CN103520444A - Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw medicinal materials of angiospermae, saxifrage, pericarpium citri reticulatae, aqueous fennel, lindley eupatorium herb, reineckia carnea, argyreia acuta, usnea, parnassia palustris, gardenia, begonia fimbristipula, herbof paniculate spotflower, delavay greenleaf elaeagnus leaves and globe amaranth. The traditional Chinese medicine is used for dispelling wind, clearing heat, tonifying spleen, eliminating dampness, regulating qi, relieving the asthma, relieving cough and reducing sputum and has a definite treating effect and a low side effect.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, relate in particular to a kind of Chinese medicine and preparation method for the treatment of damp and hot phlegm stagnancy type chronic bronchitis.
Background technology
Chronic bronchitis (chronicbronchitis) is trachea, the chronic nonspecific inflammation of bronchial mucosa and surrounding tissue thereof.Clinically with cough, expectoration or to wait outbreak repeatedly with asthma be cardinal symptom, lasting 3 months every year, continuous more than 2 years.Early symptom is slight, and more than winter attack, spring and summer is alleviated.Increase the weight of because of inflammation late period, and symptom can exist throughout the year.Its Pathologic Characteristics is bronchus body of gland hypertrophy and mucosa secretion increasing.The state of an illness is slowly carrying out property progress, Chang Bingfa obstructive emphysema, and often there is pulmonary hypertension in severe patient, even pulmonary heart disease.
Western medicine chronic bronchitis mainly adopts the Therapeutic Method such as infection, antitussive and antiasthmatic at present, though have certain curative effect for the control state of an illness, relief of symptoms, cannot effect a radical cure, and because abuse of antibiotics easily causes bacterial drug resistance, make to treat difficulty and strengthen.
Chronic bronchitis belongs to the traditional Chinese medical science " cough ", " the syndrome of dyspnea ", " phlegm retention " category.Dirty closely related with lung, spleen, kidney three.Chronic bronchitis is mainly reflected as lung, spleen, kidney three deficiency of five ZANG-organs and damages on pathogenesis, and their mutual relation is unbalance, simultaneously again because of the participation more sophisticated of the factors such as expectorant, fire, the stasis of blood.Its basic pathogenesis is deficiency in origin and excess in superficiality.
The traditional Chinese medical science is particular about differentiation of symptoms and signs for classification of syndrome treatment, and Chinese medicine is divided into following four types by chronic bronchitis is dialectical: the damp and hot phlegm stagnancy type of drink type (2) (3) type of deficiency of both QI and YIN (4) yang deficiency of spleen and stomache in (1) exogenous cold.And damp and hot phlegm stagnancy type bronchitis is to attack due to lung due to damp and hot, its clinical syndrome is mainly cough, asthma, heating, uncomfortable in chest, and bitter taste is not thought drink yearningly, and yellowish urine and expectorant are yellow glutinous, and tongue fur Bai Huanghou is greasy etc.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of Chinese medicine and preparation method for the treatment of damp and hot phlegm stagnancy type chronic bronchitis, Chinese medicine wind and heat dispersing of the present invention, the spleen strengthening and damp drying, regulates the flow of vital energy and relievings asthma, relieving cough and resolving phlegm, to treating damp and hot phlegm stagnancy type chronic bronchitis, have definite curative effect, side effect is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of damp and hot phlegm stagnancy type chronic bronchitis, each raw medicinal material of described Chinese medicine comprises: Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae, Caulis et Folium Argyreia eacutae, Usnea, Herba parnassiae, Flos micheliae Albae, Rhizoma Begoniae Fimbristipulatae, Herba Spilanthis Acmellae, Folium Elaeagni delavayi and Flos Gomphrenae.
Wherein, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 30～40 parts of Viola odoratas, 20～30 parts of Herba Saxifragaes, 10～20 parts of Pericarpium Citri Reticulataes, 25～35 parts of Herba Limnophilae rugosaes, 15～25 parts of Herba Eupatorii Lindleyanis, 5～15 parts of Herba Reineckeae Carneaes, 10～20 parts of Caulis et Folium Argyreia eacutae, 20～30 parts of Usneas, 15～25 parts of Herba parnassiaes, 10～20 parts of Flos micheliae Albae, 5～15 parts of Rhizoma Begoniae Fimbristipulataes, 25～40 parts of Herba Spilanthis Acmellae, 10～20 parts of 20～30 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
Wherein, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 35～40 parts of Viola odoratas, 25～30 parts of Herba Saxifragaes, 15～20 parts of Pericarpium Citri Reticulataes, 30～35 parts of Herba Limnophilae rugosaes, 20～25 parts of Herba Eupatorii Lindleyanis, 5～10 parts of Herba Reineckeae Carneaes, 10～15 parts of Caulis et Folium Argyreia eacutae, 20～25 parts of Usneas, 20～25 parts of Herba parnassiaes, 15～20 parts of Flos micheliae Albae, 10～15 parts of Rhizoma Begoniae Fimbristipulataes, 25～35 parts of Herba Spilanthis Acmellae, 10～15 parts of 20～25 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
Wherein, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 38 parts of Viola odoratas, 28 parts of Herba Saxifragaes, 16 parts of Pericarpium Citri Reticulataes, 33 parts of Herba Limnophilae rugosaes, 22 parts of Herba Eupatorii Lindleyanis, 6 parts of Herba Reineckeae Carneaes, 12 parts of Caulis et Folium Argyreia eacutae, 23 parts of Usneas, 21 parts of Herba parnassiaes, 18 parts of Flos micheliae Albae, 13 parts of Rhizoma Begoniae Fimbristipulataes, 29 parts of Herba Spilanthis Acmellae, 13 parts of 24 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
Wherein, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 36 parts of Viola odoratas, 27 parts of Herba Saxifragaes, 19 parts of Pericarpium Citri Reticulataes, 31 parts of Herba Limnophilae rugosaes, 24 parts of Herba Eupatorii Lindleyanis, 9 parts of Herba Reineckeae Carneaes, 15 parts of Caulis et Folium Argyreia eacutae, 25 parts of Usneas, 24 parts of Herba parnassiaes, 16 parts of Flos micheliae Albae, 11 parts of Rhizoma Begoniae Fimbristipulataes, 32 parts of Herba Spilanthis Acmellae, 15 parts of 22 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mix, the alcohol reflux that to add with respect to 3～5 times, mixture amount determining alcohols be 60%～70% at every turn 2～4 times, each 2～4 hours, filters respectively, each time filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;
Second step, is mixed in proportion surplus stock medical material, adds with respect to 3～5 times of water gagings of mixture, decocts 2～4 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.27～1.29;
The 3rd step, the mastic that the first step, second step are obtained mixes, and 60 ℃～65 ℃ reduced vacuum are dry, and powder gets dry extract;
The 4th step, mixes processing by described dried cream powder and starch, obtains mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.03～0.05; Described mastic mixture is carried out to pelletization treatment, dried, obtain mastic compound particles;
The 5th step, mixes processing, tabletting processing, Cotton seeds successively by described mastic compound particles and Pulvis Talci, magnesium stearate, obtains Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1～3: 0.15～0.3.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 20～40 hours, decocts 2～4 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3～6 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, decocts 2～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 3～6 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200～300 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 25%～40%, and by pouch or packing box packing for the material after mixing, every 5～10 grams is one bag or a box packing.
Beneficial effect of the present invention: Chinese medicine wind and heat dispersing of the present invention, the spleen strengthening and damp drying, regulates the flow of vital energy and relievings asthma, and relieving cough and resolving phlegm has definite curative effect to treating damp and hot phlegm stagnancy type chronic bronchitis, and side effect is little.
The specific embodiment
The invention provides a kind of Chinese medicine for the treatment of damp and hot phlegm stagnancy type chronic bronchitis, each raw medicinal material of described Chinese medicine comprises: Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae, Caulis et Folium Argyreia eacutae, Usnea, Herba parnassiae, Flos micheliae Albae, Rhizoma Begoniae Fimbristipulatae, Herba Spilanthis Acmellae, Folium Elaeagni delavayi and Flos Gomphrenae.
In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:
Viola odorata: acrid in the mouth, micro-hardship, cool in nature.Wind and heat dispersing, eliminating phlegm and stopping cough, calmness, antidiarrheal.The main cough due to common cold, pertussis, hysteria, insomnia, diarrhoea, dysentery.
Herba Saxifragae: bitter in the mouth, pungent, cold.Return lung, spleen, large intestine channel.Wind and heat dispersing, removing pathogenic heat from blood and toxic substance from the body.Main air heat cough, rubella, eczema, otitis media, erysipelas, cough is spitted blood, lung abscess, metrorrhagia, haemorrhoids." classification medical herbs ": clearing away lung-heat, control cough, treat rubella, erysipelas." Jiangxi traditional herbal medicine ": control cough due to lung-heat's QI rising in reverse order, spit blood, lung abscess is told smelly pus, pertussis, liver-fire, consumptive disease in childhood.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Herba Limnophilae rugosae: acrid in the mouth, sweet, warm in nature.Return lung, spleen, stomach warp.Invigorating spleen to remove dampness, activating QI to eliminate phlegm.For flu, laryngopharynx swelling and pain, cough due to lung-heat, bronchitis." Nanning City's medicine will ": dampness is removed expectorant, reducing swelling and alleviating pain, parasite killing removing toxic substances.Control asthma and cough, children's's milk abdominal mass, furuncle, snakebite, cold syndrome of the stomach pain.
Herba Eupatorii Lindleyani: bitter in the mouth, property is flat.Clearing away lung-heat to relieve cough, resolving phlegm and relieving asthma, blood pressure lowering.Main bronchus is scorching, cough with copious phlegm, hypertension.
Herba Reineckeae Carneae: sweet, flat.Nourishing the lung to arrest cough, dispels the wind, synthetism.For pulmonary tuberculosis, cough spitting of blood, chronic bronchitis, asthma, rheumatic arthritis; Traumatic injury is controlled in external, fracture." detailed outline is picked up any lost article from the road ": treating blood disorders, lung heat clearing, separates fire-toxin, is throat disease key medicine." Tian Bao book on Chinese herbal medicine ": clearing away lung-heat to relieve cough reduces phlegm.Control nosebleed, red skin ulcer, acute catarrhal conjunctivitis, traumatic injury.
Caulis et Folium Argyreia eacutae: pungent, micro-hardship, cool.Expelling wind and removing dampness, preventing phlegm from forming and stopping coughing, dissipating blood stasis hemostasis, removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome, edema, expands, cough with asthma abundant expectoration, leukorrhagia, metrorrhagia, hematmesis due to visceral injury, traumatic injury amasss the stasis of blood, acute mastitis, furuncle, rotten foot, eczema.
Usnea: sweet, flat.Heat-clearing and toxic substances removing, relieving cough and resolving phlegm.For pulmonary tuberculosis (sodium salt of multiplex usnic acid), chronic bronchitis; Traumatic infection is controlled in external, and postoperative incision infects, suppurative otitis media, furuncle, tuberculous lymphadenitis, mastitis, burn, cervical erosion, trichomonas vaginitis." Chinese herbal medicine is commonly used in Tibet ": heat-clearing and toxic substances removing, relieving cough and resolving phlegm.Control trauma infection contamination, pyogenic infection, venom, pulmonary tuberculosis cough with copious phlegm, cervical adenitis, mastitis.
Herba parnassiae: hardship, cool.Enter lung, liver, gallbladder three warps.Heat-clearing and toxic substances removing, relieving cough and resolving phlegm.For bacillary dysentery, laryngopharynx swelling and pain, pertussis, cough with copious phlegm.
Flos micheliae Albae: toil, temperature.Enter lung, spleen two warps.Removing dampness, circulation of qi promoting, relieving cough and resolving phlegm.Control chronic bronchitis, prostatitis, women leucorrhea.
Rhizoma Begoniae Fimbristipulatae: sweet, light, cool.Clearing away heat and cooling blood, promoting blood circulation and detoxication.Control summer-heat hyperpyrexia, cough due to lung-heat, spitting of blood, osteopatia sprain, blood stasis pain, sore scabies, burn due to hot liquid or fire." conventional Chinese herbal medicine color atlas ": control pneumonia cough, spitting of blood, chronic bronchitis.
Herba Spilanthis Acmellae: pungent, hardship, tepor.Relieving cough and asthma, detoxification and promoting urination, reducing swelling and alleviating pain.The cough that cures cold, chronic bronchitis, asthma, pertussis, pulmonary tuberculosis, venom, sore swollen toxin, toothache.Guangzhou army " conventional Chinese herbal medicine handbook ": relieving cough and relieving asthma, reducing swelling and alleviating pain.The cough that cures cold, chronic bronchitis, asthma, pertussis, pulmonary tuberculosis, venom, sore swollen toxin, toothache.
Folium Elaeagni delavayi: sweet in the mouth, acid, property is flat.Return lung, kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, Tonglin Paishi, relieving cough and asthma.Cure mainly chronic nephritis, renal calculus, urinary tract infection, icterohepatitis, chronic bronchitis, bronchial asthma, stomachache.
Flos Gomphrenae: sweet, flat.Eliminate the phlegm, relieving asthma.For chronic bronchitis, asthmatic chronic bronchitis, asthma and cough, dysentery, pertussis, infantile convulsion, scrofula is stolen, skin infection." Guangxi Chinese medicinal herbal ": inflorescence: removing heat from blood detumescence, relieving convulsion is coughed.Control pertussis; External treatment skin infection swells and ache.Among the peoplely control menoxenia.Herb pot water washout, controls traumatic injury furuncle.
Wherein, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 30～40 parts of Viola odoratas, 20～30 parts of Herba Saxifragaes, 10～20 parts of Pericarpium Citri Reticulataes, 25～35 parts of Herba Limnophilae rugosaes, 15～25 parts of Herba Eupatorii Lindleyanis, 5～15 parts of Herba Reineckeae Carneaes, 10～20 parts of Caulis et Folium Argyreia eacutae, 20～30 parts of Usneas, 15～25 parts of Herba parnassiaes, 10～20 parts of Flos micheliae Albae, 5～15 parts of Rhizoma Begoniae Fimbristipulataes, 25～40 parts of Herba Spilanthis Acmellae, 10～20 parts of 20～30 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
Wherein, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 35～40 parts of Viola odoratas, 25～30 parts of Herba Saxifragaes, 15～20 parts of Pericarpium Citri Reticulataes, 30～35 parts of Herba Limnophilae rugosaes, 20～25 parts of Herba Eupatorii Lindleyanis, 5～10 parts of Herba Reineckeae Carneaes, 10～15 parts of Caulis et Folium Argyreia eacutae, 20～25 parts of Usneas, 20～25 parts of Herba parnassiaes, 15～20 parts of Flos micheliae Albae, 10～15 parts of Rhizoma Begoniae Fimbristipulataes, 25～35 parts of Herba Spilanthis Acmellae, 10～15 parts of 20～25 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
Wherein, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 38 parts of Viola odoratas, 28 parts of Herba Saxifragaes, 16 parts of Pericarpium Citri Reticulataes, 33 parts of Herba Limnophilae rugosaes, 22 parts of Herba Eupatorii Lindleyanis, 6 parts of Herba Reineckeae Carneaes, 12 parts of Caulis et Folium Argyreia eacutae, 23 parts of Usneas, 21 parts of Herba parnassiaes, 18 parts of Flos micheliae Albae, 13 parts of Rhizoma Begoniae Fimbristipulataes, 29 parts of Herba Spilanthis Acmellae, 13 parts of 24 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
Wherein, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 36 parts of Viola odoratas, 27 parts of Herba Saxifragaes, 19 parts of Pericarpium Citri Reticulataes, 31 parts of Herba Limnophilae rugosaes, 24 parts of Herba Eupatorii Lindleyanis, 9 parts of Herba Reineckeae Carneaes, 15 parts of Caulis et Folium Argyreia eacutae, 25 parts of Usneas, 24 parts of Herba parnassiaes, 16 parts of Flos micheliae Albae, 11 parts of Rhizoma Begoniae Fimbristipulataes, 32 parts of Herba Spilanthis Acmellae, 15 parts of 22 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mix, the alcohol reflux that to add with respect to 3～5 times, mixture amount determining alcohols be 60%～70% at every turn 2～4 times, each 2～4 hours, filters respectively, each time filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;
Second step, is mixed in proportion surplus stock medical material, adds with respect to 3～5 times of water gagings of mixture, decocts 2～4 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.27～1.29;
The 3rd step, the mastic that the first step, second step are obtained mixes, and 60 ℃～65 ℃ reduced vacuum are dry, and powder gets dry extract;
The 4th step, mixes processing by described dried cream powder and starch, obtains mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.03～0.05; Described mastic mixture is carried out to pelletization treatment, dried, obtain mastic compound particles;
The 5th step, mixes processing, tabletting processing, Cotton seeds successively by described mastic compound particles and Pulvis Talci, magnesium stearate, obtains Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1～3: 0.15～0.3.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 20～40 hours, decocts 2～4 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3～6 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, decocts 2～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 3～6 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200～300 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 25%～40%, and by pouch or packing box packing for the material after mixing, every 5～10 grams is one bag or a box packing.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand whereby how application technology means solve technical problem in the present invention, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Viola odorata 360g, Herba Saxifragae 270g, Pericarpium Citri Reticulatae 190g, Herba Limnophilae rugosae 310g, Herba Eupatorii Lindleyani 240g, Herba Reineckeae Carneae 90g, Caulis et Folium Argyreia eacutae 150g, Usnea 250g, Herba parnassiae 240g, Flos micheliae Albae 160g, Rhizoma Begoniae Fimbristipulatae 110g, Herba Spilanthis Acmellae 320g, Folium Elaeagni delavayi 220g and Flos Gomphrenae 150g.
Its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mix, the alcohol reflux that to add with respect to 5 times, mixture amount determining alcohols be 60% at every turn 4 times, each 3 hours, filters respectively, each time filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.32, standby;
Second step, is mixed in proportion surplus stock medical material, adds with respect to 5 times of water gagings of mixture, decocts 3 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.29;
The 3rd step, the mastic that the first step, second step are obtained mixes, and 60 ℃ of reduced vacuum are dry, and powder gets dry extract;
The 4th step, mixes processing by described dried cream powder and starch, obtains mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.04; Described mastic mixture is carried out to pelletization treatment, dried, obtain mastic compound particles;
The 5th step, mixes processing, tabletting processing, Cotton seeds successively by described mastic compound particles and Pulvis Talci, magnesium stearate, obtains Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1.5: 0.3.
Embodiment 2: syrup
Get Viola odorata 380g, Herba Saxifragae 280g, Pericarpium Citri Reticulatae 160g, Herba Limnophilae rugosae 330g, Herba Eupatorii Lindleyani 220g, Herba Reineckeae Carneae 60g, Caulis et Folium Argyreia eacutae 120g, Usnea 230g, Herba parnassiae 210g, Flos micheliae Albae 180g, Rhizoma Begoniae Fimbristipulatae 130g, Herba Spilanthis Acmellae 290g, Folium Elaeagni delavayi 240g and Flos Gomphrenae 130g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 30 hours, decocts 3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, decocts 4 hours, filters and obtains the second filtrate, and the quality of the water adding is 6 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 30%, and by pouch or packing box packing for the material after mixing, every 10 grams is one bag or a box packing.
Toxicity test:
Acute toxicity testing: 80 of application mices, male and female half and half, body weight 18～26g, carries out acute toxicity test.Mice is divided into two groups at random, be matched group and administration group, before experiment, fasting is 12 hours, and the Chinese medicinal tablet of embodiments of the invention 1 preparation is dissolved in water, (concentration is 6.88g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 34.4 crude drugs/kg), matched group gives equivalent normal saline, administration in one day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet of the present invention is LD50 > 34.4 crude drugs/kg, every day, maximum dosage-feeding was 68.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 6.8g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.113g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 22g) oral administration gavage Chinese medicine of the present invention is quantity 609 times.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to mice by 11.54,18.38 and 15 weeks (1.0ml/100g body weight of 27.42g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Clinical data:
Case selection: whole 88 routine cases are my Out-patient Department or inpatient of in August, 2009～2012 year June.Be divided at random treatment group and matched group, treatment group 44 people wherein, male 20 people, women 24 people, 32～71 years old age; Matched group 44 people, male 18 people, women 26 people, 34～70 years old age.Two groups at aspects such as age, sex, clinical manifestations Epidemiological Analysis there was no significant difference (p > 0.05) by statistics.
Diagnostic criteria: (Chinese Medical Association writes according to " clinic diagnosis guide-respirology fascicle ", People's Health Publisher), chronic or recurrent cough, expectoration or companion pant, annual morbidity continues 3 months, continuous 2 years or more than, and get rid of other heart, lung disease (pulmonary tuberculosis, pneumoconiosis, bronchial asthma, bronchiectasis, pulmonary carcinoma, heart disease, cardiac insufficiency etc.), and clinical syndrome is mainly cough, asthma, heating, uncomfortable in chest, bitter taste, yearningly do not think drink, yellowish urine and expectorant are yellow glutinous, and tongue fur Bai Huanghou is greasy etc.
Therapeutic Method: treatment group: take the tablet of Chinese medicine embodiment 1 of the present invention, each 4, every day 3 times.It within 30 days, is a course for the treatment of.
Matched group: the each 0.25～0.5g of oral cefalexin, every day 3 times; Each 0.3～the 0.5g of oral ammonium chloride, every day 3 times; Each 0.1～the 0.2g of aminophylline, every day 3 times.It within 30 days, was 1 course for the treatment of.
Symptom curative effect judging standard: cure: cough and clinical symptom disappearance, endogenous cough is in more than two weeks not outbreak.Effective: cough alleviates, amount of expectoration reduces.Invalid: clinical symptoms is without change.
Therapeutic outcome: treat respectively after 1 course for the treatment of for two groups, statistical result is referring to table 1 and table 2.As can be seen from Table 1, adopt the damp and hot phlegm stagnancy type for the treatment of by Chinese herbs of the present invention chronic bronchitis, with respect to Western medicine, on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt the damp and hot phlegm stagnancy type for the treatment of by Chinese herbs of the present invention chronic bronchitis, with respect to Western medicine, treating significantly shortening on the course for the treatment of.
After table 1 liang group is treated respectively 1 course for the treatment of, Clinical efficacy comparison is routine
| Group | n | Cure | Effectively | Invalid | Effectively total |
| Treatment group | 44 | 34 | 9 | 1 | 43(97.7%) |
| Matched group | 44 | 20 | 14 | 10 | 34(77.3%) |
Table 2 liang group is treated respectively healing number and time comparative example (%) after 1 course for the treatment of
| Group | Number of cases | Medication 15 days | Medication 20 days | Medication 25 days | Medication 30 days |
| Treatment group | 34 | 6(17.6%) | 15(44.1%) | 12(35.3%) | 1(2.9%) |
| Matched group | 20 | 1(5%) | 4(20%) | 9(45%) | 6(30%) |
Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; The 20 routine patients that the 34 routine patients that simultaneously treatment group cured and matched group are cured follow up a case by regular visits to respectively 2 years, result statistics, and the routine patient for the treatment of group 34 is without recurrence, and relapse rate is 0%; The routine patient of matched group 20, recurs 5 people, relapse rate 25%.
Model case: Wei, female, 43 years old, autumn has set in every year started cough existing 3 years, continues more than four months every year, abundant expectoration yellow skin, expectoration thickness, poor appetite abdominal distention, bitter taste, tongue fur is white, thick greasy, stringy and rolling pulse.There is dry moist rale in auscultation base of lung portion, and it is thick that chest x-ray shows that two lung bottom textures increase.Be diagnosed as damp and hot phlegm stagnancy type chronic bronchitis.Take 11 course for the treatment of of tablet of Chinese medicine preparation embodiment of the present invention, recovery from illness, follows up a case by regular visits to not recurrence in 2 years.
Claims (9)
1. a Chinese medicine for the treatment of damp and hot phlegm stagnancy type chronic bronchitis, is characterized in that, each raw medicinal material of described Chinese medicine comprises: Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae, Caulis et Folium Argyreia eacutae, Usnea, Herba parnassiae, Flos micheliae Albae, Rhizoma Begoniae Fimbristipulatae, Herba Spilanthis Acmellae, Folium Elaeagni delavayi and Flos Gomphrenae.
2. Chinese medicine as claimed in claim 1, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 30～40 parts of Viola odoratas, 20～30 parts of Herba Saxifragaes, 10～20 parts of Pericarpium Citri Reticulataes, 25～35 parts of Herba Limnophilae rugosaes, 15～25 parts of Herba Eupatorii Lindleyanis, 5～15 parts of Herba Reineckeae Carneaes, 10～20 parts of Caulis et Folium Argyreia eacutae, 20～30 parts of Usneas, 15～25 parts of Herba parnassiaes, 10～20 parts of Flos micheliae Albae, 5～15 parts of Rhizoma Begoniae Fimbristipulataes, 25～40 parts of Herba Spilanthis Acmellae, 10～20 parts of 20～30 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
3. Chinese medicine as claimed in claim 1 or 2, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 35～40 parts of Viola odoratas, 25～30 parts of Herba Saxifragaes, 15～20 parts of Pericarpium Citri Reticulataes, 30～35 parts of Herba Limnophilae rugosaes, 20～25 parts of Herba Eupatorii Lindleyanis, 5～10 parts of Herba Reineckeae Carneaes, 10～15 parts of Caulis et Folium Argyreia eacutae, 20～25 parts of Usneas, 20～25 parts of Herba parnassiaes, 15～20 parts of Flos micheliae Albae, 10～15 parts of Rhizoma Begoniae Fimbristipulataes, 25～35 parts of Herba Spilanthis Acmellae, 10～15 parts of 20～25 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 38 parts of Viola odoratas, 28 parts of Herba Saxifragaes, 16 parts of Pericarpium Citri Reticulataes, 33 parts of Herba Limnophilae rugosaes, 22 parts of Herba Eupatorii Lindleyanis, 6 parts of Herba Reineckeae Carneaes, 12 parts of Caulis et Folium Argyreia eacutae, 23 parts of Usneas, 21 parts of Herba parnassiaes, 18 parts of Flos micheliae Albae, 13 parts of Rhizoma Begoniae Fimbristipulataes, 29 parts of Herba Spilanthis Acmellae, 13 parts of 24 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 36 parts of Viola odoratas, 27 parts of Herba Saxifragaes, 19 parts of Pericarpium Citri Reticulataes, 31 parts of Herba Limnophilae rugosaes, 24 parts of Herba Eupatorii Lindleyanis, 9 parts of Herba Reineckeae Carneaes, 15 parts of Caulis et Folium Argyreia eacutae, 25 parts of Usneas, 24 parts of Herba parnassiaes, 16 parts of Flos micheliae Albae, 11 parts of Rhizoma Begoniae Fimbristipulataes, 32 parts of Herba Spilanthis Acmellae, 15 parts of 22 parts of Folium Elaeagni delavayis and Flos Gomphrenaes.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mix, the alcohol reflux that to add with respect to 3～5 times, mixture amount determining alcohols be 60%～70% at every turn 2～4 times, each 2～4 hours, filters respectively, each time filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;
Second step, is mixed in proportion surplus stock medical material, adds with respect to 3～5 times of water gagings of mixture, decocts 2～4 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.27～1.29;
The 3rd step, the mastic that the first step, second step are obtained mixes, and 60 ℃～65 ℃ reduced vacuum are dry, and powder gets dry extract;
The 4th step, mixes processing by described dried cream powder and starch, obtains mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.03～0.05; Described mastic mixture is carried out to pelletization treatment, dried, obtain mastic compound particles;
The 5th step, mixes processing, tabletting processing, Cotton seeds successively by described mastic compound particles and Pulvis Talci, magnesium stearate, obtains Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1～3: 0.15～0.3.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 20～40 hours, decocts 2～4 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3～6 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, decocts 2～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 3～6 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200～300 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 25%～40%, and by pouch or packing box packing for the material after mixing, every 5～10 grams is one bag or a box packing.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mix, the alcohol reflux that to add with respect to 3～5 times, mixture amount determining alcohols be 60%～70% at every turn 2～4 times, each 2～4 hours, filters respectively, each time filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;
Second step, is mixed in proportion surplus stock medical material, adds with respect to 3～5 times of water gagings of mixture, decocts 2～4 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.27～1.29;
The 3rd step, the mastic that the first step, second step are obtained mixes, and 60 ℃～65 ℃ reduced vacuum are dry, and powder gets dry extract;
The 4th step, mixes processing by described dried cream powder and starch, obtains mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.03～0.05; Described mastic mixture is carried out to pelletization treatment, dried, obtain mastic compound particles;
The 5th step, mixes processing, tabletting processing, Cotton seeds successively by described mastic compound particles and Pulvis Talci, magnesium stearate, obtains Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1～3: 0.15～0.3.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 20～40 hours, decocts 2～4 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 3～6 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, decocts 2～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 3～6 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200～300 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 25%～40%, and by pouch or packing box packing for the material after mixing, every 5～10 grams is one bag or a box packing.
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