CN103127313A - Lyophilized hemsley rockvine root tuber used for treating AIDS - Google Patents

Lyophilized hemsley rockvine root tuber used for treating AIDS Download PDF

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Publication number
CN103127313A
CN103127313A CN2013100589295A CN201310058929A CN103127313A CN 103127313 A CN103127313 A CN 103127313A CN 2013100589295 A CN2013100589295 A CN 2013100589295A CN 201310058929 A CN201310058929 A CN 201310058929A CN 103127313 A CN103127313 A CN 103127313A
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radix
apioris fortunei
lespedezae buergeri
lyophilizing
medicine
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CN2013100589295A
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胡馨尹
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Abstract

The invention relates to an application of lyophilized hemsley rockvine root tuber in preparing a medicine used for treating AIDS. The lyophilized hemsley rockvine root tuber can be prepared into any medical preparation with traditional Chinese medicine preparation method. An effective dose for a patient a day comprises 1-300g of lyophilized hemsley rockvine root tuber. Compared with medicines prepared with commonly dried hemsley rockvine root tuber, the medicine prepared by using lyophilized hemsley rockvine root tuber has better functions in enhancing AIDS patient body immunity, inhibiting HIV virus, reducing patient clinical symptoms, and improving patient life qualities. Also, medicine resistance and toxic and side effects when HIV virus is treated by using antiretroviral can be effectively reduced.

Description

The lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) for the treatment of acquired immune deficiency syndrome (AIDS)
Invention field
The present invention relates to medicine, particularly a kind of medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) treatment acquired immune deficiency syndrome (AIDS), belong to medical technical field.
Background technology
Acquired immune deficiency syndrome (AIDS), i.e. acquired immune deficiency syndrome (AIDS), English name Acquired Immune DeficiencySyndrome, AIDS.The mankind because cause immunodeficiency after infecting HIV (human immunodeficiency virus) (Human ImmunodeficiencyVirus, HIV), concurrent a series of opportunistic infection and tumor, severe patient can cause dead syndrome.
The WHO report whole world in 2010 survival HIV carriers and HIV sufferers totally 3,400 ten thousand newly infects 2,700,000, annual dead 1,800,000 people.Have every day to surpass the 7000 new infection of people, district from all parts of the world all has popular, but more than 97% in, low income country, especially attach most importance to Africa.The expert estimates, the Asia may be shifted to from Africa in the Global prevalence severely afflicated area.CDC is estimated, ends to the end of the year 2011, and China survival HIV carriers and HIV sufferers be 780,000 people approximately, annual new the infected 4.8 ten thousand people, dead 2.8 ten thousand people.Epidemic situation has covered all provinces, autonomous regions and municipalities of the whole nation, and China faces acquired immune deficiency syndrome (AIDS) morbidity and dead peak period at present, and has been begun to spread to population by high-risk crowds such as drug abuse, unlicensed prostitutes.
Antiretroviral therapy is the standard care scheme of present treating AIDS, but after this type of medicine of life-time service, drug resistance increases, and the toxic and side effects of medicine can be damaged Liver and kidney.Clinical practice also proves, even the antiviral therapy effect is more satisfactory, has reached virus load decline, CD4 +The purpose that cell quantity is stable, but that the patient still has is weak, poor appetite, gradual becoming thin, low grade fever even, quality of life calibration ordinary person still has obvious gap.
Radix Apioris Fortunei (Radix Lespedezae Buergeri) is named again Radix Tetrastigmatis Hemsleyani, is the liana that overgrows, and is Vitaceae Tetrastigma plant Radix Apioris Fortunei (Radix Lespedezae Buergeri) Tetrastigma hemsleyanum Diels et Gilg, and herb all can be used as medicine, and has the effect of heat-clearing and toxic substances removing, promoting blood circulation by removing wind.Be used for the treatment of hyperpyrexia convulsion, pneumonia, asthma, hepatitis, rheumatism, menoxenia, pharyngalgia, scrofula, carbuncle furuncle furuncle, have good curative effect.
Patent of invention ZL200510050649.5 " the Chinese medicine Radix Apioris Fortunei (Radix Lespedezae Buergeri) that is used for prevention and treatment tumor " discloses the tumor of Radix Apioris Fortunei (Radix Lespedezae Buergeri) for prevention and treatment human body.
Patent of invention ZL200910156906.1 " vacuum lyophilization of Chinese medicine Radix Apioris Fortunei (Radix Lespedezae Buergeri) keeps the technique of drug activity composition " discloses the technology of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri).
We find that the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) compares with the Radix Apioris Fortunei (Radix Lespedezae Buergeri) of common drying, and acquired immune deficiency syndrome (AIDS) is strengthened patient's immunity of organisms, suppresses HIV virus, alleviates the patient clinical symptom, improves the with better function of its life quality.And can effectively reduce drug resistance and the toxic and side effects of antiretroviral therapy HIV virus.
Summary of the invention
The purpose of this invention is to provide acquired immune deficiency syndrome (AIDS) is strengthened patient's immunity of organisms, suppresses HIV virus, alleviates the patient clinical symptom, improves the with better function of its life quality.And can effectively reduce the drug resistance of antiretroviral therapy HIV virus and the medicine of toxic and side effects.
The object of the present invention is achieved like this prepares the medicine for the treatment of acquired immune deficiency syndrome (AIDS) with the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri).
The medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS), feature is that prepared medicine contains the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri).
The medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS) of the present invention, feature are that prepared medicine is by single flavor lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation.
The medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS) of the present invention, feature is the medicine made from the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri), patient's taking dose of a day contains lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) 1-300g.
The medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS) of the present invention, feature is preferably to make medicine with lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber.
The medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS) of the present invention, lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber comprises the following steps:
1) fresh Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber raw material is removed impurity, cleans, and cuts sheet;
2) sabot, sabot weight are 5-8kg/m 2, thickness 2-3cm lowered the temperature 2~3 hours gradually, to-20 ℃--and 60 ℃ are carried out pre-freeze;
3) being evacuated to system's absolute pressure is 40~60Pa, begins to be heated to 30 ℃~60 ℃, sublimation drying 15~24 hours;
4) keep temperature of charge at 35 ℃~65 ℃, make water content reach 2~3% rear dischargings.
The medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) of the present invention preparation treatment acquired immune deficiency syndrome (AIDS), feature are that the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) is directly pulverized and made powder and take.
The medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS) of the present invention adopts method of Chinese medicinal to be prepared into any pharmaceutically useful preparation the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri).For example, on the basis of existing technology, the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) is pulverized, made powder and take after mixing it with water; By further extracting, extract adds adjuvant to make tablet, capsule, granule, pill, spray etc. with the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri), but this does not limit protection scope of the present invention.
The above-mentioned extraction of the present invention comprises that low temperature, dipping, percolation extract.
Radix Apioris Fortunei (Radix Lespedezae Buergeri) of the present invention comprises herb and the tuber of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri).
So far completed the present invention, the medicine of Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation of the present invention is compared with the Radix Apioris Fortunei (Radix Lespedezae Buergeri) of common drying, and acquired immune deficiency syndrome (AIDS) is strengthened patient's immunity of organisms, suppresses HIV virus, alleviates the patient clinical symptom, improves the with better function of its life quality.And can effectively reduce the drug resistance of antiretroviral therapy HIV virus and the medicine of toxic and side effects.The beneficial effect that the present invention treats acquired immune deficiency syndrome (AIDS) is further set forth in following clinical trial.
1, physical data
AIDS patients 114 examples of confirming through epidemic disease control centre, male 81 examples wherein, female's 33 examples, age distribution: 20-30 year 13 examples; 31-40 year 48 examples; 41-50 year 32 examples; 51 years old with 21 examples.It is divided into 2 groups at random, treatment group 59 examples wherein, matched group 55 examples.2 groups of sexes, age and other physical data are learned the processing no significant difference by statistics, have comparability.
2, Therapeutic Method
Antiretroviral therapy: zidovudine, each 300mg, every day 2 times; Lamivudine, each 100mg, every day 1 time; Nevirapine, each 200mg, every day 2 times.
Matched group: on the basis of antiretroviral therapy, add the powder that the Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber that dries is made, each 10g, every day 3 times.
Treatment group: on the basis of antiretroviral therapy, add the powder that lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber is made, each 10g, every day 3 times.
Two groups for the treatment of cycle are 2 years.
3, observation item and detection method
3.1 blood, urine, just conventional are observed in safety, hepatic and renal function, and electrocardiogram, x-ray detects, and detects 1 time in every 3 months.And record untoward reaction in therapeutic process.
3.2 body weight change before and after observation of curative effect treatment, weak, heating, cough, diarrhoea, poor appetite, breathe hard, the clinical symptoms such as spontaneous perspiration, erythra mucosa ulcer observed and recorded 1 time per month.CD4 before and after treatment +The T lymphocyte detects, and detects 1 time in every 3 months.Virus load detects, and detects every half a year 1 time.
3.3 curative effect determinate standard
Produce effects: clinical symptoms is obviously improved, lab testing CD4 +Cell quantity raises more than 100/μ L.Effectively: clinical symptoms take a favorable turn, or CD4 +50/μ of cell quantity rising L.Invalid: clinical symptoms and lab testing are all without obviously improving.
4, therapeutic outcome
4.1 safety observed result
4.1.1 treat 1 year safety observed result
In treatment group 59 examples, without 1 routine untoward reaction.
Obviously anemias of 2 examples are arranged in matched group 55 examples, have 5 examples dizzy, headache to occur, have that feeling sick appears in 10 examples, a vomiting, dyspepsia.
4.1.2 treat 2 years safety observed results
In treatment group 59 examples, without 1 routine untoward reaction.
Obviously anemias of 3 examples are arranged in matched group 55 examples, have 2 examples abnormal liver function to occur, have 10 examples dizzy, headache to occur, have that feeling sick appears in 20 examples, a vomiting, dyspepsia.
4.2 efficacy determination result
4.2.1 treat 1 year efficacy determination result
In treatment group 59 examples, produce effects 33 examples, effective 17 examples, no effect 9, total effective rate 84.7%.
In matched group 55 examples, produce effects 13 examples, effective 21 examples, invalid 21 examples, total effective rate 61.8%.
4.2.2 treat 2 years efficacy determination results
In treatment group 59 examples, produce effects 39 examples, effective 19 examples, invalid 1 example, total effective rate 98.3%.
In matched group 55 examples, produce effects 9 examples, effective 22 examples, invalid 24 examples, total effective rate 56.4%.
Clinical test results explanation antiretroviral therapy acquired immune deficiency syndrome (AIDS) has effect preferably, but after this type of medicine of life-time service, drug resistance increases, and the toxic and side effects of medicine is obvious.Antiretroviral therapy acquired immune deficiency syndrome (AIDS) and common Radix Apioris Fortunei (Radix Lespedezae Buergeri) therapeutic alliance even the antiviral therapy effect is apparent in view, have reached virus load decline, CD4 +Cell quantity is stable, improve that the patient is weak, heating, cough, diarrhoea, poor appetite, breathe hard, the purpose of the clinical symptoms such as spontaneous perspiration, erythra mucosa ulcer, but compare with the therapeutic alliance of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) with the antiretroviral therapy acquired immune deficiency syndrome (AIDS), obvious gap is arranged.Particularly reduce drug resistance and the toxic and side effects aspect of antiretroviral therapy HIV virus, it is more remarkable that lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) and the Radix Apioris Fortunei (Radix Lespedezae Buergeri) of common drying are compared effect.
The specific embodiment
Embodiment 1
Get lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber powder, add appropriate low-substituted hydroxypropyl cellulose, mixing, wet granulation, drying adds appropriate Pulvis Talci, mixing, tabletting gets tablet, and every contains dried SANYE Calomelas 0.4g.Be used for the treatment of HIV sufferers, each 5, every day 3 times.
Embodiment 2
Get lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) herb 3kg, flooded 7 days with alcohol at normal temperature, reclaim ethanol, drying is pulverized, and gets the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract.Add carboxymethyl starch sodium, starch appropriate, gelatinized corn starch is granulated, and drying arranges, and adds Pulvis Talci appropriate, mixing, tabletting.For 30 routine HIV sufferers, took 6 months.
Embodiment 3
Get lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber 15kg, pulverize, cross 80 mesh sieves, add arabic gum 0.5kg, sorbic acid 3g adds water to 100kg, gets the Radix Apioris Fortunei (Radix Lespedezae Buergeri) suspensoid.Oral, each 20ml, every day 3 times.Be used for the treatment of HIV sufferers.
Embodiment 4
Get lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber 3kg, pulverize, flooded 7 days with alcohol at normal temperature, reclaim ethanol, drying is pulverized, and gets the Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract.Add carboxymethyl starch sodium, starch appropriate, gelatinized corn starch is granulated, and drying arranges, and adds Pulvis Talci appropriate, mixing, the Capsules of packing into.Be used for 15 routine HIV sufferers, took effective percentage 93.8% 1 year.
Embodiment 5
Get lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber 3kg, use ethanol percolation, percolate reclaims ethanol, and drying with the abundant mixing of appropriate dextrin, is granulated, and drying gets 600 bags of granules.
Embodiment 6
Get lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) herb 3kg, use ethanol percolation, percolate reclaims ethanol, adds 3kg lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber powder, and drying with the abundant mixing of appropriate dextrin, is granulated, and drying gets 1200 bags of granules.
Embodiment 7
Get lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) herb 5kg, pulverize, flooded 7 days with alcohol at normal temperature, reclaim ethanol, drying is pulverized, and gets lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract.
Get Herba Andrographis 15kg, Spica Prunellae 10k, Herba Violae, each 3kg of the Radix Pulsatillae; With water extraction 2 times, add for the first time 8 times of water gagings, extracted 1.5 hours, add for the second time 6 times of water gagings and extracted 1 hour, merge extractive liquid, filters, when being concentrated into relative density and being 1.10 (60 ℃), add ethanol to make to contain the alcohol amount to reach 50%, precipitation, standing 12 hours, draw supernatant, reclaim ethanol, concentrated, drying is pulverized, and powder gets dry extract;
With lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract and dried cream powder and the abundant mixing of 0.3kg dextrin, wet granulation, drying gets granule.
Embodiment 8
Get lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) herb 5kg, pulverize, flooded 7 days with alcohol at normal temperature, reclaim ethanol, drying is pulverized, and gets lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract.
Get Herba Andrographis 15kg, Radix Isatidis 10k, Herba Houttuyniae, each 3kg of the Radix Pulsatillae, Rhizoma Polygoni Cuspidati, each 2kg of Flos Lonicerae; With water extraction 2 times, add for the first time 8 times of water gagings, extracted 1.5 hours, add for the second time 6 times of water gagings and extracted 1 hour, merge extractive liquid, filters, when being concentrated into relative density and being 1.10 (60 ℃), add ethanol to make to contain the alcohol amount to reach 50%, precipitation, standing 12 hours, draw supernatant, reclaim ethanol, concentrated, drying is pulverized, and powder gets dry extract;
With lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) extract and dried cream powder and the abundant mixing of 0.3kg dextrin, wet granulation, drying gets granule.

Claims (9)

1. the medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS), is characterized in that prepared medicine contains the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri).
2. according to claim 1 the medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS), is characterized in that prepared medicine is by single flavor lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation.
3. according to claim 1 or the medicine of the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) of claim 2 preparation treatment acquired immune deficiency syndrome (AIDS), it is characterized in that patient's taking dose of a day contains lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) 1-300g.
4. according to claim 1 or the medicine of the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) of claim 2 or claim 3 preparation treatment acquired immune deficiency syndrome (AIDS), it is characterized in that making with lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) herb or tuber.
5. according to claim 4 the medicine of lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) preparation treatment acquired immune deficiency syndrome (AIDS) is characterized in that lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber comprises the following steps:
1) fresh Radix Apioris Fortunei (Radix Lespedezae Buergeri) tuber raw material is removed impurity, cleans, and cuts sheet;
2) sabot, sabot weight are 5-8kg/m 2, thickness 2-3cm lowered the temperature 2~3 hours gradually, to-20 ℃--and 60 ℃ are carried out pre-freeze;
3) being evacuated to system's absolute pressure is 40~60Pa, begins to be heated to 30 ℃~60 ℃, sublimation drying 15~24 hours;
4) keep temperature of charge at 35 ℃~65 ℃, make water content reach 2~3% rear dischargings.
6. according to claim 1 or the medicine of the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) of claim 2 or claim 3 or claim 4 preparation treatment acquired immune deficiency syndrome (AIDS), it is characterized in that the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) is directly pulverized makes powder.
7. according to claim 1 or the medicine of the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) of claim 2 or claim 3 or claim 4 preparation treatment acquired immune deficiency syndrome (AIDS), it is characterized in that adopting method of Chinese medicinal to be prepared into any pharmaceutically useful preparation the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri).
8. according to claim 1 or the medicine of the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) of claim 2 or claim 3 or claim 4 or claim 7 preparation treatment acquired immune deficiency syndrome (AIDS), it is characterized in that the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) is passed through to extract, extract adds adjuvant to make tablet, capsule, granule, pill, spray etc.
9. according to claim 7 or the medicine of the lyophilizing Radix Apioris Fortunei (Radix Lespedezae Buergeri) of claim 8 preparation treatment acquired immune deficiency syndrome (AIDS), it is characterized in that extracting is that low temperature, dipping, percolation extract.
CN2013100589295A 2013-02-25 2013-02-25 Lyophilized hemsley rockvine root tuber used for treating AIDS Pending CN103127313A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103749812A (en) * 2013-12-24 2014-04-30 福建农林大学 Processing method for radix tetrastigme tea
CN104154709A (en) * 2014-08-25 2014-11-19 济南康众医药科技开发有限公司 Drying method for radix tetrastigme
CN108653598A (en) * 2018-06-11 2018-10-16 陈华 A kind of Radix Rhodiolae health care of the anti-Chinese mugwort of anti-Chinese mugwort purifies the blood medicinal herb tea and preparation method thereof

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103749812A (en) * 2013-12-24 2014-04-30 福建农林大学 Processing method for radix tetrastigme tea
CN103749812B (en) * 2013-12-24 2015-10-14 福建农林大学 A kind of processing method of radix tetrastigme tea
CN104154709A (en) * 2014-08-25 2014-11-19 济南康众医药科技开发有限公司 Drying method for radix tetrastigme
CN108653598A (en) * 2018-06-11 2018-10-16 陈华 A kind of Radix Rhodiolae health care of the anti-Chinese mugwort of anti-Chinese mugwort purifies the blood medicinal herb tea and preparation method thereof

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Application publication date: 20130605