CN110123897A - A kind of Chinese herbal medicine effervescent tablet and preparation method thereof - Google Patents

A kind of Chinese herbal medicine effervescent tablet and preparation method thereof Download PDF

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CN110123897A
CN110123897A CN201910529122.2A CN201910529122A CN110123897A CN 110123897 A CN110123897 A CN 110123897A CN 201910529122 A CN201910529122 A CN 201910529122A CN 110123897 A CN110123897 A CN 110123897A
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chinese herbal
herbal medicine
effervescent tablet
powder
dried
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郭磊
陈信
何生虎
周云锋
边海霞
安泓霏
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NINGXIA XIAOMING AGRICULTURE ANIMAL HUSBANDRY CO Ltd
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NINGXIA XIAOMING AGRICULTURE ANIMAL HUSBANDRY CO Ltd
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
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Abstract

The invention discloses a kind of Chinese herbal medicine effervescent tablets, it is characterized in that, the formula of the effervescent tablet are as follows: Chinese herbal medicine extract powder 180g, tartaric acid 140g, sodium bicarbonate 70g, starch 80g, microcrystalline cellulose 40g, magnesium stearate 10g, superfine silica gel powder 10g, polyethylene glycol 70g, 5% poly- acetic acid pyrrolidones ethanol solution 30ml, the Chinese herbal medicine extract powder are formulated by Radix Polygalae, Radix Salviae Miltiorrhizae, dried orange peel, Divine Comedy, campanulaceae, mulberry skin, radix scutellariae, hawthorn according to the weight proportion of 1:1:1:2:2:1:2:1.By using the Chinese herbal medicine effervescent tablet; utilize the various bioactive components wherein contained; gastrointestinal peristalsis, protection mucous membrane tissue can be effectively increased; promote digestion; antibacterial anti-inflammatory; have many advantages, such as good curative effect to the alimentary canal of the prevention poultry such as chicken, respiratory disease and there is raising immunity of organisms, low-residual, nuisanceless, environmentally friendly, has played important function of the Chinese veterinarian's theory in clinical prevention poultry disease.

Description

A kind of Chinese herbal medicine effervescent tablet and preparation method thereof
Technical field
The present invention relates to field of Chinese herbal medicine technology, and in particular to a kind of Chinese herbal medicine effervescent tablet and preparation method thereof.
Background technique
In recent years, as aquaculture industry of China is to scale, intensivization development, the disease incidence of livestock and poultry constantly rises, due to this A little diseases are largely mixed infection, therefore veterinarian increases the dosage of Western medicine during treating disease, though The right state of an illness has obtained good control, but problems also occurs, such as can cause body using antibiotic, hormone medicine Canceration, deformity, physiological function damage, especially to the damage of hepatic and renal function, also be also easy to produce drug resistance, or even occur The toxic side effects such as poison, death.It, herein will be with Traditional Chinese Medicines In Chickens for Western medicine defect existing during preventing and treating livestock and poultry Later growth health-care effect is studied.Chinese herbal medicine passes through supplement somatomedin, supplement chicken later period raising stage energy and battalion It supports and needs, the health such as enteron aisle, the respiratory tract of chicken can be effectively facilitated, improve production performance.Shi Jianming test result shows in chicken The raising stage supplements the Chinese herbal formula of promoting blood circulation, sharp lung, liver protection, invigorating the spleen, the disease resistance of livestock and poultry can be improved, safeguard Immunization barrier system improves immune antiboidy titre, while can promote reaching maturity for bone, promotes the growth of poultry；Supplement Such Chinese herbal formula can effectively promote the development of enteron aisle villus growth, promote the synthesis of vitamin B complex and vitamin K, Intestinal microflora is adjusted, helps digestion, absorption of the enteron aisle to nutriment, reduces intestines problem, furthermore can have Effect supplement hepatic and renal function nutrition, liver protection protect kidney, solve immune-suppression problems caused by drug abuse, restore hepatic and renal function, improve Detoxication and toxicant eliminating function ability.
The countries such as current Japan, Korea, France, the U.S. are also increasingly extensive to the research application of natural drug, successively set up Specialized research institutions.Undoubtedly, the low-residual advantage of Chinese medicine is that antibiotic, chemicals, hormone medicine etc. are incomparable 's.It is from a wealth of sources in addition, Chinese herbal medicine is there are also cheap, it is easy to use the advantages that, be the development and use direction of veterinary drug from now on One of.It, will more extensively using herbal control livestock and poultry with the fast development of aquaculture.This research is according to Chinese herbal medicine Characteristic, optimization formula extract its effective component through modes such as water extract-alcohol precipitation, ultrasounds, and have carried out comparative test to auxiliary material, by it Chinese medicine effervescent tablet is made, while having carried out the studies and clinical application test of Control of drug quality, prevents and treats chicken later period disease to explore The development of sick novel form veterinary drug provides clinical and theoretical foundation.
Summary of the invention
The present invention solves the dosage of the existing technology that Western medicine is increased during treating livestock and poultry, though The right state of an illness has obtained good control, but problems also occurs, such as can cause body using antibiotic, hormone medicine Poisoning, deformity, physiological function damage, especially to the damage of hepatic and renal function, also be also easy to produce drug resistance, or even there is paralysis The toxic side effects problem such as paralysis, death, provides a kind of Chinese herbal medicine effervescent tablet and preparation method thereof, by being built up one's health by taking tonic with medium-height grass when application Fill somatomedin, supplement chicken later period raising stage energy and nutritional need, can effectively facilitate the enteron aisle of chicken, breathing to etc. it is strong Health improves production performance, using Chinese herbal formula in fowl raising stage, supplement promoting blood circulation, sharp lung, liver protection, invigorating the spleen, Ke Yiti The disease resistance of high livestock and poultry safeguards immunization barrier system, improves immune antiboidy titre, while can promote developing into for bone It is ripe, promote the growth of poultry, also solve immune-suppression problems caused by drug abuse, restore hepatic and renal function, improves detoxication and toxicant eliminating function Ability.
The invention is realized by the following technical scheme:
A kind of Chinese herbal medicine effervescent tablet, which is characterized in that the formula of the effervescent tablet are as follows: Chinese herbal medicine extract powder 180g, winestone Sour 140g, sodium bicarbonate 70g, starch 80g, microcrystalline cellulose 40g, magnesium stearate 10g, superfine silica gel powder 10g, Macrogol 6000 (PEG6000) 70g, 5% poly- acetic acid pyrrolidones (PVPK30) ethanol solution 30ml.
Further, a kind of Chinese herbal medicine effervescent tablet, the Chinese herbal medicine extract powder by Radix Polygalae, Radix Salviae Miltiorrhizae, dried orange peel, Divine Comedy, campanulaceae, Mulberry skin, radix scutellariae, hawthorn are formulated according to the weight proportion of 1:1:1:2:2:1:2:1, and each component extracting method is as follows:
Further, a kind of production method of Chinese herbal medicine effervescent tablet, which comprises the following steps:
To have certain hygroscopic filler starch, acid source to be dried, place it in dry in l00 DEG C of baking oven 2 hours, dried powdered extract powder, magnesium stearate, tartaric acid, sodium bicarbonate, PEG6000, superfine silica gel powder supplementary material Powder crosses the processing of 40 meshes；Weigh the NaHCO of 70gPEG6000 and 70g after being dried3Uniformly mixing, in 50-55 DEG C of water Heating makes the wherein uniform encapsulated sodium bicarbonate of PEG6000 under the conditions of bath, and pours into mortar while hot, and 40 mesh are crossed in cooling, grinding Sieve, the above powder and tartaric acid respectively with dried extract powder 180g, starch 80g, superfine silica gel powder 10g, microcrystalline cellulose The magnesium stearate and 70gPEG6000 of 40g, 10g are uniformly mixed, using 5% PVPK30 ethanol solution 30ml as wetting agent, Softwood, compression molding after drying are made into spray-dried forms.
Currently, the prior art increases the dosage of Western medicine during there is treatment livestock and poultry, although the state of an illness obtains Good control, but problems also occur, for example, using antibiotic, hormone medicine can cause body canceration, deformity, Physiological function damage, especially to the damage of hepatic and renal function, also be also easy to produce drug resistance, or even there are the poison such as paralysis, death Side-effect problem, so this application provides a kind of Chinese herbal medicine effervescent tablets and preparation method thereof, according to Radix Polygalae, Radix Salviae Miltiorrhizae, dried orange peel etc. Seven taste Chinese medicines have antiviral, inhibiting bacteria and diminishing inflammation, improve immunity and somatotrophic effect, with reference to related literatures, campanulaceae, Huang Antibacterial, the antiviral significant effect of a kind of reed mentioned in ancient books, Divine Comedy have effects that good stomach invigorating, invigorating the spleen；In addition, merging seven taste Chinese herbal medicines There is not the reaction of precipitating, discoloration in extracting solution；Accordingly, it is determined that Radix Polygalae, Radix Salviae Miltiorrhizae, dried orange peel, Divine Comedy, campanulaceae, mulberry skin, radix scutellariae are Prescriptions of traditional Chinese medicine optimizes the major auxiliary burden for influencing effervescent tablet using Orthogonal Experiment and Design, selects optimal proportion: medium-height grass Medicine extract powder 180g, tartaric acid 140g, sodium bicarbonate 70g, starch 80g, microcrystalline cellulose 40g, according to two veterinary drugs in 2010 The magnesium stearate for using 10g, the superfine silica gel powder of 10g, the Macrogol 6000 of 70g are established in this test of range criterion of allusion quotation (PEG6000), 5% poly- acetic acid pyrrolidones (PVPK30) ethanol solution 30ml, using stability testing method, in phase It is equal to the character, pH value, weight differential and the disintegration time limited indices that measure effervescent tablet in the environment that humidity is 65%-75% Meet 2010 version " Republic of China Veterinary Pharmacopoeia " two regulation, using 1.5g (3), 2g (4), 2.5g (5) Three gradients compare dosage, using initial weight and whole weight as testing index, determine that chicken dosage is 2g/L (4).To examination The initial weight end tuple for testing group (number 1-50) and control group (number 51-100) is united according to using SAS8.2 editions statistical softwares Meter analysis, obtains the weight gain significant difference (P<0.01) of test group chicken, and the weight gain difference of control group chicken is not significant (P>0.05).System The death rate for counting test group chicken is 2%, and the death rate of control group chicken is 6%, illustrates that Chinese herbal medicine effervescent tablet can reduce the dead of chicken Rate is died, can be obtained by the analysis of statistical results to 12 chicken disease incidence, test group is normal, no morbidity, and control group disease incidence is 50%, illustrate that compound Chinese herb effervescent tablet has good preventive effect to disease is often sent out in chicken later period propagation process.To lungs The inspection of histopathology slide is carried out with liver, analysis can obtain, and test group is without apparent pathological change；Control group lung tubule Accidental leukocyte infiltration, peritubular capillary visible extravasated blood have the phenomenon that bubble denaturation in liver cell.
Traditional Chinese Medicines In Chickens somatotrophic effects: Chinese herbal medicine has multiple nutritional components, and toxic side effect is small and has no drug resistance Feature can adjust the physiological function of body comprehensively.A large number of experiments proves that Chinese herbal feed additive can effectively improve animal productiong Performance prevents the disease often sent out in chicken growth course.Experimental study shows during fowl raising for different days, different product The chicken of kind adds different Chinese herbal medicines, and every growth performance index significantly improves.Its mechanism of action mainly passes through Chinese herbal medicine invigorating the spleen The characteristic of qi-regulating class, the class that helps digestion and fragrance seasoning reaches its purpose to reinforce lipid metabolism, improves body anti-fatty liver and is formed Ability, promote the utilization of mineral matter element, promote the synthesis of protein.In terms of adjusting livestock and poultry endocrine, some Chinese herbal medicines Have estrogenic activity effect, in conjunction with the estradiol receptors such as hypothalamus, hypophysis after, enhance the generation of animal testosterone, moreover it is possible to increase The generation of strong somatotropin (GH) and somatomedin (IGF-1), GH are that animal tissue is promoted to grow parahormone, can be promoted Absorption of the livestock and poultry to amino acid and glucose, and the synthesis of protein can be accelerated, GH influences IGF- by liver growth hormone receptor 1, to promote the synthesis of muscle protein and the growth of musculature.
Inhibiting effect of the Chinese herbal medicine to pathogen: has been done to the extracorporeal bacteria inhibitor test of Chinese traditional herbs by a large amount of research for China Work, it was demonstrated that most of Chinese herbal medicines are to various harmful pathogenic bacterias inhibited.Many Chinese herbal medicines have antibacterial or kill The effect of bacterium, it is to inhibit thallus sugar that antibacterial mechanism, which mainly has directly antibacterial and indirectly antibacterial, the directly antibacterial mechanism of action, The oxidation of metabolic intermediate, dehydrogenation, deamination, and the synthesis of bacterium protein and nucleic acid can be inhibited.The Chinese bulbul clinically can Effectively treatment chronic diarrhea, Tang Yanhong's research shows that in vitro, Escherichia coli, salmonella to itself and it is insensitive therefore white Head father-in-law may be by vivo other approach indirectly-acting in Escherichia coli, salmonella rather than directly act on, or It is that the contained active material of Chinese bulbul itself and parmacodynamics-less activity need to the competence exertion drug effects after metabolism in vivo.
Effect of the Chinese herbal medicine to beneficial bacterium: most Chinese herbal medicines by oral administration, are absorbed in alimentary canal intracellular metabolite, and animal disappears Change road endoparasitism a large amount of microorganism.Therefore, when Chinese herbal medicine, which enters, contacts enteric microorganism in alimentary canal, the work of Chinese herbal medicine Property ingredient is likely to have a certain impact to enteric microorganism.Some in vitro test discoveries, radix scutellariae can promote the life of chicken lactic acid bacteria It is long, inhibit the growth of enterobacteria and salmonella.Beneficial bacterium and conditioned pathogen exist simultaneously in the alimentary canal of animal, and composition is dynamic It the microorganism region of object can when many internal and external tests show that Chinese herbal medicine passes through alimentary canal by oral administration and flora contacts To influence microbiota.Result, it is believed that certain effect is played in terms of adjusting intestinal microecology balance, to pass through improvement Digestive function improves the utilization rate of feed, achievees the effect that improve production performance.
The influence of Traditional Chinese Medicines In Chickens immunity function: immunization is mainly resistant to microorganism and other injurious factors invade machine Body makes body keep fit the autoimmune response reaction of state, and body prevents the height of external cause of disease infiltration capability and immune Biphasic Regulation has very close relationship, is the important component of body.With the aging of body, thymus gland, leaching Bar Telatrophy, various immunocytes and its subgroup reduction can lead to immune function decline, lead to the generation of disease.Chicken is producing In the process, since drug abuse and the vaccine effect of inoculation are bad, the immune function of body is caused to decline, especially lymph is thin The immunocytes such as born of the same parents, macrophage are at a low ebb or holddown, and poultry disease new in recent years continuously emerges, old disease The reason of the pathogen variation and the enhancing of virulence of disease.That wants solves the problems, such as this, must just take effective means activation immune System, improves the activity of immune factor, to enhance the premunition of body.The research in this field is very active at present, especially It is that the research of chemicals reinforcing agent makes great progress, lays a good foundation to the development of aquaculture.But chemicals The all different degrees of production performance for reducing body of immunopotentiator has medicament residue and toxic side effect to generate, harmful to human The drawbacks such as health.
The oxidation resistant effect of Traditional Chinese Medicines In Chickens: chicken itself contains more fat in vivo, so being easy to happen lipid mistake Oxidation reaction, metabolite will lead to body and phenomena such as aging, oxidation resistance weakens, free radical is superfluous occur.The sweet peptide of Guang Peroxidase (GSH-PX) is a kind of antioxidase containing selenium, has its presence in body in each organ-tissue, passes through spy It is catalyzed the reduction reaction of hydroperoxides anisotropicly, thus a large amount of Peroxidation Product in scavenger-cell, moreover it is possible to prevent lipid mistake Oxidation causes the reaction of other damage cells, and maximum feature is to remove the H generated in mitochondria and endochylema2O2。
In conclusion it is of the invention following the utility model has the advantages that
1, a kind of Chinese herbal medicine effervescent tablet of the present invention and preparation method thereof, by using compound Chinese herb effervescent tablet, utilizes it In the various bioactive components that contain, gastrointestinal peristalsis can be effectively increased, promote digestion, antibacterial anti-inflammatory, to birds such as prevention chickens Enteron aisle, respiratory tract class disease with good curative effect and having improve immunity of organisms, low-residual, nuisanceless, environmentally friendly etc. Advantage has played important function of the Chinese veterinarian's theory in clinical prevention poultry disease.
2, a kind of Chinese herbal medicine effervescent tablet of the present invention and preparation method thereof, the Antibiotic Additive clinically used not only causes The generation of antibody-resistant bacterium, and it is expensive, cause treatment cost to dramatically increase.The preparation process letter of compound Chinese herb effervescent tablet It is single, special installation is not needed, cost of manufacture is substantially less than the treatment cost of antibiotic.
3, a kind of Chinese herbal medicine effervescent tablet of the present invention and preparation method thereof, the development and exploitation of Chinese herbal medicine effervescent tablet both met Traditional Chinese medicine theory, and have the characteristics that Modern preparations: 1. meet TCM Modernization developing direction, meets Chinese medicine tradition use Medicine habit；2. application method is easy, comfortable, safety, enhance the compliance of poultry；3. this product preventing chicken diseases and raising production It is avoided that liver renal toxicity when performance, there is self-character and advantage compared with antibiotic treatment.Production to Chinese herbal and crude drugs preparations are accelerated Industry paces push the change of Chinese herbal and crude drugs preparations and innovation to be of great significance.
Detailed description of the invention
Attached drawing described herein is used to provide to further understand inventive embodiments, constitutes part of this application, The restriction to the embodiment of the present invention is not constituted.In the accompanying drawings:
Fig. 1 is schematic diagram of the present invention.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, below with reference to embodiment, the present invention is made Further to be described in detail, exemplary embodiment of the invention and its explanation for explaining only the invention, are not intended as to this The restriction of invention.
Embodiment
A kind of Chinese herbal medicine effervescent tablet, the formula of the effervescent tablet are as follows: Chinese herbal medicine extract powder 180g, tartaric acid 140g, carbonic acid Hydrogen sodium 70g, starch 80g, microcrystalline cellulose 40g, magnesium stearate 10g, superfine silica gel powder 10g, Macrogol 6000 (PEG6000) 70g, 5% poly- acetic acid pyrrolidones (PVPK30) ethanol solution 30ml, the Chinese herbal medicine extract powder by Radix Polygalae, Radix Salviae Miltiorrhizae, Dried orange peel, Divine Comedy, campanulaceae, mulberry skin, radix scutellariae, hawthorn are formulated according to the weight proportion of 1:1:1:2:2:1:2:1, described one kind The production method of Chinese herbal medicine effervescent tablet, comprising the following steps: will have certain hygroscopic filler starch, acid source to be dried Processing places it in 2 hours dry in l00 DEG C of baking oven, dried powdered extract powder, magnesium stearate, tartaric acid, carbonic acid Hydrogen sodium, PEG6000, superfine silica gel powder supplementary material powder cross the processing of 40 meshes；Weigh the 70gPEG6000's after being dried and 70g NaHCO3Uniformly mixing, heating makes the wherein uniform encapsulated sodium bicarbonate of PEG6000 under 50 DEG C of water bath conditions, and pours into grind while hot In alms bowl, 40 meshes are crossed in cooling, grinding, the above powder and tartaric acid respectively with dried extract powder 180g, starch 80g, micro mist Silica gel 10g, the magnesium stearate of microcrystalline cellulose 40g, 10g and 70gPEG6000 are uniformly mixed, with 5% PVPK30 dehydrated alcohol Solution 30ml is wetting agent, is made into softwood, compression molding after drying with spray-dried forms.
The laying hen for randomly selecting 12 40 week old has been inoculated with newcastle disease, highly pathogenic bird flu vaccine, has passed Zhi Erlian jelly Dry vaccine, infectious bursa of Fabricius vaccine, mycoplasma gallinarum vaccine, fowl pox vaccine etc..It is classified as test group and control group, every group each 6, it is put in the poor henhouse downwind area of environment, experimental period is 30 days.This test grows chicken using pathological section as standard The preventive effect of later period disease is further to be studied.
Materials: test group extracts three chickens, and control group extracts three chickens for having clinical symptoms, puts to death, takes lungs, liver, It is put into 10% formalin and is fixed.Carry out the preparation and inspection of pathological section.
Fixed: the fixed purpose of sample is to save the complete morphological structure of liver and lung tissue cell, convenient fixed Position.This test carries out sample using 10% formalin and fixes.Sample is no matter large or small, is fixed (in 30min) immediately after in vitro. The volume of fixer should be 10 times of tissue volume.Set time is 48 hours.It is needed during fixation light every now and then It is light to shake specimen bottle, to guarantee all tissue suspensions in fixer.
Embathe: tap water rinses 24 hours, and water flow should not be too large to prevent breaking tissue block into pieces when flushing, it is fixed after tissue Washing is had to pass through, dyeing effect can be made to reach best in this way.
Dehydration: after tissue sufficiently washing in 80% ethyl alcohol overnight, then in each 1h of 95% ethyl alcohol, 100% ethyl alcohol It is washed after 40min, 100% ethyl alcohol 30min, according to this laboratory experience, group is woven in overlong time in high concentration ethanol, right The contraction of tissue compared in dimethylbenzene overlong time it is more serious, therefore, the time controlled in high concentration ethanol is particularly important. Tissue block must be blotted when exchanging for every time, dehydration is completely otherwise transparent bad.
Transparent: transparent is a crucial link, and commonly using clarifier is dimethylbenzene.According to this laboratory experience, when transparent Between be 45min, this process needs strict control clearing time, and the time is too short, and the ethyl alcohol in tissue can not be replaced completely, directly The effect that is impregnated with of paraffin is influenced, overlong time organizes variable cirrhosis crisp, and the integrality for being not easy embedding and institutional framework is difficult to protect Card, transparent good tissue block detect by an unaided eye the shape that is translucent, if there is small white spots, completely caused by dehydration.
Waxdip: selecting fusing point is 56-58 DEG C of paraffin wax, and cured during waxdip must be melting state.
Embedding: embedding needs to select the paraffin of high-quality free from admixture with paraffin, and otherwise chipping qualities will receive the influence of impurity. It is fast to embed speed, embedding is smooth, and organization embedding face is best with maximum area.It avoids generating minute bubbles when injecting paraffin liquid, It is generated if any minute bubbles, embedded box can be gently pressed with tweezers, bubble is discharged.Wax liquor rapid condensation is avoided after embedding, especially in room temperature When lower, imbedded mold be not placed directly in cold bench, otherwise wax stone easily splits, and influences to be sliced.Wax liquor is complete at room temperature Condensation places into 4 DEG C of refrigerator after wax stone is separated with embedding mould.When being molded into again to embedding into wax liquor, speed is fast, no When then fixed through sample mould, easily there is a phenomenon where wax stones after compression separates with embedded box.
Slice: slice is the committed step of pathology film-making, and the superiority and inferiority of wax disk(-sc) depends on the shape of the skill of slice, slicer State, the factors such as processing of tissue.Sharp unnotched slicer should be selected, slicer is adjusted, microtome angle is 5 degree, slice thick Spend it is 6-8 microns general, lungs slice be 8 microns, liver section be 5 microns.Prepare a container with cover and is put into trash ice.
Exhibition piece and fishing piece: the water temperature for opening up piece is traditionally arranged to be 45 DEG C or so, and the water of exhibition piece machine is distilled water, because of tap water There is a large amount of bubble, some sightless bubbles meeting dociles easily influence its flatness when baking piece under wax disk(-sc).Fish out piece when need by After glass slide is placed and dried vertically, then carry out drying slice again, wax disk(-sc) after roasting 30min, can be transferred on roasting piece machine In oven, required time is 24-48 hours.
Dyeing: it will first enter the slice after distilled water and be put into hematoxylin aqueous solution to dye 2 minutes.Again in sour water and ammonium hydroxide Middle color separation 20 seconds enters distilled water a moment after flowing water rinses 1 hour, is dehydrated each 10 minutes in 70% and 90% alcohol, enters wine Smart eosin stains liquid dyes 2-3 minutes.
Test result: test group, chicken appetite is normal, without apparent clinical symptoms change.Control group, part chicken spirit Dispirited, expiratory dyspnea, coat are inverse vertical, and loose unglazed, nasal cavity exudate increases, has a large amount of secretion, and wing is sagging.
Histopathological examination result:
Lungs: the accidental leukocyte infiltration of lung tubule in control group pathological section, the visible extravasated blood of peritubular capillary；Examination Group pathological section is tested almost without apparent pathological change.
Liver: control group pathological section has the phenomenon that bubble denaturation into the cell.Test group pathological section is almost without apparent Pathological change.
The statistical result of disease incidence: the disease incidence of test group chicken is 0%, and the disease incidence of control group is 50%, is as a result seen below Table:
Above-described specific embodiment has carried out further the purpose of the present invention, technical scheme and beneficial effects It is described in detail, it should be understood that being not intended to limit the present invention the foregoing is merely a specific embodiment of the invention Protection scope, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should all include Within protection scope of the present invention.

Claims (3)

1. a kind of Chinese herbal medicine effervescent tablet, which is characterized in that the formula of the effervescent tablet are as follows: Chinese herbal medicine extract powder 180g, tartaric acid 140g, sodium bicarbonate 70g, starch 80g, microcrystalline cellulose 40g, magnesium stearate 10g, superfine silica gel powder 10g, polyethylene glycol (6000) 70g, 5% poly- acetic acid pyrrolidones ethanol solution 30ml.
2. a kind of Chinese herbal medicine effervescent tablet according to claim 1, which is characterized in that the Chinese herbal medicine extract powder by Radix Polygalae, Radix Salviae Miltiorrhizae, dried orange peel, Divine Comedy, campanulaceae, mulberry skin, radix scutellariae, hawthorn are formulated according to the weight proportion of 1:1:1:2:2:1:2:1.
3. a kind of production method of Chinese herbal medicine effervescent tablet according to claim 1, which comprises the following steps:
To have certain hygroscopic filler starch, acid source to be dried, it is small to place it in drying 2 in l00 DEG C of baking oven When, dried powdered extract powder, magnesium stearate, tartaric acid, sodium bicarbonate, polyethylene glycol (6000), superfine silica gel powder are former Auxiliary material powder crosses the processing of 40 meshes；It weighs the 70g polyethylene glycol after being dried uniformly to mix with the sodium bicarbonate of 70g, 50 Heating makes wherein polyethylene glycol (6000) uniform encapsulated sodium bicarbonate under DEG C water bath condition, and pours into mortar while hot, cooling, grind Mill, crosses 40 meshes, the above powder and tartaric acid respectively with dried extract powder 180g, starch 80g, superfine silica gel powder 10g, crystallite The magnesium stearate and 70g polyethylene glycol (6000) of cellulose 40g, 10g are uniformly mixed, anhydrous with 5% poly- acetic acid pyrrolidones Ethanol solution 30ml is wetting agent, is made into softwood, compression molding after drying with spray-dried forms.
CN201910529122.2A 2019-06-19 2019-06-19 A kind of Chinese herbal medicine effervescent tablet and preparation method thereof Pending CN110123897A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1682798A (en) * 2004-09-06 2005-10-19 毛友昌 Shenbao solid preparation good for kidney and its preparing method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1682798A (en) * 2004-09-06 2005-10-19 毛友昌 Shenbao solid preparation good for kidney and its preparing method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
吴学荣: "中草药泡腾片对肉鸡生长后期保健作用的研究", 《中国优秀硕士学位论文全文数据库 农业科技辑》 *

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Application publication date: 20190816