory disorder |
-
2006
- 2006-04-30 CN CN 200610020947 patent/CN1879803A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520444A (en) * | 2013-10-23 | 2014-01-22 | 冯伟 | Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine |
| CN103520444B (en) * | 2013-10-23 | 2015-04-22 | 冯伟 | Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine |
| CN107468964A (en) * | 2017-08-11 | 2017-12-15 | 裴然 | A kind of Chinese medicine and boiling method of effectively treatment respiratory disorder |
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