CN1926237A - 用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白 - Google Patents

用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白 Download PDF

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Publication number
CN1926237A
CN1926237A CNA2005800062581A CN200580006258A CN1926237A CN 1926237 A CN1926237 A CN 1926237A CN A2005800062581 A CNA2005800062581 A CN A2005800062581A CN 200580006258 A CN200580006258 A CN 200580006258A CN 1926237 A CN1926237 A CN 1926237A
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China
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fsh
fusion rotein
subunit
fragment
amino acid
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CNA2005800062581A
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Chinese (zh)
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苏珊·C·洛
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Bioverativ Therapeutics Inc
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Syntonix Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA2005800062581A 2004-01-28 2005-01-27 用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白 Pending CN1926237A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54023604P 2004-01-28 2004-01-28
US60/540,236 2004-01-28

Publications (1)

Publication Number Publication Date
CN1926237A true CN1926237A (zh) 2007-03-07

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CNA2005800062581A Pending CN1926237A (zh) 2004-01-28 2005-01-27 用于治疗不育症的异二聚体促卵泡激素－Fc(FSH－Fc)融合蛋白

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Country Link
US (2) US7601516B2 (cg-RX-API-DMAC7.html)
EP (1) EP1711610A2 (cg-RX-API-DMAC7.html)
JP (1) JP2008504012A (cg-RX-API-DMAC7.html)
CN (1) CN1926237A (cg-RX-API-DMAC7.html)
AU (1) AU2005207960A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0507174A (cg-RX-API-DMAC7.html)
CA (1) CA2553187A1 (cg-RX-API-DMAC7.html)
IL (2) IL177049A (cg-RX-API-DMAC7.html)
NO (1) NO20063807L (cg-RX-API-DMAC7.html)
WO (1) WO2005073383A2 (cg-RX-API-DMAC7.html)

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CN101909642B (zh) * 2007-11-30 2013-04-17 阿斯彭生物制药有限公司 重组型马科动物促卵泡激素的活性
CN103509121A (zh) * 2012-11-22 2014-01-15 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
CN103930134A (zh) * 2011-07-18 2014-07-16 阿茨生物股份有限公司 长效促黄体激素(lh)化合物
CN104524553A (zh) * 2014-12-12 2015-04-22 薛传校 一种长效促排卵注射液
CN105567733A (zh) * 2016-01-11 2016-05-11 佛山安普泽生物医药股份有限公司 CHO细胞表达凝血酶-Fc融合蛋白的方法
CN107082815A (zh) * 2017-06-28 2017-08-22 杭州皓阳生物技术有限公司 一种fsh‑hsa融合蛋白及其制备方法
CN107540748A (zh) * 2017-09-15 2018-01-05 北京伟杰信生物科技有限公司 长效重组猪fsh融合蛋白及其制备方法与应用
CN107969127A (zh) * 2015-09-08 2018-04-27 赛瑞品股份有限公司 Apoa-1融合多肽及相关组合物和方法
CN110305903A (zh) * 2019-07-31 2019-10-08 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113599503A (zh) * 2021-07-28 2021-11-05 安徽中起生物科技有限公司 一种调节卵巢功能的生物制剂及其制备方法和应用
CN115947860A (zh) * 2022-07-06 2023-04-11 华兰基因工程有限公司 一种重组人促卵泡生成素Fc融合蛋白及制备方法
CN115975043A (zh) * 2021-09-30 2023-04-18 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN116768979A (zh) * 2022-07-06 2023-09-19 华兰基因工程有限公司 一种重组人促卵泡生成素CTP-Fc融合蛋白及制备方法

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US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
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WO2005059517A2 (en) * 2003-12-16 2005-06-30 University Of Massachusetts Toll-like receptor assays
US7601516B2 (en) 2004-01-28 2009-10-13 Syntomix Pharmaceuticals, Inc. Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
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EP4086338A1 (en) 2011-03-17 2022-11-09 Minerva Biotechnologies Corporation Method for making pluripotent stem cells
CA2835453A1 (en) * 2011-05-09 2012-11-15 Minerva Biotechnologies Corporation Genetically engineered growth factor variants
KR101967345B1 (ko) * 2012-10-18 2019-04-09 삼성전자주식회사 안지오포이에틴-2와 인테그린 간의 결합을 저해하는 펩타이드 및 그 용도
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CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
EA201691027A1 (ru) 2013-11-20 2016-12-30 Ридженерон Фармасьютикалз, Инк. Модуляторы aplnr и их применение
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CN106046176B (zh) 2016-08-16 2019-09-10 中国药科大学 一种高活性长效降糖融合蛋白及其制备方法与医药用途
CN120569412A (zh) * 2023-12-28 2025-08-29 江苏众红生物工程创药研究院有限公司 新型长效人fsh与lh融合蛋白及其制备方法与应用

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101909642B (zh) * 2007-11-30 2013-04-17 阿斯彭生物制药有限公司 重组型马科动物促卵泡激素的活性
CN103930134A (zh) * 2011-07-18 2014-07-16 阿茨生物股份有限公司 长效促黄体激素(lh)化合物
CN103930134B (zh) * 2011-07-18 2016-12-21 阿茨生物股份有限公司 长效促黄体激素(lh)化合物
CN103509121A (zh) * 2012-11-22 2014-01-15 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
WO2014079384A1 (zh) * 2012-11-22 2014-05-30 苏州康宁杰瑞生物科技有限公司 促激素融合蛋白及其制备方法和用途
CN103509121B (zh) * 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
US9969786B2 (en) 2012-11-22 2018-05-15 Suzhou Alphamab Co, Ltd. Trophic hormone fusion protein, preparation method and application thereof
CN104524553A (zh) * 2014-12-12 2015-04-22 薛传校 一种长效促排卵注射液
WO2016090701A1 (zh) * 2014-12-12 2016-06-16 薛传校 一种长效促排卵注射液
CN107969127A (zh) * 2015-09-08 2018-04-27 赛瑞品股份有限公司 Apoa-1融合多肽及相关组合物和方法
CN107969127B (zh) * 2015-09-08 2022-09-06 赛瑞品股份有限公司 Apoa-1融合多肽及相关组合物和方法
CN105567733A (zh) * 2016-01-11 2016-05-11 佛山安普泽生物医药股份有限公司 CHO细胞表达凝血酶-Fc融合蛋白的方法
CN105567733B (zh) * 2016-01-11 2019-04-23 佛山安普泽生物医药股份有限公司 CHO细胞表达凝血酶-Fc融合蛋白的方法
CN107082815A (zh) * 2017-06-28 2017-08-22 杭州皓阳生物技术有限公司 一种fsh‑hsa融合蛋白及其制备方法
CN107540748A (zh) * 2017-09-15 2018-01-05 北京伟杰信生物科技有限公司 长效重组猪fsh融合蛋白及其制备方法与应用
CN110305903A (zh) * 2019-07-31 2019-10-08 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113599503A (zh) * 2021-07-28 2021-11-05 安徽中起生物科技有限公司 一种调节卵巢功能的生物制剂及其制备方法和应用
CN115975043A (zh) * 2021-09-30 2023-04-18 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN115975043B (zh) * 2021-09-30 2024-07-12 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN118562018A (zh) * 2021-09-30 2024-08-30 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN115947860A (zh) * 2022-07-06 2023-04-11 华兰基因工程有限公司 一种重组人促卵泡生成素Fc融合蛋白及制备方法
CN116768979A (zh) * 2022-07-06 2023-09-19 华兰基因工程有限公司 一种重组人促卵泡生成素CTP-Fc融合蛋白及制备方法

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Publication number Publication date
NO20063807L (no) 2006-10-25
AU2005207960A1 (en) 2005-08-11
WO2005073383A2 (en) 2005-08-11
IL177049A (en) 2010-11-30
US8293707B2 (en) 2012-10-23
WO2005073383A3 (en) 2005-11-24
CA2553187A1 (en) 2005-08-11
US7601516B2 (en) 2009-10-13
US20050186662A1 (en) 2005-08-25
BRPI0507174A (pt) 2008-04-01
US20100291079A1 (en) 2010-11-18
JP2008504012A (ja) 2008-02-14
IL206518A0 (en) 2010-12-30
EP1711610A2 (en) 2006-10-18
IL177049A0 (en) 2006-12-10

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