CN103520444B - Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine Download PDFInfo
- Publication number
- CN103520444B CN103520444B CN201310502677.0A CN201310502677A CN103520444B CN 103520444 B CN103520444 B CN 103520444B CN 201310502677 A CN201310502677 A CN 201310502677A CN 103520444 B CN103520444 B CN 103520444B
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- chinese medicine
- mastic
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw medicinal materials of angiospermae, saxifrage, pericarpium citri reticulatae, aqueous fennel, lindley eupatorium herb, reineckia carnea, argyreia acuta, usnea, parnassia palustris, gardenia, begonia fimbristipula, herbof paniculate spotflower, delavay greenleaf elaeagnus leaves and globe amaranth. The traditional Chinese medicine is used for dispelling wind, clearing heat, tonifying spleen, eliminating dampness, regulating qi, relieving the asthma, relieving cough and reducing sputum and has a definite treating effect and a low side effect.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of damp and hot phlegm stagnancy type chronic bronchitis.
Background technology
Chronic bronchitis (chronicbronchitis) is trachea, the chronic nonspecific inflammation of bronchial mucosa and surrounding tissue thereof.Clinically with cough, expectoration or be cardinal symptom with asthma recurrent exerbation of etc.ing, lasting 3 months every year, continuous more than 2 years.Early symptom is slight, and more than winter attack, spring and summer is alleviated.Late period, symptom can exist throughout the year because of increased inflammation.Its Pathologic Characteristics is bronchus glandular hyperplasia and mucosa secretion increasing.The state of an illness is slow Progressive symmetric erythrokeratodermia progress, and Chang Bingfa obstructive emphysema, severe patient often pulmonary hypertension occurs, even pulmonary heart disease.
Current western medicine chronic bronchitis mainly adopts infection, the Therapeutic Method such as antitussive and antiasthmatic, though have certain curative effect for symptom management, relief of symptoms, cannot effect a radical cure, and easily causes bacterial drug resistance due to abuse of antibiotics, and treatment difficulty is strengthened.
Chronic bronchitis belongs to " cough ", " the syndrome of dyspnea ", " phlegm retention " category of the traditional Chinese medical science.Dirty closely related with lung, spleen, kidney three.Chronic bronchitis is mainly reflected as lung on pathogenesis, spleen, kidney three deficiency of five ZANG-organs damage, and their mutual relation is unbalance, simultaneously the more sophisticated because of the participation of the factors such as expectorant, fire, the stasis of blood again.Its basic pathogenesis is deficiency in origin and excess in superficiality.
The traditional Chinese medical science is particular about differentiation of symptoms and signs for classification of syndrome treatment, and Chinese medicine is divided into following four types by dialectical for chronic bronchitis: (1) external cold internal rheum type (2) damp and hot phlegm stagnancy type (3) type of deficiency of both QI and YIN (4) yang deficiency of spleen and stomache.And damp and hot phlegm stagnancy type bronchitis is attacked caused by lung due to damp and hot, its clinical syndrome is mainly cough, asthma, heating, uncomfortable in chest, and bitter taste, does not think drink yearningly, yellowish urine and expectorant Huang glutinous, tongue fur Bai Huanghou is greasy.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of Chinese medicine and preparation method for the treatment of damp and hot phlegm stagnancy type chronic bronchitis, Chinese medicine wind and heat dispersing of the present invention, the spleen strengthening and damp drying, regulates the flow of vital energy and relievings asthma, relieving cough and resolving phlegm, have definite curative effect to the damp and hot phlegm stagnancy type chronic bronchitis for the treatment of, side effect is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of damp and hot phlegm stagnancy type chronic bronchitis, each raw medicinal material of described Chinese medicine comprises: Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae, Caulis et Folium Argyreia eacutae, Usnea, Herba parnassiae, Flos micheliae Albae, Rhizoma Begoniae Fimbristipulatae, Herba Spilanthis Acmellae, Folium Elaeagni delavayi and Flos Gomphrenae.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 30 ~ 40 parts, Herba Saxifragae 20 ~ 30 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Herba Limnophilae rugosae 25 ~ 35 parts, Herba Eupatorii Lindleyani 15 ~ 25 parts, Herba Reineckeae Carneae 5 ~ 15 parts, Caulis et Folium Argyreia eacutae 10 ~ 20 parts, Usnea 20 ~ 30 parts, Herba parnassiae 15 ~ 25 parts, Flos micheliae Albae 10 ~ 20 parts, Rhizoma Begoniae Fimbristipulatae 5 ~ 15 parts, Herba Spilanthis Acmellae 25 ~ 40 parts, Folium Elaeagni delavayi 20 ~ 30 parts and Flos Gomphrenae 10 ~ 20 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 35 ~ 40 parts, Herba Saxifragae 25 ~ 30 parts, Pericarpium Citri Reticulatae 15 ~ 20 parts, Herba Limnophilae rugosae 30 ~ 35 parts, Herba Eupatorii Lindleyani 20 ~ 25 parts, Herba Reineckeae Carneae 5 ~ 10 parts, Caulis et Folium Argyreia eacutae 10 ~ 15 parts, Usnea 20 ~ 25 parts, Herba parnassiae 20 ~ 25 parts, Flos micheliae Albae 15 ~ 20 parts, Rhizoma Begoniae Fimbristipulatae 10 ~ 15 parts, Herba Spilanthis Acmellae 25 ~ 35 parts, Folium Elaeagni delavayi 20 ~ 25 parts and Flos Gomphrenae 10 ~ 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 38 parts, Herba Saxifragae 28 parts, Pericarpium Citri Reticulatae 16 parts, Herba Limnophilae rugosae 33 parts, Herba Eupatorii Lindleyani 22 parts, Herba Reineckeae Carneae 6 parts, Caulis et Folium Argyreia eacutae 12 parts, Usnea 23 parts, Herba parnassiae 21 parts, Flos micheliae Albae 18 parts, Rhizoma Begoniae Fimbristipulatae 13 parts, Herba Spilanthis Acmellae 29 parts, Folium Elaeagni delavayi 24 parts and Flos Gomphrenae 13 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 36 parts, Herba Saxifragae 27 parts, Pericarpium Citri Reticulatae 19 parts, Herba Limnophilae rugosae 31 parts, Herba Eupatorii Lindleyani 24 parts, Herba Reineckeae Carneae 9 parts, Caulis et Folium Argyreia eacutae 15 parts, Usnea 25 parts, Herba parnassiae 24 parts, Flos micheliae Albae 16 parts, Rhizoma Begoniae Fimbristipulatae 11 parts, Herba Spilanthis Acmellae 32 parts, Folium Elaeagni delavayi 22 parts and Flos Gomphrenae 15 parts.
Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be at every turn 60% ~ 70% alcohol reflux 2 ~ 4 times, each 2 ~ 4 hours, filter respectively, each time filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, decocts 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 60 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.03 ~ 0.05; Described mastic mixture is carried out pelletization treatment, dried, obtains mastic compound particles;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 20 ~ 40 hours, decocts 2 ~ 4 hours, decoction liquor filtered, obtain the first filtrate, the quality of the water added is 3 ~ 6 times of the powder quality of first step acquisition;
3rd step, filters second step the filtering residue obtained and again adds in cold water, decoct 2 ~ 4 hours, filter acquisition second filtrate, and the quality of the water added is 3 ~ 6 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200 ~ 300 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 25% ~ 40%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
Beneficial effect of the present invention: Chinese medicine wind and heat dispersing of the present invention, the spleen strengthening and damp drying, regulates the flow of vital energy and relievings asthma, relieving cough and resolving phlegm, and have definite curative effect to the damp and hot phlegm stagnancy type chronic bronchitis for the treatment of, side effect is little.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of damp and hot phlegm stagnancy type chronic bronchitis, each raw medicinal material of described Chinese medicine comprises: Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae, Caulis et Folium Argyreia eacutae, Usnea, Herba parnassiae, Flos micheliae Albae, Rhizoma Begoniae Fimbristipulatae, Herba Spilanthis Acmellae, Folium Elaeagni delavayi and Flos Gomphrenae.
In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:
Viola odorata: acrid in the mouth, micro-hardship, cool in nature.Wind and heat dispersing, eliminating phlegm and stopping cough, calm, antidiarrheal.The main cough due to common cold, pertussis, hysteria, insomnia, diarrhoea, dysentery.
Herba Saxifragae: bitter in the mouth, pungent, cold.Return lung, spleen, large intestine channel.Wind and heat dispersing, removing pathogenic heat from blood and toxic substance from the body.Main air heat cough, rubella, eczema, otitis media, erysipelas, cough is spitted blood, lung abscess, metrorrhagia, haemorrhoids." classifying herbal ": clearing away lung-heat, control cough, treat rubella, erysipelas." Jiangxi traditional herbal medicine ": control cough due to lung-heat's QI rising in reverse order, spit blood, lung abscess tells smelly pus, pertussis, liver-fire, consumptive disease in childhood.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Herba Limnophilae rugosae: acrid in the mouth, sweet, warm in nature.Return lung, spleen, stomach warp.Invigorating spleen to remove dampness, activating QI to eliminate phlegm.For flu, laryngopharynx swelling and pain, cough due to lung-heat, bronchitis." Nanning City's medicine will ": dampness removes expectorant, reducing swelling and alleviating pain, parasite killing detoxifies.Control asthma and cough, children's's milk abdominal mass, furuncle, snakebite, cold syndrome of the stomach pain.
Herba Eupatorii Lindleyani: bitter in the mouth, property is put down.Clearing away lung-heat to relieve cough, resolving phlegm and relieving asthma, blood pressure lowering.Main bronchus is scorching, cough with copious phlegm, hypertension.
Herba Reineckeae Carneae: sweet is flat.Nourishing the lung to arrest cough, dispels the wind, synthetism.For pulmonary tuberculosis, cough spitting of blood, chronic bronchitis, asthma, rheumatic arthritis; Traumatic injury is controlled in external, fracture." detailed outline is picked up any lost article from the road ": treating blood disorders, lung heat clearing, separating fire-toxin, is throat disease key medicine." Tian Bao book on Chinese herbal medicine ": clearing away lung-heat to relieve cough reduces phlegm.Control nosebleed, red skin ulcer, acute catarrhal conjunctivitis, traumatic injury.
Caulis et Folium Argyreia eacutae: pungent, micro-hardship, cool.Expelling wind and removing dampness, preventing phlegm from forming and stopping coughing, dissipating blood stasis stops blooding, removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome, edema, expand, cough with asthma abundant expectoration, leukorrhagia, metrorrhagia, hematmesis due to visceral injury, traumatic injury amasss the stasis of blood, acute mastitis, furuncle, rotten foot, eczema.
Usnea: sweet, flat.Heat-clearing and toxic substances removing, relieving cough and resolving phlegm.For pulmonary tuberculosis (sodium salt of multiplex usnic acid), chronic bronchitis; Traumatic infection is controlled in external, and postoperative incision infects, suppurative otitis media, furuncle, tuberculous lymphadenitis, mastitis, burn, cervical erosion, trichomonas vaginitis." Chinese herbal medicine is commonly used in Tibet ": heat-clearing and toxic substances removing, relieving cough and resolving phlegm.Control trauma infection contamination, pyogenic infection, venom, pulmonary tuberculosis cough with copious phlegm, cervical adenitis, mastitis.
Herba parnassiae: bitter, cool.Enter lung, liver, gallbladder three warp.Heat-clearing and toxic substances removing, relieving cough and resolving phlegm.For bacillary dysentery, laryngopharynx swelling and pain, pertussis, cough with copious phlegm.
Flos micheliae Albae: toil, temperature.Enter lung, spleen two warp.Removing dampness, circulation of qi promoting, relieving cough and resolving phlegm.Control chronic bronchitis, prostatitis, women leucorrhea.
Rhizoma Begoniae Fimbristipulatae: sweet is light, cool.Clearing away heat and cooling blood, promoting blood circulation and detoxication.Control summer-heat hyperpyrexia, cough due to lung-heat, spitting of blood, osteopatia sprain, blood stasis pain, sore scabies, burn due to hot liquid or fire." conventional Chinese herbal medicine color atlas ": control pneumonia cough, spitting of blood, chronic bronchitis.
Herba Spilanthis Acmellae: pungent, bitter, tepor.Relieving cough and asthma, detoxification and promoting urination, reducing swelling and alleviating pain.Cure cold cough, chronic bronchitis, asthma, pertussis, pulmonary tuberculosis, venom, sore swollen toxin, toothache.Guangzhou army " conventional Chinese herbal medicine handbook ": relieving cough and relieving asthma, reducing swelling and alleviating pain.Cure cold cough, chronic bronchitis, asthma, pertussis, pulmonary tuberculosis, venom, sore swollen toxin, toothache.
Folium Elaeagni delavayi: sweet in the mouth, acid, property is put down.Return lung, kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, Tonglin Paishi, relieving cough and asthma.Cure mainly chronic nephritis, renal calculus, urinary tract infection, icterohepatitis, chronic bronchitis, bronchial asthma, stomachache.
Flos Gomphrenae: sweet, flat.Eliminate the phlegm, relieving asthma.For chronic bronchitis, asthmatic chronic bronchitis, asthma and cough, dysentery, pertussis, infantile convulsion, scrofula is stolen, skin infection." Guangxi Chinese medicinal herbal ": inflorescence: removing heat from blood is subsided a swelling, and relieving convulsion is coughed.Control pertussis; External treatment skin infection swells and ache.Among the peoplely control menoxenia.Herb pot water washout, controls traumatic injury furuncle.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 30 ~ 40 parts, Herba Saxifragae 20 ~ 30 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Herba Limnophilae rugosae 25 ~ 35 parts, Herba Eupatorii Lindleyani 15 ~ 25 parts, Herba Reineckeae Carneae 5 ~ 15 parts, Caulis et Folium Argyreia eacutae 10 ~ 20 parts, Usnea 20 ~ 30 parts, Herba parnassiae 15 ~ 25 parts, Flos micheliae Albae 10 ~ 20 parts, Rhizoma Begoniae Fimbristipulatae 5 ~ 15 parts, Herba Spilanthis Acmellae 25 ~ 40 parts, Folium Elaeagni delavayi 20 ~ 30 parts and Flos Gomphrenae 10 ~ 20 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 35 ~ 40 parts, Herba Saxifragae 25 ~ 30 parts, Pericarpium Citri Reticulatae 15 ~ 20 parts, Herba Limnophilae rugosae 30 ~ 35 parts, Herba Eupatorii Lindleyani 20 ~ 25 parts, Herba Reineckeae Carneae 5 ~ 10 parts, Caulis et Folium Argyreia eacutae 10 ~ 15 parts, Usnea 20 ~ 25 parts, Herba parnassiae 20 ~ 25 parts, Flos micheliae Albae 15 ~ 20 parts, Rhizoma Begoniae Fimbristipulatae 10 ~ 15 parts, Herba Spilanthis Acmellae 25 ~ 35 parts, Folium Elaeagni delavayi 20 ~ 25 parts and Flos Gomphrenae 10 ~ 15 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 38 parts, Herba Saxifragae 28 parts, Pericarpium Citri Reticulatae 16 parts, Herba Limnophilae rugosae 33 parts, Herba Eupatorii Lindleyani 22 parts, Herba Reineckeae Carneae 6 parts, Caulis et Folium Argyreia eacutae 12 parts, Usnea 23 parts, Herba parnassiae 21 parts, Flos micheliae Albae 18 parts, Rhizoma Begoniae Fimbristipulatae 13 parts, Herba Spilanthis Acmellae 29 parts, Folium Elaeagni delavayi 24 parts and Flos Gomphrenae 13 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 36 parts, Herba Saxifragae 27 parts, Pericarpium Citri Reticulatae 19 parts, Herba Limnophilae rugosae 31 parts, Herba Eupatorii Lindleyani 24 parts, Herba Reineckeae Carneae 9 parts, Caulis et Folium Argyreia eacutae 15 parts, Usnea 25 parts, Herba parnassiae 24 parts, Flos micheliae Albae 16 parts, Rhizoma Begoniae Fimbristipulatae 11 parts, Herba Spilanthis Acmellae 32 parts, Folium Elaeagni delavayi 22 parts and Flos Gomphrenae 15 parts.
Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be at every turn 60% ~ 70% alcohol reflux 2 ~ 4 times, each 2 ~ 4 hours, filter respectively, each time filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, decocts 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 60 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.03 ~ 0.05; Described mastic mixture is carried out pelletization treatment, dried, obtains mastic compound particles;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 20 ~ 40 hours, decocts 2 ~ 4 hours, decoction liquor filtered, obtain the first filtrate, the quality of the water added is 3 ~ 6 times of the powder quality of first step acquisition;
3rd step, filters second step the filtering residue obtained and again adds in cold water, decoct 2 ~ 4 hours, filter acquisition second filtrate, and the quality of the water added is 3 ~ 6 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200 ~ 300 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 25% ~ 40%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Viola odorata 360g, Herba Saxifragae 270g, Pericarpium Citri Reticulatae 190g, Herba Limnophilae rugosae 310g, Herba Eupatorii Lindleyani 240g, Herba Reineckeae Carneae 90g, Caulis et Folium Argyreia eacutae 150g, Usnea 250g, Herba parnassiae 240g, Flos micheliae Albae 160g, Rhizoma Begoniae Fimbristipulatae 110g, Herba Spilanthis Acmellae 320g, Folium Elaeagni delavayi 220g and Flos Gomphrenae 150g.
Its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mixing, add relative to mixture 5 times amount determining alcohol be at every turn 60% alcohol reflux 4 times, each 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, decocts 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.04; Described mastic mixture is carried out pelletization treatment, dried, obtains mastic compound particles;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1.5: 0.3.
Embodiment 2: syrup
Get Viola odorata 380g, Herba Saxifragae 280g, Pericarpium Citri Reticulatae 160g, Herba Limnophilae rugosae 330g, Herba Eupatorii Lindleyani 220g, Herba Reineckeae Carneae 60g, Caulis et Folium Argyreia eacutae 120g, Usnea 230g, Herba parnassiae 210g, Flos micheliae Albae 180g, Rhizoma Begoniae Fimbristipulatae 130g, Herba Spilanthis Acmellae 290g, Folium Elaeagni delavayi 240g and Flos Gomphrenae 130g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 30 hours, decocts 3 hours, decoction liquor filtered, obtain the first filtrate, the quality of the water added is 4 times of the powder quality of first step acquisition;
3rd step, filters second step the filtering residue obtained and again adds in cold water, decoct 4 hours, filter acquisition second filtrate, and the quality of the water added is 6 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 200 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 30%, and by the material pouch after mixing or packing box subpackage, every 10 grams is one bag or a box subpackage.
Toxicity test:
Acute toxicity testing: application mice 80, male and female half and half, body weight 18 ~ 26g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 6.88g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 34.4 crude drugs/kg), matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>34.4 crude drug/kg, every day, maximum dosage-feeding was 68.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.113g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 22g) oral administration gavage Chinese medicine of the present invention is 609 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention presses 11.54,18.38 and 27.42g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 88 routine cases are my Out-patient Department or inpatient in August, 2009 ~ in June, 2012.Be divided into treatment group and matched group at random, wherein treatment group 44 people, male 20 people, women 24 people, 32 ~ 71 years old age; Matched group 44 people, male 18 people, women 26 people, 34 ~ 70 years old age.Two groups in age, sex, clinical manifestation etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: (Chinese Medical Association writes according to " clinic diagnosis guide-respirology fascicle ", People's Health Publisher), chronic or recurrent cough, expectoration or companion pant, annual morbidity continues 3 months, continuous 2 years or more, and get rid of other heart, lung disease (pulmonary tuberculosis, pneumoconiosis, bronchial asthma, bronchiectasis, pulmonary carcinoma, heart disease, cardiac insufficiency etc.), and clinical syndrome is mainly cough, asthma, heating, uncomfortable in chest, bitter taste, yearningly do not think drink, yellowish urine and expectorant Huang stick, and tongue fur Bai Huanghou is greasy.
Therapeutic Method: treatment group: the tablet taking Chinese medicine embodiment 1 of the present invention, each 4, every day 3 times.It within 30 days, is a course for the treatment of.
Matched group: each 0.25 ~ 0.5g of oral cefalexin, every day 3 times; Each 0.3 ~ the 0.5g of oral ammonium chloride, every day 3 times; Each 0.1 ~ the 0.2g of aminophylline, every day 3 times.It within 30 days, was 1 course for the treatment of.
Symptom curative effect judging standard: cure: cough and clinical symptom disappearance, endogenous cough did not show effect more than two weeks.Effective: cough alleviates, amount of expectoration reduces.Invalid: clinical symptoms is without change.
Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.As can be seen from Table 1, adopt treatment by Chinese herbs of the present invention damp and hot phlegm stagnancy type chronic bronchitis, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs of the present invention damp and hot phlegm stagnancy type chronic bronchitis, relative to Western medicine, treatment the course for the treatment of on significantly shorten.
After table 1 liang group treats 1 course for the treatment of respectively, Clinical efficacy comparison is routine
| Group | n | Cure | Effectively | Invalid | Effectively total |
| Treatment group | 44 | 34 | 9 | 1 | 43(97.7%) |
| Matched group | 44 | 20 | 14 | 10 | 34(77.3%) |
Number and time comparative example (%) is cured after a table 2 liang group treats 1 course for the treatment of respectively
| Group | Number of cases | Medication 15 days | Medication 20 days | Medication 25 days | Medication 30 days |
| Treatment group | 34 | 6(17.6%) | 15(44.1%) | 12(35.3%) | 1(2.9%) |
| Matched group | 20 | 1(5%) | 4(20%) | 9(45%) | 6(30%) |
According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Follow up a case by regular visits to 2 years respectively to the 20 routine patients that 34 routine patients and the matched group for the treatment of group healing are cured, result is added up, and the routine patient for the treatment of group 34 is without recurrence, and relapse rate is 0% simultaneously; The routine patient of matched group 20, recurs 5 people, relapse rate 25%.
Model case: Wei, female, 43 years old, autumn has set in every year started cough existing 3 years, and continue more than four months every year, abundant expectoration yellow skin, expectoration thickness, poor appetite abdominal distention, bitter taste, tongue fur is white, thick greasy, stringy and rolling pulse.There is dry moist rale in auscultation base of lung portion, and it is thick that chest x-ray shows that two lung bottom textures increase.Be diagnosed as damp and hot phlegm stagnancy type chronic bronchitis.Take Chinese medicine preparation embodiment 1 tablet 1 of the present invention course for the treatment of, recovery from illness, follows up a case by regular visits to and does not recur for 2 years.
Claims (4)
1. treat a Chinese medicine for damp and hot phlegm stagnancy type chronic bronchitis, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 30 ~ 40 parts, Herba Saxifragae 20 ~ 30 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Herba Limnophilae rugosae 25 ~ 35 parts, Herba Eupatorii Lindleyani 15 ~ 25 parts, Herba Reineckeae Carneae 5 ~ 15 parts, Caulis et Folium Argyreia eacutae 10 ~ 20 parts, Usnea 20 ~ 30 parts, Herba parnassiae 15 ~ 25 parts, Flos micheliae Albae 10 ~ 20 parts, Rhizoma Begoniae Fimbristipulatae 5 ~ 15 parts, Herba Spilanthis Acmellae 25 ~ 40 parts, Folium Elaeagni delavayi 20 ~ 30 parts and Flos Gomphrenae 10 ~ 20 parts;
The dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, by Viola odorata, Herba Saxifragae, Pericarpium Citri Reticulatae, Herba Limnophilae rugosae, Herba Eupatorii Lindleyani, Herba Reineckeae Carneae and Caulis et Folium Argyreia eacutae mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be at every turn 60% ~ 70% alcohol reflux 2 ~ 4 times, each 2 ~ 4 hours, filter respectively, each time filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, decocts 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 60 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; The weight ratio of described dried cream powder and described starch is 1: 0.03 ~ 0.05; Described mastic mixture is carried out pelletization treatment, dried, obtains mastic compound particles;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicinal tablet finished product; The weight ratio of described mastic compound particles granule, described Pulvis Talci and described magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 35 ~ 40 parts, Herba Saxifragae 25 ~ 30 parts, Pericarpium Citri Reticulatae 15 ~ 20 parts, Herba Limnophilae rugosae 30 ~ 35 parts, Herba Eupatorii Lindleyani 20 ~ 25 parts, Herba Reineckeae Carneae 5 ~ 10 parts, Caulis et Folium Argyreia eacutae 10 ~ 15 parts, Usnea 20 ~ 25 parts, Herba parnassiae 20 ~ 25 parts, Flos micheliae Albae 15 ~ 20 parts, Rhizoma Begoniae Fimbristipulatae 10 ~ 15 parts, Herba Spilanthis Acmellae 25 ~ 35 parts, Folium Elaeagni delavayi 20 ~ 25 parts and Flos Gomphrenae 10 ~ 15 parts.
3. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 38 parts, Herba Saxifragae 28 parts, Pericarpium Citri Reticulatae 16 parts, Herba Limnophilae rugosae 33 parts, Herba Eupatorii Lindleyani 22 parts, Herba Reineckeae Carneae 6 parts, Caulis et Folium Argyreia eacutae 12 parts, Usnea 23 parts, Herba parnassiae 21 parts, Flos micheliae Albae 18 parts, Rhizoma Begoniae Fimbristipulatae 13 parts, Herba Spilanthis Acmellae 29 parts, Folium Elaeagni delavayi 24 parts and Flos Gomphrenae 13 parts.
4. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Viola odorata 36 parts, Herba Saxifragae 27 parts, Pericarpium Citri Reticulatae 19 parts, Herba Limnophilae rugosae 31 parts, Herba Eupatorii Lindleyani 24 parts, Herba Reineckeae Carneae 9 parts, Caulis et Folium Argyreia eacutae 15 parts, Usnea 25 parts, Herba parnassiae 24 parts, Flos micheliae Albae 16 parts, Rhizoma Begoniae Fimbristipulatae 11 parts, Herba Spilanthis Acmellae 32 parts, Folium Elaeagni delavayi 22 parts and Flos Gomphrenae 15 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310502677.0A CN103520444B (en) | 2013-10-23 | 2013-10-23 | Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310502677.0A CN103520444B (en) | 2013-10-23 | 2013-10-23 | Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103520444A CN103520444A (en) | 2014-01-22 |
| CN103520444B true CN103520444B (en) | 2015-04-22 |
Family
ID=49923031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310502677.0A Expired - Fee Related CN103520444B (en) | 2013-10-23 | 2013-10-23 | Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103520444B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877391B (en) * | 2014-04-20 | 2016-04-20 | 杜彩霞 | One treats bronchitic Chinese medicine preparation and preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879803A (en) * | 2006-04-30 | 2006-12-20 | 周建祥 | A cough-stopping granule and method for preparing same |
| CN101926970A (en) * | 2010-07-30 | 2010-12-29 | 胡新海 | Medicament for treating chronic bronchitis and cough and preparation method thereof |
| CN102125669A (en) * | 2010-10-27 | 2011-07-20 | 宋爱民 | Chinese medicinal preparation for treating chronic bronchitis of phlegm-dampness accumulation in lung |
-
2013
- 2013-10-23 CN CN201310502677.0A patent/CN103520444B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879803A (en) * | 2006-04-30 | 2006-12-20 | 周建祥 | A cough-stopping granule and method for preparing same |
| CN101926970A (en) * | 2010-07-30 | 2010-12-29 | 胡新海 | Medicament for treating chronic bronchitis and cough and preparation method thereof |
| CN102125669A (en) * | 2010-10-27 | 2011-07-20 | 宋爱民 | Chinese medicinal preparation for treating chronic bronchitis of phlegm-dampness accumulation in lung |
Non-Patent Citations (2)
| Title |
|---|
| 中医药治疗慢性支气管炎研究进展;杨艳明;《中国医学创新》;20130630;第10卷(第16期);第160-162页 * |
| 中医辨证治疗慢性支气管炎肺气肿效果分析;李雄;《中医临床研究》;20121231;第4卷(第7期);第42-43页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103520444A (en) | 2014-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103212006A (en) | Traditional Chinese medicine for treating chronic bronchitis | |
| CN100457170C (en) | A Medicine for treatment of gastrointestinal diseases | |
| CN103990025B (en) | Traditional Chinese medicine for treating children cough variant asthma and preparation method of traditional Chinese medicine | |
| CN104042971A (en) | Medicine composition for treating yin deficiency toxic heat lung cancer and preparation method thereof | |
| CN103816323A (en) | Pill for treating helicobacter pylori related gastritis | |
| CN103446445B (en) | Traditional Chinese medicine preparation for treating qi-yin deficiency-type chronic bronchitis and preparation method thereof | |
| CN103520444B (en) | Traditional Chinese medicine for treating damp-heat phlegm depression type chronic bronchitis and preparation method of traditional Chinese medicine | |
| CN103520550B (en) | Traditional Chinese medicine for treating external cold internal rheum type chronic bronchitis and preparation method thereof | |
| CN103055286B (en) | Traditional Chinese medicine for treating chronic atrophic gastritis and preparation method thereof | |
| CN100415288C (en) | A Chinese traditional medicinal preparation for treatment of psoriasis | |
| CN103394002A (en) | Medicinal composition for treating cutaneous pruritus as well as preparation method and application thereof | |
| CN103585341A (en) | Traditional Chinese medicine composition for treating acute pancreatitis and preparation method of composition | |
| CN105327182A (en) | Medicine for treating child pertussis and preparation method thereof | |
| CN102949572A (en) | Medicinal composition for treating throat diseases, and its preparation method | |
| CN105535730A (en) | Novel traditional Chinese medicine composition for treating coughs and preparation method thereof | |
| CN101317990A (en) | Traditional Chinese medicine preparation for treating cough after common cold and preparation method thereof | |
| CN104398904B (en) | Chinese herbal preparation for oral care after esophagus cancer surgery and preparation method | |
| CN104173683A (en) | Traditional Chinese medicine composition for treating hyperthyroidism and preparation method thereof | |
| CN103251846B (en) | Traditional Chinese medicine composition for treating qi-deficiency type qi-reversed-flow-syndrome imagined bolus in throat | |
| CN103463601B (en) | Traditional Chinese medicine preparation for treating spleen and kidney yang-deficiency type chronic bronchitis and preparation method of traditional Chinese medicine preparation | |
| CN100546623C (en) | The psoriatic Chinese medicine preparation of a kind of treatment | |
| CN104784567B (en) | A kind of pharmaceutical composition for the treatment of urinary system infection | |
| CN104958672A (en) | Pharmaceutical composition for treating helicobacter pylori infectious gastropathy and preparation method of pharmaceutical composition | |
| CN105434670A (en) | Traditional Chinese medicine preparation for treating costal chondritis and preparation method thereof | |
| CN105497267A (en) | Traditional Chinese medicine composition for treating extreme noxious heat type infantile jaundice |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150422 Termination date: 20151023 |
|
| EXPY | Termination of patent right or utility model |