IL177049A - HETERODIMERIC FOLLICLE STIMULATING HORMONE - Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY - Google Patents

HETERODIMERIC FOLLICLE STIMULATING HORMONE - Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY

Info

Publication number
IL177049A
IL177049A IL177049A IL17704906A IL177049A IL 177049 A IL177049 A IL 177049A IL 177049 A IL177049 A IL 177049A IL 17704906 A IL17704906 A IL 17704906A IL 177049 A IL177049 A IL 177049A
Authority
IL
Israel
Prior art keywords
fsh
heterodimeric
infertility
treatment
fusion proteins
Prior art date
Application number
IL177049A
Other languages
English (en)
Other versions
IL177049A0 (en
Original Assignee
Syntonix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntonix Pharmaceuticals Inc filed Critical Syntonix Pharmaceuticals Inc
Publication of IL177049A0 publication Critical patent/IL177049A0/en
Publication of IL177049A publication Critical patent/IL177049A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL177049A 2004-01-28 2006-07-24 HETERODIMERIC FOLLICLE STIMULATING HORMONE - Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY IL177049A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54023604P 2004-01-28 2004-01-28
PCT/US2005/003034 WO2005073383A2 (en) 2004-01-28 2005-01-27 HETERODIMERIC FOLLICLE STIMULATING HORMONE-Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY

Publications (2)

Publication Number Publication Date
IL177049A0 IL177049A0 (en) 2006-12-10
IL177049A true IL177049A (en) 2010-11-30

Family

ID=34826205

Family Applications (2)

Application Number Title Priority Date Filing Date
IL177049A IL177049A (en) 2004-01-28 2006-07-24 HETERODIMERIC FOLLICLE STIMULATING HORMONE - Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY
IL206518A IL206518A0 (en) 2004-01-28 2010-06-21 HETERODIMERIC FOLLICLE STIMULATING HORMONE - Fc (FSH-Fc) FUSION PROTEINS

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL206518A IL206518A0 (en) 2004-01-28 2010-06-21 HETERODIMERIC FOLLICLE STIMULATING HORMONE - Fc (FSH-Fc) FUSION PROTEINS

Country Status (10)

Country Link
US (2) US7601516B2 (cg-RX-API-DMAC7.html)
EP (1) EP1711610A2 (cg-RX-API-DMAC7.html)
JP (1) JP2008504012A (cg-RX-API-DMAC7.html)
CN (1) CN1926237A (cg-RX-API-DMAC7.html)
AU (1) AU2005207960A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0507174A (cg-RX-API-DMAC7.html)
CA (1) CA2553187A1 (cg-RX-API-DMAC7.html)
IL (2) IL177049A (cg-RX-API-DMAC7.html)
NO (1) NO20063807L (cg-RX-API-DMAC7.html)
WO (1) WO2005073383A2 (cg-RX-API-DMAC7.html)

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US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US8110665B2 (en) 2003-11-13 2012-02-07 Hanmi Holdings Co., Ltd. Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
EP1682584B1 (en) 2003-11-13 2013-04-17 Hanmi Science Co., Ltd. A pharmaceutical composition comprising an immunoglobulin fc region as a carrier
WO2005059517A2 (en) * 2003-12-16 2005-06-30 University Of Massachusetts Toll-like receptor assays
US7601516B2 (en) 2004-01-28 2009-10-13 Syntomix Pharmaceuticals, Inc. Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
GB0510627D0 (en) 2005-05-25 2005-06-29 Avidex Ltd Polypeptides
US20090238822A1 (en) * 2005-10-13 2009-09-24 Virexx Medical Corp. Chimeric Hepatitis C Virus Antigens For Eliciting an Immune Response
ES2437581T3 (es) 2005-11-17 2014-01-13 Zogenix, Inc. Suministro de formulaciones viscosas por inyección sin aguja
EP1801121A1 (en) * 2005-12-23 2007-06-27 CONARIS research institute AG Soluble gp130 molecule variants useful as a medicament
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
BRPI0821097A2 (pt) * 2007-11-30 2017-05-23 Aspenbio Pharma Inc aitividade de hormônio equino folículo estimulante recombinante
WO2009080764A2 (en) * 2007-12-20 2009-07-02 Abylnx N.V. Oral or nasal administration of compounds comprising amino acid sequences
AR081755A1 (es) * 2010-04-02 2012-10-17 Hanmi Holdings Co Ltd Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
FR2958936A1 (fr) * 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
EP4086338A1 (en) 2011-03-17 2022-11-09 Minerva Biotechnologies Corporation Method for making pluripotent stem cells
CA2835453A1 (en) * 2011-05-09 2012-11-15 Minerva Biotechnologies Corporation Genetically engineered growth factor variants
CA2842323A1 (en) * 2011-07-18 2013-01-24 Arts Biologics A/S Long acting biologically active luteinizing hormone (lh) compound
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CN103509121B (zh) * 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
AU2014236451B2 (en) * 2013-03-14 2018-08-09 Regeneron Pharmaceuticals, Inc. Apelin fusion proteins and uses thereof
CN103539862B (zh) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 一种长效重组促卵泡激素及其应用
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
EA201691027A1 (ru) 2013-11-20 2016-12-30 Ридженерон Фармасьютикалз, Инк. Модуляторы aplnr и их применение
CN104524553B (zh) * 2014-12-12 2015-07-29 薛传校 一种长效促排卵注射液
EP3260139A4 (en) * 2015-02-17 2018-09-05 Hanmi Pharm. Co., Ltd. Long-acting insulin or insulin analogue complex
EP3328881B1 (en) * 2015-09-08 2019-08-28 Theripion, Inc. Apoa-1 fusion polypeptides and related compositions and methods
CN105567733B (zh) * 2016-01-11 2019-04-23 佛山安普泽生物医药股份有限公司 CHO细胞表达凝血酶-Fc融合蛋白的方法
CN106046176B (zh) 2016-08-16 2019-09-10 中国药科大学 一种高活性长效降糖融合蛋白及其制备方法与医药用途
CN107082815A (zh) * 2017-06-28 2017-08-22 杭州皓阳生物技术有限公司 一种fsh‑hsa融合蛋白及其制备方法
CN107540748B (zh) * 2017-09-15 2020-07-14 北京伟杰信生物科技有限公司 长效重组猪fsh融合蛋白及其制备方法与应用
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113599503A (zh) * 2021-07-28 2021-11-05 安徽中起生物科技有限公司 一种调节卵巢功能的生物制剂及其制备方法和应用
CN118562018B (zh) * 2021-09-30 2024-12-13 宁波三生生物科技股份有限公司 重组促卵泡激素融合蛋白
CN116768979B (zh) * 2022-07-06 2025-04-29 华兰基因工程有限公司 一种重组人促卵泡生成素CTP-Fc融合蛋白及制备方法
CN115947860B (zh) * 2022-07-06 2025-04-25 华兰基因工程有限公司 一种重组人促卵泡生成素Fc融合蛋白及制备方法
CN120569412A (zh) * 2023-12-28 2025-08-29 江苏众红生物工程创药研究院有限公司 新型长效人fsh与lh融合蛋白及其制备方法与应用

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Also Published As

Publication number Publication date
NO20063807L (no) 2006-10-25
AU2005207960A1 (en) 2005-08-11
CN1926237A (zh) 2007-03-07
WO2005073383A2 (en) 2005-08-11
US8293707B2 (en) 2012-10-23
WO2005073383A3 (en) 2005-11-24
CA2553187A1 (en) 2005-08-11
US7601516B2 (en) 2009-10-13
US20050186662A1 (en) 2005-08-25
BRPI0507174A (pt) 2008-04-01
US20100291079A1 (en) 2010-11-18
JP2008504012A (ja) 2008-02-14
IL206518A0 (en) 2010-12-30
EP1711610A2 (en) 2006-10-18
IL177049A0 (en) 2006-12-10

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Legal Events

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FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees