CN1682798A - Shenbao solid preparation good for kidney and its preparing method - Google Patents
Shenbao solid preparation good for kidney and its preparing method Download PDFInfo
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Abstract
The solid Shenbao preparation for kidney is prepared with 22 kinds of Chinese medicinal materials, including prepared fleeceflower root, prepared rhizome of rehmannia, epimedium as well as additives. The solid Shenbao preparation for kidney may be capsule, tablet, granule, etc. and has the advantages of wide application, high curative effect, easy taking and carrying about, etc. The medicine has the functions of regulating Yin and Yang, warming Yang and invigorating kidney, tranquilizing and strengthening body's resistance. It is used in treating impotence, apontaneous emission, menorrhagia and other diseases clinically and has obvious curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, specifically a kind of SHENBAO GUTI ZHIJI and preparation method thereof.
Background technology
The Shenbao preparation of being made up of 22 flavor medicines such as Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, Herba Epimedii has YIN and YANG balance regulating, temperature male wind-supplying kidney, and the controlling nocturnal emission with astringent drugs of calming the nerves, the function of strengthening the body resistance is used for sexual impotence, seminal emission, waist and leg ache, lassitude, nocturia, fear of cold is afraid of cold; Women's menorrhagia, all diseases of clear and thin leucorrhea are evident in efficacy.Renal aid syrup, SHENBAO HEJI (recording for the 17th and the 15th of Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ") are arranged at present.But former dosage form contains antiseptic, and sugar content height (the renal aid syrup contains 60% sucrose, and mixture also contains 20% sucrose) is unfavorable for that diabetes patient and body obesity person take, and liquid preparation is stable inadequately simultaneously, carries inconvenience.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, provide a kind of diabetes patient of being suitable for and body obesity person to take, have wide adaptability, good effect, take and carry the SHENBAO GUTI ZHIJI of storing advantages such as convenience, further satisfy and ensure the medication demand of extensive patients.
Purpose of the present invention can take following method to realize:
A kind of SHENBAO GUTI ZHIJI is characterized in that it is that component is formed or made the various solid preparations that active component and pharmaceutically acceptable additives are formed by the extract of following main materials by following main materials, as tablet, capsule, granule, pill etc.;
Fructus Cnidii 140-850 weight portion, Rhizoma Chuanxiong 140-860 weight portion, Semen Cuscutae 330-2000 weight portion, Fructus Psoraleae 140-860 weight portion, Poria 150-900 weight portion, Radix Ginseng Rubra 100-600 weight portion, Fructus Foeniculi 72-450 weight portion, Fructus Schisandrae Chinensis 180-1100 weight portion, Fructus Rosae Laevigatae 470-2850 weight portion, Rhizoma Atractylodis Macrocephalae 70-440 weight portion, Radix Angelicae Sinensis 230-1500 weight portion, Fructus Rubi 165-1000 weight portion, Radix Polygoni Multiflori Preparata 372-2500 weight portion, Semen Plantaginis 80-500 weight portion, Radix Rehmanniae Preparata 470-2900 weight portion, Fructus Lycii 330-2000 weight portion, Rhizoma Dioscoreae 230-1500 weight portion, Herba Epimedii 470-2900 weight portion, Semen Trigonellae 470-2900 weight portion, Radix Astragali 250-1600 weight portion, Herba Cistanches 230-1500 weight portion, Radix Glycyrrhizae Preparata 70-450 weight portion.
Its formula optimization is:
Fructus Cnidii 280 weight portions, Rhizoma Chuanxiong 283 weight portions, Semen Cuscutae 660 weight portions, Fructus Psoraleae 285 weight portions, Poria 300 weight portions, Radix Ginseng Rubra 200 weight portions, Fructus Foeniculi 144 weight portions, Fructus Schisandrae Chinensis 360 weight portions, Fructus Rosae Laevigatae 946 weight portions, the Rhizoma Atractylodis Macrocephalae 142 weight portions, Radix Angelicae Sinensis 468 weight portions, Fructus Rubi 329 weight portions, Radix Polygoni Multiflori Preparata 744 weight portions, Semen Plantaginis 165 weight portions, Radix Rehmanniae Preparata 940 weight portions, Fructus Lycii 660 weight portions, Rhizoma Dioscoreae 463 weight portions, Herba Epimedii 946 weight portions, Semen Trigonellae 940 weight portions, the Radix Astragali 514 weight portions, Herba Cistanches 473 weight portions, Radix Glycyrrhizae Preparata 142 weight portions.
Described pharmaceutically acceptable additives are following one or more:
Dextrin, starch, sucrose, lactose, Aspartane, stevioside, micropowder silica gel, methylcellulose, pregelatinized Starch, sodium alginate, citric acid, tartaric acid, sodium bicarbonate, magnesium stearate, 30 POVIDONE K 30 BP/USP
30, microcrystalline Cellulose, hydroxypropyl cellulose, carboxymethyl starch sodium, sodium carboxymethyl cellulose, carboxymethylcellulose calcium, ethylparaben, Oleum Sesami, soybean oil, Oleum Arachidis hypogaeae semen, beta-schardinger dextrin-, hydroxypropyl, glycerol, gelatin, Polyethylene Glycol, essence etc.
Described tablet can be ordinary tablet, fast disintegrating tablet, effervescent tablet or other various suitable tablets, and available suitable coating material coating is coating not also.
Described capsule can be soft capsule, hard capsule or other various suitable capsules.
Described granule can be plain particles, effervescent granule or other various suitable granules, can also can be Sugarless type for sugared type is arranged.
Described pill can be the common watered pill, honeyed pill etc., also can be drop pill, micropill or other suitable pill, and wherein micropill can directly be taken in the capsulae vacuus of also can packing into and take.
The preparation method of SHENBAO GUTI ZHIJI is characterized in that it may further comprise the steps:
(1) in the prescription Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Cnidii, Fructus Foeniculi pulverize or superfine powder be broken into fine powder directly use adopt alcohol extraction or first alcohol extraction medicinal residues again water carry or extract earlier the volatile ingredient medicinal residues again alcohol extraction method or extract method or other the suitable method that volatile ingredient medicinal residues reuse alcohol and water extracts respectively earlier and extract;
(2) Herba Epimedii pulverizing or superfine powder are broken into fine powder and directly use or adopt the method extraction that water is proposed or other is suitable again of alcohol extraction or first alcohol extraction medicinal residues in the prescription;
(3) in the prescription Radix Ginseng Rubra pulverize or superfine powder be broken into fine powder directly use or adopt after alcohol extraction or the alcohol extraction medicinal residues again water carry or all beat that fine powder is used or extract with other suitable method;
(4) Fructus Schisandrae Chinensis, Fructus Psoraleae are pulverized or superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or the first alcohol extraction medicinal residues method that water is carried or other is suitable is again extracted in the prescription;
(5) 14 flavors such as all the other Fructus Rubies are pulverized or superfine powder is broken into fine powder and directly uses or adopt water to carry or the first alcohol extraction medicinal residues method that water is carried or other is suitable is again extracted in the prescription;
(6) fine powder that is ground into described in the step was a 100-160 purpose fine powder, and the best is broken into 200-300 purpose fine powder for superfine powder;
(7) the alcohol extraction condition of the Radix Ginseng Rubra described in the step is: with 10-30% ethanol or 50-95% ethanol is solvent, can adopt heating reflux method or percolation or other suitable method to extract; The alcohol extraction condition of all the other each medicines is: with 50-95% ethanol is solvent, can adopt heating reflux method or percolation or other suitable method to extract;
(8) extraction of the volatile ingredient described in the step can adopt the way of distillation or supercritical methanol technology or other suitable method to extract.Extracting the volatile ingredient of gained can directly use or use or make clathrate with an amount of medicated powder absorption and use;
(9) condition carried of the water described in the step is: decoct with water/extract 1-3 time at 90-98 ℃, each 1-3 hour, best for decoct/90-98 ℃ of extraction secondary, each 2 hours.The medicinal residues of all the other flavour of a drug add when frying in shallow oil together, can add when second fries in shallow oil;
(10) extracting gained water extract in the step (9) can adopt precipitate with ethanol or acid precipitation or add the flocculating agent sedimentation or method that other is suitable is further handled;
(11) filter, can adopt conventional the filtration, centrifugal, ultrafiltration adds filtrations/centrifugal/ultrafiltration or other method that suits behind the clarifier;
(12) concentrate, can adopt concentrating under reduced pressure or thin film concentration or vacuum film to concentrate or other proper method;
(13) drying can adopt vacuum drying or spray drying or lyophilization or other suitable method;
(14) add described additives as required, adopt suitable moulding process, be prepared into various solid preparations, as tablet, capsule, granule, pill etc.
The specific embodiment
Embodiment 1:
Get Fructus Cnidii 280g, Rhizoma Chuanxiong 283g, Semen Cuscutae 660g, Fructus Psoraleae 285g, Poria 300g, Radix Ginseng Rubra 200g, Fructus Foeniculi 144g, Fructus Schisandrae Chinensis 360g, Fructus Rosae Laevigatae 946g, Rhizoma Atractylodis Macrocephalae 142g, Radix Angelicae Sinensis 468g, Fructus Rubi 329g, Radix Polygoni Multiflori Preparata 744g, Semen Plantaginis 165g, Radix Rehmanniae Preparata 940g, Fructus Lycii 660g, Rhizoma Dioscoreae 463g, Herba Epimedii 946g, Semen Trigonellae 940g, Radix Astragali 514g, Herba Cistanches 473g, Radix Glycyrrhizae Preparata 142g.
Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi are ground into coarse powder/be cut into decoction pieces, make solvent with 70% ethanol, flood after 48 hours, slowly percolation is collected percolate, reclaims ethanol, is concentrated into standby in right amount; Get red ginseng powder and be broken into coarse powder and make solvent, flood after 8 hours with 20% ethanol, the backflow secondary, each 2 hours, merge backflow, filter, filtrate recycling ethanol is concentrated into standby in right amount; Get ten Six-elements such as Fructus Rubi,, decoct with water secondary with the Radix Ginseng Rubra medicinal residues, each 2 hours, merge decoction liquor, filter, filtrate is concentrated into thick paste, adds the triplication ethanol precipitation 48 hours, gets supernatant and reclaims ethanol, be concentrated in right amount, merge with extracting solution such as above-mentioned red ginseng extract, Fructus Cnidiis, spray drying is made dried cream powder, with the appropriate amount of auxiliary materials mixing, granulate drying, granulate is packed 1000 parts, promptly gets granule for strengthening kidney.
Embodiment 2:
Get Fructus Cnidii 140g, Rhizoma Chuanxiong 140g, Semen Cuscutae 330g, Fructus Psoraleae 140g, Poria 150g, Radix Ginseng Rubra 100g, Fructus Foeniculi 72g, Fructus Schisandrae Chinensis 180g, Fructus Rosae Laevigatae 470g, Rhizoma Atractylodis Macrocephalae 70g, Radix Angelicae Sinensis 230g, Fructus Rubi 165g, Radix Polygoni Multiflori Preparata 372g, Semen Plantaginis 80g, Radix Rehmanniae Preparata 470g, Fructus Lycii 330g, Rhizoma Dioscoreae 230g, Herba Epimedii 470g, Semen Trigonellae 470g, Radix Astragali 250g, Herba Cistanches 230g, Radix Glycyrrhizae Preparata 70g.
Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi, Fructus Schisandrae Chinensis, Fructus Psoraleae are ground into coarse powder/be cut into decoction pieces, with 70% alcohol reflux secondary, each 2 hours, merge backflow twice, filter, filtrate recycling ethanol is standby; Medicinal residues add water 95-98 ℃ of extraction once again, and 2 hours time, extracting solution filters standby; Get red ginseng powder and be broken into coarse powder with 20% alcohol reflux secondary, each 2 hours, merge backflow, filter, filtrate recycling ethanol is standby; Get 14 flavors such as Fructus Rubi, with the Radix Ginseng Rubra medicinal residues, add water and extract secondary at 95-98 ℃, each 2 hours, merge extractive liquid, filtered standby; The water extracts of the water extract of Fructus Cnidii etc. and Fructus Rubi etc. merged carry out flocculating sedimentation, the alcohol extract of cleaner liquid and Radix Ginseng Rubra alcohol extract, Fructus Cnidii etc. merges, and is evaporated in right amount, spray drying is collected dried cream powder, encapsulated 1000, packing promptly gets kidney capsule.
Embodiment 3:
Get Fructus Cnidii 420g, Rhizoma Chuanxiong 420g, Semen Cuscutae 990g, Fructus Psoraleae 430g, Poria 450g, Radix Ginseng Rubra 300g, Fructus Foeniculi 220g, Fructus Schisandrae Chinensis 540g, Fructus Rosae Laevigatae 1420g, Rhizoma Atractylodis Macrocephalae 220g, Radix Angelicae Sinensis 700g, Fructus Rubi 490g, Radix Polygoni Multiflori Preparata 1120g, Semen Plantaginis 250g, Radix Rehmanniae Preparata 1410g, Fructus Lycii 990g, Rhizoma Dioscoreae 695g, Herba Epimedii 1410g, Semen Trigonellae 1410g, Radix Astragali 770g, Herba Cistanches 710g, Radix Glycyrrhizae Preparata 220g.
Get Radix Angelicae Sinensis, Rhizoma Chuanxiong power and be broken into coarse powder/be cut into decoction pieces and add the water distillation, extract volatile oil, it is standby to make Benexate Hydrochloride; Aqueous solution after the distillation filters standby; Medicinal residues and Fructus Cnidii, Herba Epimedii, Fructus Foeniculi, Fructus Schisandrae Chinensis, Fructus Psoraleae coarse powder/decoction pieces be with 70% alcohol reflux secondary, and each 2 hours, merge backflow twice, filter, filtrate recycling ethanol is standby; Get red ginseng powder and be broken into coarse powder with 20% alcohol reflux secondary, each 2 hours, merge backflow, filter, filtrate recycling ethanol is standby; Get 14 flavors such as Fructus Rubi,, decoct with water secondary, each 2 hours with the Radix Ginseng Rubra medicinal residues, medicinal residues such as Fructus Cnidii add when second fries in shallow oil, merge extractive liquid,, and ultrafiltration, the alcohol extract of filtrate and Radix Ginseng Rubra alcohol extract, Fructus Cnidii etc. merges, be evaporated in right amount, spray drying, it is standby to collect dried cream powder; Above-mentioned dried cream powder and above-mentioned Benexate Hydrochloride and appropriate amount of auxiliary materials mixing are granulated, drying, and 1000 of tablettings, packing promptly gets the renal aid sheet.
Embodiment 4:
Get Fructus Cnidii 280g, Rhizoma Chuanxiong 283g, Semen Cuscutae 660g, Fructus Psoraleae 285g, Poria 300g, Radix Ginseng Rubra 200g, Fructus Foeniculi 144g, Fructus Schisandrae Chinensis 540g, Fructus Rosae Laevigatae 1420g, Rhizoma Atractylodis Macrocephalae 220g, Radix Angelicae Sinensis 700g, Fructus Rubi 490g, Radix Polygoni Multiflori Preparata 1120g, Semen Plantaginis 250g, Radix Rehmanniae Preparata 1410g, Fructus Lycii 990g, Rhizoma Dioscoreae 695g, Herba Epimedii 1410g, Semen Trigonellae 1410g, Radix Astragali 770g, Herba Cistanches 710g, Radix Glycyrrhizae Preparata 220g.
Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi are ground into coarse powder/be cut into decoction pieces, make solvent with 70% ethanol, the reflux, extract, secondary, each 2 hours, extracting solution reclaimed ethanol, is concentrated into standby in right amount; Get red ginseng powder and be broken into coarse powder and make solvent, flood after 8 hours with 20% ethanol, the backflow secondary, each 2 hours, merge backflow, filter, filtrate recycling ethanol is concentrated into standby in right amount; Get ten Six-elements such as Fructus Rubi,, decoct with water secondary, each 2 hours with the Radix Ginseng Rubra medicinal residues, merge decoction liquor, filter, filtrate is concentrated into thick paste, added the triplication ethanol precipitation 48 hours, and got supernatant and reclaim ethanol, be concentrated into an amount of, merge with extracting solution such as above-mentioned red ginseng extract, Fructus Cnidiis, drying under reduced pressure is pulverized, dried cream powder and appropriate amount of auxiliary materials and effervescent mixing, dehydrated alcohol is granulated, drying, granulate is packed 1000 parts, promptly gets the renal aid effervescent granule.
Embodiment 5:
Get Fructus Cnidii 280g, Rhizoma Chuanxiong 283g, Semen Cuscutae 660g, Fructus Psoraleae 285g, Poria 300g, Radix Ginseng Rubra 100g, Fructus Foeniculi 72g, Fructus Schisandrae Chinensis 180g, Fructus Rosae Laevigatae 470g, Rhizoma Atractylodis Macrocephalae 70g, Radix Angelicae Sinensis 230g, Fructus Rubi 165g, Radix Polygoni Multiflori Preparata 744g, Semen Plantaginis 80g, Radix Rehmanniae Preparata 940g, Fructus Lycii 660g, Rhizoma Dioscoreae 463g, Herba Epimedii 946g, Semen Trigonellae 940g, Radix Astragali 250g, Herba Cistanches 230g, Radix Glycyrrhizae Preparata 70g.
Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi, Fructus Schisandrae Chinensis, Fructus Psoraleae are ground into coarse powder/decoction pieces, with 70% alcohol reflux secondary, each 2 hours, merge backflow twice, filter, filtrate recycling ethanol is standby; Medicinal residues add water 95-98 ℃ of extraction once again, and 2 hours time, extracting solution filters standby; Get red ginseng powder and be broken into coarse powder with 20% alcohol reflux secondary, each 2 hours, merge backflow, filter, filtrate recycling ethanol is standby; Get 14 flavors such as Fructus Rubi, with the Radix Ginseng Rubra medicinal residues, add water and extract secondary at 95-98 ℃, each 2 hours, merge extractive liquid, filtered standby; The water extracts of the water extract of Fructus Cnidii etc. and Fructus Rubi etc. merged carry out flocculating sedimentation, the alcohol extract of cleaner liquid and Radix Ginseng Rubra alcohol extract, Fructus Cnidii etc. merges, and is evaporated in right amount, drying under reduced pressure is ground into fine powder, with suitable drop pill substrate mixing, make drop pill, promptly get the renal aid drop pill.
Embodiment 6:
Fructus Cnidii 850 weight portions, Rhizoma Chuanxiong 860 weight portions, Semen Cuscutae 2000 weight portions, Fructus Psoraleae 860 weight portions, Poria 900 weight portions, Radix Ginseng Rubra 600 weight portions, Fructus Foeniculi 450 weight portions, Fructus Schisandrae Chinensis 1100 weight portions, Fructus Rosae Laevigatae 2850 weight portions, the Rhizoma Atractylodis Macrocephalae 440 weight portions, Radix Angelicae Sinensis 1500 weight portions, Fructus Rubi 1000 weight portions, Radix Polygoni Multiflori Preparata 2500 weight portions, Semen Plantaginis 500 weight portions, Radix Rehmanniae Preparata 2900 weight portions, Fructus Lycii 2000 weight portions, Rhizoma Dioscoreae 1500 weight portions, Herba Epimedii 2900 weight portions, Semen Trigonellae 2900 weight portions, the Radix Astragali 1600 weight portions, Herba Cistanches 1500 weight portions, Radix Glycyrrhizae Preparata 450 weight portions.
Get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Cnidii and be ground into coarse powder/decoction pieces and add the water distillation, extract volatile oil, it is standby to make Benexate Hydrochloride; Aqueous solution after the distillation filters standby; Medicinal residues and Herba Epimedii, Fructus Foeniculi, Fructus Schisandrae Chinensis, Fructus Psoraleae coarse powder/decoction pieces be with 95% alcohol reflux secondary, and each 2 hours, merge backflow twice, filter, filtrate recycling ethanol is standby; Get red ginseng powder and be broken into coarse powder with 20% alcohol reflux secondary, each 2 hours, merge backflow, filter, filtrate recycling ethanol is standby; Get 14 flavors such as Fructus Rubi,, decoct with water secondary, each 2 hours with medicinal residues such as Radix Ginseng Rubra medicinal residues, Herba Epimedii, merge extractive liquid, filters, and the alcohol extract of filtrate and Radix Ginseng Rubra alcohol extract, Fructus Cnidii etc. merges, be evaporated in right amount, spray drying, it is standby to collect dried cream powder; Clathrate and appropriate amount of auxiliary materials and effervescent mixings such as above-mentioned dried cream powder and above-mentioned Radix Angelicae Sinensis are granulated, drying, and 1000 of tablettings, packing promptly gets the renal aid effervescent tablet.
Embodiment 7:
Get Fructus Cnidii 140g, Rhizoma Chuanxiong 140g, Semen Cuscutae 330g, Fructus Psoraleae 140g, Poria 150g, Radix Ginseng Rubra 100g, Fructus Foeniculi 72g, Fructus Schisandrae Chinensis 180g, Fructus Rosae Laevigatae 470g, Rhizoma Atractylodis Macrocephalae 70g, Radix Angelicae Sinensis 230g, Fructus Rubi 165g, Radix Polygoni Multiflori Preparata 372g, Semen Plantaginis 80g, Radix Rehmanniae Preparata 470g, Fructus Lycii 330g, Rhizoma Dioscoreae 230g, Herba Epimedii 470g, Semen Trigonellae 470g, Radix Astragali 250g, Herba Cistanches 230g, Radix Glycyrrhizae Preparata 70g.
Get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Cnidii, Fructus Foeniculi and be ground into coarse powder/decoction pieces and add the water distillation, it is standby to extract volatile oil; Aqueous solution after the distillation filters standby; Medicinal residues and Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Psoraleae coarse powder/decoction pieces be with 70% alcohol reflux secondary, and each 2 hours, merge backflow twice, filter, filtrate recycling ethanol is standby; Get red ginseng powder and be broken into coarse powder with 20% alcohol reflux secondary, each 2 hours, merge backflow, filter, filtrate recycling ethanol is standby; Get 14 flavors such as Fructus Rubi,, decoct with water secondary with the Radix Ginseng Rubra medicinal residues, each 2 hours, merge extractive liquid, filtered, the alcohol extract of filtrate and Radix Ginseng Rubra alcohol extract, Fructus Cnidii etc. merges, and is evaporated in right amount drying under reduced pressure, be ground into fine powder, stir evenly with an amount of Oleum Glycines, add above-mentioned volatile oil, fully stir evenly, be pressed into 1000 of soft capsules, promptly get the renal aid soft capsule.
Embodiment 8:
Get Fructus Cnidii 420g, Rhizoma Chuanxiong 420g, Semen Cuscutae 990g, Fructus Psoraleae 430g, Poria 450g, Radix Ginseng Rubra 300g, Fructus Foeniculi 220g, Fructus Schisandrae Chinensis 540g, Fructus Rosae Laevigatae 1420g, Rhizoma Atractylodis Macrocephalae 220g, Radix Angelicae Sinensis 700g, Fructus Rubi 490g, Radix Polygoni Multiflori Preparata 1120g, Semen Plantaginis 250g, Radix Rehmanniae Preparata 1410g, Fructus Lycii 990g, Rhizoma Dioscoreae 695g, Herba Epimedii 1410g, Semen Trigonellae 1410g, Radix Astragali 770g, Herba Cistanches 710g, Radix Glycyrrhizae Preparata 220g.
Getting red ginseng powder, to be broken into fine powder standby, and Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi are ground into coarse powder, makes solvent with 70% ethanol, floods after 48 hours, and slowly percolation is collected percolate, reclaims ethanol, is concentrated into standby in right amount; Get ten Six-element medicines such as Fructus Rubi and decoct with water secondary, each 2 hours, merge decoction liquor with medicinal residues such as Fructus Cnidiis, filtration, filtrate are concentrated into thick paste, add the triplication ethanol precipitation 48 hours, and got supernatant and reclaim ethanol, concentrate extracting solution such as back and above-mentioned Fructus Cnidii, red ginseng extract merging, being concentrated into relative density is 1.05-1.15 (60 ℃), spray drying is made dried cream powder, with above-mentioned Radix Ginseng Rubra fine powder and appropriate amount of auxiliary materials mixing, pill, drying promptly gets the renal aid ball.
Embodiment 9:
Get Fructus Cnidii 280g, Rhizoma Chuanxiong 283g, Semen Cuscutae 660g, Fructus Psoraleae 285g, Poria 300g, Radix Ginseng Rubra 100g, Fructus Foeniculi 72g, Fructus Schisandrae Chinensis 180g, Fructus Rosae Laevigatae 470g, from art 70g, Radix Angelicae Sinensis 230g, Fructus Rubi 165g, Radix Polygoni Multiflori Preparata 744g, Semen Plantaginis 80g, Radix Rehmanniae Preparata 940g, Fructus Lycii 660g, Rhizoma Dioscoreae 463g, Herba Epimedii 946g, Semen Trigonellae 940g, Radix Astragali 250g, Herba Cistanches 230g, Radix Glycyrrhizae Preparata 70g.
Getting red ginseng powder, to be broken into coarse powder be solvent with 20% ethanol, flood after 8 hours, and the backflow secondary, each 2 hours, merge backflow, filter, filtrate recycling ethanol is concentrated into standby in right amount; Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi are ground into coarse powder, make solvent with 70% ethanol, flood after 48 hours, slowly percolation is collected percolate, reclaims ethanol, is concentrated into standby in right amount; Get ten Six-elements such as Fructus Rubi and decoct with water secondary, each 2 hours, merge decoction liquor with the medicinal residues of Radix Ginseng Rubra, filtration, filtrate are concentrated into thick paste, add the triplication ethanol precipitation 48 hours, get supernatant and reclaim ethanol, concentrate extracting solution such as back and above-mentioned Fructus Cnidii, red ginseng extract merging, being concentrated into relative density is 1.05-1.15 (60 ℃), and spray drying is made dried cream powder, with appropriate amount of auxiliary materials, mixing, pill, drying, coating promptly gets the renal aid ball.
Embodiment 9:
Get Fructus Cnidii 140g, Rhizoma Chuanxiong 140g, Semen Cuscutae 330g, Fructus Psoraleae 140g, Poria 150g, Radix Ginseng Rubra 100g, Fructus Foeniculi 72g, Fructus Schisandrae Chinensis 180g, Fructus Rosae Laevigatae 470g, Rhizoma Atractylodis Macrocephalae 70g, Radix Angelicae Sinensis 230g, Fructus Rubi 165g, Radix Polygoni Multiflori Preparata 372g, Semen Plantaginis 80g, Radix Rehmanniae Preparata 470g, Fructus Lycii 330g, Rhizoma Dioscoreae 230g, Herba Epimedii 470g, Semen Trigonellae 470g, Radix Astragali 250g, Herba Cistanches 230g, Radix Glycyrrhizae Preparata 70g.
Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi are ground into coarse powder/be cut into decoction pieces, make solvent with 70% ethanol, flood after 48 hours, slowly percolation is collected percolate, reclaims ethanol, is concentrated into standby in right amount; Getting Radix Ginseng Rubra pulverizing/superfine powder, to be broken into fine powder standby; Get ten Six-elements such as Fructus Rubi, decoct with water secondary, each 2 hours, merge decoction liquor, filter, filtrate is concentrated into thick paste, added the triplication ethanol precipitation 48 hours, and got supernatant and reclaim ethanol, be concentrated into an amount of, merge with extracting solution such as above-mentioned Fructus Cnidii, spray drying is made dried cream powder, with the appropriate amount of auxiliary materials mixing, granulate drying, encapsulated 1000, packing promptly gets kidney capsule.
Embodiment 10:
Get Fructus Cnidii 280g, Rhizoma Chuanxiong 283g, Semen Cuscutae 660g, Fructus Psoraleae 285g, Poria 300g, Radix Ginseng Rubra 200g, Fructus Foeniculi 144g, Fructus Schisandrae Chinensis 360g, Fructus Rosae Laevigatae 946g, Rhizoma Atractylodis Macrocephalae 142g, Radix Angelicae Sinensis 468g, Fructus Rubi 329g, Radix Polygoni Multiflori Preparata 744g, Semen Plantaginis 165g, Radix Rehmanniae Preparata 940g, Fructus Lycii 660g, Rhizoma Dioscoreae 463g, Herba Epimedii 946g, Semen Trigonellae 940g, Radix Astragali 514g, Herba Cistanches 473g, Radix Glycyrrhizae Preparata 142g.
Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi are ground into coarse powder/be cut into decoction pieces, make solvent with 95% ethanol, flood after 48 hours, slowly percolation is collected percolate, reclaims ethanol, is concentrated into standby in right amount; Getting Radix Ginseng Rubra pulverizing/superfine powder, to be broken into fine powder standby; Get ten Six-elements such as Fructus Rubi, decoct with water secondary, each 2 hours with the medicinal residues of above-mentioned Fructus Cnidii etc., merge decoction liquor, add the clarifier ultrafiltration, filtrate is concentrated in right amount, merge with extracting solution such as above-mentioned Fructus Cnidii, spray drying is made dried cream powder, with the appropriate amount of auxiliary materials mixing, granulates, dry, granulate is packed 1000 parts, promptly gets granule for strengthening kidney.
Embodiment 11:
Get Fructus Cnidii 280g, Rhizoma Chuanxiong 283g, Semen Cuscutae 660g, Fructus Psoraleae 285g, Poria 300g, Radix Ginseng Rubra 200g, Fructus Foeniculi 144g, Fructus Schisandrae Chinensis 360g, Fructus Rosae Laevigatae 946g, Rhizoma Atractylodis Macrocephalae 142g, Radix Angelicae Sinensis 468g, Fructus Rubi 329g, Radix Polygoni Multiflori Preparata 744g, Semen Plantaginis 165g, Radix Rehmanniae Preparata 940g, Fructus Lycii 660g, Rhizoma Dioscoreae 463g, Herba Epimedii 946g, Semen Trigonellae 940g, Radix Astragali 514g, Herba Cistanches 473g, Radix Glycyrrhizae Preparata 142g.
Fructus Cnidii, Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi, Fructus Schisandrae Chinensis, Fructus Psoraleae, red ginseng powder are broken into coarse powder/decoction pieces, with 70% alcohol reflux secondary, each 2 hours, merge backflow twice, filter, filtrate recycling ethanol is standby; Medicinal residues add water and extract secondary, each 2 hours at 95-98 ℃ with 14 flavors such as Fructus Rubies, merge extractive liquid, adds clarifier, ultrafiltration, the alcohol extract of filtrate and Fructus Cnidii etc. merges, and is evaporated in right amount spray drying, collect dried cream powder,, granulate with an amount of dispersible tablet auxiliary materials and mixing, dry, 1000 of tablettings, packing promptly gets the renal aid dispersible tablet.
Embodiment 12:
Fructus Cnidii 850 weight portions, Rhizoma Chuanxiong 860 weight portions, Semen Cuscutae 2000 weight portions, Fructus Psoraleae 860 weight portions, Poria 900 weight portions, Radix Ginseng Rubra 600 weight portions, Fructus Foeniculi 450 weight portions, Fructus Schisandrae Chinensis 1100 weight portions, Fructus Rosae Laevigatae 2850 weight portions, from art 440 weight portions, Radix Angelicae Sinensis 1500 weight portions, Fructus Rubi 1000 weight portions, Radix Polygoni Multiflori Preparata 2500 weight portions, Semen Plantaginis 500 weight portions, Radix Rehmanniae Preparata 2900 weight portions, Fructus Lycii 2000 weight portions, Rhizoma Dioscoreae 1500 weight portions, Herba Epimedii 2900 weight portions, Semen Trigonellae 2900 weight portions, the Radix Astragali 1600 weight portions, Herba Cistanches 1500 weight portions, Radix Glycyrrhizae Preparata 450 weight portions.
Get Fructus Cnidii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi and be ground into coarse powder/decoction pieces and add the water distillation, extract volatile oil, it is standby to make Benexate Hydrochloride; Aqueous solution after the distillation filters standby; Medicinal residues and Herba Epimedii, Fructus Schisandrae Chinensis, Fructus Psoraleae, Radix Ginseng Rubra coarse powder/decoction pieces be with 90% alcohol reflux secondary, and each 1.5 hours, merge backflow twice, filter, filtrate recycling ethanol is concentrated into standby in right amount; Get 14 flavors such as Fructus Rubi and decoct with water secondary with above-mentioned alcohol extraction medicinal residues, each 2 hours, collecting decoction, ultrafiltration, filtrate is concentrated in right amount, and with the alcohol extract merging of Fructus Cnidii etc., drying under reduced pressure, it is standby to be ground into dried cream powder; Clathrate and appropriate amount of auxiliary materials mixings such as above-mentioned dried cream powder and above-mentioned Radix Angelicae Sinensis, directly/granulate back encapsulated 1000, packing promptly gets kidney capsule.
Claims (8)
1, a kind of SHENBAO GUTI ZHIJI is characterized in that it is that component is formed or made the various solid preparations that active component and pharmaceutically acceptable additives are formed by the extract of following main materials by following main materials, as tablet, capsule, granule, pill;
Fructus Cnidii 140-850 weight portion, Rhizoma Chuanxiong 140-860 weight portion, Semen Cuscutae 330-2000 weight portion, Fructus Psoraleae 140-860 weight portion, Poria 150-900 weight portion, Radix Ginseng Rubra 100-600 weight portion, Fructus Foeniculi 72-450 weight portion, Fructus Schisandrae Chinensis 180-1100 weight portion, Fructus Rosae Laevigatae 470-2850 weight portion, Rhizoma Atractylodis Macrocephalae 70-440 weight portion, Radix Angelicae Sinensis 230-1500 weight portion, Fructus Rubi 165-1000 weight portion, Radix Polygoni Multiflori Preparata 372-2500 weight portion, Semen Plantaginis 80-500 weight portion, Radix Rehmanniae Preparata 470-2900 weight portion, Fructus Lycii 330-2000 weight portion, Rhizoma Dioscoreae 230-1500 weight portion, Herba Epimedii 470-2900 weight portion, Semen Trigonellae 470-2900 weight portion, Radix Astragali 250-1600 weight portion, Herba Cistanches 230-1500 weight portion, Radix Glycyrrhizae Preparata 70-450 weight portion.
2, a kind of SHENBAO GUTI ZHIJI according to claim 1 is characterized in that its formula optimization is:
Fructus Cnidii 280 weight portions, Rhizoma Chuanxiong 283 weight portions, Semen Cuscutae 660 weight portions, Fructus Psoraleae 285 weight portions, Poria 300 weight portions, Radix Ginseng Rubra 200 weight portions, Fructus Foeniculi 144 weight portions, Fructus Schisandrae Chinensis 360 weight portions, Fructus Rosae Laevigatae 946 weight portions, the Rhizoma Atractylodis Macrocephalae 142 weight portions, Radix Angelicae Sinensis 468 weight portions, Fructus Rubi 329 weight portions, Radix Polygoni Multiflori Preparata 744 weight portions, Semen Plantaginis 165 weight portions, Radix Rehmanniae Preparata 940 weight portions, Fructus Lycii 660 weight portions, Rhizoma Dioscoreae 463 weight portions, Herba Epimedii 946 weight portions, Semen Trigonellae 940 weight portions, the Radix Astragali 514 weight portions, Herba Cistanches 473 weight portions, Radix Glycyrrhizae Preparata 142 weight portions.
3, a kind of SHENBAO GUTI ZHIJI according to claim 1 is characterized in that described pharmaceutically acceptable additives are following one or more:
Dextrin, starch, sucrose, lactose, Aspartane, stevioside, micropowder silica gel, methylcellulose, pregelatinized Starch, sodium alginate, citric acid, tartaric acid, sodium bicarbonate, magnesium stearate, 30 POVIDONE K 30 BP/USP
30, microcrystalline Cellulose, hydroxypropyl cellulose, carboxymethyl starch sodium, sodium carboxymethyl cellulose, carboxymethylcellulose calcium, ethylparaben, Oleum Sesami, soybean oil, Oleum Arachidis hypogaeae semen, beta-schardinger dextrin-, hydroxypropyl, glycerol, gelatin, Polyethylene Glycol, essence.
4, a kind of SHENBAO GUTI ZHIJI according to claim 1 is characterized in that: described tablet can be ordinary tablet, fast disintegrating tablet, effervescent tablet or other various suitable tablets, and available suitable coating material coating is coating not also.
5, a kind of SHENBAO GUTI ZHIJI according to claim 1 is characterized in that: described capsule can be soft capsule, hard capsule or other various suitable capsules.
6, a kind of SHENBAO GUTI ZHIJI according to claim 1 is characterized in that: described granule can be plain particles, effervescent granule or other various suitable granules, can also can be Sugarless type for sugared type is arranged.
7, a kind of SHENBAO GUTI ZHIJI according to claim 1, it is characterized in that: described pill can be the common watered pill, honeyed pill etc., also can be drop pill, micropill or other suitable pill, wherein micropill can directly be taken in the capsulae vacuus of also can packing into and take.
8, a kind of preparation method of SHENBAO GUTI ZHIJI is characterized in that it may further comprise the steps:
(1) in the prescription Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Cnidii, Fructus Foeniculi pulverize or superfine powder be broken into fine powder directly use adopt alcohol extraction or first alcohol extraction medicinal residues again water carry or extract earlier the volatile ingredient medicinal residues again alcohol extraction method or extract method or other the suitable method that volatile ingredient medicinal residues reuse alcohol and water extracts respectively earlier and extract;
(2) Herba Epimedii pulverizing or superfine powder are broken into fine powder and directly use or adopt the method extraction that water is proposed or other is suitable again of alcohol extraction or first alcohol extraction medicinal residues in the prescription;
(3) in the prescription Radix Ginseng Rubra pulverize or superfine powder be broken into fine powder directly use or adopt after alcohol extraction or the alcohol extraction medicinal residues again water carry or all beat that fine powder is used or extract with other suitable method;
(4) Fructus Schisandrae Chinensis, Fructus Psoraleae are pulverized or superfine powder is broken into that alcohol extraction is directly used or adopted to fine powder or water is carried or the first alcohol extraction medicinal residues method that water is carried or other is suitable is again extracted in the prescription;
(5) 14 flavors such as all the other Fructus Rubies are pulverized or superfine powder is broken into fine powder and directly uses or adopt water to carry or the first alcohol extraction medicinal residues method that water is carried or other is suitable is again extracted in the prescription:
(6) fine powder that is ground into described in the step was a 100-160 purpose fine powder, and the best is broken into 200-300 purpose fine powder for superfine powder;
(7) the alcohol extraction condition of the Radix Ginseng Rubra described in the step is: with 10-30% ethanol or 50-95% ethanol is solvent, can adopt heating reflux method or percolation or other suitable method to extract; The alcohol extraction condition of all the other each medicines is: with 50-95% ethanol is solvent, can adopt heating reflux method or percolation or other suitable method to extract;
(8) extraction of the volatile ingredient described in the step can adopt the way of distillation or supercritical methanol technology or other suitable method to extract.Extracting the volatile ingredient of gained can directly use or use or make clathrate with an amount of medicated powder absorption and use;
(9) condition carried of the water described in the step is: decoct with water/extract 1-3 time at 90-98 ℃, each 1-3 hour, best for decoct/90-98 ℃ of extraction secondary, each 2 hours.The medicinal residues of all the other flavour of a drug add when frying in shallow oil together, can add when second fries in shallow oil;
(10) extracting gained water extract in the step (9) can adopt precipitate with ethanol or acid precipitation or add the flocculating agent sedimentation or method that other is suitable is further handled;
(11) filter, can adopt conventional the filtration, centrifugal, ultrafiltration adds filtrations/centrifugal/ultrafiltration or other method that suits behind the clarifier;
(12) concentrate, can adopt concentrating under reduced pressure or thin film concentration or vacuum film to concentrate or other proper method;
(13) drying can adopt vacuum drying or spray drying or lyophilization or other suitable method;
(14) add described additives as required, adopt suitable moulding process, be prepared into various solid preparations, as tablet, capsule, granule, pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046743 CN1682798A (en) | 2004-09-06 | 2004-09-06 | Shenbao solid preparation good for kidney and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410046743 CN1682798A (en) | 2004-09-06 | 2004-09-06 | Shenbao solid preparation good for kidney and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100594920C (en) * | 2006-05-19 | 2010-03-24 | 浙江省医学科学院 | Kidney-replenishing sperm-supplementing granule |
| CN105998292A (en) * | 2016-07-21 | 2016-10-12 | 张红 | Preparation method of drug for treating postpartum frequent urination |
| CN110123897A (en) * | 2019-06-19 | 2019-08-16 | 宁夏晓鸣农牧股份有限公司 | A kind of Chinese herbal medicine effervescent tablet and preparation method thereof |
-
2004
- 2004-09-06 CN CN 200410046743 patent/CN1682798A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100594920C (en) * | 2006-05-19 | 2010-03-24 | 浙江省医学科学院 | Kidney-replenishing sperm-supplementing granule |
| CN105998292A (en) * | 2016-07-21 | 2016-10-12 | 张红 | Preparation method of drug for treating postpartum frequent urination |
| CN110123897A (en) * | 2019-06-19 | 2019-08-16 | 宁夏晓鸣农牧股份有限公司 | A kind of Chinese herbal medicine effervescent tablet and preparation method thereof |
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